公开(公告)号：US07741449B2

公开(公告)日：2010-06-22

申请号：US11009410

申请日：2004-12-10

申请人： Alison Witte ,  Denise Williams ,  Josephine M. Cardarelli ,  David King ,  David Passmore

发明人： Alison Witte ,  Denise Williams ,  Josephine M. Cardarelli ,  David King ,  David Passmore

IPC分类号： C07K16/00 ,  C07K16/24 ,  A61K39/395

CPC分类号： C07K16/249 ,  A61K51/1021 ,  A61K2039/505 ,  C07K16/24 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/76

摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.

摘要翻译： 本发明提供分离的抗干扰素α单克隆抗体，特别是人单克隆抗体，其抑制多种干扰素（IFN）α亚型的生物学活性，但基本上不抑制IFNα21的生物活性或IFNβ的生物学活性 或IFNγ。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制IFNα的生物学活性的方法，以及通过施用本发明的抗体来治疗由IFNα介导的疾病或病症的方法，例如自身免疫疾病，移植排斥反应和移植物抗宿主病 本发明的抗体。

公开(公告)号：US20090239078A1

公开(公告)日：2009-09-24

申请号：US12381270

申请日：2009-03-10

申请人： Jes Asmussen ,  Timothy Grotjohn ,  Donnie Reinhard ,  Rahul Ramamurti ,  M. Kagan Yaran ,  Thomas Schuelke ,  Michael Becker ,  David King

发明人： Jes Asmussen ,  Timothy Grotjohn ,  Donnie Reinhard ,  Rahul Ramamurti ,  M. Kagan Yaran ,  Thomas Schuelke ,  Michael Becker ,  David King

IPC分类号： C23C16/27 ,  H05H1/46 ,  B32B9/00

CPC分类号： C30B25/105 ,  C23C16/274 ,  C23C16/278 ,  C23C16/4585 ,  C23C16/4586 ,  C30B25/08 ,  C30B25/12 ,  C30B29/04 ,  H01J37/32192 ,  Y10T428/30

摘要： The present invention relates to a microwave plasma deposition process and apparatus for producing diamond, preferably as single crystal diamond (SCD). The process and apparatus enables the production of multiple layers of the diamond by the use of an extending device to increase the length and the volume of a recess in a holder containing a SCD substrate as layers of diamond are deposited. The diamond is used for abrasives, cutting tools, gems, electronic substrates, heat sinks, electrochemical electrodes, windows for high power radiation and electron beams, and detectors.

摘要翻译： 本发明涉及微波等离子体沉积工艺和用于生产金刚石，优选为单晶金刚石（SCD）的设备。 该方法和装置能够通过使用延伸装置来生产多层金刚石，以增加包含SCD衬底的保持器中的凹槽的长度和体积，因为沉积了金刚石层。 金刚石用于磨料，切割工具，宝石，电子基板，散热片，电化学电极，大功率辐射窗和电子束以及探测器。

公开(公告)号：US20090211845A1

公开(公告)日：2009-08-27

申请号：US12378633

申请日：2009-02-18

申请人： Patrick Hoffman ,  David King ,  Tom Murphy

发明人： Patrick Hoffman ,  David King ,  Tom Murphy

IPC分类号： E06C1/00

CPC分类号： E06C1/16

摘要： A two-piece locking folding stair is provided with a spring-like locking mechanism. The spring-like device, deployed one on of the two members, includes a protruding member which engages a notch on the other member when the stairs are in the full open, or locked position. When the stairs are opened, the device moves into a position which prevents the stairs from folding unintentionally. To unlock the assembly, the spring-like device is depressed thus releasing the protruding member from a corresponding notch, allowing the stairs to be folded to the closed position for stowing or transport.

摘要翻译： 两件式的锁定折叠楼梯设置有弹簧状锁定机构。 在两个构件之一上展开的弹簧状装置包括当楼梯处于完全打开或锁定位置时与另一构件上的凹口接合的突出构件。 当楼梯打开时，装置移动到防止楼梯无意折叠的位置。 为了解锁组件，弹簧状装置被压下，从而将突出构件从相应的凹口释放，允许楼梯被折叠到关闭位置用于收起或运输。

公开(公告)号：US20080281079A1

公开(公告)日：2008-11-13

申请号：US10513567

申请日：2003-05-07

申请人： Fabien Pinaud ,  David King ,  Shimon Weiss

发明人： Fabien Pinaud ,  David King ,  Shimon Weiss

IPC分类号： C07K1/107 ,  C07K2/00

CPC分类号： B82Y30/00 ,  A61K49/0056 ,  A61K49/0067 ,  B82Y5/00 ,  B82Y10/00 ,  Y10T428/2982

摘要： Particles are bioactivated by attaching bioactivation peptides to the particle surface. The bioactivation peptides are peptide-based compounds that impart one or more biologically important functions to the particles. Each bioactivation peptide includes a molecular or surface recognition part that binds with the surface of the particle and one or more functional parts. The surface recognition part includes an amino-end and a carboxy-end and is composed of one or more hydrophobic spacers and one or more binding clusters. The functional part(s) is attached to the surface recognition part at the amino-end and/or said carboxy-end.

摘要翻译： 通过将生物活性肽连接到颗粒表面来生物活化颗粒。 生物活化肽是赋予颗粒一个或多个生物重要功能的基于肽的化合物。 每个生物活化肽包括与颗粒的表面和一个或多个功能部分结合的分子或表面识别部分。 表面识别部分包括氨基末端和羧基末端，并且由一个或多个疏水间隔物和一个或多个结合簇构成。 功能部分在氨基末端和/或所述羧基末端连接到表面识别部分。

公开(公告)号：US20080136205A1

公开(公告)日：2008-06-12

申请号：US11833711

申请日：2007-08-03

申请人： Patrick Hoffman ,  David King ,  Thomas B. Murphy

发明人： Patrick Hoffman ,  David King ,  Thomas B. Murphy

IPC分类号： B60R27/00

CPC分类号： B60R21/06

摘要： A net pet barrier designed for installation behind the front or rear seat in a vehicle to keep pets off vehicle seats and in the back of the vehicle. Netting formed of micro-mesh material is attached to a pop-up wire frame which keeps the net from sagging and facilitates installation and removal. Adjustable side expansion panels allow installation of the barrier in vehicles of various sizes and configurations, from sedans to full-size SUVs.

摘要翻译： 一个净宠物屏障，设计用于安装在车辆前后座椅后面，以保持宠物离开车辆座椅和车辆后方。 由微网材料形成的网状物连接到弹性线框架上，其使网不会下垂并且便于安装和移除。 可调节的侧面扩展面板允许在各种尺寸和配置的车辆中安装屏障，从轿车到全尺寸SUV。

公开(公告)号：US20080110236A1

公开(公告)日：2008-05-15

申请号：US11558432

申请日：2006-11-09

申请人： Abraham Hajishah ,  David King ,  Michael J. Claus

发明人： Abraham Hajishah ,  David King ,  Michael J. Claus

IPC分类号： G01L27/00

CPC分类号： G01L27/002 ,  A61B2017/00725 ,  A61B2090/064 ,  A61F9/00745

摘要： A method and system for calibrating an analog sensor used in a digital measurement system is provided. The design comprises generating a precise pressure value set at multiple calibration points and supplying said precise pressure value set to an uncalibrated pressure sensor, detecting sensor changes for the uncalibrated pressure sensor based on each precise pressure value generated, polling an actual pressure reading associated with a sensor change for the uncalibrated pressure sensor for each calibration point, and establishing a mathematical relationship between measured value readings and actual pressure for the uncalibrated sensor. Establishing the mathematical relationship converts the uncalibrated sensor to a newly calibrated sensor. A known good sensor may be employed to enhance calibration reliability.

摘要翻译： 提供了一种用于校准在数字测量系统中使用的模拟传感器的方法和系统。 该设计包括产生在多个校准点处设置的精确压力值，并将所设定的精确压力值提供给未校准的压力传感器，基于产生的每个精确压力值检测未校准的压力传感器的传感器变化，轮询与 对于每个校准点的未校准的压力传感器的传感器变化，以及为未校准的传感器建立测量值读数与实际压力之间的数学关系。 建立数学关系将未校准的传感器转换为新校准的传感器。 可以使用已知的良好传感器来增强校准可靠性。

公开(公告)号：US20070176982A1

公开(公告)日：2007-08-02

申请号：US11345092

申请日：2006-02-01

申请人： David King ,  George Parish ,  James Powers ,  Lucas Barkley

发明人： David King ,  George Parish ,  James Powers ,  Lucas Barkley

IPC分类号： B41J2/175

CPC分类号： B41J2/1753 ,  B41J2/14145 ,  B41J2202/11

摘要： Inkjet printheads and actuator chips, such as an inkjet printhead actuator chip having a substrate, ink vias formed in the substrate, and columnar arrays of actuators in operational communication with the ink vias. At least one of the ink vias has at least one of a different length, width and a via to via pitch than another one of the ink vias. Imaging devices for use with the printheads are also disclosed.

摘要翻译： 喷墨打印头和致动器芯片，例如具有基板的喷墨打印头致动器芯片，形成在基板中的油墨通孔和与油墨通孔操作连通的致动器柱状阵列。 油墨通孔中的至少一个具有与另一个墨通孔不同的长度，宽度和通孔间距中的至少一个。 还公开了与打印头一起使用的成像装置。

公开(公告)号：US20070171885A1

公开(公告)日：2007-07-26

申请号：US11695569

申请日：2007-04-02

申请人： Pravin Bhagwat ,  Shantanu Gogate ,  David King

发明人： Pravin Bhagwat ,  Shantanu Gogate ,  David King

IPC分类号： H04Q7/24

CPC分类号： H04W12/12 ,  H04L43/00 ,  H04L63/1408 ,  H04L63/1416 ,  H04L63/1466 ,  H04L63/1475 ,  H04L69/16 ,  H04L69/161 ,  H04L69/163 ,  H04W8/26 ,  H04W12/06 ,  H04W84/04 ,  H04W84/12

摘要： A method for protecting local area networks within a selected local geographic region (e.g. office, apartment, building, coffee shop, hot-spot etc.) from wireless attacks, using a wireless sniffer apparatus. The method includes placing one or more wireless sniffer apparatus spatially to provide substantial radio coverage over at least a portion of the selected local geographic region comprising one or more local area networks. Moreover the method includes coupling one or more of the wireless sniffer apparatus to one or more of the local area networks.

摘要翻译： 使用无线嗅探装置从无线攻击中保护选定的本地地理区域（例如办公室，公寓，建筑物，咖啡店，热点等）内的局域网的方法。 该方法包括在空间上放置一个或多个无线嗅探装置，以在包括一个或多个局域网的所选择的局部地理区域的至少一部分上提供实质的无线电覆盖。 此外，该方法包括将无线嗅探装置中的一个或多个耦合到一个或多个局域网。

公开(公告)号：US20070139475A1

公开(公告)日：2007-06-21

申请号：US11676551

申请日：2007-02-20

申请人： David King ,  Kristi Rowe

发明人： David King ,  Kristi Rowe

IPC分类号： B41J2/14 ,  B41J2/16

CPC分类号： B41J2/04541 ,  B41J2/04548 ,  B41J2/04563 ,  B41J2/0458 ,  B41J2/14072 ,  B41J2/14129

摘要： A semiconductor substrate for a micro-fluid ejection device. The substrate includes plurality of micro-fluid ejection actuators disposed adjacent a fluid supply slot in the semiconductor substrate. A plurality of power transistors, occupying a power transistor active area of the substrate, are disposed adjacent the ejection actuators and are connected through a first metal conductor layer to the ejection actuators. An array of logic circuits, occupying a logic circuit area of the substrate, is disposed adjacent the plurality of power transistors and is connected through a polysilicon conductor layer to the power transistors. A power conductor and a ground conductor for the ejection actuators is routed in a second metal conductor layer. The power conductor overlaps at least a portion of the power transistor active area of the substrate and the ground conductor overlaps at least a portion of the logic circuit area of the substrate.

摘要翻译： 一种用于微流体喷射装置的半导体衬底。 衬底包括邻近半导体衬底中的流体供应槽设置的多个微流体喷射致动器。 占据基板的功率晶体管有源区的多个功率晶体管被设置在喷射致动器附近，并且通过第一金属导体层连接到喷射致动器。 占据基板的逻辑电路区域的逻辑电路阵列被布置成与多个功率晶体管相邻，并且通过多晶硅导体层连接到功率晶体管。 用于喷射致动器的电源导体和接地导体在第二金属导体层中布线。 电源导体与衬底的功率晶体管有源区域的至少一部分重叠，并且接地导体与衬底的逻辑电路区域的至少一部分重叠。

公开(公告)号：US20070096729A1

公开(公告)日：2007-05-03

申请号：US10581308

申请日：2004-12-16

申请人： Kevin Brunson ,  David King

发明人： Kevin Brunson ,  David King

IPC分类号： G01R33/02

CPC分类号： G01R33/0286 ,  G01R33/022 ,  G01R33/0283

摘要： A magnetic field sensor device (2) is described that comprises an oscillatory member (8) and current control means (6). The current control means (6) is arranged to pass an alternating current (AC) along at least first (10) and second (12) current paths provided through the oscillatory member (8) and is arranged to provide magnetic gradiometer mode operation (i.e. to measure magnetic field gradient) in which current flow through the first current path (10) is in substantially the opposite direction to current flow through the second current path (12). The current control means (6) can also prove magnetometer mode operation (i.e. to measure magnetic field strength). The magnetic field sensor (2) may be used in a compass.

摘要翻译： 描述了包括振荡构件（8）和电流控制装置（6）的磁场传感器装置（2）。 电流控制装置（6）被布置成沿着穿过振荡构件（8）提供的至少第一（10）和第二（12）电流路径传递交流电（AC），并且被布置成提供磁梯度计模式操作 以测量磁场梯度），其中流过第一电流路径（10）的电流基本上与通过第二电流路径（12）的电流相反。 电流控制装置（6）还可以证明磁力计模式操作（即测量磁场强度）。 磁场传感器（2）可以用于罗盘。