公开(公告)号：US07858304B2

公开(公告)日：2010-12-28

申请号：US11450973

申请日：2006-06-09

申请人： Joffre B. Baker ,  Maureen T. Cronin ,  Michael C. Kiefer ,  Steve Shak ,  Michael Graham Walker

发明人： Joffre B. Baker ,  Maureen T. Cronin ,  Michael C. Kiefer ,  Steve Shak ,  Michael Graham Walker

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P19/34

CPC分类号： G01N33/57484 ,  C12N15/1003 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57415

摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.

公开(公告)号：US07695913B2

公开(公告)日：2010-04-13

申请号：US11653102

申请日：2007-01-11

申请人： Wayne Cowens ,  Joffre B. Baker ,  Kim Clark ,  James Hackett ,  Drew Watson ,  Soonmyung Paik

发明人： Wayne Cowens ,  Joffre B. Baker ,  Kim Clark ,  James Hackett ,  Drew Watson ,  Soonmyung Paik

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  G01N33/57419 ,  G01N33/57446

摘要： A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the subject.

摘要翻译： 一种预测患有结肠直肠癌的受试者的临床结果的方法，包括确定从受试者获得的癌细胞的生物样品中一种或多种预测性RNA转录物或其表达产物的表达的证据。

公开(公告)号：US07081340B2

公开(公告)日：2006-07-25

申请号：US10388360

申请日：2003-03-12

申请人： Joffre B. Baker ,  Maureen T. Cronin ,  Michael C. Kiefer ,  Steve Shak ,  Michael Graham Walker

发明人： Joffre B. Baker ,  Maureen T. Cronin ,  Michael C. Kiefer ,  Steve Shak ,  Michael Graham Walker

IPC分类号： C07H21/04 ,  C12Q1/68

CPC分类号： G01N33/57484 ,  C12N15/1003 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57415

摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.

公开(公告)号：US20190256923A1

公开(公告)日：2019-08-22

申请号：US16250179

申请日：2019-01-17

申请人： GENOMIC HEALTH, INC.

发明人： Joffre B. BAKER ,  Dominick SINICROPI ,  Robert J. PELHAM ,  Michael R. CRAGER ,  Francois COLLIN ,  James C. STEPHANS ,  Mei-Lan LIU ,  John D. MORLAN ,  Kunbin QU

IPC分类号： C12Q1/6886 ,  G16B20/00 ,  C12Q1/686 ,  G01N33/574

摘要： The present invention relates to biomarkers associated with breast cancer prognosis. These biomarkers include coding transcripts and their expression products, as well as non-coding transcripts, and are useful for predicting the likelihood of breast cancer recurrence in a breast cancer patient. The present invention also relates to a novel method of identifying intergenic sequences that correlate with a clinical outcome.

公开(公告)号：US20190095575A1

公开(公告)日：2019-03-28

申请号：US16199707

申请日：2018-11-26

申请人： Genomic Health, Inc.

发明人： Steven SHAK ,  George Andrew WATSON ,  Michael R. CRAGER ,  Tara MADDALA ,  Margarita LOPATIN ,  Audrey GODDARD ,  Dejan KNEZEVIC ,  Christer SVEDMAN

IPC分类号： G06F19/18 ,  G16H50/30 ,  G06F19/00 ,  C12Q1/6886

摘要： The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the quantitative score and the gene subsets may be weighted according to their contribution to cancer recurrence.

公开(公告)号：US10181008B2

公开(公告)日：2019-01-15

申请号：US14779428

申请日：2014-05-29

申请人： Genomic Health, Inc.

发明人： Steven Shak ,  George Andrew Watson ,  Michael R. Crager ,  Tara Maddala ,  Margarita Lopatin ,  Audrey Goddard ,  Dejan Knezevic ,  Christer Svedman

IPC分类号： G06F19/00 ,  G06F19/18 ,  C12Q1/6886 ,  G16H50/30

摘要： The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the quantitative score and the gene subsets may be weighted according to their contribution to cancer recurrence.

公开(公告)号：US20180230548A1

公开(公告)日：2018-08-16

申请号：US15897617

申请日：2018-02-15

申请人： Genomic Health, Inc.

发明人： Melody A. Cobleigh ,  Steven Shak ,  Joffre B. Baker ,  Maureen T. Cronin

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.

公开(公告)号：US20180208968A1

公开(公告)日：2018-07-26

申请号：US15866840

申请日：2018-01-10

申请人： Genomic Health, Inc.

发明人： Dominick Sinicropi ,  John Morlan

IPC分类号： C12Q1/6806 ,  C12Q1/6848 ,  C12N15/10

CPC分类号： C12Q1/6806 ,  C12N15/1003 ,  C12Q1/6848 ,  C12Q2521/325

摘要： The invention relates to methods of depleting RNA from a nucleic acid sample. The RNA may be any RNA, including, but not limited to, rRNA, tRNA, and mRNA. The method is useful for depleting RNA from a nucleic acid sample obtained from a fixed paraffin-embedded tissue (FPET) sample. The method may also be used to prepare cDNA, in particular, a cDNA library for further analysis or manipulation.

公开(公告)号：US20180051348A1

公开(公告)日：2018-02-22

申请号：US15674817

申请日：2017-08-11

申请人： Genomic Health, Inc. ,  NSABP Foundation, Inc.

发明人： Joffre B. BAKER ,  John L. BRYANT ,  Soonmyung PAIK ,  Steven SHAK

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of cancer, in particular of breast cancer.

公开(公告)号：US09605318B2

公开(公告)日：2017-03-28

申请号：US12941877

申请日：2010-11-08

申请人： Joffre B. Baker ,  Steven Shak ,  Luca Gianni

发明人： Joffre B. Baker ,  Steven Shak ,  Luca Gianni

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  Y10S435/96

摘要： The present invention provides sets of genes the expression of which is important in the prognosis of cancer. In particular, the invention provides gene expression information useful for predicting whether cancer patients are likely to have a beneficial treatment response to chemotherapy FHIT; MTA1; ErbB4; FUS; BBC3; IGF1R; CD9; TP53BP1; MUC1; IGFBP5; rhoC; RALBP1; STAT3; ERK1; SGCB; DHPS; MGMT; CRIP2; ErbB3; RAP1GDS1; CCND1; PRKCD; Hepsin; AK055699; ZNF38; SEMA3F; COL1A1; BAG1; AKT1; COL1A2; Wnt.5a; PTPD1; RAB6C; GSTM1, BCL2, ESR1; or the corresponding expression product, is determined, said report includes a prediction that said subject has a decreased likelihood of response to chemotherapy.