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68 条记录 (耗时 0.073 秒)

    Pump apparatus, systems and methods
    54.
    发明授权
    Pump apparatus, systems and methods 有权
    泵装置，系统和方法

    公开(公告)号：US08485798B2

    公开(公告)日：2013-07-16

    申请号：US12830540

    申请日：2010-07-06

    申请人： Ketankumar K. Sheth ,  Thurkral Mandeep ,  John D. Rowatt ,  Steven L. Anyan ,  Michael W. Miller

    发明人： Ketankumar K. Sheth ,  Thurkral Mandeep ,  John D. Rowatt ,  Steven L. Anyan ,  Michael W. Miller

    IPC分类号： F04B35/04

    CPC分类号： F04D13/022 ,  Y10T29/49826 ,  Y10T29/49963 ,  Y10T403/51 ,  Y10T403/57 ,  Y10T403/7026 ,  Y10T403/7135

    摘要： Pump apparatus, systems and methods of making and using same are disclosed. One inventive system includes a coupling member, a first shaft and a second shaft, the coupling member connecting the first shaft with the second shaft, the coupling member defining a first axial chamber accepting the first shaft, and a second axial chamber accepting the second shaft, the chambers separated by a coupling plate, the chambers including torsional motion transmitting elements and axial motion securing elements in the first and second axial chambers for axially securing the shafts in the coupling member. This abstract allows a searcher or other reader to quickly ascertain the subject matter of the disclosure. It will not be used to interpret or limit the scope or meaning of the claims.

    摘要翻译： 公开了制造和使用其的泵装置，系统和方法。 一个本发明的系统包括联接构件，第一轴和第二轴，联接构件将第一轴与第二轴连接，联接构件限定容纳第一轴的第一轴向室，以及容纳第二轴的第二轴向室 所述腔室由联接板分隔开，所述腔室包括在第一和第二轴向室中的扭转运动传递元件和轴向运动固定元件，用于将轴轴向固定在联接构件中。 该摘要允许搜索者或其他读者快速确定本公开的主题。 它不会用于解释或限制权利要求的范围或含义。

    Piperidine derivatives useful as CCR5 antagonists
    57.
    发明授权
    Piperidine derivatives useful as CCR5 antagonists 失效
    哌啶衍生物可用作CCR5拮抗剂

    公开(公告)号：US08034933B2

    公开(公告)日：2011-10-11

    申请号：US12104914

    申请日：2008-04-17

    申请人： Anandan Palani ,  Michael W. Miller ,  Jack D. Scott

    发明人： Anandan Palani ,  Michael W. Miller ,  Jack D. Scott

    IPC分类号： C07D401/14 ,  C07D239/02

    CPC分类号： C07D401/14

    摘要： The present invention provides a compound of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, R9, R10, A and B are as defined in the specification. The present invention also provides pharmaceutical compositions containing the compound of this invention, and methods of treatment using the compound of this invention. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.

    摘要翻译： 本发明提供下式化合物或其药学上可接受的盐或溶剂化物，其中R1，R2，R3，R9，R10，A和B如说明书中所定义。 本发明还提供含有本发明化合物的药物组合物和使用本发明化合物的治疗方法。 本发明还涉及本发明化合物与一种或多种可用于治疗人类免疫缺陷病毒（HIV）的抗病毒剂或其它药剂的组合的用途。 本发明还涉及本发明化合物单独或与另一种药剂组合用于治疗实体器官移植排斥，移植物抗宿主病，关节炎，类风湿性关节炎，炎症性肠病，特应性皮炎，牛皮癣 ，哮喘，过敏或多发性硬化。

    Piperazine derivatives useful as CCR5 antagonists
    59.
    发明授权
    Piperazine derivatives useful as CCR5 antagonists 有权
    哌嗪衍生物可用作CCR5拮抗剂

    公开(公告)号：US07825121B2

    公开(公告)日：2010-11-02

    申请号：US11255643

    申请日：2005-10-21

    申请人： Ragulan Ramanathan ,  Anima Ghosal ,  Michael W. Miller ,  Swapan K. Chowdhury ,  Kevin B. Alton

    发明人： Ragulan Ramanathan ,  Anima Ghosal ,  Michael W. Miller ,  Swapan K. Chowdhury ,  Kevin B. Alton

    IPC分类号： A61K31/497 ,  A01N43/54 ,  C07D403/00 ,  C07D239/00

    CPC分类号： C07D401/14 ,  C07D401/06 ,  C07H17/02

    摘要： The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1 is hydrogen or alkyl; R2 is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenylmethyl or optionally substituted phenyl- or heteroaryl-alkyl; R3 is hydrogen, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, or optionally substituted phenyl, phenylalkyl, naphthyl, naphthylalkyl, heteroaryl or heteroarylalkyl; R4, R5 and R7 are hydrogen or alkyl; R6 is hydrogen, alkyl or alkenyl; for the treatment of HIV, solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis is disclosed, as well as novel compounds, pharmaceutical compositions comprising them, and the combination of CCR5 antagonists of the invention in combination with antiviral agents useful in the treatment of HIV or agents useful in the treatment of inflammatory diseases.

    摘要翻译： 使用下式的CCR5拮抗剂或其药学上可接受的盐，其中R是任选取代的苯基，吡啶基，噻吩基或萘基; R1是氢或烷基; R 2是取代的苯基，取代的杂芳基，萘基，芴基，二苯基甲基或任选取代的苯基或杂芳基 - 烷基; R 3是氢，烷基，烷氧基烷基，环烷基，环烷基烷基或任选取代的苯基，苯基烷基，萘基，萘基烷基，杂芳基或杂芳基烷基; R4，R5和R7是氢或烷基; R6是氢，烷基或烯基; 公开了用于治疗HIV，实体器官移植排斥，移植物抗宿主病，关节炎，类风湿性关节炎，炎症性肠病，特应性皮炎，牛皮癣，哮喘，过敏或多发性硬化的新型化合物，以及包含它们的药物组合物 ，以及本发明的CCR5拮抗剂与可用于治疗HIV的抗病毒剂或可用于治疗炎性疾病的药剂的组合。