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公开(公告)号：US20090104622A1
公开(公告)日：2009-04-23
申请号：US12144864
申请日：2008-06-24
申请人： Henrik S. Olsen , Haodong Li
发明人： Henrik S. Olsen , Haodong Li
CPC分类号： C07K14/485 , A61K38/00 , A61K48/00 , C07K14/47 , C12N2799/026
摘要： The present invention discloses an extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include induction of DNA synthesis, stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
摘要翻译： 本发明公开了细胞外/表皮生长因子多肽和编码这些多肽的多核苷酸。 还提供了通过重组技术和多肽的治疗用途产生此类多肽的方法，其包括诱导DNA合成，刺激伤口愈合，治疗神经障碍，治疗眼部疾病，治疗肾脏和肝脏疾病以及刺激胚胎发生和血管发生。 还公开了抗这种多肽的拮抗剂及其作为治疗瘤形成的治疗剂的用途。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。
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公开(公告)号：US20090036370A1
公开(公告)日：2009-02-05
申请号：US12029050
申请日：2008-02-11
申请人： Haodong Li , Brent L. Kreider
发明人： Haodong Li , Brent L. Kreider
CPC分类号： C07K14/521 , A61K38/00 , C07K14/522 , C07K14/523 , C07K14/5421 , Y02A50/473 , Y10S930/14
摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion inhibitor-1 (LAI-1) polypeptide (previously termed chemokine α1 (CKα1 or cka-1), as well as Ck beta-11 and/or LAI-1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
摘要翻译： 公开了使用编码人趋化因子β-11（Ckβ-11）多肽和人白细胞粘附抑制剂-1（LAI-1）多肽的分离的核酸分子的治疗组合物和方法（先前称为趋化因子α1（CKalpha1或cka- 1）以及Ckβ-11和/或LAI-1多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。
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公开(公告)号：US07026299B2
公开(公告)日：2006-04-11
申请号：US09901910
申请日：2001-07-11
CPC分类号： C07K14/475 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention relates to a human CTGF-2 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist/inhibitors against such polypeptide. Also provided are methods of using the polypeptide therapeutically for stimulating angiogenesis enhancing the repair of connective and support tissue, promoting the attachment, fixation and stabilization of tissue implants and enhancing wound healing. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
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公开(公告)号：US20050244867A1
公开(公告)日：2005-11-03
申请号：US11091334
申请日：2005-03-29
申请人： Daniel Soppet , Haodong Li
发明人： Daniel Soppet , Haodong Li
IPC分类号： C07H21/04 , C07K14/475 , C07K14/495 , C07K16/22 , C12N15/09 , C12Q1/68
CPC分类号： C07K14/475 , A61K38/00 , C07K14/495
摘要： The present invention discloses Growth Factor HTTER36 (GDF3) polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include the diagnosis, prevention, and treatment of wasting disorders. Also disclosed are antagonists against such polypeptide and their therapeutic uses which include the diagnosis, prevention, and treatment of obesity and obesity-related disorders. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
摘要翻译： 本发明公开了生长因子HTTER36（GDF3）多肽和编码这种多肽的多核苷酸。 还提供了通过重组技术和包括诊断，预防和治疗消耗性疾病的多肽的治疗用途产生此类多肽的方法。 还公开了抗这种多肽及其治疗用途的拮抗剂，包括诊断，预防和治疗肥胖症和肥胖相关疾病。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。
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公开(公告)号：US06921645B2
公开(公告)日：2005-07-26
申请号：US10164621
申请日：2002-06-10
申请人： Haodong Li , Mark D. Adams
发明人： Haodong Li , Mark D. Adams
IPC分类号： A01N37/18 , A61K38/00 , A61K38/19 , C07H21/04 , C07K5/00 , C07K7/00 , C07K14/52 , C07K16/00 , C07K16/24 , C07K17/00 , C12N5/00 , C12N5/02 , C12N5/06 , C12N15/00 , C12N15/09 , C12N15/19 , C12N15/63 , C12N15/70 , C12N15/74 , C12P21/02 , C12P21/06 , C12Q1/68 , G01N33/53 , G01N33/567
CPC分类号： C07K14/521 , A61K38/00 , G01N33/564 , G01N2500/04 , G01N2800/26
摘要： Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译： 公开了人趋化因子多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。
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公开(公告)号：US06713052B1
公开(公告)日：2004-03-30
申请号：US09567225
申请日：2000-05-09
申请人： John R. White , Louis Pelus , Haodong Li , Brendt L. Kreider
发明人： John R. White , Louis Pelus , Haodong Li , Brendt L. Kreider
IPC分类号： A61K3819
CPC分类号： C07K14/523 , A61K38/00 , Y10S930/14
摘要： Novel chemokines for mobilizing stem cells are provided. Methods of mobilizing stem cells are also provided.
摘要翻译： 提供用于动员干细胞的新型趋化因子。 还提供了移动干细胞的方法。
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公开(公告)号：US06410268B1
公开(公告)日：2002-06-25
申请号：US08816772
申请日：1997-03-18
申请人： Jian Ni , Haodong Li , Jeffrey Su
发明人： Jian Ni , Haodong Li , Jeffrey Su
IPC分类号： C12N120
CPC分类号： C07K14/522
摘要： Human chemokine Alpha-3 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, sepsis, wound healing and psoriasis and to stimulate stem cell mobilization. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, ARDS and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.
摘要翻译： 公开了人趋化因子α-3多肽和编码这种趋化性细胞因子的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，败血症，伤口愈合和牛皮癣并刺激干细胞移动的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫和慢性和急性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧，ARDS和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。
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公开(公告)号：US6139832A
公开(公告)日：2000-10-31
申请号：US943336
申请日：1997-10-03
申请人： Haodong Li , Brent L. Kreider
发明人： Haodong Li , Brent L. Kreider
CPC分类号： C07K14/521 , C07K14/522 , C07K14/523 , C07K14/5421 , A61K38/00 , Y10S930/14
摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion inhibitor-1 (LAI-1) polypeptide (previously termed chemokine .alpha.1(CK.alpha.1 or ck.alpha.-1), as well as Ck beta-11 and/or LAI-1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
摘要翻译： 公开了使用编码人趋化因子β-11（Ckβ-11）多肽和人白细胞粘附抑制剂-1（LAI-1）多肽（先前称为趋化因子α1（CKα1））多肽的分离的核酸分子的治疗组合物和方法 或ckα-1）以及Ckβ-11和/或LAI-1多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。
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公开(公告)号：US5650295A
公开(公告)日：1997-07-22
申请号：US460528
申请日：1995-06-02
申请人： Haodong Li , Lisa M. Fitzgerald
发明人： Haodong Li , Lisa M. Fitzgerald
摘要： The present invention relates to a human MIF-3 and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the polypeptide therapeutically for treating cancer, infections, acceleration of wound healing, stimulating the immune system, as an anti-inflammatory. Methods of using antibodies and antagonists for therapeutic purposes, is also disclosed, for example, for treating lethal endotoxaemia, ocular inflammation and diagnosing immune diseases. Also disclosed are diagnostic methods for detecting conditions related to a mutation in a nucleic acid sequence encoding a polypeptide of the present invention and altered levels of the polypeptide of the present invention.
摘要翻译： 本发明涉及编码这种多肽的人MIF-3和DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用该多肽治疗癌症，感染，加速伤口愈合，刺激免疫系统作为抗炎剂的方法。 还公开了用于治疗目的的抗体和拮抗剂的方法，例如用于治疗致死性内毒素血症，眼部炎症和诊断免疫疾病。 还公开了用于检测与编码本发明的多肽的核酸序列中的突变相关的病症的诊断方法以及本发明的多肽的改变的水平。
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公开(公告)号：US07393832B2
公开(公告)日：2008-07-01
申请号：US11017065
申请日：2004-12-21
申请人： Henrik S. Olsen , Haodong Li
发明人： Henrik S. Olsen , Haodong Li
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： C07K14/485 , A61K38/00 , A61K48/00 , C07K14/47 , C12N2799/026
摘要： The present invention discloses an extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include induction of DNA synthesis, stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
摘要翻译： 本发明公开了细胞外/表皮生长因子多肽和编码这些多肽的多核苷酸。 还提供了通过重组技术和多肽的治疗用途产生此类多肽的方法，其包括诱导DNA合成，刺激伤口愈合，治疗神经障碍，治疗眼部疾病，治疗肾脏和肝脏疾病以及刺激胚胎发生和血管发生。 还公开了抗这种多肽的拮抗剂及其作为治疗瘤形成的治疗剂的用途。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。
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