摘要:
The present invention provides a most suitable prodrug of a cinnamide compound. The prodrug is represented by Formula (I) wherein Ra and Rb each denote a C1-6 alkyl group or the like; Xa denotes a methoxy group or a fluorine atom; Y denotes a phosphono group or the like; and A denotes a cyclic lactam derivative.
摘要:
A crystal of 1-[1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)-ethyl]piperidin-4-yl]-N-methyl-1H-indole-6-carboxamide fumarate which has peaks at chemical shifts of about 124.0 ppm and about 26.8 ppm in a 13C solid NMR spectrum.
摘要:
The present invention relates to a compound represented by the following formula, a pharmacologically acceptable salt thereof, or a use thereof as a pharmaceutical: wherein R1 and R2 are substituents adjacent to each other, and together with two carbon atoms to each of which they attach, form a 5- to 7-membered non-aromatic carbocyclic group or the like, which may be substituted by 1 to 4 substituents selected from (1) an oxo group, (2) a hydroxyl group, and the like; R3 represents a hydrogen atom or the like; and R6 represents a hydrogen atom or the like. This compound has a superior strength of binding to a 5-HT1A receptor and an antagonism to the receptor, and is useful as an agent for treating or preventing lower urinary tract symptoms, and particularly symptoms regarding urinary storage.
摘要翻译:本发明涉及由下式表示的化合物,其药理学上可接受的盐或其作为药物的用途:其中R 1和R 2是相邻的取代基 并且与它们各自连接的两个碳原子一起形成5-至7-元非芳族碳环基等,其可以被1至4个选自以下的取代基取代:(1)氧代 基团,(2)羟基等; R 3表示氢原子等; R 6表示氢原子等。 该化合物与5-HT 1A受体的结合强度优异,对受体具有拮抗作用,可用作治疗或预防下尿路症状的药剂,特别是有关尿液储存的症状。
摘要:
A vacuum cleaner has a suction air inlet disposed in front of an electric blower and a dust chamber detachably installed to the rear of the electric blower. The vacuum cleaner further embodies a swivel caster and wheels for facilitating transportability thereof, wherein the swivel caster is provided in front of the electric blower. By not having the dust chamber above the swivel caster, regardless of the amount of dust accumulated in the dust chamber, the load that is distributed on the swivel caster stays substantially unchanged, thereby enhancing durability of the swivel caster. Furthermore, in such configuration loading and unloading of the dust chamber can be carried out without being interfered with a hose due to the placement of the suction air outlet connected with the hose and the dust chamber on opposite ends of the vacuum cleaner.
摘要:
An iris authentication apparatus includes an iris area extraction unit, registration pattern generating unit, collation pattern generating unit, and collation unit. The iris area extraction unit extracts iris areas from a sensed registration eyeball image and a sensed collation eyeball image. When the iris area extraction unit extracts an iris area from the registration eyeball image, the registration pattern generating unit generates a registration iris pattern image by performing polar coordinate transformation of an image in the extracted iris area. When the iris area extraction unit extracts an iris area from the collation eyeball image, the collation pattern generating unit generates a collation iris pattern image by performing polar coordinate transformation of an image in the extracted iris area. The collation unit collates the registration iris pattern image output from the registration pattern generating unit and the collation iris pattern image output from the collation pattern generating unit on the basis of a correlation therebetween.
摘要:
In this invention, wireless video telephone communication between mobile telephones MS1 and MS2 using the MPEG-2 standard is performed when the reception field strength falls below a threshold value of H continuously for a specific period of T3 or longer in the course of receiving the data at one mobile telephone MS2, the telephone MS2 monitors the restoration of the reception field strength. After detecting the restoration, mobile telephone MS2 transmits a request for the transmission of an I frame to mobile telephone MS1. Upon receipt of the request, mobile telephone MS1 creates an I frame in place of a P frame and transmits the I frame.
摘要:
A method for coating a porous polyurethane resin substrate with an aromatic isocyanate coating composition is provided comprising the steps of (i) providing a porous substrate of a polyurethane foam resin comprising at least one surface upon which the aromatic isocyanate coating composition is to be applied; (ii) applying at least one coating of a primary layer to the substrate surface, the primary layer comprising an aqueous solution of a compound that includes at least one —OH reactive group in its non-aqueous, dry state, and capable, upon drying, of forming a self-supporting, continuous film on the substrate surface at room temperature; (iii) optionally subjecting the applied primary layer to forced drying conditions at a temperature below the softening point of the porous polyurethane resin substrate; and (iv) after allowing the primary layer to substantially dry, applying a secondary layer comprising an aromatic isocyanate compound to the primary layer to form a continuous, film-forming coating on the substrate surface, preferably one having the property of being water-impermeable or water-impermeable and water vapor-permeable.
摘要:
The present invention provides a novel nitrile compound useful as an intermediate for the production of, for example, N,N-substituted cyclic amine derivatives or phenylacetonitrile derivatives that are useful as a medicine. Specifically it provides a nitrile carboxylic acid compound, nitrile ester compound and nitrile alcohol compound. That is, it provides a nitrile compound represented by the following formula (I): wherein R1 and R2 means substituents; m means 0 or an integer of from 1 to 6; n means 0 or an integer of from 1 to 5; and R3 means carboxyl group, a lower alkoxycarbonyl group or hydroxymethyl group.
摘要翻译:本发明提供了可用作制备例如可用作药物的N,N-取代的环胺衍生物或苯乙腈衍生物的中间体的新型腈化合物。 具体地说,它提供了一种腈羧酸化合物,腈酯化合物和腈醇化合物。 也就是说,它提供由下式(I)表示的腈化合物:其中R 1和R 2表示取代基; m表示0或1〜6的整数; n表示0或1至5的整数; R 3表示羧基,低级烷氧基羰基或羟甲基。
摘要:
An adhesive resin composition comprising: (A) At least one component selected from the group consisting of (i) polyolefins having a melt flow rate of 0.1 to 30 g/10 min and (ii) olefinic polymers having at least one functional group capable of reacting with an epoxy group; and (B) an epoxy compound having at least two epoxy groups in the molecule and having a number average molecular weight of 3000 or less, wherein the ratio of the component (B) to the total weight of the components (A) and (B) is 0.01 to 5% by weight, and a laminate of (a) a layer composed of the above-mentioned adhesive resin composition and a substrate contacted therewith.
摘要:
An air-conditioning system alternately produces a cooled air stratum and a heated air stratum as viewed from an air outlet opening, and the guide length a1 of a first guide wall is set from 0.05 time or more to 0.5 times or less than the length L1. The guide length a2 of a second guide wall is set from 0.05 time or more to 0.5 times or less than the length L2. Consequently if the air mixing chamber has a small capacity (the length parallel to the direction of air flow), it is possible to mix the heated air and the cooled air sufficiently.