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697 条记录 (耗时 0.028 秒)

    Detection of co-occurring receptor-coding nucleic acid segments
    51.
    发明授权
    Detection of co-occurring receptor-coding nucleic acid segments 有权

    公开(公告)号：US11466310B2

    公开(公告)日：2022-10-11

    申请号：US16659509

    申请日：2019-10-21

    申请人： Akoya Biosciences, Inc.

    发明人： Steven Daniel

    IPC分类号： C12Q1/6818 ,  C07K14/705

    摘要： Methods for identifying co-occurrence of nucleic acid segments in a nucleic acid sample from a specimen including obtaining a nucleic acid sample from a specimen, determining sequences of first and second nucleic acid segments in nucleic acid fragments of the sample to generate a first and second sets of sequences, generating a first and second sets of probes from the first and second sets of sequences, exposing a detection sample to a member of the first set of probes and a member of the second set of probes, performing a hybridization analysis to determine whether the members of the first and second sets of probes hybridize to the detection sample, and determining whether the first and second nucleic acid segments co-occur in a common cell of the specimen.

    Optical Instruments and Systems for Forensic DNA Quantitation
    52.
    发明申请
    Optical Instruments and Systems for Forensic DNA Quantitation 有权

    公开(公告)号：US20220315996A1

    公开(公告)日：2022-10-06

    申请号：US17836825

    申请日：2022-06-09

    申请人： ANDE Corporation

    发明人： Eugene Tan ,  Richard F. Selden ,  Rosemary S. Turingan

    IPC分类号： C12Q1/6825 ,  B01L7/00 ,  C12Q1/6816 ,  C12N15/10 ,  B01L3/00 ,  C12Q1/6818

    摘要： Described herein are methods and devices for nucleic acid quantification and, in particular, to microfluidic methods and devices for nucleic acid quantification. In certain embodiments methods of quantifying a target nucleic acid without the need for amplification are provided. The methods involve, in some embodiments, allowing a binding agent to become immobilized with respect to the target nucleic acid. In some cases, the binding agent comprises a signaling moiety that can be used to quantify the amount of target nucleic acid. In another aspect, the quantification can be carried out rapidly. For example, in certain embodiments, the quantification can be completed within 5 minutes. In yet another aspect, samples containing a low amount of target nucleic acid can be quantified. For instance, in some cases, samples containing less than 100 nanograms per microliter may be quantified. Also described are devices and kits for performing such methods, or the like.

    COMBINATORIAL DNA SCREENING
    54.
    发明申请
    COMBINATORIAL DNA SCREENING 有权

    公开(公告)号：US20220290229A1

    公开(公告)日：2022-09-15

    申请号：US17678829

    申请日：2022-02-23

    申请人： MYRIAD WOMEN'S HEALTH, INC.

    发明人： Jared Robert Maguire ,  Clement S. Chu ,  Imran Saeedul Haque ,  Eric Andrew Evans ,  Noah Welker

    IPC分类号： C12Q1/6874 ,  C12Q1/6818

    摘要： The present disclosure relates to methods for detecting unique genetic signatures derived from markers such as, for example, mutations, somatic or germ-line, in nucleic acids obtained from biological samples. The sensitivity of the methods provides for detection of mutations associated with a disease, e.g., cancer mutations, or with inherited disease, e.g., an autosomal recessive disease, in a noninvasive manner at ultra-low proportions of sequences carrying mutations to sequences carrying normal, e.g., non-cancer sequences, or a reference sequence, e.g., a human reference genome.