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    Apparatus for Evaluation of a Device for Measuring Lung Diffusion Capacity
    51.
    发明申请
    Apparatus for Evaluation of a Device for Measuring Lung Diffusion Capacity 有权
    用于评估肺扩散能力的装置的装置

    公开(公告)号：US20100312134A1

    公开(公告)日：2010-12-09

    申请号：US12791576

    申请日：2010-06-01

    申请人： Antonius Fransiscus Marie Verbraak ,  Wilhelmus Petrus Johannes Holland

    发明人： Antonius Fransiscus Marie Verbraak ,  Wilhelmus Petrus Johannes Holland

    IPC分类号： A61B5/08

    CPC分类号： A61B5/0813

    摘要： A test apparatus for evaluating a measuring device for measuring a diffusion capacity of a person's lungs by measuring a change of concentration of a gas species in a mixture, when the mixture is inhaled and subsequently exhaled by a person, wherein the test apparatus includes (a) a port for connecting to the measuring device; (b) a compartment coupled to the port; (c) a circulation circuit configured to circulate gas from the compartment back to the compartment; and (d) a gas species removing element configured to selectively reduce a partial pressure of the gas species at a point in the circulation circuit.

    摘要翻译： 一种测试装置，用于通过测量混合物中的气体种类的浓度的变化来测量人的肺的扩散能力，所述测量装置当所述混合物被人吸入并随后呼出时，所述测试装置包括（a ）用于连接到测量装置的端口; （b）连接到该端口的舱室; （c）循环回路，其构造成使得气体从隔室循环回隔室; 和（d）气体物质去除元件，其被配置为选择性地降低循环回路中的一个点处的气体物质的分压。

    Method and apparatus for evaluation of a device for measuring lung diffusion capacity
    52.
    发明授权
    Method and apparatus for evaluation of a device for measuring lung diffusion capacity 有权
    用于评估肺扩散能力的装置的方法和装置

    公开(公告)号：US07814774B2

    公开(公告)日：2010-10-19

    申请号：US12095769

    申请日：2006-03-27

    申请人： Antonius Fransiscus Marie Verbraak ,  Wilhelmus Petrus Johannes Holland

    发明人： Antonius Fransiscus Marie Verbraak ,  Wilhelmus Petrus Johannes Holland

    IPC分类号： G01N21/00

    CPC分类号： A61B5/0813

    摘要： A method of evaluating a measuring device for measuring, in normal operation, a diffusion capacity of a person's lungs by measuring a change of concentration of a gas species in a mixture, when the mixture is inhaled and subsequently exhaled by the person or imposed by an artificial ventilator, the method comprising the steps of: (a) receiving the mixture in a compartment; (b) circulating gas from the compartment back to the compartment through a circulation circuit; and (c) selectively reducing partial pressure of the gas species in the circulation circuit to a predetermined level. A device for implementing the evaluation method is also disclosed.

    摘要翻译： 一种评估测量装置的方法，用于在正常操作中通过测量混合物中的气体种类的浓度变化来测量人的肺的扩散能力，当混合物被吸入并随后由人呼出或由 人造呼吸机，该方法包括以下步骤：（a）将混合物接收在隔室中; （b）通过循环回路从隔室将气体循环回到隔室; 和（c）选择性地将循环回路中的气体种类的分压降低至预定水平。 还公开了一种用于实现评估方法的装置。

    Method to diagnose or screen for inflammatory diseases
    54.
    发明申请
    Method to diagnose or screen for inflammatory diseases 审中-公开
    诊断或筛查炎性疾病的方法

    公开(公告)号：US20060286586A1

    公开(公告)日：2006-12-21

    申请号：US11446458

    申请日：2006-06-02

    申请人： Hemmo Drexhage ,  Cindy Ruwhof ,  Robbert Benner

    发明人： Hemmo Drexhage ,  Cindy Ruwhof ,  Robbert Benner

    IPC分类号： C12Q1/68 ,  C12M1/34

    CPC分类号： C12Q1/6883 ,  C12Q2600/158

    摘要： The invention relates to the field of medical diagnostics. More specifically, the invention relates to methods to diagnose or screen for inflammatory conditions or disease, including auto-inflammatory disease and affective disorder, in a subject, preferably a human subject, by assaying for a marker for an inflammatory disease. Provided is a method to diagnose, screen for or predict the development of an affective disorder (AD), preferably bipolar disorder (BP), in a subject, the method comprising determining the level of at least one, preferably at least two, more preferably at least three, most preferred at least four, AD-specific gene product(s) in a biological sample isolated from the subject, preferably peripheral blood monocytes, wherein the gene is selected from the group comprising ATF3, phosphodiesterase 4 B, CXCL2, BCL2-related protein A2, Dual specificity phosphatase 2, TNFα-induced protein 3/A20, BTEB1 CXCL3, Chemokine CCL-3 like, CCL-4, CCL20, CX2CR1, Amphiregulin, Thrombomodulin, Heparin-binding EGF-like growth factor, DNA-damaged inducible transcript, V28 chemokine-like receptor, TRAIL. MAPK6, B4BP4, PBEF1, Thrombospondin 1, MAFF, HSP70, CCL2, MCP-3, CCR2, CX3CR1, DOK1, HBB, G-gamma globin, THBD, PHLDA1, DTR and GNLY.

    摘要翻译： 本发明涉及医疗诊断领域。 更具体地，本发明涉及通过测定炎症性疾病的标志物来诊断或筛选受试者，优选人受试者中的炎性疾病或疾病，包括自身炎性疾病和情感障碍的方法。 提供了一种在受试者中诊断，筛选或预测情感障碍（AD），优选双相情感障碍（BP）的发展的方法，所述方法包括确定至少一个，优选至少两个更优选的水平 分离自受试者，优选外周血单核细胞的生物样品中至少三种，最优选至少四种AD特异性基因产物，其中该基因选自ATF3，磷酸二酯酶4B，CXCL2，BCL2 相关蛋白A2，双特异性磷酸酶2，TNFα诱导的蛋白3 / A20，BTEB1 CXCL3，趋化因子CCL-3，CCL-4，CCL20，CX2CR1，Amphiregulin，血栓调节蛋白，肝素结合EGF样生长因子， 损伤的诱导型转录物，V28趋化因子样受体，TRAIL。 MAPK6，B4BP4，PBEF1，血小板反应蛋白1，MAFF，HSP70，CCL2，MCP-3，CCR2，CX3CR1，DOK1，HBB，G-γ珠蛋白，THBD，PHLDA1，DTR和GNLY。

    Method for detecting low levels of a fusion protein
    55.
    发明申请
    Method for detecting low levels of a fusion protein 审中-公开
    检测融合蛋白低水平的方法

    公开(公告)号：US20060172345A1

    公开(公告)日：2006-08-03

    申请号：US11351879

    申请日：2006-02-10

    申请人： Frank Staal ,  Jacobus van Dongen

    发明人： Frank Staal ,  Jacobus van Dongen

    IPC分类号： G01N33/542 ,  G01N33/53

    CPC分类号： G01N33/57426 ,  G01N33/54306 ,  G01N33/57484

    摘要： The invention relates to the detection of, among others, tumor-specific fusion proteins. Provided is a method for detecting a fusion protein in a sample, the fusion protein comprising an amino-terminal fragment and a carboxy-terminal fragment that each correspond to a native protein. The method comprises contacting the sample with at least one binding molecule specifically reactive with a part of the native protein that is not present in the fusion protein, under conditions that allow for the formation of a complex between at least one binding molecule and the native protein, removing the complex from the sample to deplete the sample of the native protein but not of the fusion protein; and detecting the fusion protein in the sample using at least one antibody probe directed against the fusion protein. Also provided is a diagnostic kit for carrying out a method of the invention.

    摘要翻译： 本发明涉及特异性检测肿瘤特异性融合蛋白。 提供了一种用于检测样品中的融合蛋白的方法，所述融合蛋白包含氨基末端片段和羧基末端片段，其各自对应于天然蛋白质。 该方法包括在允许在至少一个结合分子和天然蛋白质之间形成复合物的条件下，将样品与至少一种特异性与天然蛋白质中不存在于融合蛋白中的部分特异性反应的结合分子接触 从样品中除去复合物以消耗天然蛋白质的样品而不是融合蛋白质的样品; 以及使用针对融合蛋白的至少一种抗体探针检测样品中的融合蛋白。 还提供了用于实施本发明的方法的诊断试剂盒。

    METHOD FOR DETERMINING GLOBAL BISULFITE CONVERSION EFFICIENCY
    60.
    发明申请
    METHOD FOR DETERMINING GLOBAL BISULFITE CONVERSION EFFICIENCY 有权

    公开(公告)号：US20220372574A1

    公开(公告)日：2022-11-24

    申请号：US17642104

    申请日：2020-09-11

    申请人： Erasmus University Medical Center Rotterdam

    发明人： Athina VIDAKI

    IPC分类号： C12Q1/6883

    摘要： The present invention relates to a method to determine bisulfite conversion of unmethylated cytosine to uracil in genomic DNA, comprising the steps of providing a first set of amplification primers for amplifying bisulfite converted copies of a repetitive DNA element by qPCR and a second set of amplification primers for amplifying unconverted copies of said repetitive DNA element by qPCR, performing a multiplex qPCR with said first and second set of amplification primers to generate amplicons, and determining the bisulfite conversion efficiency by comparing the amounts of said first and second amplicon.