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公开(公告)号：US06360122B1
公开(公告)日：2002-03-19
申请号：US09628977
申请日：2000-08-02
IPC分类号： A61B504
CPC分类号： A61B5/0476 , A61B5/4094 , A61B5/6814 , A61N1/36025 , A61N1/3605 , A61N1/36082 , A61N1/37211 , G06F19/00
摘要： Disclosed is a multiple electrode, closed-loop, responsive system for the treatment of certain neurological diseases such as epilepsy, migraine headaches and Parkinson's disease. Brain electrodes would be placed in close proximity to the brain or deep within brain tissue. When a neurological event such as the onset of an epileptic seizure occurs, EEG signals from the electrodes are processed by signal conditioning in a control module that can be placed beneath the patient's scalp, within the patient's chest, or situated externally on the patient. Neurological event detection means in the control module will then cause a response to be generated for stopping the neurological event. The response could be an electrical signal to brain electrodes or to electrodes located remotely in the patient's body. The response could also be the release of medication or the application of a sensory input such as sound, light or mechanical vibration or electrical stimulation of the skin. The response to the neurological event can originate from devices either internal or external to the patient. The system also has the capability for multi-channel recording of EEG related signals that occur both before and after the detection of a neurological event. Programmability of many different operating parameters of the system by means of external equipment provides adaptability for treating patients who manifest different symptoms and who respond differently to the response generated by the system.
摘要翻译： 公开了一种用于治疗某些神经系统疾病如癫痫，偏头痛和帕金森病的多重电极闭环应答系统。 脑电极将放置在靠近脑部或脑组织深处。 当出现诸如发作癫痫发作的神经系统事件时，来自电极的EEG信号通过控制模块中的信号调节进行处理，所述控制模块可以放置在患者的头皮之下，患者的胸部内，或位于患者的外部。 然后，控制模块中的神经事件检测装置将产生用于停止神经系统事件的响应。 响应可以是对脑电极或位于病人身体远端的电极的电信号。 该反应也可以是药物的释放或者诸如声音，光或机械振动或电刺激皮肤的感觉输入的应用。 对神经系统事件的反应可以来自患者内部或外部的装置。 该系统还具有在检测神经系统事件之前和之后发生的EEG相关信号的多通道记录的能力。 通过外部设备对系统的许多不同操作参数的可编程性提供了适应性，用于治疗表现不同症状的患者，并且对系统产生的反应有不同的反应。
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公开(公告)号：US06354299B1
公开(公告)日：2002-03-12
申请号：US09609086
申请日：2000-06-30
IPC分类号： A61B1900
CPC分类号： A61N1/37217 , A61N1/36025 , A61N1/36082 , A61N1/36135
摘要： An implantable device incorporating an acoustic transducer allows information and alerts to be communicated from the device to a patient. Sounds, including but not limited to buzzes, tones, sequences of tones, combinations of tones, complex sounds, and segments of reproduced or simulated human speech, are transmitted from an intracranially implanted portion of the device via bone conduction to the patient's ears, particularly the inner ears. In the disclosed embodiment, the acoustic transducer is used in cooperation with an implantable closed-loop system for the treatment of certain neurological disorders such as epilepsy, migraine headaches and Parkinson's disease, to warn the patient of an imminent seizure or other episode, to provide information to the patient on the state of the implantable apparatus, and to provide reminders and other information to the patient.
摘要翻译： 结合声学换能器的可植入装置允许将信息和警报从装置传送到患者。 特别是通过骨传导从设备的颅内植入部分发送声音，包括但不限于嗡嗡声，音调，音调序列，音调的组合，复合声音和再现或模拟人类语言的段 内耳。 在所公开的实施例中，声换能器与用于治疗某些神经障碍如癫痫，偏头痛和帕金森病的可植入闭环系统配合使用，以警告患者即将发作或其他发作，以提供 向患者提供关于植入式装置的状态的信息，并向患者提供提醒和其他信息。
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公开(公告)号：US06350226B1
公开(公告)日：2002-02-26
申请号：US09637999
申请日：2000-08-15
IPC分类号： A61N500
CPC分类号： A61N5/1029
摘要： Disclosed is a novel wound dressing which applies ionizing radiation to the surface of the wound as soon after the wound is created as is possible. Optimally, the radiation has a range which extends to the bottom surface of the skin but not significantly beyond that depth. An example of a radioactive source that can apply this type of radiation dosing is a beta particle emitting radioisotope such as phosphorous-32 which has a range of approximately 3.5 mm for 90% of the electrons that it emits. Even very small amounts of phosphorous-32 can provide a sufficiently high level of irradiation to significantly diminish scar tissue formation. The radioactive bandage would typically be an elongated flexible structure which can be applied along a wound or surgical incision. Typically, the radioactive bandage would extend for approximately 1 to 5 mm beyond the cut in all directions. The radioactive bandage would include a shield structure which surrounds the thin, elongated radioactive portion thus disallowing stray radiation outward from the patient's skin. A radiation dose applied to the top of the incision of between 500 and 2000 cGy can substantially reduce scar tissue formation for most patients.
摘要翻译： 公开了一种新颖的伤口敷料，其可以在伤口创建之后尽可能快地向伤口的表面施加电离辐射。 最佳地，辐射具有延伸到皮肤底部表面但不超过该深度的范围。 可以应用这种辐射剂量的放射源的一个例子是发射放射性同位素的β粒子，例如磷32，其发射的电子的90％具有大约3.5mm的范围。 甚至非常少量的磷32可以提供足够高的照射水平以显着减少瘢痕组织形成。 放射性绷带通常是可以沿着伤口或手术切口施用的细长柔性结构。 通常，放射性绷带将在所有方向上延伸超过切口约1至5毫米。 放射性绷带将包括围绕细长的放射性部分的屏蔽结构，从而不允许从患者皮肤向外的杂散辐射。 施加到切口顶部的辐射剂量在500和2000cGy之间可以大大减少大多数患者的瘢痕组织形成。
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54.发明授权Implantable electronic system with acute myocardial infarction detection and patient warning capabilities 有权具有急性心肌梗死检测和患者警戒能力的植入式电子系统公开(公告)号：US06272379B1
公开(公告)日：2001-08-07
申请号：US09271219
申请日：1999-03-17
IPC分类号： A61N139
CPC分类号： A61B5/0031 , A61B5/0006 , A61N1/3925
摘要： Disclosed is a system for detecting a myocardial infarction (i.e., a heart attack) at the earliest possible time and promptly warning the patient that he should immediately seek medical care. Specifically, a first embodiment of the present invention has an implantable electronic system that can sense a change in the patient's electrogram that is indicative of a myocardial infarction. If a myocardial infarction is sensed, the device would then cause an implantable or externally located alarm means such as an audio sound to be actuated to warn the patient of his condition. The patient could then promptly seek medical care, for example, at a hospital emergency room. Having been trained to recognize such an alarm, most patient would neither fail to recognize such an indication of a myocardial infarction nor would they ignore such an alarm signal if it were to occur. Since an implantable heart pacemaker or defibrillator already has within its structure many of the elements required for the device to recognize a myocardial infarction, it would be expeditious to add a capability to these existing devices to detect a myocardial infarction and provide an implantable or external alarm means to inform the patient to take appropriate action.
摘要翻译： 公开了一种用于早期检测心肌梗死（即心脏病发作）的系统，并且及时警告患者应立即求医。 具体地，本发明的第一实施例具有可以感测指示心肌梗塞的患者电描记图变化的可植入电子系统。 如果感测到心肌梗塞，则该装置然后将引起可植入或外部定位的报警装置，例如音频声音被致动以警告患者他的状况。 患者可以立即就医，例如在医院急诊室就医。 经过训练以识别这样的警报，大多数患者既不会认识到这种心肌梗塞的指示，也不会忽视这种报警信号，如果发生。 由于植入式心脏起搏器或除颤器在其结构内已经具有设备识别心肌梗塞所需要的许多元件，因此将快速地向这些现有装置添加能力以检测心肌梗死并提供可植入或外部警报 意味着通知患者采取适当的行动。
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55.发明授权Integrated system for EEG monitoring and electrical stimulation with a multiplicity of electrodes 有权用于EEG监测和电刺激与多个电极的集成系统公开(公告)号：US06230049B1
公开(公告)日：2001-05-08
申请号：US09373676
申请日：1999-08-13
IPC分类号： A61B0500
CPC分类号： A61B5/4094 , A61B5/0002 , A61B5/0476 , A61N1/36017 , A61N1/36025 , A61N1/36082
摘要： The disclosed invention is an integrated system for EEG monitoring and electrical stimulation from a multiplicity of scalp or intracranial implanted electrodes. The system integrates EEG monitoring and brain stimulation, supports remote electrode selection for stimulation and provides a wireless connection between the patient's brain electrodes and the EEG analysis workstation used to collect EEG data, analyze EEG signals and control system functionality.
摘要翻译： 所公开的发明是用于从多个头皮或颅内植入电极进行脑电监测和电刺激的集成系统。 该系统集成了EEG监测和脑刺激，支持远程电极选择进行刺激，并提供患者脑电极与用于收集EEG数据的EEG分析工作站之间的无线连接，分析脑电信号和控制系统功能。
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公开(公告)号：US06221043B1
公开(公告)日：2001-04-24
申请号：US09373552
申请日：1999-08-13
IPC分类号： A61M2900
CPC分类号： A61M25/1002
摘要： Disclosed is a balloon on a distal portion of a balloon angioplasty catheter. The section of the balloon onto which a stent can be mounted has a central segment that is substantially cylindrical in shape that is centered between two segments each having the shape of a sector of a prolate spheroid. This shape for a balloon for a stent delivery catheter provides a more cylindrical shape for the stent after it is implanted in an artery that has a typical distribution of plaque in an arterial stenosis, which distribution of plaque is greatest for some limited length at a central region of the stenosis and then decreases somewhat uniformly as one approaches the edges of the stenosis. Another embodiment of the invention utilizes two segments that are frustums of a cone instead of sectors of a prolate spheroid, which conical segments surround the central cylindrical segment. Also disclosed is a balloon whose compliance decreases continuously as a function of the distance away from either end of the central segment. Any of these embodiments can employ dual conical end segments at each end of the balloon which consist of two adjacent frustums of a cone making different half-angles with the longitudinal axis of the balloon.
摘要翻译： 公开了一种在球囊血管成形术导管的远端部分上的气囊。 可以安装支架的气囊部分具有基本圆柱形的中心段，该中心段的形状中心在两个段之间，每段具有扁平球状体的扇形。 用于支架输送导管的球囊的这种形状在支架植入植入动脉狭窄的典型分布的动脉中之后为支架提供更圆柱形的形状，其中斑块的分布在中心的一些有限的长度处是最大的 狭窄区域然后随着接近狭窄边缘而稍微均匀地减小。 本发明的另一个实施例利用作为锥体的平截头体的两个部分，而不是长椭球形的扇形部分，该锥形部分围绕中心圆柱形部分。 还公开了一种球囊，其气囊的顺从性随距离中心段的任一端的距离而连续减小。 这些实施例中的任何一个可以在球囊的每个端部处使用双锥形端部段，其由与球囊的纵向轴线形成不同半角的圆锥体的两个相邻平截头体组成。
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公开(公告)号：US6128538A
公开(公告)日：2000-10-03
申请号：US450303
申请日：1999-11-29
IPC分类号： A61N1/36
CPC分类号： A61B5/0476 , A61B5/4094 , A61B5/6814 , A61N1/3605 , A61N1/36025 , A61N1/36082 , A61N1/37211
摘要： Disclosed is a multiple electrode, closed-loop, responsive system for the treatment of certain neurological diseases such as epilepsy, migraine headaches and Parkinson's disease. Brain electrodes would be placed in close proximity to the brain or deep within brain tissue. When a neurological event such as the onset of an epileptic seizure occurs, EEG signals from the electrodes are processed by signal conditioning means in a control module that can be placed beneath the patient's scalp, within the patient's chest, or situated externally on the patient. Neurological event detection means in the control module will then cause a response to be generated for stopping the neurological event. The response could be an electrical signal to brain electrodes or to electrodes located remotely in the patient's body. The response could also be the release of medication or the application of a sensory input such as sound, light or mechanical vibration or electrical stimulation of the skin. The response to the neurological event can originate from devices either internal or external to the patient. The system also has the capability for multi-channel recording of EEG related signals that occur both before and after the detection of a neurological event. Programmability of many different operating parameters of the system by means of external equipment provides adaptability for treating patients who manifest different symptoms and who respond differently to the response generated by the system.
摘要翻译： 公开了一种用于治疗某些神经系统疾病如癫痫，偏头痛和帕金森病的多重电极闭环应答系统。 脑电极将放置在靠近脑部或脑组织深处。 当出现诸如癫痫发作的神经系统事件时，来自电极的EEG信号由控制模块中的信号调节装置处理，该控制模块可以放置在患者的头皮之下，患者的胸部内，或者位于病人的外部。 然后，控制模块中的神经事件检测装置将产生用于停止神经系统事件的响应。 响应可以是对脑电极或位于病人身体远端的电极的电信号。 该反应也可以是药物的释放或者诸如声音，光或机械振动或电刺激皮肤的感觉输入的应用。 对神经系统事件的反应可以来自患者内部或外部的设备。 该系统还具有在检测神经系统事件之前和之后发生的EEG相关信号的多通道记录的能力。 通过外部设备对系统的许多不同操作参数的可编程性提供了适应性，用于治疗表现不同症状的患者，并且对系统产生的反应有不同的反应。
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公开(公告)号：US6074371A
公开(公告)日：2000-06-13
申请号：US150908
申请日：1998-09-10
申请人： Robert E. Fischell
发明人： Robert E. Fischell
CPC分类号： A61M5/3286 , A61M25/0662 , A61M39/04
摘要： Disclosed is a needle assembly to be used with a pen-type injector and a percutaneously placed catheter device for intravenous infusion or a subcutaneously inserted cannula that is part of an injection set. Unlike all prior art needle assemblies which have a sharp point at the needle's distal end, the needle assembly described herein has a blunt tip so as to avoid any inadvertent needle sticks. This invention envisions using such a blunt tipped needle assembly connected to a pen-type injector and used with an injection set that has a cannula placed in the subcutaneous tissue. This invention also envisions using such a blunt tipped needle assembly with a pen-type injector for intravenous injections of medication through any intravenous catheter that has a septum through which the blunt needle of the pen-type injector can be placed.
摘要翻译： 公开了一种针组件，其用于笔式注射器和用于静脉内输注的经皮放置的导管装置或作为注射组的一部分的皮下插入的插管。 与在针的远端具有尖锐点的所有现有技术的针组件不同，本文所述的针组件具有钝头，以避免任何无意的针刺。 本发明设想使用连接到笔式注射器的这种钝头针组件，并与具有放置在皮下组织中的插管的注射组一起使用。 本发明还设想使用具有笔式注射器的这种钝头针组件，用于通过具有隔膜的任何静脉内导管静脉内注射药物，通过该隔膜可以放置笔式注射器的钝针。
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公开(公告)号：US6017328A
公开(公告)日：2000-01-25
申请号：US695596
申请日：1996-08-12
CPC分类号： A61M5/3202 , A61M25/0606 , A61M5/158 , A61M2005/1581 , A61M2005/1585 , A61M2005/1587 , A61M5/001
摘要： The present invention is an injection port assembly for subcutaneous delivery of medication. A single molded body has a soft cannula extending downward from a generally flat bottom surface and a self-sealing septum mounted at the center of a top surface which is generally of a concave shape sloping downward towards its outer perimeter at which point the single body is very thin. The single body also has a tubular extension which is directed outward parallel to the skin's surface. A metal needle which penetrates through the septum and through the lumen of the soft cannula is used for inserting the cannula through the skin. Once the soft cannula is placed subcutaneously, the needle is removed and an adhesive tape is placed over the single body and onto the skin beyond the body's outer perimeter. By having a distal section of the needle which is smaller in diameter as compared to most of the needle's length, and by having the soft cannula fit tightly onto the needle, most of the cannula's length will be in tension during insertion thereby preventing an accordion-like compressional failure of the cannula. A quick-release connector on the proximal end of the tubular extension or mounted directly on the injection port assembly allows the tubing connecting the injection port assembly to a portable medication pump to be disconnected when the patient showers or performs some similar activity.
摘要翻译： 本发明是用于皮下递送药物的注射口组件。 单个成型体具有从大致平坦的底部表面向下延伸的软套管和安装在顶表面的中心处的自密封隔膜，该顶部表面通常具有朝向其外周向下倾斜的凹形，在该点处，单体为 很瘦。 单体还具有向外平行于皮肤表面指向的管状延伸部。 穿过隔膜并通过软套管的内腔的金属针用于插入套管穿过皮肤。 一旦软套管皮下放置，取下针头，并将胶带放置在单个身体上方并超过身体外周的皮肤上。 通过使针的远端部分与针的大部分长度相比直径较小，并且通过使软管紧紧地配合到针上，插管的大部分长度将在插入期间处于张力状态，从而防止手风琴 - 像套管的压缩失败。 管状延伸部的近端上的快速释放连接器或直接安装在注射口组件上的快速连接器允许当患者淋浴或执行某些类似的活动时将连接注射口组件的便携式药物泵断开连接。
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公开(公告)号：US5607442A
公开(公告)日：1997-03-04
申请号：US557355
申请日：1995-11-13
CPC分类号： A61F2/915 , A61F2/91 , A61B90/39 , A61F2/0077 , A61F2002/9155 , A61F2250/0032 , A61F2250/0098
摘要： A stent (10) is plated with a high density, radiopaque metal (or alloy) such as gold or tantalum. Specifically, the stent (10) is plated to a sufficient thickness (15) on its longitudinal wires (12) to make it clearly radiopaque in fluoroscopy, but the generally circumferential wires (11) are plated to a much lesser thickness (14) so that they are not distinctly radiopaque. Before the stent (10) is deployed radially outward in a vessel of the human body, the longitudinal wires (12) are very close together so the implanting physician can easily discern the proximal and distal extremities of the stent (10). Furthermore, the physician can readily discern that the stent (10) has been deployed because the longitudinals (12) will separate to an increased distance from each other after proper deployment. Still further, if the stent does not properly deploy, fluoroscopy will indicate that there is an indentation (12A) or (12C) in one or more longitudinal hence informing the physician that he should inflate a high pressure balloon at the end of a balloon angioplasty catheter to further deploy the stent (10) radially outward against the inner wall of the vessel. Proper stent deployment is characterized by a generally parallel relationship between opposite longitudinal wires (12). Because the stent (10) has a single metal outer coating (albeit of varying thickness) on all stent outer surfaces, electrolytic corrosion of the stent (10) is avoided. Furthermore, there may be other advantages associated with plating a stent (10) with a greater thickness on some wires and a lesser thickness on others. Still further, a stent (10) that is gold plated over all its surfaces would provide a most attractive appearance.
摘要翻译： 支架（10）镀有高密度，不透射线的金属（或合金）如金或钽。 具体地说，支架（10）在其纵向导线（12）上被镀覆成足够的厚度（15），使其在荧光透视中清晰地不透射线，但是大致圆周的电线（11）被镀覆成更小的厚度（14），所以 他们没有明显的不透射线。 在支架（10）径向向外展开在人体容器中之前，纵向线（12）非常紧密地在一起，因此植入医生可以容易地辨别支架（10）的近端和远端。 此外，医师可以容易地辨别出支架（10）已被展开，因为在正确部署之后，纵骨（12）将彼此分开，从而彼此分开。 此外，如果支架没有正确展开，则荧光透视将指示在一个或多个纵向中存在凹陷（12A）或（12C），因此通知医生他应该在球囊血管成形术结束时使高压气囊膨胀 导管，以进一步将支架（10）径向向外展开抵靠容器的内壁。 正确的支架展开的特征在于相对的纵向线（12）之间的大致平行的关系。 由于支架（10）在所有支架外表面上具有单个金属外涂层（尽管具有变化的厚度），所以避免了支架（10）的电解腐蚀。 此外，可能存在与在一些电线上具有更大厚度的支架（10）电镀并且在其它电线上具有较小厚度相关联的其它优点。 此外，在其所有表面上镀金的支架（10）将提供最有吸引力的外观。
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