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公开(公告)号：US20200048682A1
公开(公告)日：2020-02-13
申请号：US16595167
申请日：2019-10-07
发明人： Igor Kozlov , Amar Gupta , Randall Saiki , Alison Tsan
IPC分类号： C12Q1/686 , C12Q1/6851 , C12Q1/6876
摘要： The present invention describes methods for performing higher multiplexed real-time PCR for detection and quantitation of target nucleic acids using tagged hydrolysis probes.
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2.发明申请公开(公告)号：US20150099747A1
公开(公告)日：2015-04-09
申请号：US14508618
申请日：2014-10-07
发明人： Xiaoju Max Ma , Chitra Manohar , Alison Tsan
IPC分类号： C12Q1/68 , A61K31/5377 , A61K31/496 , A61K31/4439
CPC分类号： C12Q1/6886 , A61K31/4439 , A61K31/496 , A61K31/5377 , C12Q2600/106 , C12Q2600/156
摘要： The invention comprises reagents and methods for detecting cancer-associated mutations in the human EZH2 gene. Further, a method of detecting the mutations and a method of treatment are disclosed.
摘要翻译： 本发明包括用于检测人EZH2基因中癌症相关突变的试剂和方法。 此外，公开了检测突变的方法和治疗方法。
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公开(公告)号：US11198903B2
公开(公告)日：2021-12-14
申请号：US16595167
申请日：2019-10-07
发明人： Igor Kozlov , Amar Gupta , Randall Saiki , Alison Tsan
IPC分类号： C12Q1/68 , C12Q1/686 , C12Q1/6851 , C12Q1/6876
摘要： The present invention describes methods for performing higher multiplexed real-time PCR for detection and quantitation of target nucleic acids using tagged hydrolysis probes.
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公开(公告)号：US11028433B2
公开(公告)日：2021-06-08
申请号：US15705772
申请日：2017-09-15
发明人： Igor Kozlov , Amar Gupta , Randall Saiki , Alison Tsan
IPC分类号： C12Q1/68 , C12Q1/686 , C12Q1/6823 , C12Q1/6811 , C12Q1/6883 , C12Q1/6804 , C12Q1/6818 , C12Q1/6837
摘要： The present invention describes methods for performing higher multiplexed PCR for detection and quantitation of target nucleic acids using tagged hydrolysis probes.
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公开(公告)号：US10260102B2
公开(公告)日：2019-04-16
申请号：US14508618
申请日：2014-10-07
发明人： Xiaoju Max Ma , Chitra Manohar , Alison Tsan
IPC分类号： A61K31/496 , C12Q1/6886 , A61K31/4439 , A61K31/5377
摘要： The invention comprises reagents and methods for detecting cancer-associated mutations in the human EZH2 gene. Further, a method of detecting the mutations and a method of treatment are disclosed.
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公开(公告)号：US20180073064A1
公开(公告)日：2018-03-15
申请号：US15705821
申请日：2017-09-15
发明人： Igor Kozlov , Amar Gupta , Randall Saiki , Alison Tsan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6804 , C12Q1/6811 , C12Q1/6818 , C12Q1/6823 , C12Q1/6837 , C12Q1/6883 , C12Q2531/113 , C12Q2537/143 , C12Q2561/113 , C12Q2600/16 , C12Q2525/161 , C12Q2527/107 , C12Q2565/101
摘要： The present invention describes methods for performing higher multiplexed real-time PCR for detection and quantitation of target nucleic acids using tagged hydrolysis probes.
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公开(公告)号：US09738935B2
公开(公告)日：2017-08-22
申请号：US13664333
申请日：2012-10-30
发明人： Wei-min Liu , Alison Tsan
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： Six new mutations were found in exon 19 of the EGFR gene, the exon that is often mutated in tumors. The invention comprises methods of detecting the mutations, methods of prognosis and methods of predicting response to treatment based on the presence of absence of the mutations.
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8.发明申请Novel Complex Mutations in the Epidermal Growth Factor Receptor Kinase Domain 审中-公开表皮生长因子受体激酶域中的新型复合突变公开(公告)号：US20140341884A1
公开(公告)日：2014-11-20
申请号：US14070310
申请日：2013-11-01
发明人： Yan Li , Wei-Min Liu , Alison Tsan
IPC分类号： C12Q1/68 , A61K31/517 , A61K31/5377 , C07K16/28
CPC分类号： C12Q1/6886 , A61K31/517 , A61K31/5377 , C07K16/2863 , C12Q2600/106 , C12Q2600/156
摘要： New mutations were found in exon 19 of the EGFR gene, the exon that is often mutated in tumors. The invention comprises methods of detecting the mutations, methods of prognosis and methods of predicting response to treatment based on the presence of absence of the mutations.
摘要翻译： 在EGFR基因的外显子19中发现了新突变，外显子通常在肿瘤中突变。 本发明包括检测突变的方法，预后方法和基于不存在突变的预测治疗反应的方法。
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公开(公告)号：US20130078630A1
公开(公告)日：2013-03-28
申请号：US13624077
申请日：2012-09-21
CPC分类号： C12Q1/6858 , C12Q1/6883 , C12Q1/6886 , C12Q2600/156 , C12Q2525/117 , C12Q2535/125
摘要： The present invention includes a method of allele-specific amplification, utilizing an allele-specific oligonucleotide, at least partially complementary to more than one variant of the target sequence, but having at least one selective nucleotide complementary to only one variant of the target sequence and incorporating at least one “G-clamp” nucleotide.
摘要翻译： 本发明包括等位基因特异性扩增的方法，利用与目标序列的多于一个变体至少部分互补但具有与目标序列仅一个变体互补的至少一个选择性核苷酸的等位基因特异性寡核苷酸，以及 并入至少一个G-钳位核苷酸。
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公开(公告)号：US11345958B2
公开(公告)日：2022-05-31
申请号：US17314470
申请日：2021-05-07
发明人： Igor Kozlov , Amar Gupta , Randall Saiki , Alison Tsan
IPC分类号： C07H21/04 , C12Q1/686 , C12Q1/6823 , C12Q1/6811 , C12Q1/6883 , C12Q1/6804 , C12Q1/6818 , C12Q1/6837
摘要： The present invention describes methods for performing higher multiplexed real-time PCR for detection and quantitation of target nucleic acids using tagged hydrolysis probes.
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