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公开(公告)号：US20060078588A1
公开(公告)日：2006-04-13
申请号：US11288754
申请日：2005-11-28
Applicant: Syed Hossainy
Inventor： Syed Hossainy
CPC classification number: A61L31/16 , A61L31/10 , A61L2300/606
Abstract: A coating for a medical device, particularly for a stent, is described. The coating comprises a polymer and a biologically responsive compound. The coating can also contain a drug to provide enhanced therapeutic effect.
Abstract translation: 描述了用于医疗装置的涂层，特别是用于支架的涂层。 涂层包含聚合物和生物响应性化合物。 涂层还可以含有药物以提供增强的治疗效果。
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52.发明申请Implantable devices comprising biologically absorbable polymers having constant rate of degradation and methods for fabricating the same 审中-公开可植入装置包括具有恒定降解速率的生物可吸收聚合物及其制造方法公开(公告)号：US20060041102A1
公开(公告)日：2006-02-23
申请号：US10925257
申请日：2004-08-23
Applicant: Syed Hossainy , Stephen Pacetti , David Gale
Inventor： Syed Hossainy , Stephen Pacetti , David Gale
IPC: C08G63/08
CPC classification number: A61L31/16 , A61L31/06 , A61L31/10 , A61L31/14 , A61L2300/606 , C08G63/06 , C08G63/08 , C08G64/0208 , C08G64/0241 , C09D167/04 , C09D169/00 , C08L67/04
Abstract: Polymers that can form the substrate of an implantable medical device and form coatings for implantable medical devices and methods for their fabrication are disclosed, the coatings comprising polymers that are hydrolyzed at a substantially constant rate or that have been prepared so that they degrade at a rate closer to constant.
Abstract translation: 公开了可以形成可植入医疗装置的基底并形成用于可植入医疗装置的涂层的聚合物及其制造方法，所述涂层包含以基本上恒定的速率水解或已被制备以使其以一定速率降解的聚合物 更接近常数。
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53.发明申请Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same 审中-公开含聚（酯酰胺）的聚合物和用于医疗制品的试剂及其制造方法公开(公告)号：US20050265960A1
公开(公告)日：2005-12-01
申请号：US10855294
申请日：2004-05-26
Applicant: Stephen Pacetti , Charles Claude , Thierry Glauser , Jessica DesNoyer , Syed Hossainy
Inventor： Stephen Pacetti , Charles Claude , Thierry Glauser , Jessica DesNoyer , Syed Hossainy
IPC: A61L27/34 , A61L29/08 , A61L31/10 , C08G69/44 , A61K31/765
Abstract: Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a polymer comprising a polymeric product of a reaction comprising a polyol, a polycarboxylic acid, an amino acid and an agent.
Abstract translation: 公开了含有聚（酯酰胺）的聚合物和用于医疗制品的试剂及其制造方法。 医疗制品通常包括具有涂层的可植入基底，并且该涂层含有包含包含多元醇，多元羧酸，氨基酸和试剂的反应的聚合产物的聚合物。
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公开(公告)号：US20050233062A1
公开(公告)日：2005-10-20
申请号：US10856984
申请日：2004-05-27
Applicant: Syed Hossainy , Yiwen Tang , Manish Gada
Inventor： Syed Hossainy , Yiwen Tang , Manish Gada
CPC classification number: A61F2/82 , A61F2/91 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2420/02 , B29C71/02 , C08L67/04
Abstract: A method of manufacturing an implantable medical device, such as a drug eluting stent, is disclosed. The method includes subjecting an implantable medical device that includes a polymer to a thermal condition. The thermal condition can result in reduction of the rate of release of an active agent from the device subsequent to the implantation of the device and/or improve the mechanical properties of a polymeric coating on the device.
Abstract translation: 公开了一种制造可植入医疗装置的方法，例如药物洗脱支架。 该方法包括使包含聚合物的可植入医疗装置经受热条件。 加热条件可导致活性剂从植入装置之后的装置释放速率降低，和/或改善装置上的聚合物涂层的机械性能。
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公开(公告)号：US20050191332A1
公开(公告)日：2005-09-01
申请号：US11053184
申请日：2005-02-07
Applicant: Syed Hossainy
Inventor： Syed Hossainy
IPC: A61F2/02 , A61K31/4745 , A61L2/00 , A61L15/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , B05D3/00 , B32B27/18 , B32B27/30 , B32B27/36
CPC classification number: A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , Y10T428/31504 , Y10T428/31786 , Y10T428/31855 , Y10T428/31935
Abstract: A method is disclosed for forming a coating on implantable medical devices including an interpenetrating polymer network that serves as a rate limiting barrier.
Abstract translation: 公开了用于在可植入医疗装置上形成涂层的方法，其包括用作限速屏障的互穿聚合物网络。
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Patent Agency Ranking
公开(公告)号：US20050107864A1
公开(公告)日：2005-05-19
申请号：US11020826
申请日：2004-12-22
Applicant: James Hong , Rahul Bhagat , Syed Hossainy , Santosh Prabhu , K.T. Venkateswara Rao , Ashok Shah , Srinivasan Sridharan
Inventor： James Hong , Rahul Bhagat , Syed Hossainy , Santosh Prabhu , K.T. Venkateswara Rao , Ashok Shah , Srinivasan Sridharan
CPC classification number: A61F2/915 , A61F2/07 , A61F2/91 , A61F2002/072 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2220/0058 , A61F2230/0013 , A61F2230/0054 , A61L31/10 , A61L31/16 , Y10S623/901
Abstract: A hybrid stent is formed which exhibits both high flexibility and high radial strength. The expandable hybrid stent for implantation in a body lumen, such as a coronary artery, consists of radially expandable cylindrical rings generally aligned on a common longitudinal axis and interconnected by one or more links. In one embodiment, a dip-coated covered stent is formed by encapsulating cylindrical rings within a polymer material. In other embodiments, at least some of the rings and links are formed of a polymer material which provides longitudinal and flexural flexibility to the stent. These polymer rings and links are alternated with metallic rings and links in various configurations to attain sufficient column strength along with the requisite flexibility in holding open the target site within the body lumen. Alternatively, a laminated, linkless hybrid stent is formed by encapsulating cylindrical rings within a polymer tube.
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公开(公告)号：US06866805B2
公开(公告)日：2005-03-15
申请号：US10033380
申请日：2001-12-27
Applicant: James Hong , Rahul Bhagat , Syed Hossainy , Santosh Prabhu , K.T. Venkateswara Rao , Ashok Shah , Srinivasan Sridharan
Inventor： James Hong , Rahul Bhagat , Syed Hossainy , Santosh Prabhu , K.T. Venkateswara Rao , Ashok Shah , Srinivasan Sridharan
CPC classification number: A61F2/915 , A61F2/07 , A61F2/91 , A61F2002/072 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2220/0058 , A61F2230/0013 , A61F2230/0054 , A61L31/10 , A61L31/16 , Y10S623/901
Abstract: A hybrid stent is formed which exhibits both high flexibility and high radial strength. The expandable hybrid stent for implantation in a body lumen, such as a coronary artery, consists of radially expandable cylindrical rings generally aligned on a common longitudinal axis and interconnected by one or more links. In one embodiment, a dip-coated covered stent is formed by encapsulating cylindrical rings within a polymer material. In other embodiments, at least some of the rings and links are formed of a polymer material which provides longitudinal and flexural flexibility to the stent. These polymer rings and links are alternated with metallic rings and links in various configurations to attain sufficient column strength along with the requisite flexibility in holding open the target site within the body lumen. Alternatively, a laminated, linkless hybrid stent is formed by encapsulating cylindrical rings within a polymer tube.
Abstract translation: 形成具有高柔性和高径向强度的混合支架。 用于植入体腔（例如冠状动脉）中的可扩张混合支架由径向可扩展的圆柱形环构成，其通常在公共纵向轴线上对齐并且由一个或多个连杆相互连接。 在一个实施例中，通过将圆柱形环封装在聚合物材料内而形成浸涂的覆盖支架。 在其它实施例中，至少一些环和链节由聚合物材料形成，该聚合物材料向支架提供纵向和弯曲的柔性。 这些聚合物环和链环与金属环和各种结构的链接交替，以获得足够的柱强度以及在体腔内保持打开靶部位所需的灵活性。 或者，通过在聚合物管内封装圆柱形环来形成层压的无环式混合支架。
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公开(公告)号：US20050033411A1
公开(公告)日：2005-02-10
申请号：US10911968
申请日：2004-08-04
Applicant: Steven Wu , Sameer Harish , Deborra Sanders-Millare , Judy Guruwaiya , Daryush Mirzaee , Syed Hossainy , Charlene Chen
Inventor： Steven Wu , Sameer Harish , Deborra Sanders-Millare , Judy Guruwaiya , Daryush Mirzaee , Syed Hossainy , Charlene Chen
CPC classification number: A61F2/0077 , A61F2/848 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2230/0013 , A61F2250/0067 , A61F2250/0068 , Y10S623/901
Abstract: An implantable medical device, such as a stent or graft, having asperities on a designated region of its outer surface is disclosed. The asperities can serve to improve retention of one or more layers of a coating on the device and to increase the amount of coating that can be carried by the device. The asperities can be formed by using a stream of pressurized grit to roughen the surface. The asperities can also be formed by removing material from the outer surface, for example, by chemical etching with or without a patterned mask. Alternatively, the asperities can be formed by adding material to the outer surface, for example, by welding powder particles to the outer surface or sputtering.
Abstract translation: 公开了一种在其外表面的指定区域上具有凹凸的可植入医疗装置，例如支架或移植物。 粗糙度可用于改善设备上一层或多层涂层的保留性并增加该装置可承载的涂层量。 可以通过使用加压砂粒流粗糙表面来形成凹凸。 也可以通过从外表面去除材料来形成凹凸，例如通过具有或不具有图案化掩模的化学蚀刻来形成。 或者，可以通过向外表面添加材料，例如通过将粉末颗粒焊接到外表面或溅射来形成凹凸。
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59.发明申请Biologically absorbable coatings for implantable devices and methods for fabricating the same 有权用于可植入装置的生物可吸收涂层及其制造方法公开(公告)号：US20050025799A1
公开(公告)日：2005-02-03
申请号：US10630261
申请日：2003-07-30
Applicant: Syed Hossainy , Eugene Michal , Yiwen Tang
Inventor： Syed Hossainy , Eugene Michal , Yiwen Tang
CPC classification number: A61L31/16 , A61L31/10 , A61L2300/114 , A61L2300/606 , C08L67/04 , C08L71/02
Abstract: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising a biologically degradable, biologically erodable, and/or biologically resorbable ABA or AB block copolymer. A biologically active agent can be conjugated to the block copolymer.
Abstract translation: 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含生物可降解，生物可侵蚀和/或生物可再吸收的ABA或AB嵌段共聚物。 生物活性剂可以与嵌段共聚物缀合。
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公开(公告)号：US06764505B1
公开(公告)日：2004-07-20
申请号：US09834012
申请日：2001-04-12
Applicant: Syed Hossainy , Fuh-Wei Tang , Brian P. Cahill
Inventor： Syed Hossainy , Fuh-Wei Tang , Brian P. Cahill
IPC: A61F208
CPC classification number: A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2210/0095 , A61F2230/0013 , A61F2250/0025 , A61F2250/0067 , A61F2250/0068
Abstract: A stent of variable surface area as determined by stent struts. The stent can have a variable surface area per unit length which accommodates a therapeutic agent. A patterned distribution of therapeutic agent can be provided throughout the stent. The stent can have an increased level of therapeutic agent near an end of the stent. A decreased level of therapeutic agent can be provided near an end of one embodiment of a stent. Indentations can be provided at the surface of the stent with therapeutic agent disposed therein. The stent can be cut with struts of variable thickness to provide the variable stent surface area.
Abstract translation: 由支架支柱确定的可变表面积的支架。 支架可以具有容纳治疗剂的每单位长度的可变表面积。 可以在整个支架中提供治疗剂的图案化分布。 支架可以在支架的端部附近具有增加的治疗剂水平。 在支架的一个实施方案的末端附近可以提供降低的治疗剂水平。 可以在支架的表面设置缺陷，其中设置有治疗剂。 可以用可变厚度的支柱切割支架，以提供可变的支架表面积。
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