公开(公告)号：US5716454A

公开(公告)日：1998-02-10

申请号：US631602

申请日：1996-04-19

申请人： James Michael Carr

发明人： James Michael Carr

IPC分类号： A61B19/00 ,  B08B3/04 ,  B08B3/12 ,  B08B3/08

CPC分类号： B08B3/04 ,  A61B90/70 ,  B08B3/12

摘要： Used or partially used devices or instruments which have been in contact with animal tissue are decontaminated and made available for reuse by a three step process effective for removal of protein tissue, bone tissue, and lipids.

摘要翻译： 已经与动物组织接触的已使用或部分使用的装置或仪器被净化并可通过有效去除蛋白质组织，骨组织和脂质的三步法重新使用。

公开(公告)号：US5549626A

公开(公告)日：1996-08-27

申请号：US362835

申请日：1994-12-23

申请人： Theodore T. Miller ,  Bernard Ghelman

发明人： Theodore T. Miller ,  Bernard Ghelman

IPC分类号： A61B17/50 ,  A61F2/00 ,  A61F2/01 ,  A61M29/00

CPC分类号： A61F2/01 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

摘要： A co-axial filtering device for removing particles from arteries and veins comprises an outer catheter that can be inserted into a blood vessel and an inner catheter with a filter at its distal end. The filter is a radially expandable receptacle made of an elastic mesh structure of spring wires or plastic monofilaments. The filter expands into engagement with the walls of the blood vessel when it is pushed from the distal end of the outer catheter. A syringe is attached to the proximal end of the inner catheter and particles entrapped within the filter are aspirated through the inner catheter into the syringe. When filtering is no longer necessary, the filter can easily be removed by pulling the elastic material through the outer catheter.

摘要翻译： 用于从动脉和静脉除去颗粒的同轴过滤装置包括可以在其远端插入血管的外导管和具有过滤器的内导管。 过滤器是由弹簧丝或塑料单丝的弹性网状结构制成的可径向扩张的容器。 当从外导管的远端被推压时，过滤器膨胀成与血管的壁接合。 将注射器连接到内导管的近端，并且将捕获在过滤器内的颗粒通过内导管吸入注射器。 当不再需要过滤时，可以通过将弹性材料拉过外导管来容易地去除过滤器。

公开(公告)号：US5480895A

公开(公告)日：1996-01-02

申请号：US766751

申请日：1991-09-27

申请人： Steven M. Friedman ,  Mary K. Crow ,  David Posnett

发明人： Steven M. Friedman ,  Mary K. Crow ,  David Posnett

IPC分类号： G01N33/53 ,  A61K39/395 ,  A61P37/00 ,  C07K14/195 ,  C07K14/41 ,  C07K14/705 ,  C07K14/715 ,  C07K14/725 ,  C07K16/00 ,  C07K16/10 ,  C07K16/12 ,  C07K16/28 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577

CPC分类号： C07K16/2809 ,  C07K14/7051

摘要： This invention relates to a method of obtaining antibodies specific to a population of T-lymphocytes (T cells) restricted by V.beta. gene usage. The invention also relates to the antibodies obtained and to methods of using them. According to the invention, T cells are incubated with an effective amount of a superantigen under conditions and for a time sufficient to allow division and growth of T-cells reactive to the superantigen. The incubated T-cells are injected into a mammal, and thereafter serum containing antibodies specific to the incubated and injected T-cells is removed from the mammal.

摘要翻译： 本发明涉及获得由Vβ基因使用限制的T淋巴细胞群体（T细胞）特异性抗体的方法。 本发明还涉及获得的抗体及其使用方法。 根据本发明，在足以允许与超抗原反应的T细胞分裂和生长的条件下，将T细胞与有效量的超抗原一起温育。 将孵育的T细胞注射到哺乳动物中，然后从哺乳动物中除去含有对培养和注射的T细胞特异的抗体的血清。

公开(公告)号：US11992517B2

公开(公告)日：2024-05-28

申请号：US16368042

申请日：2019-03-28

申请人： NEW YORK SOCIETY FOR THE RUPTURED AND CRIPPLED MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY

发明人： Matthew E. Cunningham ,  Agata Krzyzanowska

IPC分类号： C12N5/077 ,  A61K9/00 ,  A61K31/195 ,  A61K31/675 ,  A61K31/7076 ,  A61K31/7088 ,  A61K31/713 ,  A61K35/32 ,  A61K38/19 ,  A61K38/20 ,  A61K38/46 ,  A61K39/00 ,  A61K45/06 ,  A61K48/00 ,  A61L27/36 ,  A61L27/38 ,  A61L27/54 ,  A61L27/58 ,  A61P19/02 ,  C07K14/47 ,  C12N5/10 ,  C12N15/11 ,  C12N15/113 ,  C12N15/55 ,  C12N15/86

CPC分类号： A61K38/465 ,  A61K9/0019 ,  A61K9/0085 ,  A61K31/195 ,  A61K31/675 ,  A61K31/7076 ,  A61K31/7088 ,  A61K31/713 ,  A61K35/32 ,  A61K38/191 ,  A61K38/2006 ,  A61K39/00 ,  A61K45/06 ,  A61K48/00 ,  A61L27/3658 ,  A61L27/3687 ,  A61L27/3821 ,  A61L27/3856 ,  A61L27/3895 ,  A61L27/54 ,  A61L27/58 ,  C07K14/4702 ,  C12N5/0655 ,  C12N15/1138 ,  C12N15/86 ,  A61L2300/412 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2430/38 ,  C12N2310/122 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/31 ,  C12N2320/32 ,  C12N2501/2301 ,  C12N2501/73 ,  C12N2740/16043 ,  C12Y301/03001 ,  A61K31/195 ,  A61K2300/00 ,  A61K31/675 ,  A61K2300/00 ,  A61K31/7076 ,  A61K2300/00

摘要： This invention relates to compositions and methods for activating and promoting mineralization in tissue that does not normally mineralize, specifically intervertebral discs. The composition comprises agents that increase the expression of the gene that encodes TNAP and/or the activation, amount or activity of TNAP protein, and agents that decrease the expression of ANK and/or ENPP and/or the activation, amount or activity of these proteins. The composition can be in the form of a cell or cells. The invention also relates to methods of using the composition.

公开(公告)号：US11969265B2

公开(公告)日：2024-04-30

申请号：US16975910

申请日：2019-03-04

申请人： THE MEDICAL COLLEGE OF WISCONSIN, INC. ,  New York Society for the Relief of the Ruptured and Crippled, Maintaining the Hospital for Special Surgery

发明人： Kevin M. Koch ,  Andrew S. Nencka ,  Robin A. Karr ,  Bradley J. Swearingen ,  Hollis Potter ,  Matthew F. Koff

IPC分类号： A61B5/00 ,  A61B5/055 ,  G06F18/213 ,  G06F18/24 ,  G06N3/045 ,  G06N3/088 ,  G06T7/00 ,  G06T7/11 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  G16H50/30 ,  G16H50/50 ,  G16H50/70

CPC分类号： A61B5/7267 ,  A61B5/055 ,  A61B5/4504 ,  A61B5/4851 ,  G06F18/213 ,  G06F18/24 ,  G06N3/045 ,  G06N3/088 ,  G06T7/0012 ,  G06T7/11 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  G16H50/30 ,  G16H50/50 ,  G16H50/70 ,  A61B2576/02 ,  G06T2207/10088 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30008

摘要： Systems and methods for training and implementing a machine learning algorithm to generate feature maps depicting spatial patterns of features associated with osteolysis, synovitis, or both. MRI data, including multispectral imaging data, are input to the trained machine learning algorithm to generate the feature maps, which may indicate features such as a location and probability of a pathology classification, a severity of synovitis, a type of synovitis, a synovial membrane thickness, and other features associated with osteolysis or synovitis. In some implementations, synovial anatomy are segmented in the MRI data before inputting the MRI data to the machine learning algorithm. These segmented MRI data may be generated using another trained machine learning algorithm.

公开(公告)号：USD980976S1

公开(公告)日：2023-03-14

申请号：US29788317

申请日：2021-04-30

申请人： New York Society for the Relief of the Ruptured and Crippled, maintaining the Hospital for Special Surgery

设计人： Sohrab Virk ,  Harvinder Sandhu ,  Sheeraz Qureshi

公开(公告)号：US11083535B2

公开(公告)日：2021-08-10

申请号：US16023460

申请日：2018-06-29

申请人： Hospital for Special Surgery

发明人： Suzanne Maher ,  Scott Rodeo ,  Russell Warren ,  Hongsheng Wang ,  Mario Lustri

IPC分类号： A61B90/00 ,  A61F2/46 ,  A61B5/00 ,  A61B90/60 ,  A61B17/00 ,  A61F2/38

摘要： A method for intraoperatively measuring joint contact mechanics of a patient's joint is provided. The method includes inserting a sensor between first and second bones of a joint. Then a predetermined force is applied to one of the first and second bones. Afterwards, contact mechanics such as, contact stresses, contact areas and/or forces are measured between the first and second bones in response to the applied predetermined force.

公开(公告)号：US20210038766A1

公开(公告)日：2021-02-11

申请号：US16757191

申请日：2018-10-19

申请人： NEW YORK SOCIETY FOR THE RUPTURED AND CRIPPLED MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY

发明人： Tony Chen ,  Suzanne A. Maher ,  Russell Warren

IPC分类号： A61L27/36 ,  A61L27/22 ,  A61L27/24 ,  C08L5/08 ,  A61L27/16 ,  C08L29/04

摘要： An improved method of making, manufacturing and/or producing engineered orthopedic soft tissue including cartilage, meniscus, annulus fibrosus, and tendon/ligaments which results in engineered soft tissue in which the fibers are aligned the same or nearly the same as naturally occurring tissue. The present invention also includes molds and other apparatus for carrying out the methods of the invention and kits.

公开(公告)号：US10789858B2

公开(公告)日：2020-09-29

申请号：US16266594

申请日：2019-02-04

申请人： Hospital for Special Surgery

发明人： Carl Imhauser ,  Kevin Schafer

IPC分类号： G09B23/30

摘要： The present invention provides a method for creating a computer model of a patient specific joint for treatment planning. The method includes identifying a ligament of a joint of a patient under a load at a predefined position of the joint. The method further includes constructing, with the use of a computer, a computer model of the joint of the patient having: a first bone model, a second bone model, and a ligament model connecting the first and second bone models corresponding to the identified ligament, wherein the ligament model is constructed as at least one fiber based on a predefined slack length.

公开(公告)号：US10583057B2

公开(公告)日：2020-03-10

申请号：US15667274

申请日：2017-08-02

申请人： NEW YORK SOCIETY FOR THE RUPTURED AND CRIPPLED MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY

发明人： Tazeem Bux

IPC分类号： A61G7/00 ,  A61G7/10 ,  A61G7/05

摘要： A system for controllably turning over a patient in a bed includes a flexible body sling and a ratchet device. The flexible body sling includes a main torso portion that terminates in a first end and an opposing second end and is configured for placement under the patient between a head and a tailbone of the patient. The flexible sling has a first sling strap that is coupled to the first end and a second sling strap that is coupled to the second end. The ratchet device has a mount that includes a curved portion for placement over a side rail of the bed to detachably secure the ratchet device to the bed. The ratchet device has a rotatable spool with a slot for receiving one of the first sling strap and the second sling strap. The ratchet device has a pivotable handle for driving the rotatable spool.