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公开(公告)号：US09943595B2
公开(公告)日：2018-04-17
申请号：US14959453
申请日：2015-12-04
申请人： TRANSLATE BIO, INC.
发明人： Frank DeRosa , Michael Heartlein
IPC分类号： A61K39/395 , A61K38/17 , A61K9/127 , C07K16/00 , A61K48/00
CPC分类号： A61K39/3955 , A61K9/1272 , A61K38/177 , A61K48/00 , A61K48/0025 , A61K48/005 , A61K48/0075 , C07K16/00
摘要： The present invention provides, among other things, a method of intra-articular delivery of messenger RNA (mRNA), comprising administering into a joint of a subject in need of delivery a composition comprising an mRNA encoding a protein, such that the administering of the composition results in expression of the protein encoded by the mRNA in the joint.
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公开(公告)号：US12121592B2
公开(公告)日：2024-10-22
申请号：US17832196
申请日：2022-06-03
申请人： Translate Bio, Inc.
IPC分类号： A61K48/00 , A61K9/00 , A61K9/127 , A61K9/51 , A61K31/713 , A61K38/18 , A61K38/47 , A61K38/48 , A61K38/57 , C07K14/505 , C07K14/81 , C12N9/40 , C12N9/64 , C12N15/52 , C12N15/85
CPC分类号： A61K48/0008 , A61K9/0019 , A61K9/0073 , A61K9/1271 , A61K9/1272 , A61K9/5123 , A61K31/713 , A61K38/1816 , A61K38/47 , A61K38/4846 , A61K38/57 , A61K48/0075 , A61K48/0091 , C07K14/505 , C07K14/8125 , C12N9/2465 , C12N9/644 , C12N15/52 , C12N15/85 , C12Y302/01022 , C12Y304/21022 , A61K48/00
摘要： Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
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公开(公告)号：US11969480B2
公开(公告)日：2024-04-30
申请号：US17185587
申请日：2021-02-25
申请人： Translate Bio, Inc.
发明人： Shrirang Karve , Ashish Sarode , Frank DeRosa
IPC分类号： C07H21/02 , A61K9/51 , A61K47/60 , A61K47/69 , A61K48/00 , B01F23/451 , B01F33/301 , B01J13/20 , B01F101/22
CPC分类号： A61K48/0091 , A61K9/5123 , A61K47/60 , A61K47/6925 , A61K48/0033 , B01F23/451 , B01F33/3017 , B01J13/203 , B01F2101/22
摘要： The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a suspension of preformed lipid nanoparticles and mRNA.
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公开(公告)号：US11951179B2
公开(公告)日：2024-04-09
申请号：US18295150
申请日：2023-04-03
申请人： Translate Bio, Inc.
IPC分类号： C12Q1/00 , A61K9/00 , A61K9/127 , A61K9/51 , A61K31/7105 , A61K31/713 , A61K38/18 , A61K38/47 , A61K38/48 , A61K38/57 , A61K48/00 , C07K14/505 , C07K14/81 , C12N9/40 , C12N9/64 , C12N15/52 , C12N15/85
CPC分类号： A61K48/0008 , A61K9/0019 , A61K9/0073 , A61K9/1271 , A61K9/1272 , A61K9/5123 , A61K31/713 , A61K38/1816 , A61K38/47 , A61K38/4846 , A61K38/57 , A61K48/0075 , A61K48/0091 , C07K14/505 , C07K14/8125 , C12N9/2465 , C12N9/644 , C12N15/52 , C12N15/85 , C12Y302/01022 , C12Y304/21022 , A61K48/00
摘要： Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
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公开(公告)号：US20240041789A1
公开(公告)日：2024-02-08
申请号：US18328206
申请日：2023-06-02
申请人： Translate Bio, Inc.
发明人： Shrirang Karve , Frank DeRosa , Zarna Bhavsar , Michael Heartlein
IPC分类号： A61K9/51 , A61K38/45 , A61K38/18 , A61K38/17 , A61K38/44 , A61K38/53 , A61K9/127 , A61K47/22 , C12N15/88 , A61K47/28
CPC分类号： A61K9/5192 , A61K9/5123 , A61K38/45 , C12Y201/03003 , A61K38/1816 , C12Y603/04005 , A61K38/177 , A61K38/44 , C12Y114/16001 , A61K38/53 , A61K9/1272 , A61K47/22 , C12N15/88 , A61K47/28
摘要： The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA.
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公开(公告)号：US20230330262A1
公开(公告)日：2023-10-19
申请号：US18295159
申请日：2023-04-03
申请人： Translate Bio, Inc.
IPC分类号： A61K31/713 , C07K14/505 , C12N9/40 , C12N9/64 , A61K38/48 , A61K38/57 , A61K9/127 , C12N15/52 , A61K38/18 , A61K38/47 , A61K48/00 , A61K9/00 , C07K14/81 , C12N15/85 , A61K9/51
CPC分类号： A61K48/0008 , A61K9/0019 , A61K9/0073 , A61K9/1271 , A61K9/1272 , A61K9/5123 , A61K31/713 , A61K38/1816 , A61K38/47 , A61K38/4846 , A61K38/57 , A61K48/0075 , A61K48/0091 , C07K14/505 , C07K14/8125 , C12N9/2465 , C12N9/644 , C12N15/52 , C12N15/85 , C12Y302/01022 , C12Y304/21022 , A61K48/00
摘要： Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
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公开(公告)号：US20230285593A1
公开(公告)日：2023-09-14
申请号：US18295152
申请日：2023-04-03
申请人： Translate Bio, Inc.
IPC分类号： A61K48/00 , A61K38/18 , A61K38/47 , A61K38/48 , A61K38/57 , A61K31/713 , A61K9/00 , A61K9/127 , C07K14/505 , C07K14/81 , C12N9/40 , C12N9/64 , C12N15/52 , C12N15/85 , A61K9/51
CPC分类号： A61K48/0008 , A61K38/1816 , A61K38/47 , A61K38/4846 , A61K38/57 , A61K31/713 , A61K9/0019 , A61K9/0073 , A61K9/1271 , A61K9/1272 , C07K14/505 , C07K14/8125 , C12N9/2465 , C12N9/644 , C12N15/52 , C12N15/85 , A61K9/5123 , A61K48/0075 , A61K48/0091 , C12Y302/01022 , C12Y304/21022 , A61K48/00
摘要： Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
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公开(公告)号：US20230285592A1
公开(公告)日：2023-09-14
申请号：US18295150
申请日：2023-04-03
申请人： Translate Bio, Inc.
IPC分类号： A61K48/00 , A61K38/18 , A61K38/47 , A61K38/48 , A61K38/57 , A61K31/713 , A61K9/00 , A61K9/127 , C07K14/505 , C07K14/81 , C12N9/40 , C12N9/64 , C12N15/52 , C12N15/85 , A61K9/51
CPC分类号： A61K48/0008 , A61K38/1816 , A61K38/47 , A61K38/4846 , A61K38/57 , A61K31/713 , A61K9/0019 , A61K9/0073 , A61K9/1271 , A61K9/1272 , C07K14/505 , C07K14/8125 , C12N9/2465 , C12N9/644 , C12N15/52 , C12N15/85 , A61K9/5123 , A61K48/0075 , A61K48/0091 , C12Y302/01022 , C12Y304/21022 , A61K48/00
摘要： Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
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公开(公告)号：US11692189B2
公开(公告)日：2023-07-04
申请号：US17835725
申请日：2022-06-08
申请人： Translate Bio, Inc.
发明人： Frank DeRosa , Anusha Dias , Michael Heartlein , Shrirang Karve
CPC分类号： C12N15/10 , C07H21/02 , C12N15/1017
摘要： The present invention provides, among other things, methods of purifying messenger RNA (mRNA) including the steps of subjecting an impure preparation comprising in vitro synthesized mRNA to a denaturing condition, and purifying the mRNA from the impure preparation from step (a) by tangential flow filtration, wherein the mRNA purified from step (b) is substantially free of prematurely aborted RNA sequences and/or enzyme reagents used in in vitro synthesis.
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公开(公告)号：US20230092238A1
公开(公告)日：2023-03-23
申请号：US17619040
申请日：2020-06-19
申请人： Translate Bio, Inc.
发明人： Shrirang Karve , Frank DeRosa
IPC分类号： A61K9/127 , A61K38/52 , A61K38/45 , A61K48/00 , C07C229/12 , C07C233/18
摘要： Disclosed are cationic lipids which are compounds of Formula (A). Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
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