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    DIODE CUTOFF AND SAFE PACKAGING SYSTEM FOR DETONATING CORD
    53.
    发明申请
    DIODE CUTOFF AND SAFE PACKAGING SYSTEM FOR DETONATING CORD 有权
    二极管切割和安全包装系统

    公开(公告)号：US20080169213A1

    公开(公告)日：2008-07-17

    申请号：US11366103

    申请日：2006-03-02

    申请人： John P. O'Brien ,  Timothy J. O'Brien

    发明人： John P. O'Brien ,  Timothy J. O'Brien

    IPC分类号： B65H55/00

    CPC分类号： F42B39/14 ,  F42B39/30

    摘要： A block molded from a polymeric material has a through passageway to contain a percussive shock wave. Angularly related channels communicate with the containment passageway for receiving arcuate segments of detonation cord. Alignment of a plurality of blocks provides a convenient packaging setup for the cord. A percussive signal traveling along the cord can be short-circuited in the packaging setup. A diode version of the block can react to the signal in a given direction of travel.

    摘要翻译： 由聚合材料模制的块具有通过通道以容纳冲击波。 角度相关的通道与容纳通道连通，用于接收引爆线的弧形段。 多个块的对准提供了用于绳索的方便的包装设置。 沿着绳索行进的撞击信号可能在包装设置中短路。 块的二极管版本可以在给定的行进方向上对信号做出反应。

    Multi-epitope peptide-loaded dendritic cell immunotherapy for cancer
    54.
    发明申请
    Multi-epitope peptide-loaded dendritic cell immunotherapy for cancer 有权
    多表位肽加载的树突状细胞免疫治疗癌症

    公开(公告)号：US20080152663A1

    公开(公告)日：2008-06-26

    申请号：US11986352

    申请日：2007-11-21

    申请人： Martin J. Cannon ,  Kristina L. Bondurant ,  Timothy J. O'Brien

    发明人： Martin J. Cannon ,  Kristina L. Bondurant ,  Timothy J. O'Brien

    IPC分类号： A61K39/00 ,  C07K14/00 ,  A61P35/00 ,  C07K7/00

    CPC分类号： C12N9/6445 ,  A61K38/00 ,  C12N9/6424

    摘要： The invention involves peptides of from about 7 to about 50 amino acid residues in length that have epitopes that bind to more than one HLA class II protein and stimulate CD4+ T cells for treatment of cancer from one of three serine proteases overexpressed in ovarian cancer and other cancers—stratum corneum chymotryptic enzyme, matriptase, and hepsin. Since the peptides bind to more than one HLA class II protein variant, they can be used to treat cancer in most patients of a population having a variety of HLA class II alleles. The peptides can be loaded onto autologous dendritic cells of a cancer patient and infused into the patient to activate a CD4+ and CD8+ T cell response that recognizes tumor cells expressing the peptide antigen.

    摘要翻译： 本发明涉及长度为约7至约50个氨基酸残基的肽，其具有结合多于一个HLA II类蛋白的表位并刺激CD4 + T细胞用于治疗来自卵巢癌和其它过表达的三种丝氨酸蛋白酶之一的癌症 癌症角质层糜蛋白酶，脱氧核糖核酸酶和hepsin。 由于肽结合多于一个HLA II类蛋白质变体，所以它们可用于治疗具有多种HLA II类等位基因的群体的大多数患者中的癌症。 肽可以加载到癌症患者的自体树突状细胞上，并输注到患者中以激活识别表达肽抗原的肿瘤细胞的CD4 +和CD8 + T细胞应答。

    Repeat sequences of the CA125 gene and their use for diagnostic and therapeutic interventions
    55.
    发明授权
    Repeat sequences of the CA125 gene and their use for diagnostic and therapeutic interventions 有权
    重复CA125基因的序列及其用于诊断和治疗干预

    公开(公告)号：US07309760B2

    公开(公告)日：2007-12-18

    申请号：US09965738

    申请日：2001-09-27

    申请人： Timothy J. O'Brien ,  John B. Beard ,  Lowell J. Underwood

    发明人： Timothy J. O'Brien ,  John B. Beard ,  Lowell J. Underwood

    IPC分类号： C07K1/00 ,  C07K16/00

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain has numerous O-glycosylation sites. Domain 2 is a repeat domain comprising homologous repeat units of 156 amino acids. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. The repeat units are the sites of OC125 and M11 antibody binding. The CA125 molecule is anchored at its carboxy terminal through a transmembrane domain and a short cytoplasmic tail.

    摘要翻译： 已经克隆了CA125基因，并且已经鉴定了多个重复序列以及羧基末端。 CA125分子包含三个主要的结构域：细胞外氨基末端结构域（Domain 1）; 一个大的多重重复域（域2）; 和包含具有短细胞质结构域的跨膜锚的羧基末端结构域（结构域3）。 氨基末端结构域具有许多O-糖基化位点。 域2是包含156个氨基酸的同源重复单元的重复结构域。 已经确定，排序和连续地排列在CA125领域结构中的60多个重复单位。 重复单元是OC125和M11抗体结合位点。 CA125分子在其羧基末端通过跨膜结构域和短的胞质尾部锚定。

    TADG-15: an extracellular serine protease overexpressed in carcinomas
    56.
    发明授权
    TADG-15: an extracellular serine protease overexpressed in carcinomas 有权
    TADG-15：细胞外丝氨酸蛋白酶在癌中过表达

    公开(公告)号：US07291462B2

    公开(公告)日：2007-11-06

    申请号：US10600187

    申请日：2003-06-20

    申请人： Timothy J. O'Brien ,  Hirotoshi Tanimoto

    发明人： Timothy J. O'Brien ,  Hirotoshi Tanimoto

    IPC分类号： C12Q1/68 ,  C12Q1/00 ,  G01N33/53 ,  G01N33/574 ,  G01N33/48 ,  G01N21/00 ,  G01N21/75 ,  C12N15/00 ,  C12N15/09 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74 ,  A61K38/00 ,  C07K14/00

    CPC分类号： C12N9/6424 ,  A61K39/00 ,  C12Q1/6851 ,  C12Q1/6886 ,  C12Q2600/136 ,  Y10T436/25

    摘要： The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity, methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The methods described are useful in the diagnosis, treatment and prevention of cancer, particularly breast and ovarian cancer.

    摘要翻译： 本发明提供编码TADG-15蛋白质和TADG-15蛋白质的DNA。 还提供了能够表达适于在重组细胞中表达的本发明的DNA的载体和在细胞中表达DNA所需的调节元件。 本发明还提供了抑制TADG-15表达和/或蛋白酶活性的方法，检测TADG-15mRNA和/或蛋白质的方法以及筛选TADG-15抑制剂的方法。 另外，本发明提供了通过TADG-15进行的细胞特异性靶向和针对TADG-15接种个体的方法。 所描述的方法可用于诊断，治疗和预防癌症，特别是乳腺癌和卵巢癌。

    Extracellular serine protease
    58.
    发明授权
    Extracellular serine protease 失效

    公开(公告)号：US07067250B1

    公开(公告)日：2006-06-27

    申请号：US09137944

    申请日：1998-08-21

    申请人： Lowell J. Underwood ,  Timothy J. O'Brien

    发明人： Lowell J. Underwood ,  Timothy J. O'Brien

    IPC分类号： C12Q1/68

    CPC分类号： C12N9/6424

    摘要： The present invention provides a DNA encoding a TADG-14 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-14 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-14 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-14 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell.

    Modular lavatory faucet spout mounting
    59.
    发明授权
    Modular lavatory faucet spout mounting 有权
    模块化盥洗室水龙头喷口安装

    公开(公告)号：US06918400B2

    公开(公告)日：2005-07-19

    申请号：US10026210

    申请日：2001-12-19

    申请人： Daniel C. Buchner ,  John H. Daniel, III ,  Todd C. Loschelder ,  Allen L. Talley ,  Timothy J. O'Brien ,  William R. Markowitz ,  Erwin F. Mikol

    发明人： Daniel C. Buchner ,  John H. Daniel, III ,  Todd C. Loschelder ,  Allen L. Talley ,  Timothy J. O'Brien ,  William R. Markowitz ,  Erwin F. Mikol

    IPC分类号： E03C1/04 ,  F16K43/00

    CPC分类号： E03C1/0402 ,  E03C1/0401 ,  E03C2001/0416 ,  Y10T29/53596 ,  Y10T137/0402 ,  Y10T137/6014 ,  Y10T137/6109 ,  Y10T137/6977 ,  Y10T137/698 ,  Y10T137/9464

    摘要： A faucet spout fixture provides for spout mounting and removal from above a supporting surface such as a sink deck, without disconnection of the water supply conduits beneath the sink deck. The fixture includes a faucet spout which has a water passage and a water discharge in communication with the passage. There is a water inlet in the spout which communicates with the passage. A water supply assembly is located beneath the supporting surface and there is a spout waterway adjustably connected to the water supply assembly, which spout waterway extends into the spout water inlet. There is a clamp member adjustably mounted on the spout waterway to be positioned against and on top of the supporting surface sink deck. A spout fastener extends through an opening in the clamp member and is held in position therein by a portion of the spout waterway. The spout fastener adjustably cooperates with a threaded bore on the spout to removably fasten the spout against and on top of the supporting surface.

    摘要翻译： 水龙头喷嘴固定装置提供喷嘴安装和从水面板上的支撑表面上方移除，而不会断开水槽甲板下方的供水管道。 该固定装置包括具有与通道连通的水通道和排水口的水龙头喷口。 喷嘴中有一个进水口与通道相通。 供水组件位于支撑表面下方，并且具有可调节地连接到供水组件的喷口水道，喷水口水口延伸到出水口中。 存在可调节地安装在喷口水道上的夹紧构件，以抵靠和支撑在支撑表面水槽平台的顶部。 喷嘴紧固件延伸穿过夹紧构件中的开口并且通过喷口水道的一部分保持在其中。 喷嘴紧固件可调节地与喷嘴上的螺纹孔配合，以可移除地将喷嘴紧固在支撑表面上和顶部上。