公开(公告)号：US09476956B2

公开(公告)日：2016-10-25

申请号：US13984537

申请日：2012-01-19

申请人： Yo Taniguchi ,  Suguru Yokosawa ,  Yoshitaka Bito

发明人： Yo Taniguchi ,  Suguru Yokosawa ,  Yoshitaka Bito

IPC分类号： G01R33/56 ,  A61B5/055 ,  G01R33/565 ,  G01R33/561

CPC分类号： G01R33/56 ,  A61B5/055 ,  G01R33/5614 ,  G01R33/5616 ,  G01R33/56554 ,  G01R33/56572

摘要： In order to improve image quality, a technique for obtaining information for eliminating distortions of the k-space in the readout direction and the phase encoding direction caused by the waveform distortion of the gradient magnetic field pulse is provided. A pulse sequence for the main scan is used to repeatedly measure echoes with changing the time integral value of the dephasing pulse for the readout gradient magnetic field. In the above measurement, the phase encoding pulse is not made zero, but two-dimensional data are measured in the same manner as that of the main scan. By using the measured two-dimensional data, correction information for eliminating distortions of the k-space in the readout direction and the phase encoding direction caused by the waveform distortion of the gradient magnetic field pulse is calculated in each of the readout direction and the phase encoding direction.

摘要翻译： 为了提高图像质量，提供了一种用于获得用于消除由梯度磁场脉冲的波形失真引起的读出方向和相位编码方向上的k空间的失真的信息的技术。 用于主扫描的脉冲序列用于通过改变读出梯度磁场的去相位脉冲的时间积分值来重复测量回波。 在上述测量中，相位编码脉冲不为零，而是以与主扫描相同的方式测量二维数据。 通过使用所测量的二维数据，在每个读出方向和相位上计算用于消除由梯度磁场脉冲的波形失真引起的读出方向上的k空间的失真和相位编码方向的校正信息 编码方向。

公开(公告)号：US09091744B2

公开(公告)日：2015-07-28

申请号：US13697122

申请日：2011-05-02

申请人： Satoshi Hirata ,  Yoshitaka Bito

发明人： Satoshi Hirata ,  Yoshitaka Bito

IPC分类号： G01V3/00 ,  G01R33/485 ,  G01R33/483 ,  G01R33/56 ,  G01R33/561

CPC分类号： G01R33/485 ,  G01R33/4833 ,  G01R33/5607 ,  G01R33/5617

摘要： An object of the present invention is to provide a measuring technique which allows in the MRS measurement to suppress with a high degree of precision, incorporation of a signal of unwanted compounds which hinders measurement of a measurement object signal, independent of an imaging object region and the measurement object signal, thereby obtaining a stable and favorable signal spectrum. In the MRS measuring sequence, a spectrum selective inversion RF pulse, having a narrow band characteristic for selectively inverting only a signal peak of a compounds to be suppressed, and phase dispersion-refocusing GC pulses are applied at least one of before and after a region selective RF pulse. This MRS measuring sequence is repeated while changing the echo time TE at predetermined intervals, and nuclear magnetic resonance signals being obtained by the repetition are integrated. The amount of the spectrum selective inversion RF pulse to be applied may be changed according to the echo time TE.

摘要翻译： 本发明的目的是提供一种测量技术，其允许在MRS测量中以高精确度抑制，不依赖于成像对象区域而引入妨碍测量对象信号的测量的不想要的化合物的信号，以及 测量对象信号，从而获得稳定和有利的信号频谱。 在MRS测量序列中，具有用于选择性地仅反转待抑制的化合物的信号峰的窄带特性和相位色散重新聚焦GC脉冲的频谱选择性反转RF脉冲施加在区域之前和之后的至少一个 选择性RF脉冲。 在以预定间隔改变回波时间TE的同时重复该MRS测量序列，并且通过重复获得的核磁共振信号被积分。 可以根据回波时间TE改变要施加的频谱选择性反转RF脉冲的量。

公开(公告)号：US08547101B2

公开(公告)日：2013-10-01

申请号：US13123299

申请日：2009-07-22

申请人： Satoshi Hirata ,  Yoshitaka Bito

发明人： Satoshi Hirata ,  Yoshitaka Bito

IPC分类号： G01V3/00

CPC分类号： G01R33/485 ,  G01R33/4833 ,  G01R33/5617

摘要： In MRS measurement using magnetic resonance highly precise results are efficiently obtained with coincidence of axes with axes in positioning image. In measurement according to the PRESS method for a plurality of regions each localized (specified) with a set of perpendicularly intersecting three slices, wherein one or two slices are common to the sets of three slices localizing the regions, and slices not common do not intersect, a slice not common to those of a region to be selectively excited is excited with a radio frequency magnetic field of which phase is different by 180 degrees from that of a radio frequency magnetic field used for exciting the region to be selectively excited a number of times equal to the number of common slices, and during the measurement of the region to be selectively excited, a group of regions other than the region to be selectively excited are thermally equilibrated.

摘要翻译： 在使用磁共振的MRS测量中，通过定位图像中的轴与轴的重合而有效地获得高精度结果。 在根据PRESS方法对多个区域进行测量，每个区域具有一组垂直相交的三个片段（指定），其中一个或两个切片对于定位该区域的三个切片的组是共同的，并且不共同的切片不相交 与被选择性地激励的区域不共同的切片被与用于激励该区域的射频磁场的相位相差180度的射频磁场激发，以选择性地激发多个 时间等于公共切片的数量，并且在要选择性激发的区域的测量期间，除了要选择性激发的区域之外的一组区域被热平衡。

公开(公告)号：US20120301007A1

公开(公告)日：2012-11-29

申请号：US13577355

申请日：2011-01-28

申请人： Toru Shirai ,  Yoshitaka Bito

发明人： Toru Shirai ,  Yoshitaka Bito

IPC分类号： G06K9/36

CPC分类号： G01R33/4828 ,  A61B5/055 ,  A61B5/4869 ,  A61B5/4872

摘要： Water/fat separation imaging is performed by an MRI device, even if the measurement is not performed with such echo times that the phases of water and fat signals become in-phase or out-of-phase. A determination is made as to which of two obtained separation images is a water image or a fat image. Two water/fat ratio maps are calculated from two original images obtained with such two echo times that phase differences of water and fat signals do not become positive and negative values, and do not becomes integral multiples of π. Two phase maps are calculated from the two water/fat ratio maps and are combined to calculate two minimum phase difference maps showing minimum spatial phase difference. From dispersion in differential maps obtained by spatially differentiating the minimum phase difference maps, a correct minimum phase difference map is determined, and is used to perform phase correction of the original image.

摘要翻译： 水分/脂肪分离成像由MRI装置进行，即使不进行水分和脂肪信号的相位成为同相或异相的回波时间的测量。 确定两个获得的分离图像中的哪一个是水图像或胖图像。 从两个回波时间获得的两个原始图像计算出两个水/脂肪比例图，其中水分和脂肪信号的相位差不会变为正值和负值，并不成为＆pgr的整数倍。 两个相位图由两个水/脂肪比图计算，并被组合以计算显示最小空间相位差的两个最小相位差图。 从通过空间微分最小相位差图获得的差分图中的色散，确定正确的最小相位差图，并用于执行原始图像的相位校正。

公开(公告)号：US20110196225A1

公开(公告)日：2011-08-11

申请号：US13123299

申请日：2009-07-22

申请人： Satoshi Hirata ,  Yoshitaka Bito

发明人： Satoshi Hirata ,  Yoshitaka Bito

IPC分类号： A61B5/055

CPC分类号： G01R33/485 ,  G01R33/4833 ,  G01R33/5617

摘要： In the MRS measurement using magnetic resonance for performing measurement of two regions in the same section, highly precise results are efficiently obtained with coincidence of axes with axes in positioning image. In measurement according to the PRESS method for a plurality of regions each localized (specified) with a set of perpendicularly intersecting three slices, wherein one or two slices are common to the sets of three slices localizing the regions, and slices not common do not intersect, a slice not common to those of a region to be selectively excited is excited with a radio frequency magnetic field of which phase is different by 180 degrees from that of a radio frequency magnetic field used for exciting the region to be selectively excited a number of times equal to the number of common slices, and during the measurement of the region to be selectively excited, a group of regions other than the region to be selectively excited are thermally equilibrated.

摘要翻译： 在使用磁共振进行MRS测量的同一部分中的两个区域的测量中，通过定位图像中的轴与轴的一致性有效地获得高精度的结果。 在根据PRESS方法对多个区域进行测量，每个区域具有一组垂直相交的三个片段（指定），其中一个或两个切片对于定位该区域的三个切片的组是共同的，并且不共同的切片不相交 与被选择性地激励的区域不共同的切片被与用于激励该区域的射频磁场的相位相差180度的射频磁场激发，以选择性地激发多个 时间等于公共切片的数量，并且在要选择性激发的区域的测量期间，除了要选择性激发的区域之外的一组区域被热平衡。

公开(公告)号：US20110112393A1

公开(公告)日：2011-05-12

申请号：US13054155

申请日：2009-07-22

申请人： Yo Taniguchi ,  Yoshitaka Bito ,  Shoichi Miyawaki ,  Hiroyuki Takeuchi ,  Suguru Yokosawa

发明人： Yo Taniguchi ,  Yoshitaka Bito ,  Shoichi Miyawaki ,  Hiroyuki Takeuchi ,  Suguru Yokosawa

IPC分类号： A61B5/055

CPC分类号： G01R33/56518 ,  A61B5/055 ,  A61B5/7257 ,  G01R33/5616 ,  G01R33/56341 ,  G01R33/56563

摘要： In the diffusion-weighted imaging, amounts of distortion and amounts of phase offset of k-space data due to a temporally changing magnetic field error induced by eddy currents and vibrations associated with application of a diffusion-weighted gradient magnetic field pulse are corrected with good precision to improve image quality. Characteristic data for correcting distortion of k-space data are calculated for every position in the slice direction as peak shifts of projections observed between the cases of applying and not applying an MPG pulse. As the characteristic data, amounts of distortion in the read-out direction and the phase encoding direction and phase offset amounts in a slice plane are calculated.

摘要翻译： 在扩散加权成像中，由于由涡流引起的瞬时变化的磁场误差和与施加扩散加权梯度磁场脉冲相关的振动引起的k空间数据的失真量和相位偏移量被校正为良好 精度提高图像质量。 针对切片方向上的每个位置计算用于校正k空间数据的失真的特征数据，作为施加和不施加MPG脉冲的情况之间观察到的投影的峰值偏移。 作为特征数据，计算读取方向上的失真量和切片平面中的相位编码方向和相位偏移量。

公开(公告)号：US20100272337A1

公开(公告)日：2010-10-28

申请号：US12741086

申请日：2008-07-07

申请人： Toru Shirai ,  Yoshitaka Bito ,  Yukari Yamamoto ,  Satoshi Hirata

发明人： Toru Shirai ,  Yoshitaka Bito ,  Yukari Yamamoto ,  Satoshi Hirata

IPC分类号： G06K9/00

CPC分类号： G01R33/56518 ,  G01R33/485 ,  G01R33/5618

摘要： While removing signals unnecessary for measuring signals from a metabolite, data required for eddy current correction are obtained in a short period of time. Signals from an unnecessary substance which is not an object of the measurement are removed, and phase data for correcting spectral distortion caused by an eddy current are obtained by a single measurement. Two kinds of frequency-selective pulses of which intensities are adjusted so that the signals from the unnecessary substance should have the same absolute values of intensities and opposite polarities are applied with changing intensities for every phase encoding for at least one axis, and the obtained signals are arranged in a k-space. By removing aliasing of image data obtained from the k-space data, signals from an unnecessary substance are removed, and phase data for eddy current correction are calculated by using a part of the k-space data.

摘要翻译： 在消除从代谢物测量信号所不必要的信号的同时，在短时间内获得涡流校正所需的数据。 除去不是测量对象的不必要物质的信号，并且通过单次测量获得用于校正由涡流引起的光谱失真的相位数据。 调整强度的两种频率选择脉冲，使得来自不需要的物质的信号应具有相同的强度绝对值和相反的极性，对于至少一个轴的每个相位编码的变化强度，并且获得的信号 被布置在k空间中。 通过去除从k空间数据获得的图像数据的混叠，去除来自不需要的物质的信号，并且通过使用k空间数据的一部分来计算用于涡流校正的相位数据。

公开(公告)号：US07723987B2

公开(公告)日：2010-05-25

申请号：US12071896

申请日：2008-02-27

申请人： Yoshitaka Bito ,  Yo Taniguchi ,  Toru Shirai ,  Shinji Kurokawa

发明人： Yoshitaka Bito ,  Yo Taniguchi ,  Toru Shirai ,  Shinji Kurokawa

IPC分类号： G01V3/00

CPC分类号： G01R33/4833 ,  G01R33/4835 ,  G01R33/561

摘要： A magnetic resonance measurement technique is provided which shortens the measurement time while suppressing artifacts caused by body movement of a measuring object and enables high-speed imaging. An excitation pulse which excites a plurality of slice planes and an excitation pulse which excites slice planes perpendicular to the slice planes are applied and a plurality of substantially parallel linear crossing areas are simultaneously measured. Spatial information of a linear direction of the crossing areas is acquired by modulating a magnetic resonance signal from the crossing areas by a gradient magnetic field. A spatial information of a direction perpendicular to the linear direction is acquired by changing the position of the plane and an image is reconstructed.

摘要翻译： 提供一种磁共振测量技术，其可以在抑制由测量对象的身体移动引起的伪像的同时缩短测量时间并且能够进行高速成像。 激励激发多个切片平面的激励脉冲和激发与切片平面垂直的切片平面的激励脉冲，同时测量多个基本上平行的线性交叉区域。 交叉区域的线性方向的空间信息是通过梯度磁场调制来自交叉区域的磁共振信号而得到的。 通过改变平面的位置并且重建图像来获取垂直于线性方向的方向的空间信息。

公开(公告)号：US20070271214A1

公开(公告)日：2007-11-22

申请号：US11798889

申请日：2007-05-17

申请人： Shigeo Sumino ,  Tomohiro Yasuda ,  Yoshitaka Bito ,  Yoshiki Niwa

发明人： Shigeo Sumino ,  Tomohiro Yasuda ,  Yoshitaka Bito ,  Yoshiki Niwa

IPC分类号： G06F17/30

CPC分类号： G06F19/3456 ,  G06F16/40 ,  G06F19/326

摘要： A clinical trial support system suitable for the investigation of an adverse event or the like. A clinical trial database stores: information about sponsors; information about trial sites; product information including the product names, classification, chemical structure, and pharmacokinetics of trial drugs; trial information including trial name, target disease, phase, and completed status; contract information including trial site name, contracted number of cases, and completed status; trial subject information including sex, birth of date, height, weight, and completed status; and visit information including visit date, inspection result, and medical imaging data. An information control unit distributes a search interface for the analysis of an adverse event to the trial sponsor and a retrieval result to the trial site.

摘要翻译： 适用于不良事件等的调查的临床试验支援系统。 临床试验数据库存储：关于赞助商的信息; 有关试验场的信息; 产品信息，包括试药的产品名称，分类，化学结构和药代动力学; 试用信息包括试验名称，目标疾病，阶段和完成状态; 合同信息包括试验地点名称，合同案件数量和完成情况; 试验主题信息包括性别，出生日期，身高，体重和完成状态; 访问信息，包括访问日期，检查结果和医学影像数据。 信息控制单元将用于分析不良事件的搜索界面分发给试用发起者，并将检索结果分发到试用站点。

公开(公告)号：US5808467A

公开(公告)日：1998-09-15

申请号：US653315

申请日：1996-05-24

申请人： Hisaaki Ochi ,  Yo Taniguchi ,  Kenichi Okajima ,  Yoshitaka Bito ,  Etsuji Yamamoto

发明人： Hisaaki Ochi ,  Yo Taniguchi ,  Kenichi Okajima ,  Yoshitaka Bito ,  Etsuji Yamamoto

IPC分类号： G01R33/3415 ,  G01V3/00

CPC分类号： G01R33/3415

摘要： In the inspection system using nuclear magnetic resonance comprising magnetic field generators such as a static magnetic field, a gradient magnetic field, and an RF magnetic field, an RF probe for detecting an NMR signal from a subject, and a calculator for operating a detected signal by the RF probe, a RF probe for detection comprises a plurality of coils arranged in the predetermined direction and includes a plurality of switching elements and the inspection system selects two or more coils from the plurality of coils for each measurement of NMR signals, turns the switching elements connected to the selected coils ON, turns the switching elements connected to coils other than the selected coils OFF, changes a combination of two or more coils for each measurement of NMR signals, and changes the sensitivity distribution of the RF probe in the predetermined direction according to the Wavelet basis function for each measurement of NMR signals.

摘要翻译： 在使用包括诸如静磁场，梯度磁场和RF磁场的磁场发生器的核磁共振的检查系统中，用于检测来自被检体的NMR信号的RF探针和用于操作检测信号的计算器 通过RF探头，用于检测的RF探针包括沿预定方向布置的多个线圈，并且包括多个开关元件，并且检查系统从每个测量NMR信号中选择来自多个线圈的两个或更多个线圈， 连接到所选择的线圈的开关元件接通，将与所选线圈以外的线圈相连的开关元件断开，对每个NMR信号的测量改变两个或更多个线圈的组合，并将RF探针的灵敏度分布改变为预定的 根据每个NMR信号测量的小波基函数的方向。