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51.发明授权Isolated cytolytic T cells which are specific for complexes OF HLA- B35 molecules and the peptide PHE Pro Ser Asp Ser Trp Cys Tyr PHE, and uses thereof 失效对HLA- B35分子和肽PHE Pro Ser Asp Ser Trp Cys Tyr PHE的复合物特异性的分离的溶细胞T细胞及其用途
公开(公告)号：US5952228A
公开(公告)日：1999-09-14
申请号：US59964
申请日：1998-04-14
IPC分类号： G01N33/53 , A61K35/14 , A61K38/00 , A61P35/00 , A61P37/04 , C07K7/06 , C07K14/47 , C12N15/09 , C12Q1/04 , G01N33/566 , G01N33/569 , G01N33/574 , C12N15/85
CPC分类号： G01N33/56977 , C07K14/4748 , G01N33/57492 , G01N2333/96466
摘要： The invention relates to isolated cytolytic T cells which recognize complexes of HLA-B35 molecules and the peptide defined by SEQ ID NO: 2, as well as methods for identifying HLA-B35 positive cells. The method involves contacting the cytolytic T cells to a sample, and determining activity of these cytolytic T cells.
摘要翻译： 本发明涉及识别HLA-B35分子和由SEQ ID NO：2定义的肽的复合物的分离的溶细胞T细胞以及鉴定HLA-B35阳性细胞的方法。 该方法包括将溶细胞T细胞接触样品，并测定这些溶细胞T细胞的活性。
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52.发明授权Isolated RAGE-1 derived peptides which complex with HLA-B7 molecules and uses thereof 失效与HLA-B7分子复合的分离的RAGE-1衍生肽及其用途
公开(公告)号：US5939526A
公开(公告)日：1999-08-17
申请号：US530569
申请日：1995-09-20
申请人： Beatrice Gaugler , Benoit Van den Eynde , Peter Schrier , Nathalie Brouwenstijn , Thierry Boon-Falleur
发明人： Beatrice Gaugler , Benoit Van den Eynde , Peter Schrier , Nathalie Brouwenstijn , Thierry Boon-Falleur
CPC分类号： C07K14/4748 , A61K38/00 , Y10S530/828
摘要： The invention describes the RAGE tumor rejection antigen precursor family, including nucleic acids encoding such tumor rejection antigen precursors, tumor rejection antigen peptides or precursors thereof and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a RAGE tumor rejection antigen precursor.
摘要翻译： 本发明描述了RAGE肿瘤排斥抗原前体家族，包括编码这种肿瘤排斥抗原前体的核酸，肿瘤排斥抗原肽或其前体以及与之相关的抗体。 还提供了用于诊断和治疗以RAGE肿瘤排斥抗原前体的表达为特征的病症的方法和产品。
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53.发明授权
公开(公告)号：US5648226A
公开(公告)日：1997-07-15
申请号：US370648
申请日：1995-01-10
IPC分类号： G01N33/566 , A61K35/12 , A61K38/00 , A61K48/00 , A61K49/00 , A61P35/00 , C07H21/04 , C07K14/47 , C07K14/74 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/574 , C07K7/00 , C07K14/82
CPC分类号： C07K14/4748 , A61K38/00 , Y10S530/828
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as GAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described. Tumor rejection antigens are also shown.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为GAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为GAGE编码分子。 描述了编码序列和肿瘤排斥抗原及其前体分子的各种诊断和治疗用途。 还显示肿瘤排斥抗原。
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公开(公告)号：US08951747B2
公开(公告)日：2015-02-10
申请号：US13429873
申请日：2012-03-26
IPC分类号： G01N33/00 , C12N5/00 , C12N5/07 , A61K31/7016 , A61K31/4745 , A61K45/06 , C07K14/725 , C07K14/705 , G01N33/50 , C12N5/0783 , C07K16/28 , A61K39/00
CPC分类号： A61K31/7016 , A61K31/4745 , A61K45/06 , A61K2039/5158 , C07K14/7051 , C07K14/70517 , C12N5/0636 , C12N2500/22 , C12N2500/34 , C12N2501/59 , C12N2501/73 , G01N33/505 , A61K2300/00
摘要： The invention relates to methods and compositions which modulate T lymphocyte activity. It has been found that two, T lymphocyte receptors, especially TCR and CD8, are present at a distance from each other on T lymphocyte surfaces. Via use of modulators which change the distance between these receptors, the activity of the T lymphocyte is modulated.
摘要翻译： 本发明涉及调节T淋巴细胞活性的方法和组合物。 已经发现，两种T淋巴细胞受体，特别是TCR和CD8在T淋巴细胞表面上彼此间隔一定距离。 通过使用改变这些受体之间距离的调节剂，调节T淋巴细胞的活性。
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公开(公告)号：US08247379B2
公开(公告)日：2012-08-21
申请号：US12175589
申请日：2008-07-18
CPC分类号： C07K14/4748 , A61K39/00 , A61K39/0011 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The invention describes SAGE (sdph3.10) and sdp3.5 tumor associated nucleic acids, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such nucleic acid molecules, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a sdph3.10 and/or sdp3.5 gene product.
摘要翻译： 本发明描述了SAGE（sdph3.10）和sdp3.5肿瘤相关核酸，包括其片段和生物功能变体。 还包括由这种核酸分子编码的多肽和其片段，以及与其相关的抗体。 还提供了用于诊断和治疗以sdph3.10和/或sdp3.5基因产物表达为特征的病症的方法和产品。
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公开(公告)号：US20110305722A1
公开(公告)日：2011-12-15
申请号：US13182037
申请日：2011-07-13
IPC分类号： A61K39/385 , A61P37/04 , C07K14/76 , A61P35/00 , C07K7/06 , G01N33/566
CPC分类号： C07K14/4748 , A61K38/00
摘要： This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, ∃2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.
摘要翻译： 本发明涉及衍生自MAGE-C2的分离的肽，编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽，包含核酸分子的表达载体，用核酸分子转化或转染的宿主细胞 表达载体和包含肽，HLA分子，∃2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽，核酸分子，表达载体，四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。
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公开(公告)号：US20090274716A1
公开(公告)日：2009-11-05
申请号：US12502274
申请日：2009-07-14
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/154
摘要： The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LAGE-1 gene product.
摘要翻译： 本发明描述了LAGE-1肿瘤相关基因，包括片段，等位变体和剪接变体。 还包括由这些基因编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以LAGE-1基因产物表达为特征的病症的方法和产品。
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公开(公告)号：US07572885B2
公开(公告)日：2009-08-11
申请号：US10271617
申请日：2002-10-16
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/158
摘要： The invention relates to new members of the GAGE family referred to as GAGE-7B and GAGE-8. There are differences between these two molecules and the previously described members of the GAGE family on the genomic DNA, complementary DNA, and amino acid level.
摘要翻译： 本发明涉及GAGE家族的新成员，称为GAGE-7B和GAGE-8。 在基因组DNA，互补DNA和氨基酸水平上，这两个分子和前述GAGE家族成员之间存在差异。
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公开(公告)号：US20060127356A1
公开(公告)日：2006-06-15
申请号：US11253240
申请日：2005-10-17
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K16/30
摘要： The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-3. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Uses of these materials in therapeutic and diagnostic contexts are also a part of the invention.
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公开(公告)号：US07022819B2
公开(公告)日：2006-04-04
申请号：US10160237
申请日：2002-06-04
IPC分类号： C07K14/00
CPC分类号： G01N33/56977 , C07K14/4748
摘要： The invention relates to isolated nucleic acid molecules which code for antigens expressed by tumor cells which maybe recognized by cytotoxic T cells, leading to lysis of the tumor cells which express it. This invention also relates to vectors which are designed to encode the antigen expressed by tumor cells and also to cells transfected by the nucleic acid molecules or vectors which comprise the nucleic acid molecules. Various therapeutic and diagnostic uses arising out of the properties of the nucleic acid molecules and the antigens for which these code are also part of this invention.
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