摘要:
This invention is directed to acyl piperazine derivatives, for example, of the following formula (1a): wherein R1a, R2, R3, R4, R5, and R6are descried herein. These derivatives are useful as anti-inflammatory agents. This invention is also directed to pharmacetutical compostions containing the derivatives, and methods of using the derivatives to treat inflammatory disorders in humans.
摘要:
This invention is directed to acyl piperazine derivatives of formula (Ia): wherein R1a, R2, R3, R4, R5 and R6 are defined herein, which are useful as anti-inflammatory agents. This invention is also directed to other acyl piperazine derivatives, pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.
摘要:
A gearbox assembly includes a gearbox housing and a planetary gear system configured within the gearbox housing. The planetary gear system includes a plurality of planet gears, at least one sun gear, at least one ring gear, at least one planetary carrier operatively coupled with the plurality of planet gears, and a plurality of pin shafts. Each of the plurality of planet gears are arranged so as to rotate around one of the plurality of pin shafts. Further, the plurality of planet gears are engaged with the ring gear and configured to rotate about the sun gear. The gearbox assembly also includes a first lubricant path defined from a first location to a second location through the at least one planetary carrier. Moreover, the first lubricant path is located outside of the plurality of pin shafts.
摘要:
A method and system for single-PDP dual-stack serial dialing is provided. A mobile terminal sets a single-PDP dual-stack serial dialing parameter according to a parameter setting command transmitted by a host; then the mobile terminal initiates a PDP activation request to a mobile communication network according to a first dialing instruction transmitted by the host and the configured single-PDP dual-stack serial dialing parameter, acquires activation response information fed back by the mobile communication network, generates dialing response information according to the activation response information, and feeds back the dialing response information to the host, wherein the dialing response information includes cause reference information. And after receiving the dialing response information, the host can acquire a specific condition of the current mobile network according to the cause reference information included in the dialing response information to determine a dialing mode.
摘要:
A foldable input device is described. In one or more implementations, an input device includes a first housing having a first collection of sensors configured to generate inputs responsive to user interaction and a second housing having a second collection of sensors configured to generate inputs responsive to user interaction. The input device also includes a wireless communication device configured to communicate the generated inputs to a computing device that are usable to initiate one or more operations of the computing device and a flexible hinge securing the first and second housings to each other and configured to permit rotational movement of the first and second housings in relation to each other.
摘要:
Quinazoline derivatives represented by general formula (1) and quinazoline complexes as protein kinase inhibitors, and their preparation methods are provided. Wherein, in general formula (1), at least one of R and R′ is a group containing an atom capable of coordinating with noble metals, m and n are either the same or different and are integers from 0 to 5. Said quinazoline complex as protein kinase inhibitor is formed by coordination compound containing noble metal and said quinazoline derivative ligand capable of coordinating with noble metal in the coordination compound. Used as tyrosine protein kinase inhibitors, Quinazoline derivatives and quinazoline complexes as protein kinase inhibitors provided by the present invention have exhibited good inhibitory effect on proliferation of various tumor cells including human breast cancer cells line (drug-resistant) MCF-7/A, human breast cancer cell line (sensitive) MCF-7/S, prostate cancer cell PC-3, keratinocytes Colo-16, human non-small cell lung cancer cell line A549, etc.
摘要:
Software for managing access control functions in a network. The software includes a host that receives access control commands or information and calls one or more methods. The methods perform access control functions and communicate access control results or messages to be transmitted. The host may be installed in a network peer seeking access to the network or in a server controlling access to the network. When installed in a peer, the host receives commands and exchanges information with a supplicant. When installed in an access control server, the host receives commands and exchanges information with an authenticator. The host has a flexible architecture that enables multiple features, such as allowing the same methods to be used for authentication by multiple supplicants, providing ready integration of third party access control software, simplifying network maintenance by facilitating upgrades of authenticator software and enabling access control functions other than peer authentication.
摘要:
Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
摘要:
Ordering search results may include obtaining an exposed log file from a log system, computing a Bayesian posterior probability for relevancy between the log file and a search request, computing an expected value of the relevancy between the log file and the search request based on the Bayesian posterior probability, storing the search request and an identifier of the log file as a key and the expected value of the relevancy between the log file and the search request as a value into a search data structure, in response to receiving a search request submitted by a user, finding expected values of relevancy between the submitted search request and log files that are relevant to the submitted search request from the search data structure, and ordering the found log files in a descending order of the expected values.
摘要:
A method, a device, and a system for realizing kernel online patching are provided. The method includes loading a pre-generated patch file in an operating system, setting a first breakpoint at an execution start position of the primitive function when a system thread executes the primitive function and a breakpoint exception occurs during the thread execution process due to the first breakpoint, modifying a returning execution address of the first breakpoint into the destination address of the patch function corresponding to the primitive function according to the first corresponding relation, and removing the first breakpoint. The kernel online patching implementation has a small impact on the normal operation of the operating system. The patch function becomes valid without restarting the operating system, thereby satisfying the high reliability requirements of carrier-class products.