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58 条记录 (耗时 0.09 秒)

    GLYCOPEGYLATED FACTOR IX
    51.
    发明申请
    GLYCOPEGYLATED FACTOR IX 审中-公开
    糖蛋白因子九

    公开(公告)号：US20090081188A1

    公开(公告)日：2009-03-26

    申请号：US12184956

    申请日：2008-08-01

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe ,  Krishnasamy Panneerselvam

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe ,  Krishnasamy Panneerselvam

    IPC分类号： A61K38/48 ,  C12N9/96 ,  C12P21/04 ,  A61P7/00

    CPC分类号： A61K38/4846 ,  A61K47/549 ,  A61K47/60 ,  Y02A50/471

    摘要： The present invention provides conjugates between Factor IX and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    摘要翻译： 本发明提供因子IX和PEG部分之间的缀合物。 缀合物通过插入和共价连接到肽和修饰基团之间的完整糖基连接基团连接。 通过糖基转移酶的作用，由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。

    Activated forms of water-soluble polymers
    54.
    发明申请
    Activated forms of water-soluble polymers 审中-公开
    活性形式的水溶性聚合物

    公开(公告)号：US20060276618A1

    公开(公告)日：2006-12-07

    申请号：US10549520

    申请日：2004-03-18

    申请人： Shawn DeFrees ,  David Zopf ,  Caryn Bowe

    发明人： Shawn DeFrees ,  David Zopf ,  Caryn Bowe

    IPC分类号： C08G65/34

    CPC分类号： C08G65/333 ,  C08G65/337

    摘要： The present invention provides compositions of activated water-soluble polymers for preparing water-soluble polymer-modified peptides. Exemplary compounds of the invention include water-soluble polymers covalently attached to activated leaving groups wherein the water-soluble polymer is a member selected from PEG, PPG, PEG derivatives, and PPG derivatives, and the activated leaving group is a member selected from (formula I).

    摘要翻译： 本发明提供了用于制备水溶性聚合物改性肽的活性水溶性聚合物的组合物。 本发明的示例性化合物包括共价连接到活化离去基团的水溶性聚合物，其中水溶性聚合物是选自PEG，PPG，PEG衍生物和PPG衍生物的成员，活化的离去基团是选自（式 一世）。

    Glycopegylated factor IX
    56.
    发明申请
    Glycopegylated factor IX 审中-公开
    糖基化因子IX

    公开(公告)号：US20060040856A1

    公开(公告)日：2006-02-23

    申请号：US11166028

    申请日：2005-06-23

    申请人： Shawn DeFrees ,  Robert Bayer ,  Caryn Bowe ,  Krishnasamy Panneerselvam

    发明人： Shawn DeFrees ,  Robert Bayer ,  Caryn Bowe ,  Krishnasamy Panneerselvam

    IPC分类号： A61K38/36

    CPC分类号： A61K38/4846 ,  A61K47/549 ,  A61K47/60 ,  Y02A50/471

    摘要： The present invention provides conjugates between Factor IX and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    摘要翻译： 本发明提供因子IX和PEG部分之间的缀合物。 缀合物通过插入和共价连接到肽和修饰基团之间的完整糖基连接基团连接。 通过糖基转移酶的作用，由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。