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公开(公告)号：US5470534A
公开(公告)日：1995-11-28
申请号：US236134
申请日：1994-05-02
申请人： Kyoko Imai , Kazumichi Imai , Yasushi Nomura
发明人： Kyoko Imai , Kazumichi Imai , Yasushi Nomura
IPC分类号： C12Q1/68 , G01N33/543 , G01N35/00 , G01N35/02
CPC分类号： G01N35/0092 , G01N35/00603 , G01N35/025 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/115831 , Y10T436/12
摘要： In a first measurement stage, reaction solutions of samples are optically measured by a biochemical analyzer, and the measurement result of the analysis item which is an index of the disease status regarding the samples is compared with the check index. This check index is stored in memory beforehand. When the measurement result corresponds to the check index, the sample processing goes to a second measurement stage for measuring a specific item. In the second measurement stage, the sample is measured by an immuno-assay apparatus or a nucleic acid analyzer, and the measurement result is outputted.
摘要翻译： 在第一测量阶段，通过生物化学分析仪对样品的反应溶液进行光学测量，并将作为样品疾病状态指标的分析项目的测定结果与检查指数进行比较。 此检查索引预先存储在内存中。 当测量结果对应于检查指数时，样本处理进入用于测量特定项目的第二测量阶段。 在第二测定阶段，通过免疫分析装置或核酸分析仪测定样品，输出测定结果。
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公开(公告)号：US4939098A
公开(公告)日：1990-07-03
申请号：US868439
申请日：1986-05-30
申请人： Masumi Suzuki , Kyoko Makiguchi , Yasushi Nomura
发明人： Masumi Suzuki , Kyoko Makiguchi , Yasushi Nomura
IPC分类号： G01N33/543 , A61K39/00 , C12Q1/00 , G01N33/53 , G01N33/532 , G01N33/544 , G01N33/561
CPC分类号： G01N33/532 , G01N33/53 , G01N33/561 , Y10S435/973 , Y10S436/829
摘要： A kit for simultaneous immunoassay of at least two items which comprises a development layer material comprising a development layer permitting development of a sample; at least two, preferably three or more, reagents supported in optional places on the development layer and individually containing an antibody or antigen different from those of the other reagents; and a concave sample-spotting place provided in the same place as one of the places where the aforesaid reagents are supported or in a place remote from all of these places. And a process for simultaneous immunoassay of at least two items which comprising utilizing said kit. The reagents supported in the above mentioned optional places are contained in microcapsules or liposomes.
摘要翻译： 一种用于至少两个物品的同时免疫测定的试剂盒，其包括显影层材料，所述显影层材料包含允许样品发育的显影层; 至少两个，优选三个或更多个试剂，支持在显影层上的任选位置，并且分别含有与其它试剂不同的抗体或抗原; 以及设置在与所述试剂被支撑的地方之一或远离所有这些位置的位置相同的地方的凹形样品点样地点。 以及用于同时免疫测定至少两个项目的方法，其包括利用所述试剂盒。 在上述任选地方所支持的试剂包含在微胶囊或脂质体中。
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53.发明授权Immunoassay with antigen or antibody labelled microcapsules containing fluorescent substance 失效用含有荧光物质的抗原或抗体标记的微胶囊进行免疫测定
公开(公告)号：US4916080A
公开(公告)日：1990-04-10
申请号：US927932
申请日：1986-11-07
申请人： Kyoko Imai , Yasushi Nomura
发明人： Kyoko Imai , Yasushi Nomura
IPC分类号： G01N33/544 , G01N33/532 , G01N33/543 , G01N33/58
CPC分类号： G01N33/532 , G01N33/586 , Y10S436/80 , Y10S436/808 , Y10S436/821 , Y10S436/829
摘要： Microcapsules labeled with an antigen or antibody contain a liquid containing a fluorescent substance, for example, carboxyfluorescein. The liquid in the microcapsules is prepared so as to have a viscosity different from that of a liquid outside the microcapsules. For example, the microcapsules contain polyvinyl alcohol as a substance for increasing the viscosity. Antigen-antibody reaction is caused by mixing such microcapsules, a sample and a complement, and complement is activated with resulting antigen-antibody complex, whereby the microcapsules are lysed.The reaction mixture is irradiated with exciting light, and the polarization components (I.sub..parallel. and I.sub..perp.) of fluorescence from the reaction mixture are detected. The concentration of a substance to be assayed in the sample is determined by calculating the degree of polarization fluorescence P on the basis of the intensities of the polarization components.According to this invention, the degree of polarization fluorescence of liquid before the immunoreaction is high but the degree of polarization fluorescence after the initiation of the immunoreaction is low. Therefore, immunoassay can be carried out with high accuracy.
摘要翻译： 用抗原或抗体标记的微胶囊含有含有荧光物质的液体，例如羧基荧光素。 微胶囊中的液体被制备成具有与微胶囊外部液体的粘度不同的粘度。 例如，微胶囊含有作为提高粘度的物质的聚乙烯醇。 通过混合这样的微胶囊，样品和补体引起抗原 - 抗体反应，并且用所得的抗原 - 抗体复合物活化补体，从而使微胶囊裂解。 用激发光照射反应混合物，并检测来自反应混合物的荧光的偏振分量（I PARALLEL和I ORTHOGONAL）。 通过基于偏振分量的强度计算极化荧光P的度数来确定样品中要测定的物质的浓度。 根据本发明，免疫反应前液体的极化荧光程度高，但免疫反应开始后的极化荧光程度低。 因此，可以高精度地进行免疫测定。
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公开(公告)号：US4262351A
公开(公告)日：1981-04-14
申请号：US943263
申请日：1978-09-15
IPC分类号： G04G15/00 , G04C3/00 , G04G3/02 , G04G5/04 , G04G9/00 , G04G11/00 , G04G13/02 , G04G17/08 , G04G99/00 , G04B23/02 , G04C21/16
CPC分类号： G04G99/006 , G04C3/005 , G04G11/00 , G04G13/025 , G04G5/04
摘要： An electronic timepiece includes a frequency supply for providing a relatively high frequency time base signal, a frequency converter responsive to the time base signal to provide a relatively low frequency time unit signal, timing signals, and a plurality of word pulses indicative of plurality of data words representing time data concerning the current time, and a set of additional data other than the time data. A primary register is arranged to store the time data and the additional data, and display means displays the time data and the additional data. An external control member is adapted to provide an input signal when actuated, and an indexing signal is generated in response to the input signal. A secondary register is arranged to store a plurality of sets of additional data and is operable to transfer each set of additional data to the primary register in a sequential manner as the first mentioned set of additional data in response to the indexing signal, whereupon each of the sets of additional data is sequentially displayed by the display means.
摘要翻译： 电子钟表包括用于提供相对高频时基信号的频率供应器，响应于时基信号的频率转换器，提供相对低频的时间单位信号，定时信号以及表示多个数据的多个字脉冲 表示与当前时间有关的时间数据的单词，以及除了时间数据之外的一组附加数据。 主寄存器被设置为存储时间数据和附加数据，并且显示装置显示时间数据和附加数据。 外部控制构件适于在致动时提供输入信号，并且响应于输入信号产生分度信号。 次级寄存器被布置为存储多组附加数据，并且可操作以响应于索引信号以顺序方式将每组附加数据传送到主寄存器作为第一附加数据组，因此， 显示装置依次显示附加数据组。
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公开(公告)号：US4246651A
公开(公告)日：1981-01-20
申请号：US912266
申请日：1978-06-05
申请人： Yuzo Komatsu , Yasushi Nomura
发明人： Yuzo Komatsu , Yasushi Nomura
CPC分类号： G04G13/023
摘要： An electronic timepiece equipped with an alarm system whereby an external control member is actuated a desired number of times or for a desired time duration causing a count to be set into a first counter. Subsequently, when an alarm is generated, an identical count value must be set into a second counter by actuating an external control member for the same number of times or for an appropriate time duration in order to shut off the alarm. Possibility of the user shutting off the alarm signal and then falling asleep again is thus greatly reduced. A snooze switch control function can also be easily incorporated.
摘要翻译： 一种具有报警系统的电子表，其中外部控制构件被激活期望次数或期望的持续时间，从而将计数设置为第一计数器。 随后，当产生报警时，为了关闭报警，必须通过使外部控制构件相同次数或适当的持续时间来将相同的计数值设置到第二计数器中。 因此，用户关闭报警信号然后再次入睡的可能性大大降低。 打盹开关控制功能也可以轻松并入。
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公开(公告)号：US4150536A
公开(公告)日：1979-04-24
申请号：US760890
申请日：1977-01-21
摘要： An electronic timepiece includes a reversible stepping motor to drive rotatable hands to provide a time display. In a first preferred embodiment, the electronic timepiece includes a circuit means to generate alternating current pulses having an increased pulse width or an increased amplitude to drive the stepping motor with an increased driving current during high speed time correction when a manually operable external control member is actuated during time correction. In a second preferred embodiment, the electronic timepiece comprises a clockwise correction switch, a counter-clockwise correction switch and circuit means for generating first and second alternating current pulses of first and second pulse widths at a predetermined frequency higher than normal driving pulses to drive a stepping motor in clockwise and counter-clockwise directions, respectively, to perform clockwise and counter-clockwise corrections when the clockwise and counter-clockwise correction switches are actuated during time corrections, respectively. The pulse width of the second alternating current pulses is selected to be smaller than that of the normal driving pulses.
摘要翻译： 电子钟表包括可逆步进马达来驱动可旋转的手以提供时间显示。 在第一优选实施例中，电子钟表包括电路装置，用于产生具有增加的脉冲宽度或增加幅度的交流脉冲，以在高速时间校正期间以高速时间校正中的增加的驱动电流来驱动步进电机，当可手动操作的外部控制构件为 在时间校正期间启动。 在第二优选实施例中，电子钟表包括顺时针校正开关，逆时针校正开关和用于以比正常驱动脉冲高的预定频率产生第一和第二脉冲宽度的第一和第二交流脉冲的电路装置，以驱动 分别在顺时针和逆时针方向上的步进电机分别在时间校正期间启动顺时针和逆时针校正开关时执行顺时针和逆时针校正。 选择第二交流脉冲的脉冲宽度小于正常驱动脉冲的脉冲宽度。
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公开(公告)号：US4107915A
公开(公告)日：1978-08-22
申请号：US751889
申请日：1976-12-17
申请人： Fukuo Sekiya , Shigeru Morokawa , Yasushi Nomura
发明人： Fukuo Sekiya , Shigeru Morokawa , Yasushi Nomura
摘要： A set of digital indicators in an electronic display unit of a timepiece are actuated by driving pulses transmitted thereto through respective stages of a multistage frequency divider. A switching mchanism is manually operable to advance certain of these stages, independently of the driving pulses and at a faster rate, to adjust the display. A timer discriminates between short-term and long-term switch reversals to differentiate between a gating signal, giving passage to a train of high-rate stepping pulses, and (a) selection signals identifying an indicator to be stepped or (b) manually produced pulses for adjustment at a slower rate. A protective circuit may be inserted between the switching mechanism and the display-controlling circuitry for preventing the transmission of indication-modifying signals to the display unit in the absence of a special unblocking signal, generated separately, which trips an electronic relay such as a flip-flop into an off-normal condition for the emission of an enabling signal; the flip-flop may be automatically reset to normal, after a predetermined period, in the absence of a manually generated blocking signal. Stationary digital indicators, such as those registering the triggering time of an alarm circuit, may be similarly adjusted.
摘要翻译： 钟表的电子显示单元中的一组数字指示器通过驱动通过多级分频器的各级传输的脉冲而被致动。 切换机构可手动操作以独立于驱动脉冲并以更快的速率推进这些级中的某些级，以调整显示。 定时器区分短期和长期开关反转以区分选通信号，通过高速步进脉冲串，以及（a）识别要步进的指示器的选择信号或（b）手动产生 用于以较慢速率调节的脉冲。 可以在切换机构和显示控制电路之间插入保护电路，用于在没有独立产生的特殊的解除阻塞信号的情况下防止向显示单元发送指示修改信号 - 为了发射使能信号而进入非正常状态; 在没有手动产生的阻塞信号的情况下，在预定时间段之后，触发器可以自动复位到正常状态。 可以类似地调整诸如记录报警电路的触发时间的固定数字指示器。
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公开(公告)号：US4094135A
公开(公告)日：1978-06-13
申请号：US689021
申请日：1976-05-24
申请人： Yasushi Nomura , Shigeru Morokawa
发明人： Yasushi Nomura , Shigeru Morokawa
摘要： A switch control unit for an electronic timepiece comprises a plurality of control switches and a sequence decoding circuit which detects sequences of actuations of the control switches to provide a plurality of output signals in dependence on varying combinations of sequences of actuations of the control switches. In modified form, the switch control unit comprises a plurality of control switches, a detecting circuit to detect numbers of actuations of each of the control switches thereby to provide outputs in dependence on varying combinations of numbers of actuations of the control switches, and a decoding circuit to decode the outputs from the detecting circuit to provide a plurality of output signals.
摘要翻译： 电子时计的开关控制单元包括多个控制开关和序列解码电路，其根据控制开关的动作序列的变化组合来检测控制开关的致动序列以提供多个输出信号。 在修改形式中，开关控制单元包括多个控制开关，检测电路，用于检测每个控制开关的致动次数，从而根据控制开关的致动次数的变化组合提供输出，以及解码 解码来自检测电路的输出以提供多个输出信号的电路。
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公开(公告)号：US4090350A
公开(公告)日：1978-05-23
申请号：US682667
申请日：1976-05-03
申请人： Yasushi Nomura
发明人： Yasushi Nomura
摘要： A switch mechanism for an electronic timepiece comprises a minimum number of control switches and an electric circuit means associated therewith. The electric circuit means is arranged such that when the control switches are actuated independently of each other the control switches provide respective switching functions whereas when selected ones of the control switches are concurrently actuated respective switching functions of the control switches are inhibited and, instead thereof, another switching function is provided.
摘要翻译： 电子表的开关机构包括最少数量的控制开关和与其相关联的电路装置。 电路装置被布置成使得当控制开关彼此独立地致动时，控制开关提供相应的开关功能，而当选择的控制开关同时致动时，控制开关的各个开关功能被禁止， 提供了另一个切换功能。
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公开(公告)号：US4067187A
公开(公告)日：1978-01-10
申请号：US668839
申请日：1976-03-22
申请人： Fukuo Sekiya , Shigeru Morokawa , Yasushi Nomura
发明人： Fukuo Sekiya , Shigeru Morokawa , Yasushi Nomura
摘要： A set of digital indicators in an electronic display unit of a timepiece are actuated by driving pulses transmitted thereto through respective stages of a multistage frequency divider. A switching mechanism is manually operable to advance certain of these stages, independently of the driving pulses and at a faster rate, to adjust the display. A timer discriminates between short-term and long-term switch reversals to differentiate between a gating signal, giving passage to a train of high-rate stepping pulses, and (a) selection signals identifying an indicator to be stepped or (b) manually produced pulses for adjustment at a slower rate. A protective circuit may be inserted between the switching mechanism and the display-controlling circuitry for preventing the transmisson of indication-modifying signals to the display unit in the absence of a special unblocking signal, generated separately, which trips an electronic relay such as a flip-flop into an off-normal condition for the emission of an enabling signal; the flip-flop may be automatically reset to normal, after a predetermined period, in the absence of a manually generated blocking signal. Stationary digital indicators, such as those registering the triggering time of an alarm circuit, may be similarly adjusted.
摘要翻译： 钟表的电子显示单元中的一组数字指示器通过驱动通过多级分频器的各级传输的脉冲而被致动。 切换机构可手动操作以独立于驱动脉冲并以更快的速率推进这些级中的某些级，以调整显示。 定时器区分短期和长期开关反转以区分选通信号，通过高速步进脉冲串，以及（a）识别要步进的指示器的选择信号或（b）手动产生 用于以较慢速率调节的脉冲。 可以在切换机构和显示控制电路之间插入保护电路，用于在没有独立产生的特殊的解除阻塞信号的情况下防止向显示单元传输指示修改信号 - 为了发射使能信号而进入非正常状态; 在没有手动产生的阻塞信号的情况下，在预定时间段之后，触发器可以自动复位到正常状态。 可以类似地调整诸如记录报警电路的触发时间的固定数字指示器。
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