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公开(公告)号：US07470233B2
公开(公告)日：2008-12-30
申请号：US11043819
申请日：2005-01-26
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/4519 , A61B5/7239
摘要： The present invention provides an apparatus and method for monitoring muscle function based on an index derived from a pressure or force signal. The muscle function index is derived from an instantaneous muscle stiffness ratio computed as the ratio of the first time derivative of the pressure or force waveform to the corresponding instantaneous pressure or force. The instantaneous stiffness ratio, Ė/E(t), is in units of 1/sec and relates to the rate of strong bond formation and will be influenced by calcium handling properties of the muscle fibers and the intracellular calcium concentration. As such, an index derived from Ė/E(t) provides a measure of the inotropic status of the muscle.
摘要翻译： 本发明提供了一种基于从压力或力信号导出的指标来监测肌肉功能的装置和方法。 肌肉功能指数来源于以压力或力波形的第一次导数与相应的瞬时压力或力的比值计算的瞬时肌肉僵直比。 瞬时刚度比E / E（t）以1 /秒为单位，与强键形成速率有关，并受肌肉纤维钙处理性能和细胞内钙浓度的影响。 因此，从E / E（t）得到的指数提供肌肉肌力状态的量度。
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公开(公告)号：US5626623A
公开(公告)日：1997-05-06
申请号：US640434
申请日：1996-04-30
申请人： Robert S. Kieval , Tommy D. Bennett
发明人： Robert S. Kieval , Tommy D. Bennett
CPC分类号： A61N1/3627 , A61B5/0215 , A61B5/7239 , A61N1/36564 , A61N1/3682
摘要： In a dual chamber cardiac pacemaker, a method and apparatus for determining an atrioventricular (AV) delay interval to maintain optimal left heart AV mechanical synchrony and function. When the intrinsic or paced atrial heart rate is stable, test AV delay intervals are selected and delivered as right ventricular absolute blood pressures (RVP) are measured at the opening of the pulmonary valve. The opening of the pulmonary valve is determined by the peak rate of change in the RVP (dP/dt) following depolarization of the right ventricle. The test AV delay interval providing the lowest amplitude RVP at the peak dP/dt, indicating the lowest pulmonary blood pressure, is selected as the optimal AV delay. The system may be fully contained in an implanted pacemaker system including a right ventricular absolute blood pressure sensor and automatically invoked to determine the optimum AV delay for the prevailing atrial heart rate at any time, or may be invoked at a predetermined time of day or may be invoked by a programmed-in command. The system may also be employed on a temporary basis in conjunction with an implanted dual chamber pacemaker and an external pacemaker programmer with a temporary absolute blood pressure sensor to provide the blood pressure signals.
摘要翻译： 在双室心脏起搏器中，一种用于确定房室（AV）延迟间隔以维持最佳左心脏AV机械同步和功能的方法和装置。 当内在或节奏的心房心率稳定时，在肺动脉瓣的开口处测量右心室绝对血压（RVP），选择并递送测试AV延迟间隔。 肺动脉瓣的开放由右心室去极化后的RVP（dP / dt）的峰值变化速率决定。 选择峰值dP / dt处的最低振幅RVP的测试AV延迟间隔，表示最低的肺血压，作为最佳的AV延迟。 该系统可以完全包含在包括右心室绝对血压传感器的植入式起搏器系统中，并且自动调用以在任何时间确定主要心房心率的最佳AV延迟，或者可以在一天的预定时间被调用 由编入命令调用。 该系统还可以临时使用植入的双室起搏器和具有临时绝对血压传感器的外部起搏器编程器来提供血压信号。
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公开(公告)号：US09943236B2
公开(公告)日：2018-04-17
申请号：US12571091
申请日：2009-09-30
申请人： Tommy D. Bennett , Yong K. Cho
发明人： Tommy D. Bennett , Yong K. Cho
IPC分类号： A61B5/0215 , A61M5/142 , A61M5/172 , A61N1/365 , A61N1/372
CPC分类号： A61B5/0215 , A61M5/14276 , A61M5/1723 , A61M2205/054 , A61M2210/125 , A61N1/36521 , A61N1/3655 , A61N1/36557 , A61N1/36564 , A61N1/37282
摘要： An implantable medical device system and associated method for use in guiding an acute decompensated heart failure therapy set an optimal fluid status measurement level. A physiological sensor signal sensed by an implantable medical device is used to compute the fluid status measurement. A target rate of change of the fluid status measurement is computed for guiding the therapy.
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公开(公告)号：US08827913B2
公开(公告)日：2014-09-09
申请号：US13099959
申请日：2011-05-03
IPC分类号： A61B5/02 , A61B5/00 , A61N1/37 , A61B5/0215 , A61N1/365
CPC分类号： A61N1/3702 , A61B5/0215 , A61B5/686 , A61B5/7207 , A61B5/7239 , A61N1/36564
摘要： An example system may include at least one pressure sensor configured to measure a cardiovascular pressure signal and another medical device configured to measure an electrical depolarization signal of the heart. The system determines a plurality of cardiovascular pressure metrics based on the measured cardiovascular pressure signal, including at least one cardiovascular pressure metric indicative of a timing of at least one cardiac pulse. The system also determines a metric indicative of a timing of at least one heart depolarization within the measured electrical depolarization signal. The system compares the timing of the at least one cardiac pulse to the timing of the at least one depolarization, and determines whether to discard the plurality of cardiovascular pressure metrics based on whether the timings substantially agree.
摘要翻译： 示例性系统可以包括配置成测量心血管压力信号的至少一个压力传感器和被配置成测量心脏的电去极化信号的另一医疗装置。 该系统基于所测量的心血管压力信号确定多个心血管压力指标，包括至少一个指示至少一个心脏脉搏的定时的心血管压力指标。 该系统还确定指示所测量的电去极化信号内的至少一次心脏去极化的定时的度量。 所述系统将所述至少一个心脏脉搏的定时与所述至少一个去极化的定时进行比较，并且基于所述时间是否基本上同意来确定是否丢弃所述多个心血管压力指标。
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公开(公告)号：US20130085399A1
公开(公告)日：2013-04-04
申请号：US13250092
申请日：2011-09-30
申请人： Tommy D. Bennett , Yong K. Cho
发明人： Tommy D. Bennett , Yong K. Cho
IPC分类号： A61B5/021 , A61N1/365 , A61B5/0205 , A61M5/168
CPC分类号： A61M5/14276 , A61B5/0031 , A61B5/0215 , A61M5/1723 , A61M2205/3507 , A61N1/36564
摘要： Techniques for controlling therapy based on a physiological parameter indicative of ventricular filling pressure, such as various cardiovascular pressures, are described. One or more values of the physiological parameter that are collected during nighttime, or while the patient is otherwise asleep, inactive, or within a recumbent position, may be compared to one or more values of the physiological parameter collected during daytime, or while the patient is otherwise awake, active and/or upright. A therapy, such as for treating physiological factors that may lead to worsening HF, may be initiated or adjusted based on the comparison, e.g., if the nighttime values exceed the daytime values.
摘要翻译： 描述了基于指示心室充盈压的生理参数（例如各种心血管压力）来控制治疗的技术。 可以将在夜间或患者其他睡眠，不活动或处于躺卧位置期间收集的生理参数的一个或多个值与在白天收集的生理参数的一个或多个值进行比较， 否则清醒，活跃和/或直立。 可以基于比较（例如，如果夜间值超过白天值）来开始或调整治疗，例如用于治疗可能导致恶化HF的生理因素的治疗。
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公开(公告)号：US20120290033A1
公开(公告)日：2012-11-15
申请号：US13103861
申请日：2011-05-09
IPC分类号： A61N1/365
CPC分类号： A61N1/36114 , A61N1/056 , A61N1/3611
摘要： A method includes controlling a cardiac pacing rate of an implantable medical device to control a heart rate of a patient and detecting inhalation and exhalation of the patient. The method further includes determining that the patient is in a resting state, and, in response to determining that the patient is in the resting state, incrementally increasing the pacing rate while exhalation of the patient is detected and incrementally decreasing the pacing rate while inhalation of the patient is detected.
摘要翻译： 一种方法包括控制可植入医疗装置的心脏起搏速率以控制患者的心率并检测患者的吸入和呼气。 该方法还包括确定患者处于静止状态，并且响应于确定患者处于静止状态，逐渐增加起搏速率，同时检测到患者的呼气，并逐渐降低起搏速率，同时吸入 检测到患者。
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57.发明授权公开(公告)号：US08211028B2
公开(公告)日：2012-07-03
申请号：US12112544
申请日：2008-04-30
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/02028 , A61B5/02108 , A61B5/0456 , A61B5/7239 , A61N1/36564
摘要： A system and method of determining hemodynamic parameters uses sensed ventricular blood pressure during a portion of ventricular pressure waveform following peak pressure. An estimated arterial diastolic pressure is based upon an amplitude of the sensed ventricular pressure corresponding to a time at which a first derivative of ventricular pressure as a function of time is at a minimum (dP/dtmin). Fill parameters such as isovolumetric relaxation constant, ventricular suction pressure, atrial kick pressure, and transvalve pressure gradient are derived from measured pressures representing minimum ventricular pressure, ventricular diastolic pressure, and diastasis pressure.
摘要翻译： 确定血液动力学参数的系统和方法在峰值压力之后的心室压力波形的一部分期间使用感测到的心室血压。 估计的动脉舒张压基于对应于作为时间的函数的心室压力的一阶导数在最小（dP / dtmin）的时间的感测的心室压力的幅度。 从表示最小心室压力，心室舒张压和舒张压的测量压力导出填充参数，例如等容舒张常数，心室吸入压力，心房踢压力和转化压力梯度。
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公开(公告)号：US08175694B2
公开(公告)日：2012-05-08
申请号：US13210527
申请日：2011-08-16
申请人： James D. Webb , Tommy D. Bennett
发明人： James D. Webb , Tommy D. Bennett
IPC分类号： A61B5/04
CPC分类号： A61B5/02158 , A61B5/0031 , A61B5/02055
摘要： Continuous remote monitoring of patients based on data obtained from an implantable hemodynamic monitor provides an interactive patient management system. Using network systems, patients are remotely monitored to continuously diagnose and treat heart-failure conditions. A screen displayable summary provides continuous feedback and information to physicians, patients and authorized third parties. The quick look summary includes various sites and presentation tailored to match the patients' and physicians' needs. The quick look summary further includes intelligent features that understand and retain the user's interests, preferences and use patterns. Patients, physicians and other caregivers are seamlessly connected to monitor and serve the chronic needs of heart-failure patients in a reliable and economic manner.
摘要翻译： 基于从可植入血液动力学监测器获得的数据对患者的连续远程监测提供了交互式患者管理系统。 使用网络系统，对患者进行远程监控，以不断诊断和治疗心力衰竭状况。 屏幕可显示的摘要为医生，患者和授权的第三方提供持续的反馈和信息。 快速查看摘要包括各种网站和演示文稿，以满足患者和医生的需求。 快速概述进一步包括了解和保留用户兴趣，偏好和使用模式的智能功能。 患者，医生和其他照顾者无缝连接，以可靠和经济的方式监测和服务于心力衰竭患者的长期需求。
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公开(公告)号：US20110106191A1
公开(公告)日：2011-05-05
申请号：US12609587
申请日：2009-10-30
CPC分类号： A61N1/37 , A61N1/3688 , A61N1/3718
摘要： Techniques for activating an alternative operating mode in an implantable medical device based on a determination that the device is within a relatively high noise environment or otherwise exposed to relatively high noise. The implantable medical device can automatically detect its presence in a high noise environment and automatically revert to the alternative operating mode, the device may be manually switched to alternative operating mode, or a hybrid manual/automatic approach may be used to switch the device to alternative operating mode.
摘要翻译： 基于确定该设备在相对较高的噪声环境中或以其他方式暴露于较高噪声的确定来激活可植入医疗设备中的替代操作模式的技术。 可植入医疗设备可以在高噪声环境中自动检测其存在并自动恢复到替代操作模式，该设备可以手动切换到备选操作模式，或者可以使用混合手动/自动方法将设备切换到备用 操作模式。
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60.发明授权Methods of identifying and/or assessing cardiac arrhythmias using an implantable medical device 有权使用可植入医疗装置识别和/或评估心律失常的方法公开(公告)号：US07937137B2
公开(公告)日：2011-05-03
申请号：US11342397
申请日：2006-01-30
IPC分类号： A61B5/0452
CPC分类号： A61N1/056 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/042 , A61B5/046 , A61N1/3622 , A61N1/3627 , A61N1/37 , A61N1/3925 , G06F19/00 , G06F19/3418
摘要： Apparatus using one or more modes of statistical analysis with one or more monitored parameters of a patient's heart to identify and/or assess arrhythmias. Through use of the one or more modes of statistical analysis, a medical professional can be aided during evaluation of patient data for diagnosis of the patient. At least one of the monitored parameters may include one or more values used representatively for storage intervals of a selected length. As such, for each storage interval, a value may be determined for the one monitored parameter occurring at an upper percentile and a lower percentile. In addition, a median value may be determined for the one monitored parameter for each storage interval. Over a plurality of the storage intervals, these determined values can be used in one or more modes of statistical analysis to better identify and assess the arrhythmias.
摘要翻译： 一种使用一种或多种统计分析模式的患者心脏的一个或多个监测参数来识别和/或评估心律失常的装置。 通过使用一种或多种统计分析模式，可以在评估用于患者诊断的患者数据时辅助医学专业人员。 所监视的参数中的至少一个可以包括代表性地用于所选长度的存储间隔的一个或多个值。 因此，对于每个存储间隔，可以针对在上百分位数和下百分位数处发生的一个监视参数来确定值。 此外，可以针对每个存储间隔的一个被监视的参数确定中值。 在多个存储间隔中，这些确定的值可以用于一种或多种统计分析模式，以更好地识别和评估心律失常。
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