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公开(公告)号：US5431820A
公开(公告)日：1995-07-11
申请号：US70400
申请日：1993-06-10
CPC分类号： C02F3/1231 , C02F3/34 , C12P1/02 , Y02W10/15 , Y10S210/928 , Y10S435/911
摘要： The liquid waste after pulp bleaching can be treated by using a microorganism having lignin degradation activity and having been pre-cultured in a culture medium supplemented with the liquid waste after pulp bleaching and/or lignin related substances, the cultured products thereof and/or the treated products thereof.The scarcely degradable colored ingredients and/or chlorinated phenols contained in the liquid waste after pulp bleaching can be decomposed and removed, whereby the efficient treatment of the liquid waste after pulp bleaching can be achieved.
摘要翻译： PCT No.PCT / JP92 / 01238 Sec。 371日期：1993年6月10日 102（e）日期1993年6月10日PCT提交1992年9月28日PCT公布。 公开号WO93 / 07333 日期：1993年04月15日。纸浆漂白后的废液可以通过使用具有木质素降解活性的微生物进行处理，并且在纸浆漂白和/或木质素相关物质补充有液体废料的培养基中预培养， 其培养产物和/或其处理产物。 纸浆漂白后废液中含有的几乎不降解的有色成分和/或氯化酚可以分解除去，从而可以实现纸浆漂白后的废液的有效处理。
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公开(公告)号：US5149648A
公开(公告)日：1992-09-22
申请号：US651632
申请日：1991-02-06
CPC分类号： C12N9/0065 , C12P7/22 , C12Y111/01014 , D21C5/005 , Y10S435/911
摘要： According to this invention, pulps can be produced in high yields while saving energy by previously fiberizing wood chips used as the original material and then treating with a microorganism having a high lignin-degrading activity and a low fiber-degrading activity upon the wood.In addition, new lignin-degrading enzymes produced by a microorganism used in this invention were identified.
摘要翻译： 根据本发明，可以以高产率生产纸浆，同时通过预先使用作为原始材料的木片进行纤维化，然后用对木材具有高木质素降解活性和低纤维降解活性的微生物进行处理，从而节省能量。 此外，鉴定了由本发明中使用的微生物产生的新的木质素降解酶。
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3.发明授权Method for producing pulp by treatment using a microorganism, and its related enzymes 失效使用微生物处理生产纸浆的方法及其相关酶
公开(公告)号：US5081027A
公开(公告)日：1992-01-14
申请号：US493778
申请日：1990-03-15
CPC分类号： C12N9/0065 , C12P7/22 , C12Y110/03002 , D21C5/005 , Y10S435/911
摘要： According to this invention, pulps can be produced in high yields while saving energy by previously fiberizing wood chips used as the original material and then treating with a microorganism having a high lignin-degrading activity and a low fiber-degrading activity upon the wood.In addition, new lignin-degrading enzymes produced by a microorganism used in this invention were identified.
摘要翻译： 根据本发明，可以以高产率生产纸浆，同时通过预先使用作为原始材料的木片进行纤维化，然后用对木材具有高木质素降解活性和低纤维降解活性的微生物进行处理，从而节省能量。 此外，鉴定了由本发明中使用的微生物产生的新的木质素降解酶。
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公开(公告)号：US4332904A
公开(公告)日：1982-06-01
申请号：US30766
申请日：1979-04-17
IPC分类号： C02F3/28 , C02F3/32 , C09K3/00 , C12N1/00 , C12N11/14 , C12P1/00 , C12R1/365 , C13B30/14 , C13K1/06 , C13K3/00 , C13K11/00 , C12N1/20 , C02F3/00 , C12P7/50
CPC分类号： C12N11/14 , C12P1/00 , Y10S435/813 , Y10S435/872
摘要： A vessel capable of passing a liquid therethrough is packed with a support having at least hydrophilicity and microorganism cells are inoculated to the support, retained and cultivated therein. A reaction substrate is fed to the vessel and brought into contact with the microorganism, whereby the microorganism is allowed to propagate within the support and act upon the reaction substrate to induce decomposition or synthetic reactions thereof.
摘要翻译： 能够使液体通过的容器装填有至少具有亲水性的载体，并将微生物细胞接种到载体中，保留并培养在其中。 将反应底物加入到容器中并与微生物接触，由此允许微生物在载体内传播并作用于反应底物以诱导其分解或合成反应。
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公开(公告)号：US5378738A
公开(公告)日：1995-01-03
申请号：US78296
申请日：1993-06-25
CPC分类号： C08K5/0033 , C08L101/00 , C12P1/00 , C08L2201/06
摘要： A biodegradable plastic added at an amount of a hydrophilic property imparting-substance providing wettability such that the contact angle of plastic surface to water is 70.degree. or less whereby the decomposability thereof with Basidiomycetes, the cultured products thereof and/or the processed products thereof is improved. A method for decomposing plastic under the conditions with limitation to nitrogen and/or carbon in decomposing such biodegradable plastic. In accordance with the present invention, the plastic which has conventionally been decomposed with difficulty can be decomposed efficiently.
摘要翻译： PCT No.PCT / JP92 / 01411 Sec。 371日期：1993年6月25日 102（e）日期1993年6月25日PCT提交1992年10月30日PCT公布。 出版物WO93 / 09184 日期：1993年5月13日。一种生物降解性塑料，其以提供润湿性的亲水性赋予物质的量添加，使得塑料表面与水的接触角为70℃以下，由此其与担子菌纲的分解性，其培养产物和/ 或者其加工产物得到改善。 在分解这种生物可降解塑料的条件下，限制氮和/或碳的分解塑料的方法。 根据本发明，通常难以分解的塑料可以有效地分解。
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公开(公告)号：US4921799A
公开(公告)日：1990-05-01
申请号：US93497
申请日：1987-07-17
CPC分类号： C12P7/40 , C12M21/04 , C12M25/00 , Y02E50/343
摘要： This invention provides a new fermentation method and apparatus for the same for producing a substance by a microbial action from a gaseous substrate, wherein the cells of a microorganism fixed to a carrier are held in a reactor, an aqueous solution is fed to said reactor so as to moisten at least part of the surface of said microbial cells, and said gaseous substrate is forced to pass through the interstices of said microbial cells, thereby causing direct reaction between the microorganism and the gaseous substrate and effecting efficient biosynthesis of methane, formic acid and other substances.
摘要翻译： PCT No.PCT / JP87 / 00156 Sec。 371日期1987年7月17日 102（e）1987年7月17日PCT 1987年3月13日PCT。本发明提供了一种新的发酵方法和装置，用于通过微生物作用从气态底物生产物质，其中微生物的细胞固定 将载体保持在反应器中，将水溶液进料到所述反应器中，以润湿所述微生物细胞的至少一部分表面，并且迫使所述气态底物通过所述微生物细胞的空隙，由此引起 微生物和气态底物之间的直接反应，并能有效地生物合成甲烷，甲酸等物质。
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公开(公告)号：US4613571A
公开(公告)日：1986-09-23
申请号：US581763
申请日：1984-02-21
申请人： Akio Sato , Kenji Nakajima , Yoshimasa Takahara , Shizumasa Kijima , Hideaki Watanabe , Tamio Kawamura , Yasushi Nagai
发明人： Akio Sato , Kenji Nakajima , Yoshimasa Takahara , Shizumasa Kijima , Hideaki Watanabe , Tamio Kawamura , Yasushi Nagai
IPC分类号： A61K31/095 , A61P9/12 , A61P35/00 , C07C29/00 , C07C33/02 , C07C67/00 , C07C313/00 , C07C317/14 , C07C317/18 , C07C317/44 , C12P1/06 , C12P11/00 , C12R1/15 , C12R1/365 , F27B9/02 , F27D5/00
CPC分类号： C12R1/365 , C07C29/00 , C07C317/00 , C07C33/02 , C12P11/00 , Y10S435/872
摘要： There are disclosed polyprenyl sulfone derivatives of the general formula: ##STR1## wherein n represents an integer of 1-4, R.sub.1 represents an aryl group d R.sub.2 represents a hydroxymethyl or carboxyl group. The polyprenyl sulfone derivatives are prepared by cultivating a microorganism of the genus Nocardia capable of oxidizing a compound of the general formula: ##STR2## wherein n and R.sub.1 have the same meanings as defined above, in a culture medium containing a compound of the above general formula (II), and then collecting the oxidation product from the culture mixture. The polyprenyl sulfone derivatives are useful as intermediates for preparing various useful polyprenyl compounds.
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公开(公告)号：US4500463A
公开(公告)日：1985-02-19
申请号：US259772
申请日：1981-05-01
申请人： Akio Sato , Kenji Nakajima , Yoshimasa Takahara , Shizumasa Kijima , Yuichi Inai , Yoshiyuki Kohara , Yoshiyuki Kawakami , Tomio Tsurugi
发明人： Akio Sato , Kenji Nakajima , Yoshimasa Takahara , Shizumasa Kijima , Yuichi Inai , Yoshiyuki Kohara , Yoshiyuki Kawakami , Tomio Tsurugi
IPC分类号： A61K31/19 , A61K31/22 , A61P1/04 , A61P9/12 , C07C51/00 , C07C57/13 , C07C59/42 , C07C59/74 , C07C67/00 , C07C69/602 , C07C69/73 , C07C69/732 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/62 , C12P7/64
CPC分类号： C12P7/6409 , C07C57/13 , C07C59/42 , C07C59/74 , C12P7/42 , C12P7/44 , C12P7/62 , C12P7/6436 , C12R1/15 , C12R1/34 , C12R1/365 , C12R1/73 , Y02P20/55 , Y10S435/843 , Y10S435/866 , Y10S435/872 , Y10S435/923
摘要： Polyprenyl carboxylic acid derivatives having the general formula (I): ##STR1## in which n is an integer of from 2 to 4, R.sub.1 represents the hydrogen atom or a protecting group for the carboxylic acid group, and R.sub.2 represents a hydroxymethyl, formyl or carboxyl group, are disclosed. A process for the preparation of the polyprenyl carboxylic acid derivative involving microbiological oxidation using a strain belonging to the genus Nocardia is disclosed. The compounds have anti-ulcer activity and hypotensive activity. The compounds also are useful as intermediates for preparing polyprenyl carboxylic acids of the formula ##STR2## and esters thereof, wherein l is an integer of from 4 to 11. The polyprenyl carboxylic acids and esters thereof have hypotensive activity and anti-ulcer activity.
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公开(公告)号：US4474881A
公开(公告)日：1984-10-02
申请号：US392831
申请日：1982-06-28
申请人： Akio Sato , Kenji Nakajima , Yoshimasa Takahara , Shizumasa Kijima , Yuichi Inai , Yoshiyuki Kohara , Yoshiyuki Kawakami , Tomio Tsurugi
发明人： Akio Sato , Kenji Nakajima , Yoshimasa Takahara , Shizumasa Kijima , Yuichi Inai , Yoshiyuki Kohara , Yoshiyuki Kawakami , Tomio Tsurugi
IPC分类号： A61K31/19 , A61K31/22 , A61P1/04 , A61P9/12 , C07C51/00 , C07C57/13 , C07C59/42 , C07C59/74 , C07C67/00 , C07C69/602 , C07C69/73 , C07C69/732 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/62 , C12P7/64 , C12N1/20 , C12N9/02 , C12P7/00
CPC分类号： C12P7/6409 , C07C57/13 , C07C59/42 , C07C59/74 , C12P7/42 , C12P7/44 , C12P7/62 , C12P7/6436 , C12R1/15 , C12R1/34 , C12R1/365 , C12R1/73 , Y02P20/55 , Y10S435/843 , Y10S435/866 , Y10S435/872 , Y10S435/923
摘要： A process is disclosed for the preparation of a compound having the general formula: ##STR1## wherein n is an integer of from 2 to 4, R.sub.1 is an ester-forming moiety effective as a protecting group for a carboxyl group, and R.sub.2 is hydroxymethyl, formyl or carboxyl. The compounds (I) are useful as intermediates for the preparation of polyprenyl compounds having hypotensive and anti-ulcer activity. The process of the invention includes cultivating a microorganism selected from a strain of the genus Nocardia called BPM 1613, FERM-P No. 1609, Corynebacterium equi IAM 1038, Candida lipolytica IFO 0746, and Mycobacterium smegmatis IFO 3083, in a nutritive culture medium, in the presence of a compound having the general formula: ##STR2## wherein R.sub.3 is an ester-forming moiety effective as a protecting group for a carboxyl group, whereby the microorganism utilizes the compound (II) as a carbon source and oxidizes the compound (II), thereby converting the compound (II) into the compound (I).
摘要翻译： 公开了用于制备具有以下通式的化合物的方法：其中n是2至4的整数，R 1是有效作为羧基的保护基的酯形成部分，和 R2是羟甲基，甲酰基或羧基。 化合物（I）可用作制备具有降血压和抗溃疡活性的聚异戊二烯基化合物的中间体。 本发明的方法包括在营养培养基中培养选自诺卡氏菌属称为BPM1613的菌株，FERM-P No.1609，Corynebacterium equi IAM 1038，解脂亚油酸歧杆菌IFO 0746和耻垢分枝杆菌IFO 3083的微生物， 在具有以下通式的化合物的存在下：其中R 3是有效作为羧基的保护基的酯形成部分，由此微生物将化合物（II）用作碳源并氧化 化合物（II），从而将化合物（II）转化为化合物（I）。
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10.发明授权
公开(公告)号：US4468458A
公开(公告)日：1984-08-28
申请号：US360519
申请日：1982-03-22
申请人： Akio Sato , Kenji Nakajima , Yoshimasa Takahara , Shizumasa Kijima , Noriaki Kuwana , Shinya Abe , Kouzi Yamada
发明人： Akio Sato , Kenji Nakajima , Yoshimasa Takahara , Shizumasa Kijima , Noriaki Kuwana , Shinya Abe , Kouzi Yamada
IPC分类号： A61K31/11 , C07C29/10 , C07C33/02 , C07C47/263 , C07C47/277 , C07C59/01 , C07C59/66 , C07D309/12 , C12P7/02 , C12P7/24 , C12P7/40 , C12P7/64 , C12P17/06
CPC分类号： C12P7/6427 , A61K31/11 , C07C29/10 , C07C33/02 , C07C47/263 , C07C47/277 , C07C59/01 , C07C59/66 , C07D309/12 , C12P17/06 , C12P7/02 , C12P7/24 , C12P7/40 , C12R1/365 , Y02P20/582 , Y10S435/872
摘要： A process for the preparation of a two-functional-group-containing terpenoid having the general formula: ##STR1## in which n is an integer of from 1 to 5, R represents a hydroxymethyl, formyl or carboxyl group, and A represents the hydrogen atom, or a 2-tetrahydropyranyl, benzyl, methoxymethol or methoxyethoxymethyl group comprising the oxidation with a microorganism belonging to the genus Nocardia. Some of the terpenoids are of value as anti-ulcer agents, while others are useful as intermediates.
摘要翻译： 制备具有以下通式的双官能团的萜类化合物的方法：其中n是1至5的整数，R表示羟甲基，甲酰基或羧基，A表示氢 或包含与属于诺卡氏菌属的微生物氧化的2-四氢吡喃基，苄基，甲氧基甲基或甲氧基乙氧基甲基。 一些萜类化合物作为抗溃疡剂是有价值的，而其它萜类化合物可用作中间体。
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