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    Antibodies to MCP-4
    3.
    发明授权
    Antibodies to MCP-4 有权
    MCP-4的抗体

    公开(公告)号：US07138498B2

    公开(公告)日：2006-11-21

    申请号：US10646770

    申请日：2003-08-25

    申请人： Haodong Li ,  Mark D. Adams ,  Solange H. Gentz ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John R. White ,  Edward R. Appelbaum

    发明人： Haodong Li ,  Mark D. Adams ,  Solange H. Gentz ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John R. White ,  Edward R. Appelbaum

    IPC分类号： C07K16/24

    CPC分类号： C07K14/52 ,  C07K14/523 ,  Y10S930/14

    摘要： Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

    摘要翻译： 公开了人趋化因子多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。

    Connective Tissue Growth Factor-2
    6.
    发明申请
    Connective Tissue Growth Factor-2 审中-公开
    结缔组织生长因子-2

    公开(公告)号：US20070154908A1

    公开(公告)日：2007-07-05

    申请号：US11563870

    申请日：2006-11-28

    申请人： Haodong Li ,  Mark Adams

    发明人： Haodong Li ,  Mark Adams

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/475

    CPC分类号： C07K14/475 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K2319/00

    摘要： The present invention relates to a human CTGF-2 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist/inhibitors against such polypeptide. Also provided are methods of using the polypeptide therapeutically for enhancing the repair of connective and support tissue, promoting the attachment, fixation and stabilization of tissue implants and enhancing wound healing. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

    摘要翻译： 本发明涉及人CTGF-2多肽和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法和针对这种多肽的抗体和拮抗剂/抑制剂。 还提供了用于治疗性地增强连接和支持组织的修复，促进组织植入物的附着，固定和稳定以及增强伤口愈合的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。

    Antibodies to human chemokine beta-9
    8.
    发明授权
    Antibodies to human chemokine beta-9 有权
    人趋化因子β-9的抗体

    公开(公告)号：US07097985B2

    公开(公告)日：2006-08-29

    申请号：US10329472

    申请日：2002-12-27

    申请人： Haodong Li ,  Mark D. Adams

    发明人： Haodong Li ,  Mark D. Adams

    IPC分类号： G01N33/53 ,  C07K16/24 ,  C12N5/12

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/523 ,  G01N33/564 ,  G01N33/57426 ,  G01N33/6863 ,  G01N2333/52

    摘要： Human Ckβ-9 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Ckβ-9 polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the Ckβ-9 coding sequence and over-expression of the Ckβ-9 protein.

    摘要翻译： 公开了人Ckbeta-9多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种Ckbeta-9多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了诊断测定法，其检测Ckbeta-9编码序列中突变的存在和Ckbeta-9蛋白的过表达。

    Extracellular/epidermal growth factor like protein
    10.
    发明申请
    Extracellular/epidermal growth factor like protein 失效
    细胞外/表皮生长因子如蛋白质

    公开(公告)号：US20050181477A1

    公开(公告)日：2005-08-18

    申请号：US11017065

    申请日：2004-12-21

    申请人： Henrik Olsen ,  Haodong Li

    发明人： Henrik Olsen ,  Haodong Li

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/485 ,  A61K38/18 ,  C07K14/475

    CPC分类号： C07K14/485 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C12N2799/026

    摘要： The present invention discloses an extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include induction of DNA synthesis, stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

    摘要翻译： 本发明公开了细胞外/表皮生长因子多肽和编码这些多肽的多核苷酸。 还提供了通过重组技术和多肽的治疗用途产生此类多肽的方法，其包括诱导DNA合成，刺激伤口愈合，治疗神经障碍，治疗眼部疾病，治疗肾脏和肝脏疾病以及刺激胚胎发生和血管发生。 还公开了抗这种多肽的拮抗剂及其作为治疗瘤形成的治疗剂的用途。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。