公开(公告)号：US08224632B2

公开(公告)日：2012-07-17

申请号：US12904994

申请日：2010-10-14

Applicant: Robert G. Whirley ,  Michael V. Chobotov

Inventor： Robert G. Whirley ,  Michael V. Chobotov

IPC: G06F17/50

CPC classification number: G06F17/50 ,  A61F2/82 ,  G06G7/48 ,  G09B23/28

Abstract: A system and method of developing better-designed medical devices, particularly cardiovascular stents and endovascular grafts. The system comprises a geometry generator, a mesh generator, a stress/strain/deformation analyzer, and a visualization tool. In one embodiment, the geometry generator receives three-dimensional volumetric data of an anatomical feature and generates a geometric model. The mesh generator then receives such geometric model of an anatomical feature or an in vitro model and a geometric model of a candidate medical device. In another embodiment, the mesh generator only receives a geometric model of the candidate medical device. Using the geometric model(s) received, the mesh generator creates or generates a mesh or a finite element model. The stress/strain/deformation analyzer then receives the mesh, and the material models and loads of that mesh. Using analysis, preferably non-linear analysis, the stress/strain/deformation analyzer determines the predicted stresses, strains, and deformations on the candidate medical device. Such stresses, strains, and deformations may optionally be simulated visually using a visualization tool.

Abstract translation: 开发更好设计的医疗设备，特别是心血管支架和血管内移植物的系统和方法。 该系统包括几何生成器，网格发生器，应力/应变/变形分析器和可视化工具。 在一个实施例中，几何生成器接收解剖特征的三维体积数据并生成几何模型。 然后，网格生成器接收解剖特征或候选医疗装置的体外模型和几何模型的几何模型。 在另一个实施例中，网格生成器仅接收候选医疗设备的几何模型。 使用接收的几何模型，网格生成器创建或生成网格或有限元模型。 应力/应变/变形分析仪接收网格，以及该网格的材料模型和载荷。 使用分析，优选非线性分析，应力/应变/变形分析仪确定候选医疗设备上预测的应力，应变和变形。 可以使用可视化工具任意地模拟这种应力，应变和变形。

公开(公告)号：US08167927B2

公开(公告)日：2012-05-01

申请号：US13245661

申请日：2011-09-26

Applicant: Michael V. Chobotov

Inventor： Michael V. Chobotov

IPC: A61F2/06

CPC classification number: A61F2/07 ,  A61F2/82 ,  A61F2/844 ,  A61F2/89 ,  A61F2/915 ,  A61F2/954 ,  A61F2/958 ,  A61F2/962 ,  A61F2002/065 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2002/825 ,  A61F2002/8486 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91558 ,  A61F2002/91583 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2002/9517 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2250/0003 ,  A61F2250/0036 ,  A61M2025/0177

Abstract: The present application is directed to a stent, and more particularly to a radially self-expandable metallic stent, including a serpentine configuration having a plurality of struts and having a plurality of proximal and distal apices; and a barb integrally formed as an extension of each strut and extending outwardly from a position on each strut; where the barb has an elevation angle with respect to a longitudinal axis of a strut from which the barb extends of about 10 degrees to about 45 degrees.

Abstract translation: 本申请涉及支架，更具体地涉及径向自扩张金属支架，包括具有多个支柱并具有多个近端和远端顶点的蛇形结构; 以及整体形成为每个支柱的延伸部并从每个支柱上的位置向外延伸的倒钩; 其中倒钩相对于支撑件的纵向轴线具有大约10度至大约45度的延伸角的仰角。

公开(公告)号：US20110137404A1

公开(公告)日：2011-06-09

申请号：US12860364

申请日：2010-08-20

Applicant: Robert G. Whirley ,  James M. Shapiro

Inventor： Robert G. Whirley ,  James M. Shapiro

IPC: A61F2/06 ,  A61F2/82

CPC classification number: A61F2/07 ,  A61F2/0095 ,  A61F2/06 ,  A61F2/89 ,  A61F2002/075 ,  A61F2250/0003 ,  A61F2250/0023 ,  A61F2250/0035 ,  A61F2250/0068 ,  A61L27/507 ,  A61L27/54 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/416 ,  A61L2300/42

Abstract: The present invention provides inflatable porous implants, such as grafts, stent-grafts, and bladders, as well as methods and kits for drug delivery. In particular, the grafts and stent-grafts of the present invention provide for the delivery of a therapeutic agent into a flow conduit in the body. The inflatable porous implants provide for direct delivery of larger, more precise dosages of drugs over longer administration periods into the body. Moreover, these inflatable porous implants are often flexible when inserted and have a low profile delivery configuration for easy placement. The implants of the present invention further provide a mechanical or structural function in addition to drug delivery in a single integrated structure.

Abstract translation: 本发明提供了可膨胀的多孔植入物，例如移植物，支架移植物和囊，以及用于药物递送的方法和试剂盒。 特别地，本发明的移植物和支架移植物提供将治疗剂递送到体内的流动导管中。 可膨胀的多孔植入物可在更长的施用期内直接递送更大，更精确的药物剂量进入体内。 此外，这些可膨胀的多孔植入物在插入时通常是柔性的，并且具有便于放置的低轮廓输送构型。 本发明的植入物除了在单个整体结构中的药物递送之外还提供机械或结构功能。

公开(公告)号：US20110125255A1

公开(公告)日：2011-05-26

申请号：US12910281

申请日：2010-10-22

Applicant: Joseph W. Humphrey ,  Jeffry B. Skiba

Inventor： Joseph W. Humphrey ,  Jeffry B. Skiba

IPC: A61F2/82 ,  B29C55/00 ,  C08F214/26

CPC classification number: A61F2/82 ,  A61L27/16 ,  A61L27/507 ,  A61L27/56 ,  B29C43/222 ,  B29C43/24 ,  B29C47/0004 ,  B29C47/0021 ,  B29C55/005 ,  B29K2027/18 ,  Y10T428/1352 ,  Y10T428/139 ,  Y10T428/1393 ,  Y10T428/24802 ,  C08L27/18

Abstract: Single, continuous PTFE layers having lateral zones of varied characteristics are described. Some of the lateral zone embodiments may include PTFE material having little or no nodal and fibril microstructure. Methods of manufacturing PTFE layers allow for controllable permeability and porosity of the layers, in addition to other characteristics. The characteristics may vary from one lateral zone of a PTFE layer to a second lateral zone of a PTFE layer. In some embodiments, the PTFE layers may act as a barrier layer in an endovascular graft or other medical device.

Abstract translation: 描述了具有不同特征的侧向区域的单个连续PTFE层。 一些横向区域实施例可以包括具有很少或没有节点和原纤维微结构的PTFE材料。 制造PTFE层的方法除了具有其它特征之外还允许层的可控的渗透性和孔隙率。 特性可以从PTFE层的一个横向区域到PTFE层的第二横向区域变化。 在一些实施例中，PTFE层可以用作血管内移植物或其它医疗装置中的阻挡层。

公开(公告)号：US20100331958A1

公开(公告)日：2010-12-30

申请号：US12747499

申请日：2008-12-19

Applicant: Michael V. Chobotov

Inventor： Michael V. Chobotov

IPC: A61F2/82

CPC classification number: A61F2/07 ,  A61F2/89 ,  A61F2002/067 ,  A61F2002/826 ,  A61F2220/0091 ,  A61F2230/0034 ,  A61F2230/0054 ,  A61F2250/0003

Abstract: A hinged endovascular device including a first stent portion having a first proximal end and a first distal end and a second stent portion having a second proximal end and a second distal end. A hinge assembly couples the first distal end and the second proximal end to each other. A method of inserting the device into a body lumen is also disclosed.

Abstract translation: 铰链式血管内装置，其包括具有第一近端和第一远端的第一支架部分和具有第二近端和第二远端的第二支架部分。 铰链组件将第一远端和第二近端彼此连接。 还公开了将装置插入体腔的方法。

公开(公告)号：US20040138734A1

公开(公告)日：2004-07-15

申请号：US10686863

申请日：2003-10-16

Applicant: TriVascular, Inc.

Inventor： Michael V. Chobotov ,  Brian A. Glynn

IPC: A61F002/06

CPC classification number: A61F2/962 ,  A61F2/07 ,  A61F2/954 ,  A61F2002/065 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2002/9517 ,  A61F2250/0003

Abstract: A flexible low profile delivery system for delivery of an expandable intracorporeal device, specifically, an endovascular graft, which has at least one belt circumferentially disposed about the device in a constraining configuration. The belt is released by a release member, such as a release wire, by retracting the wire from looped ends of the belt. Multiple belts can be used and can be released sequentially so as to control the order of release and placement of the endovascular graft. An outer protective sheath may be disposed about the endovascular graft while in a constrained state which must first be retracted or otherwise removed prior to release of the graft from a constrained state. The delivery system can be configured for delivery over a guiding device such as a guidewire. The delivery system can also be configured for delivery of bifurcated intracorporeal devices.

Abstract translation: 用于递送可膨胀的体内器件，特别是血管内移植物的柔性低轮廓递送系统，其具有围绕所述装置围绕约束构型的至少一个带。 带通过诸如释放线的释放构件通过将线从带的环形端缩回而释放。 可以使用多个皮带并且可以顺序地释放，以便控制血管内移植物的释放和放置的顺序。 外部护套可以围绕血管内移植物设置，同时处于约束状态，在约束状态下必须首先将其缩回或以其它方式移除，在移植物从约束状态释放之前。 输送系统可以配置成通过引导装置（例如导丝）传送。 输送系统还可以配置用于输送分叉的体内器件。

公开(公告)号：US20030220681A1

公开(公告)日：2003-11-27

申请号：US10419312

申请日：2003-04-17

Applicant: TRIVASCULAR, INC.

Inventor： Michael V. Chobotov

IPC: A61F002/06

CPC classification number: A61F2/07 ,  A61F2/88 ,  A61F2/89 ,  A61F2/90 ,  A61F2/966 ,  A61F2002/9511 ,  A61F2002/9517 ,  A61F2230/0054

Abstract: A catheter for delivery of an expandable intracorporeal device and method of using the catheter. The catheter may have an elongate shaft with a proximal section, distal section, proximal end and distal end. The distal section has a radially expandable shear barrier which is at least partially radially constrained by an outer radially constraining section. An expandable intracorporeal device, specifically an expandable endovascular graft, is disposed within an inner space within the radially expandable shear barrier. The catheter is guided to a desired site within a patient's body and the radial constraint of the outer radially constraining section is at least partially removed from the radially expandable shear barrier so as to allow the shear barrier and expandable intracorporeal device to expand and deploy. Typically, the radial constraint of the outer radially constraining section is carried out by relative axial movement between the outer radially constraining section and the radially expandable shear barrier.

公开(公告)号：US20030004560A1

公开(公告)日：2003-01-02

申请号：US10122474

申请日：2002-04-11

Applicant: Trivascular, Inc.

Inventor： Michael V. Chobotov ,  Brian A. Glynn

IPC: A61F002/06

CPC classification number: A61F2/954 ,  A61F2/07 ,  A61F2/962 ,  A61F2002/065 ,  A61F2002/9511 ,  A61F2002/9517 ,  A61F2002/9665 ,  A61F2250/0003 ,  A61F2250/0098

Abstract: A flexible low profile delivery system for delivery of an expandable intracorporeal device, specifically, an endovascular graft, which has at least one belt circumferentially disposed about the device in a constraining configuration. The belt is released by a release member, such as a release wire, by retracting the wire from looped ends of the belt. Multiple belts can be used and can be released sequentially so as to control the order of release and placement of the endovascular graft. An outer protective sheath may be disposed about the endovascular graft while in a constrained state which must first be retracted or otherwise removed prior to release of the graft from a constrained state. The delivery system can be configured for delivery over a guiding device such as a guidewire. The delivery system can also be configured for delivery of bifurcated intracorporeal devices.

Abstract translation: 用于递送可膨胀的体内器件，特别是血管内移植物的柔性低轮廓递送系统，其具有围绕所述装置围绕约束构型的至少一个带。 带通过诸如释放线的释放构件通过将线从带的环形端缩回而释放。 可以使用多个皮带并且可以顺序地释放，以便控制血管内移植物的释放和放置的顺序。 外部护套可以围绕血管内移植物设置，同时处于约束状态，在约束状态下必须首先将其缩回或以其它方式移除，在移植物从约束状态释放之前。 输送系统可以配置成通过引导装置（例如导丝）传送。 输送系统还可以配置用于输送分叉的体内器件。

公开(公告)号：US20020151953A1

公开(公告)日：2002-10-17

申请号：US09917371

申请日：2001-07-27

Applicant: Trivascular, Inc.

Inventor： Michael V. Chobotov ,  Brian A. Glynn

IPC: A61F002/06

CPC classification number: A61F2/954 ,  A61F2/07 ,  A61F2/962 ,  A61F2002/065 ,  A61F2002/9511 ,  A61F2002/9517 ,  A61F2002/9665 ,  A61F2250/0003 ,  A61F2250/0098

Abstract: A flexible low profile delivery system for delivery of an expandable intracorporeal device, specifically, an endovascular graft, which has at least one belt circumferentially disposed about the device in a constraining configuration. The belt is released by a release member, such as a release wire, by retracting the wire from looped ends of the belt. Multiple belts can be used and can be released sequentially so as to control the order of release and placement of the endovascular graft. An outer protective sheath may be disposed about the endovascular graft while in a constrained state which must first be retracted or otherwise removed prior to release of the graft from a constrained state. The delivery system can be configured for delivery over a guiding device such as a guidewire. The delivery system can also be configured for delivery of bifurcated intracorporeal devices.

Abstract translation: 用于递送可膨胀的体内器件，特别是血管内移植物的柔性低轮廓递送系统，其具有围绕所述装置围绕约束构型的至少一个带。 带通过诸如释放线的释放构件通过将线从带的环形端缩回而释放。 可以使用多个皮带并且可以顺序地释放，以便控制血管内移植物的释放和放置的顺序。 外部护套可以围绕血管内移植物设置，同时处于约束状态，在约束状态下必须首先将其缩回或以其它方式移除，在移植物从约束状态释放之前。 输送系统可以配置成通过引导装置（例如导丝）传送。 输送系统还可以配置用于输送分叉的体内器件。

公开(公告)号：US20240325178A1

公开(公告)日：2024-10-03

申请号：US18738971

申请日：2024-06-10

Applicant: TriVascular, Inc.

Inventor： Jenine S. Vinluan ,  William P. Stephens ,  Mark Geusen ,  Carl H. Poppe ,  Christopher L. Staudenmayer ,  Michael V. Chobotov ,  James R. Watson ,  Teresa Woodson

IPC: A61F2/95 ,  A61F2/07 ,  A61F2/24 ,  A61F2/848 ,  A61F2/89 ,  A61F2/915 ,  A61F2/958 ,  A61L31/02

CPC classification number: A61F2/95 ,  A61F2/07 ,  A61F2/958 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2/243 ,  A61F2/848 ,  A61F2002/8483 ,  A61F2/89 ,  A61F2002/91591 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2250/0003 ,  A61F2250/0098 ,  A61L31/022

Abstract: Embodiments are directed in part to endovascular prostheses and methods of deploying same. Embodiments may be directed more specifically to stent grafts and methods of positioning and deploying such devices within the body of a patient.