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公开(公告)号：US20220144781A1
公开(公告)日：2022-05-12
申请号：US17517569
申请日：2021-11-02
发明人： Joel S. FREUNDLICH , David ALLAND , Matthew B. NEIDITCH , Pradeep KUMAR , Glenn CAPODAGLI , Divya AWASTHI , Sean EKINS
IPC分类号： C07D231/56 , A61P31/06 , A61K31/4409
摘要： The invention provides compounds of formula I: and salts thereof wherein R1-R5 have any of the meanings described in the specification. The compounds are useful for treating bacterial infections (e.g. tuberculosis).
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公开(公告)号：US11291984B2
公开(公告)日：2022-04-05
申请号：US17209816
申请日：2021-03-23
发明人： Alan S. Goldman , Santanu Malakar , Xiaoguang Zhou , Kun Wang , David O. Marler
摘要： Provided herein are transition metal complexes that are useful in the acceptorless dehydrogenation of various substrates, including alkanes. Also provided are methods of dehydrogenating substrates to provide unsaturated products such as olefins.
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公开(公告)号：US11291612B2
公开(公告)日：2022-04-05
申请号：US16790202
申请日：2020-02-13
IPC分类号： A61K6/71 , A61K6/17 , A61K6/831 , A61K6/853 , A61K6/829 , A61K6/84 , A61K6/849 , A61K6/851 , A61C8/00
摘要： A biomimetic composite material includes a bioactive cement material, an autologous dentin matrix, and an inorganic nano-reinforcement material. A dental implant includes a body including a biomimetic composite material, wherein the biomimetic composite material includes a bioactive cement material, an autologous dentin matrix, and an inorganic nano-reinforcement material.
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公开(公告)号：US20220097259A1
公开(公告)日：2022-03-31
申请号：US17418100
申请日：2020-01-07
发明人： Thomas J. Nosker , Arya S. Tewatia
摘要： A multi-port single screw extruder combining a heated plastication barrel having a first entrance port and an exit port on opposing ends of the barrel and a second entrance port intermediately positioned therebetween; a first hopper positioned to deliver ingredients to the first entrance port of said barrel; a second hopper positioned to deliver ingredients to the second entrance port and a helical plastication screw rotatably carried within the barrel and running the length thereof between the first entrance port and exit port that is operable to rotate and transmit the ingredients along the length of the barrel; wherein the plastication screw includes a distributive mixing element located between at least one additional entrance port and the exit port, the minor diameter of the plastication screw is reduced in advance of each additional entrance port sufficient to reduce the barrel pressure at each entrance port to a level that permits the addition of ingredients to the barrel through the entrance port, and the ingredients include a thermoplastic polymer.
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公开(公告)号：US11279936B2
公开(公告)日：2022-03-22
申请号：US16637459
申请日：2018-08-01
发明人： David S. Perlin , Gregory R. Weidman , Yanan Zhao
IPC分类号： C12N15/115 , G01N33/53
摘要： Aptamers having a G-quadruplex structure that bind specifically to the most commonly used azole-class antifungal drugs, biosensors that comprise those aptamers, and invitro methods for determining the level of one of those drugs utilizing those aptamers or biosensors.
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公开(公告)号：US11273203B2
公开(公告)日：2022-03-15
申请号：US16751961
申请日：2020-01-24
摘要： Methods and kits for mitigating a toxic effect of at least one of vesicants and caustic gases in a subject in need thereof are described. In particular, an effective amount of a thrombopoietin (TPO) mimetic, such as RWJ-800088 or romiplostim, is used to mitigate the toxic effect of the vesicant or caustic gas.
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公开(公告)号：US20220064715A1
公开(公告)日：2022-03-03
申请号：US17527576
申请日：2021-11-16
IPC分类号： C12Q1/689 , C12Q1/686 , C12Q1/6865 , G01N33/50
摘要： The present invention relates to novel primers and sloppy molecular beacon and molecular beacon probes for amplifying segments from different genes in Mycobacterium tuberculosis for identifying the presence of M.tb DNA and/or resistance to anti-tuberculosis drugs.
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公开(公告)号：US11248217B2
公开(公告)日：2022-02-15
申请号：US16545786
申请日：2019-08-20
摘要： The present invention relates to engineered carbohydrate-active enzyme constructs that are useful for glycan polymers synthesis. The construct comprises a CD domain from a GH, wherein the domain is conjugated to CBM3a via a peptidic linker. The invention also relates to a method of improving glycan polymer synthesis by using engineered carbohydrate active enzymes comprising a CD domain and CBM3a.
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公开(公告)号：US11236153B2
公开(公告)日：2022-02-01
申请号：US16335891
申请日：2017-09-22
IPC分类号： A61K39/00 , A61K39/21 , C12N7/00 , A61K39/12 , C12N15/00 , C07K16/10 , C12N15/10 , C12Q1/686
摘要： The present disclosure relates to constructs useful in expressing biotinylated monomers and tetramers produced from these monomers. Specifically, the disclosure provides a construct useful in expressing biotinylated antigen monomers, said construct comprising a viral protein of an ectodomain of Hepatitis C Virus (HCV) envelope glycoprotein E2 or Human Immunodeficiency Virus (HIV) gp140. Further disclosed are methods for production and use of these tetramers in identifying and isolating antigen specific B cells and cloning antibodies thereto.
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公开(公告)号：US11220673B2
公开(公告)日：2022-01-11
申请号：US16847360
申请日：2020-04-13
申请人： Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. , Rutgers, the State University of New Jersey , Xiamen University
发明人： Hua Zhu , Yimin Li , Ningshao Xia , Tong Cheng , Xiangzhong Ye
摘要： Provided are an ORF7 deficient varicella virus, an vaccine comprising the virus and use thereof, as well as a method for the production the virus.
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