公开(公告)号：US09975927B2

公开(公告)日：2018-05-22

申请号：US15110151

申请日：2015-01-09

申请人： Valneva Austria GmbH

发明人： Urban Lundberg ,  Wolfgang Schüler

IPC分类号： C07K14/20 ,  A61K39/02 ,  C07K16/12 ,  A61K39/39 ,  A61K39/00

CPC分类号： C07K14/20 ,  A61K39/0225 ,  A61K39/39 ,  A61K2039/55516 ,  A61K2039/70 ,  C07K16/1207 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2319/00 ,  C07K2319/21 ,  Y02A50/401

摘要： The present invention relates to compositions and methods for the prevention and treatment of Borrelia infection. Particularly, the present invention relates to a polypeptide comprising a hybrid C-terminal fragment of an outer surface protein A (OspA), a nucleic acid coding the same, an antibody specifically binding the same, a pharmaceutical composition (particularly for use as a medicament or in a method of treating or preventing a Borrelia infection) comprising the polypeptide and/or the nucleic acid and/or the antibody, a method of treating or preventing a Borrelia infection and a method of immunizing a subject.

公开(公告)号：US09932391B2

公开(公告)日：2018-04-03

申请号：US15334128

申请日：2016-10-25

申请人： The United States of America represented by the Department of Veterans Affairs ,  The Regents of the University of California ,  Cornell Research Foundation, Inc. ,  Fundação Oswaldo Cruz—FIOCRUZ

发明人： Albert I. Ko ,  Mitermayer Galvão Reis ,  Julio Henrique Rosa Croda ,  Isadora Cristina Siqueira ,  David A. Haake ,  James Matsunaga ,  Lee W. Riley ,  Michele Barocchi ,  Tracy Ann Young

IPC分类号： G01N33/53 ,  C07K16/12 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/20 ,  G01N33/569 ,  A61K39/00

CPC分类号： C07K16/1207 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/20 ,  C12Q1/68 ,  C12Q1/689 ,  G01N33/56911 ,  G01N2469/20 ,  Y02A50/56

摘要： The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.

公开(公告)号：US09655962B2

公开(公告)日：2017-05-23

申请号：US14211947

申请日：2014-03-14

申请人： Camas Incorporated

发明人： Bradley M. Mitteness ,  Connie Phillips

IPC分类号： A61K39/395 ,  A61K39/40 ,  A61K9/00 ,  C07K16/12 ,  C07K16/14 ,  A61K39/00

CPC分类号： A61K39/395 ,  A61K9/0012 ,  A61K9/0063 ,  A61K39/39575 ,  A61K39/40 ,  A61K2039/505 ,  C07K16/1203 ,  C07K16/1207 ,  C07K16/1242 ,  C07K16/1275 ,  C07K16/14 ,  C07K2317/11 ,  C07K2317/23

摘要： The present disclosure relates to methods and compositions administered to the lymphatic tissue of an animal to prevent or reduce the incidence of disease or disease symptoms caused by one or more disease causing entities. Tonsillar compositions can be administered to the lymphatic tissue in the oral/nasal region of the animal and can include avian antibodies from eggs of hens inoculated with one or more target disease causing entities. Treating the lymphatic tissue in the oral/nasal region with the compositions described herein can reduce or prevent the disease causing entities from adhering to the lymphatic tissue resulting in reduced infection rates. The present disclosure also relates to oral compositions that can be used to reduce or eliminate oral pathogens in animals.

公开(公告)号：US20170114106A1

公开(公告)日：2017-04-27

申请号：US15361162

申请日：2016-11-25

申请人： Christopher G. Earnhart ,  Richard T. Marconi

发明人： Christopher G. Earnhart ,  Richard T. Marconi

IPC分类号： C07K14/20 ,  C07K14/00

CPC分类号： C07K14/20 ,  A61K39/00 ,  A61K39/0225 ,  C07K14/001 ,  C07K16/1207 ,  C07K2319/00 ,  C07K2319/21 ,  G01N33/56911 ,  G01N2333/20 ,  G01N2469/20 ,  Y02A50/401 ,  Y02A50/57

摘要： Antigenic polypeptides comprising linear immunodominant epitopes of Borrelia outer surface protein A (OspA) or Borrelia outer surface protein C (OspC) are useful as vaccines against Lyme disease, and as diagnostics for detecting Borrelia infections. The OspA and OspC antigenic polypeptides typically comprise a plurality of peptides representing epitope containing regions from multiple distinct phyletic groups. The antigenic polypeptides may also include epitopes from both Borrelia OspA and Borrelia OspC.

公开(公告)号：US09505809B2

公开(公告)日：2016-11-29

申请号：US15134168

申请日：2016-04-20

申请人： The United States of America represented by the Department of Veterans Affairs ,  The Regents of the University of California ,  Cornell Research Foundation, Inc. ,  Fundação Oswaldo Cruz

发明人： Albert I. Ko ,  Mitermayer Galvão Reis ,  Julio Henrique Rosa Croda ,  Isadora Cristina Siqueira ,  David A. Haake ,  James Matsunaga ,  Lee W. Riley ,  Michele Barocchi ,  Tracy Ann Young

IPC分类号： C07H21/04 ,  C07K14/20

CPC分类号： C07K16/1207 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/20 ,  C12Q1/68 ,  C12Q1/689 ,  G01N33/56911 ,  G01N2469/20 ,  Y02A50/56

摘要： The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.

摘要翻译： 本发明涉及编码具有重复的细菌Ig样（Big）结构域的钩端螺菌属细菌中的蛋白质BigL1，BigL2和BigL3的三种分离的DNA分子，以及它们在诊断，治疗和疫苗应用中的应用。 根据本发明，编码BigL1，BigL2和BigL3蛋白的分离的分子用于诊断和预防能够在人和其他哺乳动物（包括具有兽医重要性的哺乳动物）中产生疾病的钩端螺旋体属物种的感染。

公开(公告)号：US20160222069A1

公开(公告)日：2016-08-04

申请号：US15134168

申请日：2016-04-20

申请人： U.S. Government represented by the Department of Veterans Affairs ,  The Regents of the University of California ,  Cornell Research Foundation, Inc. ,  Fundação Oswaldo Cruz - FIOCRUZ

发明人： Albert I. Ko ,  Mitermayer Galvão Reis ,  Julio Henrique Rosa Croda ,  Isadora Cristina Siqueira ,  David A. Haake ,  James Matsunaga ,  Lee W. Riley ,  Michele Barocchi ,  Tracy Ann Young

IPC分类号： C07K14/20

CPC分类号： C07K16/1207 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/20 ,  C12Q1/68 ,  C12Q1/689 ,  G01N33/56911 ,  G01N2469/20 ,  Y02A50/56

摘要： The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.

公开(公告)号：US09346858B2

公开(公告)日：2016-05-24

申请号：US14819045

申请日：2015-08-05

申请人： The United States of America as represented by the Department of Veterans Affairs ,  The Regents of the University of California ,  Cornell Research Foundation, Inc. ,  Fundação Oswaldo Cruz—FIOCRUZ

发明人： Albert I. Ko ,  Mitermayer Galvão Reis ,  Julio Henrique Rosa Croda ,  Isadora Cristina Siqueira ,  David A. Haake ,  James Matsunaga ,  Lee W. Riley ,  Michele Barocchi ,  Tracy Ann Young

IPC分类号： C07H21/04 ,  C07K14/20 ,  C12Q1/68

CPC分类号： C07K16/1207 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/20 ,  C12Q1/68 ,  C12Q1/689 ,  G01N33/56911 ,  G01N2469/20 ,  Y02A50/56

摘要： The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.

摘要翻译： 本发明涉及编码具有重复的细菌Ig样（Big）结构域的钩端螺菌属细菌中的蛋白质BigL1，BigL2和BigL3的三种分离的DNA分子，以及它们在诊断，治疗和疫苗应用中的应用。 根据本发明，编码BigL1，BigL2和BigL3蛋白的分离的分子用于诊断和预防能够在人和其他哺乳动物（包括具有兽医重要性的哺乳动物）中产生疾病的钩端螺旋体属物种的感染。

公开(公告)号：US20150329599A1

公开(公告)日：2015-11-19

申请号：US14819045

申请日：2015-08-05

申请人： The United States Government represented by the Department of Veterans Affairs ,  The Regents of the University of California ,  Cornell Research Foundation, Inc. ,  Fundação Oswaldo Cruz - FIOCRUZ

发明人： Albert I. Ko ,  Mitermayer Galvao Reis ,  Julio Henrique Rosa Croda ,  Isadora Cristina Siqueira ,  David A. Haake ,  James Matsunaga ,  Lee W. Riley ,  Michele Barocchi ,  Tracy Ann Young

IPC分类号： C07K14/20

CPC分类号： C07K16/1207 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/20 ,  C12Q1/68 ,  C12Q1/689 ,  G01N33/56911 ,  G01N2469/20 ,  Y02A50/56

摘要： The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.

摘要翻译： 本发明涉及编码具有重复的细菌Ig样（Big）结构域的钩端螺菌属细菌中的蛋白质BigL1，BigL2和BigL3的三种分离的DNA分子，以及它们在诊断，治疗和疫苗应用中的应用。 根据本发明，编码BigL1，BigL2和BigL3蛋白的分离的分子用于诊断和预防能够在人和其他哺乳动物（包括具有兽医重要性的哺乳动物）中产生疾病的钩端螺旋体属物种的感染。

公开(公告)号：US20140348867A1

公开(公告)日：2014-11-27

申请号：US14233414

申请日：2012-07-18

申请人： John Clare Samuel Harding ,  Janet Elizabeth Hill ,  Joseph Rubin ,  Manuel Chirino-Trejo

发明人： John Clare Samuel Harding ,  Janet Elizabeth Hill ,  Joseph Rubin ,  Manuel Chirino-Trejo

IPC分类号： C07K14/20 ,  C07K16/12 ,  C12N1/20

CPC分类号： C07K14/20 ,  A61K39/00 ,  C07K16/1207 ,  C12N1/20 ,  C12R1/01

摘要： The disclosure provides isolated—, compositions comprising—and methods of culturing —a Brachyspira sp. Sask30446 organism. The method comprises inoculating a liquid media or solid media with a sample comprising the Brachyspira sp. Sask30446 organism and incubating the liquid media or solid media at a temperature between 25-44° C. under anaerobic conditions. Also provided is isolated Brachyspira sp. Sask30446 organism, compositions comprising Brachyspira sp. Sask30446 organism and methods and uses thereof.

摘要翻译： 本公开提供了分离的组合物，以及培养方法 - Brachyspira sp。 Sask30446有机体。 该方法包括用包含Brachyspira sp。的样品接种液体培养基或固体培养基。 Sask30446生物体，并在无氧条件下在25-44℃的温度下孵育液体培养基或固体培养基。 还提供隔离的Brachyspira sp。 Sask30446生物，包含布氏螺旋体属的组合物 Sask30446生物及其方法和用途。

公开(公告)号：US20140248272A1

公开(公告)日：2014-09-04

申请号：US14196228

申请日：2014-03-04

申请人： Vicia Animal Health Science AB

发明人： Anna ROSANDER ,  Märit PRINGLE

IPC分类号： C07K14/20 ,  C07K16/12 ,  G01N33/569

CPC分类号： C07K14/20 ,  C07K16/1207 ,  G01N33/56911 ,  G01N2333/20 ,  G01N2469/20

摘要： The present invention relates to proteins and/or fragments and derivatives thereof and their use as vaccines and in biotechnological methods. The vaccines particularly include immunogenic proteins in Treponema spp. isolated from digital dermatitis in cattle. The present invention further relates to antibodies raised against said proteins or fragments thereof, and the use of said proteins in diagnostic methods in which antibodies are detected as a sign of digital dermatitis in cattle.

摘要翻译： 本发明涉及蛋白质和/或其片段及其衍生物及其作为疫苗和生物技术方法的用途。 疫苗特别包括梅毒螺旋体中的免疫原性蛋白质。 从牛的数字皮炎中分离出来 本发明还涉及针对所述蛋白质或其片段产生的抗体，以及在诊断方法中使用所述蛋白质，其中在牛中检测到抗体作为数字性皮炎的征兆。