公开(公告)号：US5985864A

公开(公告)日：1999-11-16

申请号：US870394

申请日：1997-06-06

申请人： Akio Imai ,  Hideaki Watanabe ,  Takashi Kajima ,  Yasushi Ishihama ,  Akiyo Ohtsuka ,  Tomohide Tanaka ,  Yukio Narabu

发明人： Akio Imai ,  Hideaki Watanabe ,  Takashi Kajima ,  Yasushi Ishihama ,  Akiyo Ohtsuka ,  Tomohide Tanaka ,  Yukio Narabu

IPC分类号： C07D211/32 ,  A01N43/40 ,  A01N43/46 ,  C07D207/00 ,  C07D211/20

CPC分类号： C07D211/32

摘要： Donepezil hydrochloride, 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride, is provided here in the form of four polymorphs which are stable against heat and humidity in the pharmaceutical use. They can be industrially produced. They are specified by peaks in X-ray powder diffraction pattern and absorption peaks in infrared absorption spectra in potassium bromide.

公开(公告)号：US5811197A

公开(公告)日：1998-09-22

申请号：US818450

申请日：1997-03-17

申请人： Masanori Nishiyama ,  Makoto Handa ,  Toshifumi Osawa ,  Hideaki Watanabe

发明人： Masanori Nishiyama ,  Makoto Handa ,  Toshifumi Osawa ,  Hideaki Watanabe

IPC分类号： C08J7/04 ,  C09D167/02 ,  G11B5/738 ,  B32B27/06

CPC分类号： C08J7/047 ,  C08J7/04 ,  C09D167/02 ,  G11B5/738 ,  C08J2367/02 ,  C08J2467/00 ,  Y10T428/31786

摘要： A polyester film having low electrostatic and high adhesion properties and having formed on at least one side thereof a primer layer which has a softening point of 100.degree. to 170.degree. C. and essentially consists of (1) water-dispersible polyester resin containing, as a copolymer component, a sulfonic acid metal salt group-containing compound in an amount of 0.01 mol % or more and less than 0.5 mol % of the whole dicarboxylic acid compound (component A) and (2) polyethylene oxide-monoalkyl ether or a mixture of the same and a polyethylene oxide-polypropylene oxide block copolymer (component B). This adherent polyester film has low electrostatic properties and high heat resistance and is useful as a base film for a magnetic recording medium.

摘要翻译： 一种具有低静电和高粘合性能的聚酯薄膜，并且在其至少一侧上形成了软化点为100至170℃的底漆层，并且基本上由（1）水分散性聚酯树脂组成，所述水分散性聚酯树脂含有 共聚物成分，含磺酸金属盐基化合物的总量为0.01摩尔％以上且小于0.5摩尔％的二羧酸化合物（成分A）和（2）聚环氧乙烷 - 单烷基醚或其混合物 的聚环氧乙烷 - 聚环氧丙烷嵌段共聚物（组分B）。 该贴合聚酯膜具有低静电性能和高耐热性，并且可用作磁记录介质的基膜。

公开(公告)号：US5730573A

公开(公告)日：1998-03-24

申请号：US391609

申请日：1995-02-21

申请人： Sho Masujima ,  Eisaku Miyauchi ,  Toshihiko Miyajima ,  Hideaki Watanabe

发明人： Sho Masujima ,  Eisaku Miyauchi ,  Toshihiko Miyajima ,  Hideaki Watanabe

IPC分类号： B65G49/00 ,  B65G49/07 ,  F24F3/16 ,  G11B7/26 ,  H01L21/02 ,  H01L21/673 ,  H01L21/677

CPC分类号： H01L21/67772 ,  Y10S414/139 ,  Y10S414/14

摘要： A clean transfer method and an apparatus therefor capable of facilitating storage and transfer of transferred objects by a vacuum clean box and realizing transfer of the objects to various processing units other than a vacuum unit. A vacuum clean box and a clean unit are airtightly connected to each other. The vacuum clean box includes a first shutter acting also as a lid and arranged so as to airtightly close a first opening of the box. The clean unit is provided with a second opening selectively closed by a second shutter. Airtight connection between the vacuum clean box and the clean unit is carried out while keeping the first and second openings closed by the first and second shutters, respectively, to thereby form a closed space therebetween which the first and second shutters face. Then, the closed space is evacuated to a vacuum, followed by opening of only the first shutter. Subsequently, a clean atmosphere which is substantially identical with a clean atmosphere in the clean unit is formed in the closed space and the second shutter is opened to introduce the first and second shutters into the clean unit.

摘要翻译： 一种清洁的转印方法及其装置，其能够通过真空清洁箱促进转印物体的存储和转印，并实现物体转移到除真空单元之外的各种处理单元。 真空清洁箱和清洁单元彼此气密连接。 真空清洁箱包括也用作盖子的第一快门并且被布置成气密地关闭箱子的第一开口。 清洁单元设置有由第二闸门选择性地闭合的第二开口。 在将第一和第二开口分别封闭的第一和第二开口分别保持在真空清洁箱和清洁单元之间进行密封连接，从而在第一和第二百叶窗之间形成封闭空间。 然后，将封闭的空间抽真空，然后仅打开第一挡板。 随后，在封闭空间中形成与清洁单元中的清洁气氛基本相同的清洁气氛，并打开第二挡板以将第一和第二快门引入清洁单元。

公开(公告)号：US5539532A

公开(公告)日：1996-07-23

申请号：US288901

申请日：1994-08-11

申请人： Hideaki Watanabe

发明人： Hideaki Watanabe

IPC分类号： H04N1/047 ,  H04N1/107 ,  H04N1/193 ,  H04N1/04 ,  H04N1/10 ,  H04N1/17 ,  H04N1/191

CPC分类号： H04N1/047 ,  H04N1/107 ,  H04N1/193 ,  H04N2201/0422 ,  H04N2201/04705 ,  H04N2201/04758

摘要： A scanner having an image sensor unit having a CCD linear array for electro-optically scanning an image of an original in a main scanning direction to convert the image into image data signals is used to scan, through a table sheet having a transparent document area and a pattern area which includes a stripe pattern inclined with respect to the main scanning direction, an original placed under the document area to read data of the original, and the scanner is moved relative to the original in a subscanning direction perpendicular to the main scanning direction. A pattern signal obtained by scanning the pattern area then is analyzed to detect an amount of relative movement of the scanner in the subscanning direction from the movement of the stripe pattern in the main scanning direction. Accordingly, the reading resolution in the subscanning direction which varies depending upon a high or low degree of the speed of relative movement of the scanner in the subscanning direction can be maintained suitably by adjustment of the speed of movement, or the reading speed can be raised for a predetermined resolution.

摘要翻译： 具有图像传感器单元的扫描仪具有CCD线性阵列，用于在主扫描方向上对原稿的图像进行电光扫描以将图像转换为图像数据信号，通过具有透明文档区域的表格和 包括相对于主扫描方向倾斜的条纹图案的图案区域，放置在原稿区域下方以读取原稿数据的原稿，并且扫描仪相对于原稿在与主扫描方向垂直的副扫描方向上移动 。 分析通过扫描图案区域获得的图案信号，以便检测扫描器在副扫描方向上相对于条形图案在主扫描方向上的移动的相对移动量。 因此，可以通过调整移动速度来适当地维持副扫描方向上的扫描仪在副扫描方向上的相对移动速度的高或低程度的变化的读取分辨率，或者可以提高读取速度 预定分辨率。

公开(公告)号：US4639450A

公开(公告)日：1987-01-27

申请号：US677893

申请日：1984-12-04

申请人： Isao Yamatsu ,  Yuichi Inai ,  Shinya Abe ,  Hideaki Watanabe ,  Toshiji Igarashi ,  Hiroyuki Shiojiri ,  Yoshio Tanabe ,  Kumiko Hara

发明人： Isao Yamatsu ,  Yuichi Inai ,  Shinya Abe ,  Hideaki Watanabe ,  Toshiji Igarashi ,  Hiroyuki Shiojiri ,  Yoshio Tanabe ,  Kumiko Hara

IPC分类号： C07C51/08 ,  C07C51/60 ,  C07D295/185 ,  C07D317/58 ,  A61K31/535 ,  C07D295/18

CPC分类号： C07D295/185 ,  C07C51/08 ,  C07C51/60 ,  C07D317/58 ,  Y10S514/893

摘要： This invention relates to polyprenylcarboxylic acid amides represented by the following general formula (I): ##STR1## wherein n is an integer of from 1 to 4, a and b stand for hydrogen atoms or a direct valence bond between the carbon atoms to which a and b are attached, c and d stand for hydrogen atoms or a direct valence bond between the carbon atoms to which c and d are attached, and R.sub.1 and R.sub.2 stand for a hydrogen atom, a lower alkyl group, a phenyl group which may be substituted or an aralkyl group which may be substituted, or R.sub.1 and R.sub.2 form, together with the adjacent nitrogen atom, a 5- or 6-membered heterocyclic ring which may contain other hetero atoms or may be substituted,and also to a process for the preparation of said polyprenylcarboxylic acid amide and to a pharmaceutical composition for treating liver dysfunction comprising said polyprenylcarboxylic acid amide.

摘要翻译： 本发明涉及由以下通式（I）表示的聚异戊二烯羧酸酰胺：其中n为1至4的整数，a和b代表氢原子或碳原子之间的直接键键 a和b连接在一起，c和d代表氢原子或c和d连接的碳原子之间的直接键键，R1和R2代表氢原子，低级烷基，苯基 或可以被取代的芳烷基，或者R 1和R 2与相邻的氮原子一起形成可含有其它杂原子或可被取代的5-或6-元杂环，也可以与 用于制备所述聚异戊二烯基羧酸酰胺的方法和用于治疗包含所述聚异戊二烯基羧酸酰胺的肝功能障碍的药物组合物。

公开(公告)号：US4613571A

公开(公告)日：1986-09-23

申请号：US581763

申请日：1984-02-21

申请人： Akio Sato ,  Kenji Nakajima ,  Yoshimasa Takahara ,  Shizumasa Kijima ,  Hideaki Watanabe ,  Tamio Kawamura ,  Yasushi Nagai

发明人： Akio Sato ,  Kenji Nakajima ,  Yoshimasa Takahara ,  Shizumasa Kijima ,  Hideaki Watanabe ,  Tamio Kawamura ,  Yasushi Nagai

IPC分类号： A61K31/095 ,  A61P9/12 ,  A61P35/00 ,  C07C29/00 ,  C07C33/02 ,  C07C67/00 ,  C07C313/00 ,  C07C317/14 ,  C07C317/18 ,  C07C317/44 ,  C12P1/06 ,  C12P11/00 ,  C12R1/15 ,  C12R1/365 ,  F27B9/02 ,  F27D5/00

CPC分类号： C12R1/365 ,  C07C29/00 ,  C07C317/00 ,  C07C33/02 ,  C12P11/00 ,  Y10S435/872

摘要： There are disclosed polyprenyl sulfone derivatives of the general formula: ##STR1## wherein n represents an integer of 1-4, R.sub.1 represents an aryl group d R.sub.2 represents a hydroxymethyl or carboxyl group. The polyprenyl sulfone derivatives are prepared by cultivating a microorganism of the genus Nocardia capable of oxidizing a compound of the general formula: ##STR2## wherein n and R.sub.1 have the same meanings as defined above, in a culture medium containing a compound of the above general formula (II), and then collecting the oxidation product from the culture mixture. The polyprenyl sulfone derivatives are useful as intermediates for preparing various useful polyprenyl compounds.

公开(公告)号：US4117228A

公开(公告)日：1978-09-26

申请号：US770039

申请日：1977-02-18

申请人： Satoru Tanaka ,  Hideaki Watanabe

发明人： Satoru Tanaka ,  Hideaki Watanabe

IPC分类号： C07D317/46 ,  C07D405/06

CPC分类号： C07D317/46

摘要： 1,3-Benzodioxol derivatives, the new compounds, represented by the formula: ##STR1## AND THE PHARMACOLOGICALLY ACCEPTABLE ACID-ADDITION SALTS THEREOF ARE PROVIDED, WHEREIN R.sub.1 and R.sub.2 are lower alkyls or the both together may form a divalent alkylene, R.sub.3 is a lower alkyl, phenyl, halogen-substituted phenyl or benzhydryl group, n is an integer of 2 or 3, and X stands for carbonyl (CO) or methylene (CH.sub.2) bridge. The compounds in which X stands for the methylene exhibit durable anti-histamic activity with low toxicity, and are useful for therapeutic purposes, while the compounds in which X stands for the carbonyl bridge are easily convertible by reduction into the former compounds.

公开(公告)号：US09629880B2

公开(公告)日：2017-04-25

申请号：US14003052

申请日：2011-09-15

申请人： Mitsugu Watanabe ,  Takayuki Watanabe ,  Hideaki Watanabe

发明人： Mitsugu Watanabe ,  Takayuki Watanabe ,  Hideaki Watanabe

IPC分类号： A61K35/56 ,  A61K35/34 ,  A61K35/12 ,  A61K35/618 ,  A23L33/10 ,  A23L17/20

CPC分类号： A61K35/618 ,  A23L17/20 ,  A23L33/10 ,  A23V2002/00

摘要： To provide a method for producing an oyster meat essence that more amply incorporates an antioxidant substance with high ORAC value as follows. A portion of an oyster meat extract more amply incorporating an antioxidant substance with high ORAC value is selected. An extraction method that allows incorporating further large amount of antioxidant substance with high ORAC value is employed. The beneficial oyster meat extract can be efficiently extracted in large amounts.ObjectAn oyster meat is stored in an extraction container where water is accumulated. An oyster meat essence is extracted to generate an extract liquid. The extract liquid is injected to a centrifuge, and concurrently the centrifuge is rotated at a centrifugal acceleration where an antioxidant substance with high antioxidative potency and ORAC value is separated and removed from the extract liquid. The antioxidant substance with higher antioxidative potency and ORAC value is separated. Thus, the oyster meat essence incorporating a large amount of antioxidant substance with high antioxidative potency and ORAC value is obtained.

公开(公告)号：US09245035B2

公开(公告)日：2016-01-26

申请号：US13602786

申请日：2012-09-04

申请人： Takayuki Ishida ,  Hideaki Watanabe

发明人： Takayuki Ishida ,  Hideaki Watanabe

IPC分类号： G06F17/30 ,  G06Q50/00

CPC分类号： G06F17/30867 ,  G06Q50/01

摘要： A cluster value identifying unit identifies a value of a parameter representing a level of a ground swell of interest related to provided information, which is determined in accordance with registration of information related to the provided information. A period identifying unit identifies, based on the value of the parameter, a period in which the ground swell of interest related to the provided information grows with a lapse of time. A user feature identifying unit identifies, based on the identified period, a feature of a user who registers the related information. Accordingly, the feature of the user may be identified based on the registration of the information related to the provided information.

摘要翻译： 集群值识别单元识别表示与提供的信息相关的感兴趣的地面膨胀水平的参数的值，其根据与所提供的信息相关的信息的注册确定。 期间识别单元基于参数的值来识别与所提供的信息相关的兴趣的地面膨胀随着时间的流逝而增长的时段。 用户特征识别单元基于所识别的周期识别注册相关信息的用户的特征。 因此，可以基于与所提供的信息相关的信息的注册来识别用户的特征。

公开(公告)号：US20130337079A1

公开(公告)日：2013-12-19

申请号：US14003052

申请日：2011-09-15

申请人： Mitsugu Watanabe ,  Takayuki Watanabe ,  Hideaki Watanabe

发明人： Mitsugu Watanabe ,  Takayuki Watanabe ,  Hideaki Watanabe

IPC分类号： A61K35/56

CPC分类号： A61K35/618 ,  A23L17/20 ,  A23L33/10 ,  A23V2002/00

摘要： To provide a method for producing an oyster meat essence that more amply incorporates an antioxidant substance with high ORAC value as follows. A portion of an oyster meat extract more amply incorporating an antioxidant substance with high ORAC value is selected. An extraction method that allows incorporating further large amount of antioxidant substance with high ORAC value is employed. The beneficial oyster meat extract can be efficiently extracted in large amounts.ObjectAn oyster meat is stored in an extraction container where water is accumulated. An oyster meat essence is extracted to generate an extract liquid. The extract liquid is injected to a centrifuge, and concurrently the centrifuge is rotated at a centrifugal acceleration where an antioxidant substance with high antioxidative potency and ORAC value is separated and removed from the extract liquid. The antioxidant substance with higher antioxidative potency and ORAC value is separated. Thus, the oyster meat essence incorporating a large amount of antioxidant substance with high antioxidative potency and ORAC value is obtained.