公开(公告)号：US20050037467A1

公开(公告)日：2005-02-17

申请号：US10936773

申请日：2004-09-09

申请人： Steven Ruben ,  Ping Feng ,  David LaFleur ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Yi Li ,  ZhiZhen Zeng ,  Kenneth Carter ,  Gregory Endress ,  Ying-Fei Wei ,  Ping Fan ,  Craig Rosen

发明人： Steven Ruben ,  Ping Feng ,  David LaFleur ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Yi Li ,  ZhiZhen Zeng ,  Kenneth Carter ,  Gregory Endress ,  Ying-Fei Wei ,  Ping Fan ,  Craig Rosen

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N5/02 ,  C07H21/04

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20060223077A1

公开(公告)日：2006-10-05

申请号：US11229770

申请日：2005-09-20

申请人： Jian Ni ,  Reinhard Ebner ,  David LaFleur ,  Paul Moore ,  Henrik Olsen ,  Craig Rosen ,  Steven Ruben ,  Daniel Soppet ,  Paul Young ,  Yanggu Shi ,  Kimberly Florence ,  Ying-Fei Wei ,  Charles Florence ,  Jing-Shan Hu ,  Yi Li ,  Hla Kyaw ,  Carrie Fischer ,  Ann Ferrie ,  Ping Fan ,  Ping Feng ,  Gregory Endress ,  Patrick Dillon ,  Kenneth Carter ,  Laurie Brewer ,  Guo-Liang Yu ,  Zhizhen Zeng ,  John Greene

发明人： Jian Ni ,  Reinhard Ebner ,  David LaFleur ,  Paul Moore ,  Henrik Olsen ,  Craig Rosen ,  Steven Ruben ,  Daniel Soppet ,  Paul Young ,  Yanggu Shi ,  Kimberly Florence ,  Ying-Fei Wei ,  Charles Florence ,  Jing-Shan Hu ,  Yi Li ,  Hla Kyaw ,  Carrie Fischer ,  Ann Ferrie ,  Ping Fan ,  Ping Feng ,  Gregory Endress ,  Patrick Dillon ,  Kenneth Carter ,  Laurie Brewer ,  Guo-Liang Yu ,  Zhizhen Zeng ,  John Greene

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/00 ,  C07K14/47

CPC分类号： C07K14/47 ,  A61K48/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：US20060084082A1

公开(公告)日：2006-04-20

申请号：US11144947

申请日：2005-06-06

申请人： Steven Ruben ,  Craig Rosen ,  Daniel Soppet ,  Kenneth Carter ,  Daniel Bednarik ,  Gregory Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul Young ,  John Greene ,  Ann Ferrie ,  D. Duan ,  Jing-Shan Hu ,  Kimberly Florence ,  Henrik Olsen ,  Carrie Fischer ,  Reinhard Ebner ,  Laurie Brewer ,  Paul Moore ,  Yanggu Shi ,  David LaFleur ,  Yi Li ,  ZhiZhen Zeng ,  Hla Kyaw

发明人： Steven Ruben ,  Craig Rosen ,  Daniel Soppet ,  Kenneth Carter ,  Daniel Bednarik ,  Gregory Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul Young ,  John Greene ,  Ann Ferrie ,  D. Duan ,  Jing-Shan Hu ,  Kimberly Florence ,  Henrik Olsen ,  Carrie Fischer ,  Reinhard Ebner ,  Laurie Brewer ,  Paul Moore ,  Yanggu Shi ,  David LaFleur ,  Yi Li ,  ZhiZhen Zeng ,  Hla Kyaw

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K14/47 ,  G01N33/566 ,  G01N2800/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：US20070172830A1

公开(公告)日：2007-07-26

申请号：US10849979

申请日：2004-05-21

申请人： Steven Ruben ,  Kimberly Florence ,  Jian Ni ,  Craig Rosen ,  Kenneth Carter ,  Paul Moore ,  Henrik Olsen ,  Yanggu Shi ,  Paul Young ,  Ying-Fei Wei ,  Laurie Brewer ,  Daniel Soppet ,  David LaFleur ,  Gregory Endress ,  Reinhard Ebner ,  Charles Birse

发明人： Steven Ruben ,  Kimberly Florence ,  Jian Ni ,  Craig Rosen ,  Kenneth Carter ,  Paul Moore ,  Henrik Olsen ,  Yanggu Shi ,  Paul Young ,  Ying-Fei Wei ,  Laurie Brewer ,  Daniel Soppet ,  David LaFleur ,  Gregory Endress ,  Reinhard Ebner ,  Charles Birse

IPC分类号： C12Q1/68 ,  A61K48/00 ,  A61K38/17 ,  C07K14/47 ,  C12P21/06

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20070020724A1

公开(公告)日：2007-01-25

申请号：US10886642

申请日：2004-07-09

申请人： Steven Ruben ,  Jian Ni ,  Craig Rosen ,  Ying-Fei Wei ,  Paul Young ,  Kimberly Florence ,  Daniel Soppet ,  Laurie Brewer ,  Gregory Endress ,  Kenneth Carter ,  Michael Mucenski ,  Reinhard Ebner ,  David LaFleur ,  Henrik Olsen ,  Yanggu Shi ,  Paul Moore ,  George Komatsoulis

发明人： Steven Ruben ,  Jian Ni ,  Craig Rosen ,  Ying-Fei Wei ,  Paul Young ,  Kimberly Florence ,  Daniel Soppet ,  Laurie Brewer ,  Gregory Endress ,  Kenneth Carter ,  Michael Mucenski ,  Reinhard Ebner ,  David LaFleur ,  Henrik Olsen ,  Yanggu Shi ,  Paul Moore ,  George Komatsoulis

IPC分类号： C07K14/47 ,  C07H21/04

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20080051338A1

公开(公告)日：2008-02-28

申请号：US11777133

申请日：2007-07-12

申请人： George Komatsoulis ,  Craig Rosen ,  Steven Ruben ,  Roxanne Duan ,  Paul Moore ,  Yanggu Shi ,  David LaFleur ,  Ying-Fei Wei ,  Jian Ni ,  Kimberly Florence ,  Paul Young ,  Laurie Brewer ,  Daniel Soppet ,  Gregory Endress ,  Reinhard Ebner ,  Henrik Olsen ,  Michael Mucenski

发明人： George Komatsoulis ,  Craig Rosen ,  Steven Ruben ,  Roxanne Duan ,  Paul Moore ,  Yanggu Shi ,  David LaFleur ,  Ying-Fei Wei ,  Jian Ni ,  Kimberly Florence ,  Paul Young ,  Laurie Brewer ,  Daniel Soppet ,  Gregory Endress ,  Reinhard Ebner ,  Henrik Olsen ,  Michael Mucenski

IPC分类号： A61K31/70 ,  A61K38/00 ,  C07K14/00 ,  C07K16/18 ,  C12N15/00 ,  C12N15/11 ,  C12N15/87 ,  C12N5/06 ,  C12P21/04 ,  C12Q1/68 ,  G01N33/53

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20060079670A1

公开(公告)日：2006-04-13

申请号：US11229769

申请日：2005-09-20

申请人： George Komatsoulis ,  Craig Rosen ,  Steven Ruben ,  Roxanne Duan ,  Paul Moore ,  Yanggu Shi ,  David LaFleur ,  Ying-Fei Wei ,  Jian Ni ,  Kimberly Florence ,  Paul Young ,  Laurie Brewer ,  Daniel Soppet ,  Gregory Endress ,  Reinhard Ebner ,  Henrik Olsen ,  Michael Mucenski

发明人： George Komatsoulis ,  Craig Rosen ,  Steven Ruben ,  Roxanne Duan ,  Paul Moore ,  Yanggu Shi ,  David LaFleur ,  Ying-Fei Wei ,  Jian Ni ,  Kimberly Florence ,  Paul Young ,  Laurie Brewer ,  Daniel Soppet ,  Gregory Endress ,  Reinhard Ebner ,  Henrik Olsen ,  Michael Mucenski

IPC分类号： C07K14/47 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20050069943A1

公开(公告)日：2005-03-31

申请号：US10979183

申请日：2004-11-03

申请人： Roxanne Duan ,  Steven Ruben ,  Kimberly Florence ,  John Greene ,  Craig Rosen ,  Paul Young ,  Ann Ferrie ,  Guo-Liang Yu ,  Fouad Janat ,  Jian Ni ,  Kenneth Carter ,  Gregory Endress ,  Ping Feng ,  David LaFleur ,  Yanggu Shi

发明人： Roxanne Duan ,  Steven Ruben ,  Kimberly Florence ,  John Greene ,  Craig Rosen ,  Paul Young ,  Ann Ferrie ,  Guo-Liang Yu ,  Fouad Janat ,  Jian Ni ,  Kenneth Carter ,  Gregory Endress ,  Ping Feng ,  David LaFleur ,  Yanggu Shi

IPC分类号： G01N33/53 ,  A61K31/711 ,  A61K38/00 ,  A61K48/00 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07K14/47 ,  C07K16/00 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/566 ,  G01N33/68 ,  C07H21/04 ,  C12N9/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  G01N33/6893

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US20050095612A1

公开(公告)日：2005-05-05

申请号：US10866831

申请日：2004-06-15

申请人： Steven Ruben ,  Paul Young ,  Laurie Brewer ,  Reinhard Ebner ,  Henrik Olsen ,  Kimberly Florence ,  Craig Rosen ,  Roxanne Duan ,  Paul Moore ,  Yanggu Shi ,  David LaFleur ,  Charles Florence ,  Daniel Soppet ,  Gregory Endress ,  Ping Feng ,  George Komatsoulis

发明人： Steven Ruben ,  Paul Young ,  Laurie Brewer ,  Reinhard Ebner ,  Henrik Olsen ,  Kimberly Florence ,  Craig Rosen ,  Roxanne Duan ,  Paul Moore ,  Yanggu Shi ,  David LaFleur ,  Charles Florence ,  Daniel Soppet ,  Gregory Endress ,  Ping Feng ,  George Komatsoulis

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61P43/00 ,  C07K14/47 ,  C07K16/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/68 ,  C07H21/04 ,  C12N9/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  G01N33/6893 ,  G01N2500/20

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US20070238664A1

公开(公告)日：2007-10-11

申请号：US11751886

申请日：2007-05-22

申请人： Steven Ruben ,  Craig Rosen ,  Carrie Fischer ,  Daniel Soppet ,  Kenneth Carter ,  Daniel Bednarik ,  Gregory Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul Young ,  John Greene ,  Ann Ferrie ,  Roxanne Duan ,  Jing-Shan Hu ,  Kimberly Florence ,  Henrik Olsen ,  Reinhard Ebner ,  Laurie Brewer ,  Yanggu Shi

发明人： Steven Ruben ,  Craig Rosen ,  Carrie Fischer ,  Daniel Soppet ,  Kenneth Carter ,  Daniel Bednarik ,  Gregory Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul Young ,  John Greene ,  Ann Ferrie ,  Roxanne Duan ,  Jing-Shan Hu ,  Kimberly Florence ,  Henrik Olsen ,  Reinhard Ebner ,  Laurie Brewer ,  Yanggu Shi

IPC分类号： C07K14/47 ,  A61K38/00 ,  C07H21/04 ,  C12N15/63 ,  G01N33/53 ,  G01N33/48 ,  C07K16/00 ,  C07K1/00

CPC分类号： C07K14/47 ,  Y10T436/143333

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。