公开(公告)号：US10385409B2

公开(公告)日：2019-08-20

申请号：US15600882

申请日：2017-05-22

申请人： Rutgers, The State University of New Jersey

发明人： David S. Perlin ,  Steven Park ,  David W. Denning

IPC分类号： C12Q1/6895 ,  C07H21/02

摘要： Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.

公开(公告)号：US20240158875A1

公开(公告)日：2024-05-16

申请号：US18422247

申请日：2024-01-25

申请人： Rutgers, The State University of New Jersey

发明人： Steven Park ,  David S. Perlin

IPC分类号： C12Q1/6895

CPC分类号： C12Q1/6895 ,  C12Q2600/16 ,  C12Q2600/166

摘要： Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.

公开(公告)号：US20240158874A1

公开(公告)日：2024-05-16

申请号：US18421579

申请日：2024-01-24

申请人： Rutgers, The State University of New Jersey

发明人： Steven Park ,  David S. Perlin ,  David W. Denning

IPC分类号： C12Q1/6895

CPC分类号： C12Q1/6895 ,  C12Q2600/16 ,  C12Q2600/166

摘要： Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.

公开(公告)号：US09657334B2

公开(公告)日：2017-05-23

申请号：US14305499

申请日：2014-06-16

申请人： Rutgers, The State University of New Jersey ,  Merck & Co., Inc.

发明人： David S. Perlin ,  Steven Park ,  Cameron M. Douglas ,  Jennifer N. Kahn ,  Stephen A. Parent ,  Rosemarie Kelly

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6827 ,  C12Q1/6844 ,  C12Q1/6876 ,  C12Q1/6895 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2535/131 ,  C12Q2531/113

摘要： Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.

公开(公告)号：US11279936B2

公开(公告)日：2022-03-22

申请号：US16637459

申请日：2018-08-01

申请人： Rutgers, The State University of New Jersey

发明人： David S. Perlin ,  Gregory R. Weidman ,  Yanan Zhao

IPC分类号： C12N15/115 ,  G01N33/53

摘要： Aptamers having a G-quadruplex structure that bind specifically to the most commonly used azole-class antifungal drugs, biosensors that comprise those aptamers, and invitro methods for determining the level of one of those drugs utilizing those aptamers or biosensors.

公开(公告)号：US20170356034A1

公开(公告)日：2017-12-14

申请号：US15601450

申请日：2017-05-22

申请人： Rutgers, The State University of New Jersey ,  Merck & Co., Inc.

发明人： David S. Perlin ,  Steven Park ,  Cameron M. Douglas ,  Jennifer N. Kahn ,  Stephen A. Parent ,  Rosemarie Kelly

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6827 ,  C12Q1/6844 ,  C12Q1/6876 ,  C12Q1/6895 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2535/131 ,  C12Q2531/113

摘要： Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.

公开(公告)号：US09700638B2

公开(公告)日：2017-07-11

申请号：US14889215

申请日：2014-05-08

申请人： Rutgers, The State University of New Jersey ,  New Jersey Institute of Technology

发明人： Arkady Mustaev ,  David S. Perlin ,  Laura Wirpsza

IPC分类号： A61K49/00 ,  C07D219/08 ,  C07D401/12 ,  C07K7/64 ,  C07D405/14 ,  C07D498/06

CPC分类号： A61K49/0052 ,  A61K49/0026 ,  C07D219/08 ,  C07D401/12 ,  C07D405/14 ,  C07D498/06 ,  C07K7/64

摘要： The present invention provides compounds useful as novel near-infrared labels, compositions containing these compounds, and methods of using the near-infrared labels to identify targets in vitro, in situ and in vivo. The invention also provides small or large molecule conjugates between targeting agents and NIR labels, as well as methods and kits thereof, that can be used in diagnostics and treatment of diseases related to microbes in mammalian animals.

公开(公告)号：US20150125856A1

公开(公告)日：2015-05-07

申请号：US14305499

申请日：2014-06-16

申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  Merck & Co., Inc.

发明人： David S. Perlin ,  Steven Park ,  Cameron M. Douglas ,  Jennifer N. Kahn ,  Stephen A. Parent ,  Rosemarie Kelly

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6827 ,  C12Q1/6844 ,  C12Q1/6876 ,  C12Q1/6895 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2535/131 ,  C12Q2531/113

摘要： Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.

摘要翻译： 核酸扩增测定用于两个短切片真菌基因FKS1的突变。 已经显示这些靶序列中的突变与对棘白菌素类药物的抗性相关。 测定可以包括通过测序或通过标记的杂交探针进行检测。 另外，用于进行这种测定的引物，探针和试剂盒。

公开(公告)号：US20220136072A1

公开(公告)日：2022-05-05

申请号：US17647610

申请日：2022-01-11

申请人： Rutgers, The State University of New Jersey

发明人： David S. Perlin ,  Steven Park ,  David W. Denning

IPC分类号： C12Q1/6895

摘要： Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.

公开(公告)号：US10934577B2

公开(公告)日：2021-03-02

申请号：US15601450

申请日：2017-05-22

申请人： Rutgers, The State University of New Jersey ,  Merck & Co., Inc.

发明人： David S. Perlin ,  Steven Park ,  Cameron M. Douglas ,  Jennifer N. Kahn ,  Stephen A. Parent ,  Rosemarie Kelly

IPC分类号： C12Q1/68 ,  C12Q1/6827 ,  C12Q1/6895 ,  C12Q1/6876 ,  C12Q1/6844

摘要： Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.