公开(公告)号：US20250075190A1

公开(公告)日：2025-03-06

申请号：US18727868

申请日：2023-01-13

Applicant: UNIVERSITY OF WASHINGTON

Inventor： David BAKER ,  Hsien-Wei YEH ,  Christopher NORN ,  Yakov KIPNIS

IPC: C12N9/02 ,  C12N15/52 ,  C12N15/62 ,  C12Q1/66

Abstract: Proteins having luciferse activity are disclosed, having the secondary structure arrangement H1-L1-H2-L2-E1-L3-E2-L4-H3-L5-E3-L6-E4-L7-E5-L8-E6, wherein “H” is a helical domain, “L” is a loop domain, and “E” is a beta strand domain; wherein: (a) the H1 domain is at least 18 or 19 amino acids in length; residue 14 of the H1 domain is Y, D, or E, and residue 18 of the H1 domain is D or E: (b) the E3 domain is at least 6, 7, 8, 9, or 10 amino acids in length and residue 2 of the E3 domain is R; and (c) the E5 domain is at least 10, 11, 12, 13, or 14 amino acids in length and residue 9 of the E5 domain is H or M.

公开(公告)号：US20240383964A1

公开(公告)日：2024-11-21

申请号：US18662616

申请日：2024-05-13

Applicant: UNIVERSITY OF WASHINGTON

Inventor： David BAKER ,  Xinru WANG ,  Jordi GUILLEM MARTI ,  Buwei HUANG

IPC: C07K14/705 ,  A61K38/00 ,  A61K45/06 ,  A61P9/00

Abstract: Integrin α5β1-binding polypeptides are disclosed having an amino acid sequence at least 50% identical to the amino acid sequence selected from SEQ ID NO:1-14, or selected from SEQ ID NO:11-14, not including any insertions, wherein residues 8-10 relative to the reference polypeptide are RGD, and their use for treating cancer, vascular disease, rheumatoid arthritis, and diseases associated with pathogenic angiogenesis.

公开(公告)号：US20240368233A1

公开(公告)日：2024-11-07

申请号：US18576532

申请日：2022-07-11

Applicant: UNIVERSITY OF WASHINGTON

Inventor： David BAKER ,  Danny SAHTOE ,  Florian PRAETORIUS ,  Bart TIMMERMANS ,  Yang HSIA ,  Alexis COURBET ,  Natasha EDMAN

IPC: C07K14/435

Abstract: Polypeptides and fusion proteins capable of heterodimer formation, methods for their use, and methods for their design are provided.

公开(公告)号：US20240038331A1

公开(公告)日：2024-02-01

申请号：US18459654

申请日：2023-09-01

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： David BAKER ,  Neil KING ,  Jacob BALE ,  William SHEFFLER

IPC: G16B20/50 ,  C07K14/00 ,  G01N33/68 ,  G16B20/00 ,  G16B5/00 ,  G16B15/00 ,  C07K14/195

CPC classification number: G16B20/50 ,  C07K14/00 ,  G01N33/6845 ,  G16B20/00 ,  G16B5/00 ,  G16B15/00 ,  C07K14/195 ,  G01N2570/00 ,  B82Y5/00

Abstract: Synthetic nanostructures, proteins that are useful, for example, in making synthetic nanostructures, and methods for designing such synthetic nanostructures are disclosed herein.

公开(公告)号：US20240029824A1

公开(公告)日：2024-01-25

申请号：US18310680

申请日：2023-05-02

Applicant: University of Washington

Inventor： David BAKER ,  Sherry BERMEO ,  Andrew FAVOR ,  Scott BOYKEN ,  Yang HSIA

IPC: G16B20/00 ,  G16B15/20

CPC classification number: G16B20/00 ,  G16B15/20

Abstract: Disclosed are polypeptides having an amino acid sequence at least 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence selected from the group consisting of the amino acid sequences listed in Tables 1, 2, and 3, and heteropolymers formed from such polypeptides.

公开(公告)号：US20230250134A1

公开(公告)日：2023-08-10

申请号：US18004545

申请日：2021-05-25

Applicant: University of Washington ,  NORTHWESTERN UNIVERSITY ,  WASHINGTON UNIVERSITY

Inventor： Longxing CAO ,  Brian COVENTRY ,  Inna GORESHNIK ,  Lauren MILLER ,  David BAKER ,  Lisa KOZODOY ,  John BOWEN ,  Lauren CARTER ,  James Brett CASE ,  Michael DIAMOND ,  Natasha EDMAN ,  Andrew HUNT ,  Michael Christopher JEWETT ,  Cassandra Jean OGOHARA ,  Young-jun PARK ,  Rashmi RAVICHANDRAN ,  Lance Joseph STEWART ,  David VEESLER ,  Bastian VOGELI ,  Alexandra C. WALLS ,  Kejia WU ,  Scott BOYKEN ,  George UEDA

IPC: C07K14/00 ,  A61P31/14 ,  C12N15/63

CPC classification number: C07K14/001 ,  A61P31/14 ,  C12N15/63

Abstract: Polypeptide inhibitors of SARS-COV-2 are disclosed comprising an amino acid sequence at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence selected from the group consisting of SEQ ID NOS: 1-17, 19-21, 23-34 and 100-101, and their use for treating and limiting development of SARS-COV-2 infection.

公开(公告)号：US20220226485A1

公开(公告)日：2022-07-21

申请号：US17618117

申请日：2020-06-17

Applicant: University of Washington

Inventor： Nicholas WOODALL ,  Scott BOYKEN ,  Marc Joseph LAJOIE ,  Zibo CHEN ,  Robert A. LANGAN ,  David BAKER

IPC: A61K47/64 ,  C07K14/00 ,  C12N15/62 ,  C12N15/85

Abstract: The present disclosure provides a chimeric polypeptide comprising a helical bundle which comprises between about two and about seven alpha-helices and a bioactive peptide, wherein one or more of the alpha helices form one or more inter-helix hydrogen bonds and comprise at least one phosphorylation site and wherein the bioactive peptide is conformationally placed inside the helical bundle so that the bioactive peptide is not activated or exposed. The disclosure also provides a nucleotide sequence encoding the chimeric polypeptide, a vector comprising the nucleotide sequence, a cell comprising the nucleotide sequence, and method of making, using, or designing the chimeric polypeptide.

公开(公告)号：US20220218752A1

公开(公告)日：2022-07-14

申请号：US17610083

申请日：2020-05-18

Applicant: University of Washington ,  FRED HUTCHINSON CANCER RESEARCH CENTER

Inventor： David BAKER ,  Scott BOYKEN ,  Marc Joseph LAJOIE ,  Robert A. LANGAN ,  Stanley R. RIDDELL ,  Alexander SALTER

IPC: A61K35/17 ,  C12N15/86 ,  C12N5/0783 ,  C12N15/62 ,  A61K38/17 ,  C07K14/47 ,  C07K14/725 ,  C07K14/705 ,  C07K14/005

Abstract: Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain only when the protein switch components are co/localized when bound to their targets, components of such protein switches, and their use.

公开(公告)号：US20220169681A1

公开(公告)日：2022-06-02

申请号：US17523174

申请日：2021-11-10

Applicant: UNIVERSITY OF WASHINGTON ,  INSTITUTE FOR RESEARCH IN BIOMEDICINE

Inventor： Neil P. KING ,  David BAKER ,  Brooke NICKERSON ,  Lance Joseph STEWART ,  Laurent PEREZ ,  Antonio LANZAVECCHIA ,  Jessica MARCANDALLI

IPC: C07K14/005 ,  A61P31/14 ,  A61K39/12 ,  B82Y5/00 ,  C12N7/00

Abstract: Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.

公开(公告)号：US20220162265A1

公开(公告)日：2022-05-26

申请号：US17598641

申请日：2020-04-14

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Zibo CHEN ,  David BAKER ,  Frank DIMAIO

IPC: C07K14/00 ,  G16B15/20 ,  G16B20/30 ,  C12N15/70

Abstract: Disclosed herein are polypeptides that serve as building blocks that can be used, for example, to design 2D protein arrays, methods for designing such polypeptides, and methods for their use.