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51.发明申请公开(公告)号：US20190263912A1
公开(公告)日：2019-08-29
申请号：US16348911
申请日：2017-11-07
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , The General Hospital Corporation
发明人： Adam Haber , Moshe Biton , Rebecca H. Herbst , Karthik Shekhar , Christopher Smillie , Orit Rozenblatt-Rosen , Ramnik Xavier , Aviv Regev , Jose Ordovas-Montanes , Alexander K. Shalek , Noga Rogel
IPC分类号： C07K16/28 , C07K14/47 , C07K14/52 , A61K35/17 , C07K14/71 , C12N5/0783 , G01N33/50 , C12N5/071 , A61P1/04 , A61P1/14 , G01N33/569 , A61P33/00 , A61P31/04
摘要： An atlas of intestinal epithelial cells, intestinal epithelial stem cells and intestinal immune cells identifies new cell populations, markers, networks, and responses to stimuli. Intestinal T cells drive intestinal epithelial cell differentiation and activity. Accordingly, disclosed are methods of modulating intestinal epithelial cell differentiation, maintenance and/or function, related methods for the treatment of disease, including IBD. Also disclosed are methods and kits for identifying cell types, their differentiation, homeostasis and activation.
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公开(公告)号：US20230324371A1
公开(公告)日：2023-10-12
申请号：US18021156
申请日：2021-08-12
申请人： Paola ARLOTTA , Mario L. SUVA , Aviv REGEV , Kwanghun GHUNG , Vamsi MANGENA , Rafaela SARTORE , President and Fellows of Harvard College , The Broad Institute, Inc. , The General Hospital Corporation , Massachusetts Institute of Technology
发明人： Paola Arlotta , Mario L. Suva , Aviv Regev , Kwanghun Chung , Vamsi Mangena , Rafaela Sartore
CPC分类号： G01N33/5082 , G01N33/5011 , G01N33/5023 , C12N5/0697 , C12N2513/00 , C12N2503/04
摘要： Compositions and systems comprising a dorsal forebrain organoid having a core comprising less than 25% apoptotic or hypoxic cells and one or more tumor cells in the organoid.
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公开(公告)号：US20230235400A1
公开(公告)日：2023-07-27
申请号：US17928696
申请日：2021-06-04
申请人： The General Hospital Corporation , Children's Medical Center Corporation , President and Fellows of Harvard College , The Broad Institute, Inc. , Massachusetts Institute of Technology
发明人： Vamsi Mootha , Vijay Sankaran , Caleb Lareau , Melissa Walker , Leif Ludwig , Aviv Regev
IPC分类号： C12Q1/6883 , G16B30/00 , G16B20/00
CPC分类号： C12Q1/6883 , G16B30/00 , G16B20/00 , C12Q1/6869
摘要： Described herein are methods of determining segregation dynamics of mitochondrial DNA herein. Also described herein are methods of diagnosing, prognosing, and/or monitoring a mitochondrial disease.
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公开(公告)号：US20210325387A1
公开(公告)日：2021-10-21
申请号：US16632018
申请日：2018-07-17
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , The General Hospital Corporation
发明人： Alexander K. Shalek , Christopher Smillie , Rebecca H. Herbst , Moshe Biton , Aviv Regev , Jose Ordovas-Montanes , Ramnik Xavier
IPC分类号： G01N33/569 , C12Q1/6883
摘要： The present invention provides for a human cell atlas of the colon from healthy and diseased subjects. The atlas was obtained by single sequencing of about 117,000 cells. The present invention discloses novel markers for cell types. Moreover, genes associated with disease are identified in the colon and colon specific cell types. The invention provides for diagnostic assays based on gene markers and cell composition, as well as target cell types that express genes associated with disease. Finally, disclosed are novel cell types and methods of quantitating, detecting and isolating the cell types.
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公开(公告)号：US12105089B2
公开(公告)日：2024-10-01
申请号：US16632018
申请日：2018-07-17
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , The General Hospital Corporation
发明人： Alexander K. Shalek , Christopher Smillie , Rebecca H. Herbst , Moshe Biton , Aviv Regev , Jose Ordovas-Montanes , Ramnik Xavier
IPC分类号： G01N33/569 , C12Q1/6883 , G01N33/68
CPC分类号： G01N33/56966 , C12Q1/6883 , G01N33/6893 , C12Q2600/106 , C12Q2600/158 , G01N2800/065 , G01N2800/52
摘要： The present invention provides for a human cell atlas of the colon from healthy and diseased subjects. The atlas was obtained by single sequencing of about 117,000 cells. The present invention discloses novel markers for cell types. Moreover, genes associated with disease are identified in the colon and colon specific cell types. The invention provides for diagnostic assays based on gene markers and cell composition, as well as target cell types that express genes associated with disease. Finally, disclosed are novel cell types and methods of quantitating, detecting and isolating the cell types.
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公开(公告)号：US11630103B2
公开(公告)日：2023-04-18
申请号：US16325807
申请日：2017-08-17
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , The General Hospital Corporation
发明人： Alexandra-Chloé Villani , Rahul Satija , Aviv Regev , Nir Hacohen
摘要： The present invention provides isolated immune cells, immune cell populations and compositions, as well as markers, marker signatures and molecular targets characterising the immune cells. The cell products, substances, compositions, markers, marker signatures, molecular targets, kits of parts and methods of the present invention provide for new ways to characterise, evaluate and modulate the immune system and immune responses.
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公开(公告)号：US20220170097A1
公开(公告)日：2022-06-02
申请号：US17289844
申请日：2019-10-29
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , The General Hospital Corporation
IPC分类号： C12Q1/6881 , C12N5/0783 , A61K35/17 , G01N33/50
摘要： The invention relates to gene expression profiles and signatures of CAR T cells. The invention provides methods and compositions of CAR T cells and populations. The invention provides assays and methods of screening subjects to assess efficacy and safety of CAR T cell treatments and therapies. The invention provides assays and methods of engineering and/or administering CAR T cells to promote efficacy and safety.
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公开(公告)号：US20220062394A1
公开(公告)日：2022-03-03
申请号：US17414480
申请日：2019-12-12
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , The General Hospital Corporation , Dana-Farber Cancer Institute, Inc.
发明人： Tamara Ouspenskaia , Travis Law , Aviv Regev , Steven Carr , Karl Clauser , Susan Klaeger , Nir Haochen , Catherine J. Wu , Derin Keskin
IPC分类号： A61K39/00 , G01N33/68 , C12Q1/6869 , A61K45/06
摘要： Disclosed herein are polypeptides and compositions comprising one or more neoantigens, methods of identifying neoantigens, and methods for preparing a neoantigen for an immunogenic pharmaceutical composition. The neoantigen can be specific to a subject that has a cancer, disease, or other disorder.
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公开(公告)号：US20210115407A1
公开(公告)日：2021-04-22
申请号：US16604596
申请日：2018-04-12
申请人： The Broad Institute, Inc. , The General Hospital Corporation , Massachusetts Institute of Technology
发明人： Jayaraj Rajagopal , Aviv Regev , Moshe Biton , Adam Haber , Daniel Montoro , Orit Rozenblatt-Rosen
摘要： Provided herein are methods and compositions for identifying ionocytes from respiratory epithelial cells, and uses of such cells for treatment of inflammatory lung disease. Also provided herein are methods and compositions for modulating respiratory tract epithelial cell proliferation, differentiation, maintenance, and/or function.
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公开(公告)号：US20200208114A1
公开(公告)日：2020-07-02
申请号：US16709710
申请日：2019-12-10
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , The General Hospital Corporation , President and Fellows of Harvard College
IPC分类号： C12N5/0775 , G01N33/50 , C12N15/11 , C12N9/22 , A61K35/28 , C12Q1/6886
摘要： Described herein are signatures that characterize a particular stromal cell state, type, and/or subtype. In some embodiments, the signatures can characterize a dysfunctional stromal cell. In some embodiments, the signatures can be used to diagnose, treat, and/or prevent a disease. In some embodiments, the signatures can characterize remodeling in a bone marrow microenvironment. Also described herein are cell populations having a specific signature and modulated cells that can be modulate to have a specific signature.
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