公开(公告)号：US20040142474A1

公开(公告)日：2004-07-22

申请号：US10717109

申请日：2003-11-19

Applicant: Expression Genetics, Inc.

Inventor： Ram I. Mahato ,  Sang-Oh Han ,  Darin Y. Furgeson ,  Khursheed Anwer

IPC: C08G063/48 ,  C08G063/91 ,  C12N015/88

CPC classification number: C08G73/0206 ,  A61K9/1272 ,  A61K47/645 ,  A61K48/0041

Abstract: A biodegradable cationic lipopolymer comprising a polyethylenimine (PEI), a lipid, and a biocompatible hydrophilic polymer, wherein 1) the lipid and the biocompatible hydrophilic polymer are directly linked to the PEI backbone or 2) the lipid is linked to the PEI backbone through the biocompatible hydrophilic polymer. The cationic lipopolymers of the present invention can be used for delivery of a nucleic acid or any anionic bioactive agent to various organs and tissues after local or systemic administration.

Abstract translation: 包含聚乙烯亚胺（PEI），脂质和生物相容性亲水性聚合物的可生物降解的阳离子脂质聚合物，其中1）脂质和生物相容的亲水性聚合物直接连接到PEI主链或2）脂质通过 生物相容性亲水性聚合物。 本发明的阳离子脂质体聚合物可用于在局部或全身给药后将核酸或任何阴离子生物活性剂递送至各种器官和组织。

公开(公告)号：US20040136977A1

公开(公告)日：2004-07-15

申请号：US10478150

申请日：2003-11-19

Inventor： Keiichi Miyamoto

IPC: C12N009/64 ,  A61K038/48 ,  C08G063/48 ,  C08G063/91

CPC classification number: C08H1/06 ,  A61L27/227

Abstract: The invention relates to crosslinked elastin, a water-soluble crosslinking agent to be used for crosslinking, molded elastin articles, medical instruments and regeneration tissues using the crosslinked elastin, and a surgical therapy method and regeneration treatment wherein the medical instruments are employed. There is provided a biocompatible functional material having elasticity suitable for transplantation into the body without causing detachment of cell adhesion proteins.

Abstract translation: 本发明涉及使用交联弹性蛋白的交联弹性蛋白，用于交联的水溶性交联剂，模塑弹性蛋白制品，医疗仪器和再生组织，以及使用医疗器械的外科治疗方法和再生治疗。 提供了具有弹性的生物相容性功能材料，其适合于移植到体内而不引起细胞粘附蛋白的脱离。

公开(公告)号：US20040122169A1

公开(公告)日：2004-06-24

申请号：US10729409

申请日：2003-12-05

Inventor： Christopher Detrembleur ,  Claus Rudiger ,  Rolf-Volker Meyer

IPC: C08G063/48 ,  C08G063/91

CPC classification number: C08F4/00

Abstract: A process for the preparation of (co)oligomers or (co)polymers is disclosed. The process entails first the preparation of a mixture that contains a monoethylenically unsaturated monomer conforming to HR1CnullCR2R3nullnull(M) an oxidizing agent and at least one polymer or oligomer conforming to formula (I), 1 and an optional free radical initiator and then heating the mixture at a temperature in the range of 0null C. to 220null C.

Abstract translation: 公开了制备（共）低聚物或（共）聚合物的方法。 该方法首先需要制备含有符合HR 1 C = CR 2 R 3（M）的单烯属不饱和单体的混合物，氧化剂和至少一种符合式（I）的聚合物或低聚物， 和任选的自由基引发剂，然后在0℃至220℃的温度下加热该混合物。

公开(公告)号：US20040092449A1

公开(公告)日：2004-05-13

申请号：US10633966

申请日：2003-08-04

Inventor： Nnochiri Ekwuribe

IPC: A61K038/17 ,  C08G063/48 ,  C08G063/91

CPC classification number: A61K47/60

Abstract: Proteins and/or peptides, such as luminal cholecystokinin releasing factor (LCRF) are conjugated with amphiphilic oligomers and polymers. Such conjugates may modulate the pharmacokinetic profile of the proteins and/or peptides, thereby improving their clinical utility. Such conjugates may also stabilize and deliver the proteins and/or peptides, such as LCRF, to receptors in the gut without absorption into the bloodstream.

Abstract translation: 蛋白质和/或肽，例如管腔缩胆囊素释放因子（LCRF）与两亲寡聚物和聚合物缀合。 这样的缀合物可以调节蛋白质和/或肽的药代动力学特征，从而改善其临床效用。 这样的缀合物还可以将蛋白质和/或肽（例如LCRF）稳定并递送到肠道中的受体而不吸收到血流中。

公开(公告)号：US20040087024A1

公开(公告)日：2004-05-06

申请号：US10372723

申请日：2003-02-24

Applicant: Insert Therapeutics, Inc.

Inventor： Nathalie C. Bellocq ,  Jianjun Cheng ,  Mark E. Davis ,  Suzie Hwang Pun

IPC: A61K048/00 ,  C08G063/48 ,  C08G063/91 ,  C12N015/85 ,  A61K031/795

CPC classification number: B82Y5/00 ,  A61K9/0019 ,  A61K9/146 ,  A61K47/34 ,  A61K47/40 ,  A61K47/59 ,  A61K47/60 ,  A61K47/6951 ,  A61K48/0041 ,  C08B37/0012 ,  C08B37/0015 ,  C08G73/02 ,  C08G73/0213 ,  C08G73/0694 ,  C12N15/88

Abstract: This application discloses compositions of carbohydrate-modified polymers, such as polyethylenimine modified with cyclodextrin moieties, for carrying drugs and other active agents, such as nucleic acids. Compositions are also disclosed of carbohydrate-modified polymer carriers that release such agents under controlled conditions. The invention also discloses compositions of carbohydrate-modified polymer carriers that are coupled to biorecognition molecules for targeting the delivery of drugs to their site of action.

Abstract translation: 本申请公开了用于携带药物和其它活性剂如核酸的碳水化合物改性聚合物的组合物，例如用环糊精部分修饰的聚乙烯亚胺。 还公开了在受控条件下释放这些试剂的碳水化合物改性聚合物载体的组合物。 本发明还公开了与生物识别分子偶联的碳水化合物改性聚合物载体的组合物，用于将药物递送到其作用位点。

公开(公告)号：US20040086481A1

公开(公告)日：2004-05-06

申请号：US10240877

申请日：2003-04-09

Inventor： Martin Charles Garnett ,  Nicolas Andrew Jones ,  Benjamin James Rackstraw ,  Fabio Bignotti

IPC: A61K048/00 ,  C08G063/48 ,  C08G063/91

CPC classification number: A61K48/00

Abstract: A nucleic acid complex for delivering a nucleic acid or a derivative thereof to a cell comprises the components: A. a nucleic acid or a derivative thereof; B. a cationic polymer; and C. a preformed polyethylene glycol-cationic polymer copolymer. The complex has a conformation in which the nucleic acid or derivative thereof is condensed and wherein component C is bound to component A such that the poylethylene glycol groups of component C are located at the surface of the complex. The complexes which are stable to aggregation are useful for the delivery of nucleic acids or derivatives thereof to cells in biological systems.

Abstract translation: 用于将核酸或其衍生物递送至细胞的核酸复合物包含组分：A.核酸或其衍生物; B.阳离子聚合物; 和C.预成型的聚乙二醇 - 阳离子聚合物共聚物。 复合物具有其中核酸或其衍生物被缩合的构象，并且其中组分C与组分A结合，使得组分C的聚乙二醇基团位于络合物的表面。 对聚集稳定的配合物可用于将核酸或其衍生物递送至生物系统中的细胞。

公开(公告)号：US20040039116A1

公开(公告)日：2004-02-26

申请号：US10451072

申请日：2003-06-20

Inventor： Francoise Vinet ,  Antoine Hoang

IPC: C07H021/04 ,  C08G063/48 ,  C08G063/91 ,  C07K001/02

CPC classification number: C40B99/00 ,  C07B2200/11 ,  C07F7/18 ,  C07F7/1804 ,  C07H21/00 ,  C40B40/06

Abstract: The invention relates to a solid support comprising sites intended for the immobilization of oligonucleotide probes or of proteins or of biological cells having ligands, the sites being provided with chemical species bound to the support by a chemical binding function. The chemical species have a diol group connected to the support by an alkyl chain. Application to biochips.

Abstract translation: 本发明涉及一种固体支持物，其包含用于固定寡核苷酸探针或蛋白质或具有配体的生物细胞的位点，所述位点具有通过化学结合功能结合至载体的化学物质。 化学物质具有通过烷基链连接到载体上的二醇基团。 应用于生物芯片。

公开(公告)号：US20040039115A1

公开(公告)日：2004-02-26

申请号：US10415365

申请日：2003-04-28

Inventor： Yukio Ishida

IPC: C08G063/48

CPC classification number: C08L23/06 ,  C08F110/02 ,  C08L23/02 ,  C08L23/04 ,  C08L23/0815 ,  C08L2666/06 ,  C08L2666/04 ,  C08F2500/01 ,  C08F2500/17

Abstract: A polyethylene resin composition comprising 15 to 90% by weight of a polyethylene resin composition (A) and 85 to 10% by weight of a polyolefin resin composition (B), wherein the polyethylene resin composition (A) comprises ultra-high-molecular weight polyethylene (component (a-1)) having an intrinsic viscosity nullnullnull of 10 to 40 dl/g and low-molecular weight to high-molecular weight polyethylene (component (a-2)) having an intrinsic viscosity nullnullnull of 0.1 to 5 dl/g, the amount of said component (a-1) being more than 35% by weight and not more than 90% by weight, the amount of said component (a-2) being not less than 10% by weight and less than 65% by weight, each amount being based on the total amount of the component (a-1) and the component (a-2), and the polyethylene resin composition (A) has a density of 930 to 980 kg/m3 and an intrinsic viscosity nullnullnull of 5 to 35 dl/g. The polyethylene resin composition is excellent in at least the following properties (1) to (8): (1) mechanical properties (mechanical properties equal to or higher than those of conventional ultra-high-molecular weight polyethylene), (2) abrasion resistance (abrasion resistance remarkably improved or enhanced as compared with that of conventional ultra-high-molecular weight polyethylene), (3) appearance, (4) moldability, (5) self-lubricating properties, (6) chemical resistance, (7) impact resistance (impact strength), and (8) flexibility.

Abstract translation: 一种聚乙烯树脂组合物，其包含15至90重量％的聚乙烯树脂组合物（A）和85至10重量％的聚烯烃树脂组合物（B），其中所述聚乙烯树脂组合物（A）包含超高分子量 特性粘度η为10〜40dl / g的聚乙烯（成分（a-1）），低分子量至高分子量聚乙烯（成分（a-2））的特性粘度η为 所述组分（a-1）的量（a-1）大于35重量％且不大于90重量％，所述组分（a-2）的量不小于10重量％ 重量小于65重量％，各量基于组分（a-1）和组分（a-2）的总量，聚乙烯树脂组合物（A）的密度为930至980kg / m 3，特性粘度η为5〜35dl / g。 聚乙烯树脂组合物至少具有以下特性（1）〜（8）：（1）机械性能（机械性能等于或高于常规超高分子量聚乙烯），（2）耐磨性 （耐磨性与常规超高分子量聚乙烯相比显着提高或提高），（3）外观，（4）成型性，（5）自润滑性，（6）耐化学性，（7）冲击 电阻（冲击强度）和（8）灵活性。

公开(公告)号：US20040019000A1

公开(公告)日：2004-01-29

申请号：US10199585

申请日：2002-07-19

Inventor： Muthiah Manoharan ,  Andrei P. Guzaev ,  Martin A. Maier

IPC: A61K048/00 ,  C07H021/02 ,  C07H021/04 ,  C08G063/48 ,  C08G063/91

CPC classification number: C12N15/87 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C08G73/0233 ,  C08G73/028

Abstract: The present invention relates to novel polyethylenamine-conjugated oligomeric compounds and to methods of making such compounds. The invention further relates to methods of enhancing the cellular uptake of oligomeric compounds comprising conjugating the compounds to fusogenic moieties such as polyethylenimine.

Abstract translation: 本发明涉及新型聚乙烯胺 - 共轭寡聚化合物及其制备方法。 本发明还涉及增强寡聚化合物的细胞摄取的方法，包括将化合物缀合成融合部分如聚乙烯亚胺。

公开(公告)号：US20040013626A1

公开(公告)日：2004-01-22

申请号：US10276178

申请日：2003-06-04

Inventor： Ruxandra Gref ,  Gilles Ponchel ,  Dominique Duchene ,  Patrick Couvreur

IPC: A61K007/06 ,  A61K007/11 ,  C08G063/48 ,  C08G063/91

CPC classification number: A61K9/167 ,  C08B37/00 ,  C08G81/00

Abstract: A material with controlled chemical structure includes at least a biodegradable polymer material and a polysaccharide with linear, branched or crosslinked skeleton. The material is obtained by controlled functionalizing of at least a molecule of the biodegradable polymer or one of its derivatives by covalent grafting directly at its polymeric structure, of at least a molecule of the polysaccharide. A vector preferably in the form of particles obtained from the material and its use as biological vector are also disclosed.

Abstract translation: 具有受控化学结构的材料包括至少一种可生物降解的聚合物材料和具有直链，支链或交联骨架的多糖。 该材料通过至少一种分子的生物可降解聚合物或其衍生物通过至少一种多糖分子在其聚合物结构上直接共价接枝获得。 还公开了优选以从该材料获得的颗粒形式的载体及其作为生物载体的用途。