公开(公告)号：US06768030B2

公开(公告)日：2004-07-27

申请号：US10416579

申请日：2003-05-13

申请人： Yasutaka Ishii ,  Tatsuya Nakano ,  Atsuo Tatsumi

发明人： Yasutaka Ishii ,  Tatsuya Nakano ,  Atsuo Tatsumi

IPC分类号： C07C40920

CPC分类号： C07C409/20 ,  C07C407/00 ,  C07C2601/14

摘要： A process of the invention allows a cycloalkane to react with oxygen in the presence of a catalytic imide compound having an N-hydroxy (or N-oxo) cyclic imide skeleton and thereby yields a corresponding bis(1-hydroxycycloalkyl) peroxide. The catalytic imide compound includes, for example, a compound represented by following Formula (1): wherein R1 and R2 are each, for example, a hydrogen atom, a halogen atom, an alkyl group, an aryl group or a cycloalkyl group, where R1 and R2 may be combined to form a double bond, an aromatic or non-aromatic ring; and X is an oxygen atom or a hydroxyl group. The cycloalkane includes, for example, a cycloalkane having from 5 to 15 members. The invention can easily produce bis(1-hydroxycycloalkyl) peroxide from an inexpensive material.

摘要翻译： 本发明的方法允许环烷烃在具有N-羟基（或N-氧代）环状酰亚胺骨架的催化酰亚胺化合物存在下与氧反应，从而得到相应的双（1-羟基环烷基）过氧化物。 催化酰亚胺化合物包括例如由下式（1）表示的化合物：其中R 1和R 2各自为例如氢原子，卤素原子，烷基，芳基 或环烷基，其中R 1和R 2可以结合形成双键，芳族或非芳族环; X为氧原子或羟基。 环烷烃包括例如具有5至15个成员的环烷烃。 本发明可以从廉价的材料容易地生产双（1-羟基环烷基）过氧化物。

公开(公告)号：US06392104B1

公开(公告)日：2002-05-21

申请号：US09180478

申请日：1998-11-10

申请人： Yasutaka Ishii ,  Tatsuya Nakano ,  Naruhisa Hirai

发明人： Yasutaka Ishii ,  Tatsuya Nakano ,  Naruhisa Hirai

IPC分类号： C07C3522

CPC分类号： C07C29/50 ,  C07C35/37 ,  C07C62/06 ,  C07C62/24 ,  C07C67/05 ,  C07C67/08 ,  C07C67/29 ,  C07C67/31 ,  C07C68/02 ,  C07C69/757 ,  C07C69/96 ,  C07C205/18 ,  C07C205/41 ,  C07C205/55 ,  C07C219/24 ,  C07C233/23 ,  C07C233/32 ,  C07C233/74 ,  C07C235/40 ,  C07C265/10 ,  C07C271/34 ,  C07C2603/74 ,  C07C69/753 ,  C07C69/157

摘要： In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the formula (2): wherein R1 and R2 independently represents a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cycloalkyl group; or R1 and R2 may bond together to form a double bond or an aromatic or non-aromatic ring; Y is O or OH and n=1 to 3; or the imide compound and a co-catalyst (e.g., a transition metal compound), an adamantane derivative having a functional group such as a nitro group, an amino group, a hydroxyl group, a carboxyl group, a hydroxymethyl group and an isocyanato group is oxidized with oxygen. According to the above method, an adamantane derivative having a hydroxyl group together with a functional group such as a nitro group, an amino group, a hydroxyl group, a carboxyl group, a hydroxymethyl group and an isocyanato group is efficiently obtained.

摘要翻译： 在式（2）所示的酰亚胺化合物（例如，N-羟基邻苯二甲酰亚胺）存在下，其中R1和R2独立地表示氢原子，卤素原子，烷基，芳基，环烷基; 或者R 1和R 2可以键合在一起形成双键或芳族或非芳族环; Y为O或OH且n = 1至3;或酰亚胺化合物和助催化剂（例如过渡金属化合物），具有硝基，氨基，羟基等官能团的金刚烷衍生物 ，羧基，羟甲基和异氰酸酯基被氧氧化。 根据上述方法，有效地获得具有羟基的金刚烷衍生物与硝基，氨基，羟基，羧基，羟甲基和异氰酸基等官能团。

公开(公告)号：US06375922B1

公开(公告)日：2002-04-23

申请号：US09647881

申请日：2000-10-06

申请人： Yasutaka Ishii ,  Tatsuya Nakano

发明人： Yasutaka Ishii ,  Tatsuya Nakano

IPC分类号： C01B15026

CPC分类号： C01B15/026

摘要： The invented process produces hydrogen peroxide by reacting a primary or secondary alcohol with oxygen in the presence of an imide compound of the following formula (1): wherein each of R1 and R2 is, identical to or different from each other, a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cycloalkyl group, a hydroxyl group, an alkoxy group, a carboxyl group, an alkoxycarbonyl group, or an acyl group, where R1 and R2 may be combined to form a double bond, or an aromatic or non-aromatic ring; X is an oxygen atom or a hydroxyl group, where one or two N-substituted cyclic imido groups indicated in the formula (1) may be further bonded to the R1, R2, or to the double, bond or aromatic or non-aromatic ring formed together by R1 and R2, to yield hydrogen peroxide. According to the process, hydrogen peroxide can be easily and efficiently obtained from readily available materials.

摘要翻译： 本发明的方法通过在下式（1）的酰亚胺化合物存在下使伯醇或仲醇与氧反应产生过氧化氢：其中R 1和R 2各自彼此相同或不同，为氢原子， 卤素原子，烷基，芳基，环烷基，羟基，烷氧基，羧基，烷氧基羰基或酰基，其中R 1和R 2可以结合形成双键， 或芳族或非芳族环; X是氧原子或羟基，其中式（1）中所示的一个或两个N-取代的环亚胺基可以进一步键合到R1，R2或双键，芳香或非芳香环上 由R1和R2一起形成，得到过氧化氢。 根据该方法，可以从容易获得的材料容易且有效地获得过氧化氢。

公开(公告)号：US06323346B1

公开(公告)日：2001-11-27

申请号：US09522072

申请日：2000-03-09

申请人： Yasutaka Ishii ,  Tatsuya Nakano

发明人： Yasutaka Ishii ,  Tatsuya Nakano

IPC分类号： C07D20308

CPC分类号： C07D203/08 ,  C07D203/14

摘要： In the presence of an iridium compound, an imine of the following formula (1): wherein R1, R2 and R3 are each, identical to or different from one another, a hydrogen atom or a non-reactive organic group, where R1 and R2 may be combined to form a ring together with the adjacent carbon atom, is reacted with a diazoacetic acid derivative of the following formula (2): N2CHR4  (2) wherein R4 is a cyano group, an alkoxycarbonyl group, a carbamoyl group or the like, to yield an aziridine compound of the following formula (5): wherein R1, R2, R3 and R4 have the same meanings as defined above. The process can easily and efficiently produce aziridine compounds.

摘要翻译： 在铱化合物的存在下，下式（1）的亚胺：其中R 1，R 2和R 3各自彼此相同或不同，为氢原子或非反应性有机基团，其中R1和R2 可以与相邻的碳原子一起形成环，与下式（2）的重氮乙酸衍生物反应：其中R4是氰基，烷氧基羰基，氨基甲酰基等，得到 下式（5）的氮丙啶化合物：其中R1，R2，R3和R4具有与上述相同的含义。 该方法可以容易且有效地制备氮丙啶化合物。

公开(公告)号：US06201156B1

公开(公告)日：2001-03-13

申请号：US09394101

申请日：1999-09-13

申请人： Yasutaka Ishii ,  Tatsuya Nakano

发明人： Yasutaka Ishii ,  Tatsuya Nakano

IPC分类号： C07C47542

CPC分类号： C07C45/59 ,  C07C45/27 ,  C07C45/60 ,  C07C47/544 ,  C07C47/542 ,  C07C47/55 ,  C07C47/54 ,  C07C47/546 ,  C07C47/21

摘要： An ether of the following formula (2): (wherein Ra is a hydrogen atom, a hydrocarbon group or a heterocyclic group, Rb is a hydrogen atom, a hydroxyl group or a substituted oxy group, and Rc is a hydrocarbon group or a heterocyclic group; Ra and Rc may be combined to form a ring with the adjacent carbon atom and oxygen atom) is reacted with nitrogen monoxide in the presence of a catalyst composed of an imide compound of the following formula (1): (wherein each of R1 and R2 is, identical to or different from each other, a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cycloalkyl group, a hydroxyl group, an alkoxy group, a carboxyl group, an alkoxycarbonyl group, or an acyl group; R1 and R2 may be combined to form a double bond, or an aromatic or nonaromatic ring; X is an oxygen atom or a hydroxyl group; and one or two N-substituted cyclic imido groups indicated in the formula (1) may further be formed on R1, R2, or on the double bond or aromatic or nonaromatic ring formed together by R1 and R2) to give an aldehyde of the following formula (3): Ra—CHO  (3) (wherein Ra has the same meaning as defined above).

摘要翻译： 下式（2）的醚:(其中，R a为氢原子，烃基或杂环基，R b为氢原子，羟基或取代的氧基，R c为烃基或杂环基 基团; R a和R c可以与相邻的碳原子和氧原子结合形成环）在一种由下式（1）的酰亚胺化合物组成的催化剂的存在下与一氧化氮反应:(其中R1， 和R 2彼此相同或不同，为氢原子，卤素原子，烷基，芳基，环烷基，羟基，烷氧基，羧基，烷氧基羰基或 酰基; R1和R2可以结合形成双键，或芳族或非芳香环; X是氧原子或羟基;和式（1）中所示的一个或两个N-取代的环状亚氨基可以 进一步在R1，R2或双键或芳族或非芳香环上形成 通过R 1和R 2一起），得到下式（3）的醛:(其中R a具有与上述相同的含义）。

公开(公告)号：US6111128A

公开(公告)日：2000-08-29

申请号：US213424

申请日：1998-12-17

申请人： Yasutaka Ishii ,  Tatsuya Nakano

发明人： Yasutaka Ishii ,  Tatsuya Nakano

IPC分类号： B01J27/10 ,  B01J27/122 ,  B01J27/125 ,  B01J27/128 ,  B01J27/132 ,  B01J27/135 ,  B01J31/22 ,  C07B61/00 ,  C07C51/08 ,  C07C59/01 ,  C07C59/48 ,  C07C253/00 ,  C07C253/16 ,  C07C255/14 ,  C07C255/16 ,  C07C263/00 ,  C07C249/00

CPC分类号： C07C253/00 ,  C07C51/08

摘要： In the presence of a metal catalyst such as a samarium compound, an enol ester compound shown by the formula (1) is reacted with a carbonyl compound shown by the formula (3) and a cyanogenation agent to produce an .alpha.-cyanohydrin ester shown by the formula (4): ##STR1## wherein R.sup.1, R.sup.7, and R.sup.8 are the same or different from each other, each representing a non-reactive atom or a non-reactive organic group; R.sup.2, R.sup.3, and R.sup.4 are the same or different from each other, each representing a hydrogen atom or an alkyl group having 1 to 5 carbon atoms.By hydrolyzing the obtained compound, the corresponding .alpha.-hydroxy acid or a salt thereof can be obtained. According to the above processes, an .alpha.-cyanohydrin ester and an .alpha.-hydroxy acid can be obtained in high yields.

摘要翻译： 在诸如钐化合物的金属催化剂存在下，将式（1）所示的烯醇酯化合物与式（3）所示的羰基化合物和氰化剂反应，生成α-氰基氢酯，由 式（4）：其中R 1，R 7和R 8彼此相同或不同，各自表示非反应性原子或非反应性有机基团; R 2，R 3和R 4相同或不同，各自表示氢原子或碳原子数1〜5的烷基。 通过水解所得化合物，可以得到相应的α-羟基酸或其盐。 根据上述方法，可以高产率获得α-氰基氢酯和α-羟基酸。

公开(公告)号：US20100331569A1

公开(公告)日：2010-12-30

申请号：US12919494

申请日：2009-02-27

申请人： Minoru Takano ,  Naruhisa Hirai ,  Yasutaka Ishii

发明人： Minoru Takano ,  Naruhisa Hirai ,  Yasutaka Ishii

IPC分类号： C07C51/50

CPC分类号： C07C45/33 ,  B01J27/053 ,  B01J37/0201 ,  C07C29/50 ,  C07C45/36 ,  C07C51/00 ,  C07C51/265 ,  C07C2603/74 ,  Y02P20/55 ,  C07C35/37 ,  C07C47/542 ,  C07C49/417 ,  C07C63/04

摘要： Disclosed is a process for the production of an oxygen-containing organic compound by oxidizing an organic compound with molecular oxygen in a liquid phase in the presence both of a catalytic nitrogen-containing cyclic compound and a catalyst including a solid superacid and, supported thereon, a transition metal compound, in which the nitrogen-containing cyclic compound contains, as a ring constituent, a skeleton represented by following Formula (1), wherein X represents an —OR group, and wherein R represents hydrogen atom or a hydroxyl-protecting group. The process gives the oxygen-containing organic compound in a high yield and enables easy recovery and reuse of the catalyst.

摘要翻译： 本发明公开了一种在含有催化含氮环状化合物和含有固体超强酸的催化剂存在的条件下，通过在液相中用分子氧氧化有机化合物来制备含氧有机化合物的方法， 其中含氮环状化合物含有作为环成分的由下式（1）表示的骨架的过渡金属化合物，其中X表示-OR基，其中R表示氢原子或羟基保护基 。 该方法以高产率提供含氧有机化合物，并且能够容易地回收和再利用催化剂。

公开(公告)号：US06218569B1

公开(公告)日：2001-04-17

申请号：US09600717

申请日：2000-07-20

申请人： Yasutaka Ishii ,  Keizo Inoue

发明人： Yasutaka Ishii ,  Keizo Inoue

IPC分类号： C07C6952

CPC分类号： C07C69/54 ,  C07C2602/28 ,  C07C2603/24 ,  C07C2603/68 ,  Y02P20/55

摘要： The invented polymerizable alicyclic esters are shown by the following formula (1) or (2): wherein each of ring A, ring B, ring C, ring D, and ring E is a non-aromatic carbon ring, R is a polymerizable unsaturated group, and each of Ra1, Rb1, and Rc1 is, identical to or different from one another, a hydrogen atom, a hydroxyl group which may be protected by a protective group, or an RCO2 group, where R has the same meaning as defined above. Each of the ring A, ring B, ring C, ring D, and ring E is, for example, a cyclopentane ring, a cyclohexane ring, or a bridged ring. R includes, for example, a vinyl group, an isopropenyl group, or an aryl group.

摘要翻译： 本发明的可聚合脂环族酯由下式（1）或（2）表示：其中环A，环B，环C，环D和环E均为非芳族碳环，R为可聚合不饱和 并且Ra1，Rb1和Rc1各自彼此相同或不同，为氢原子，可被保护基保护的羟基或RCO 2基团，其中R具有与所定义相同的含义 以上。 环A，环B，环C，环D和环E各自为例如环戊烷环，环己烷环或桥环。 R包括例如乙烯基，异丙烯基或芳基。

公开(公告)号：US4891460A

公开(公告)日：1990-01-02

申请号：US707601

申请日：1985-03-04

申请人： Yasutaka Ishii

发明人： Yasutaka Ishii

IPC分类号： B01J31/00 ,  B01J31/12 ,  B01J31/26 ,  C07B61/00 ,  C07C1/00 ,  C07C2/52 ,  C07C13/43 ,  C07C67/00

CPC分类号： C07C2/52 ,  C07C2102/42 ,  C07C2531/02 ,  C07C2531/12 ,  C07C2531/22

摘要： The present invention provides a process for producing alkylidenenorbornenes by reacting C.sub.4 -C.sub.6 acyclic conjugated dienes with cyclopentadiene, dicyclopentadiene, or a methyl- or dimethyl-substituted derivative thereof in the presence of a catalyst derivative composed of:(A) a titanium-containing compound, and(B) at least one metallic reducing agent containing the group IA, IIA or IIIA metals in the periodic table.

摘要翻译： 本发明提供一种通过使C4-C6无环共轭二烯与环戊二烯，二环戊二烯或其甲基或二甲基取代的衍生物在催化剂衍生物存在下反应制备亚烷基降冰片烯的方法，所述催化剂衍生物由以下组成：（A）含钛化合物 ，和（B）在元素周期表中含有IA，IIA或IIIA族金属的至少一种金属还原剂。

公开(公告)号：US20100317869A1

公开(公告)日：2010-12-16

申请号：US12526010

申请日：2008-02-28

申请人： Yasutaka Ishii ,  Minoru Takano ,  Naruhisa Hirai

发明人： Yasutaka Ishii ,  Minoru Takano ,  Naruhisa Hirai

IPC分类号： C07F7/10 ,  C07C45/38 ,  C07C51/235

CPC分类号： B01J31/0247 ,  B01J21/08 ,  B01J31/0254 ,  B01J31/04 ,  B01J2531/72 ,  B01J2531/845 ,  C07B41/06 ,  C07B41/08 ,  C07C45/36 ,  C07C51/265 ,  C07D209/48 ,  Y02P20/55 ,  C07C47/542 ,  C07C63/04 ,  C07C63/26

摘要： To provide a solid catalyst containing a cyclic imide skeleton which is easily available and easily separable from reaction products and which is easily recovered and regenerated, and free from reaction inhibitory factors; and a process for oxidation of organic compounds with the solid catalyst.An immobilized cyclic imide catalyst having a structure represented by following Formula (1), wherein X is oxygen or an —OR group (wherein R is hydrogen atom or a hydroxyl-protecting group); n is 0 or 1; Z1 is a five- or six-membered cyclic imide skeleton to which an aromatic or nonaromatic ring Z2 may be adjacent; elliptically shaped moiety S is an inorganic support; A1 is a group linking silicon atom with the cyclic imide skeleton Z1 or with the ring Z2 and is either a divalent hydrocarbon group or a group composed of a divalent hydrocarbon group and an amide bond (—NHCO—); and the cyclic imide skeleton Z1 and the ring Z2 may each be substituted.

摘要翻译： 提供含有环状酰亚胺骨架的固体催化剂，其易于获得并且易于与反应产物分离并易于回收和再生，并且没有反应抑制因子; 以及用固体催化剂氧化有机化合物的方法。 具有下式（1）表示的结构的固定化的环状酰亚胺催化剂，其中X为氧或-OR基（其中R为氢原子或羟基保护基）; n为0或1; Z1是芳族或非芳族环Z2可以相邻的五元或六元环酰亚胺骨架; 椭圆形部分S是无机载体; A1是将硅原子与环状酰亚胺骨架Z1或环Z2连接的基团，为二价烃基或由二价烃基和酰胺键（-NHCO-）构成的基团。 并且环状酰亚胺骨架Z1和环Z2可各自被取代。