公开(公告)号：US11563178B2

公开(公告)日：2023-01-24

申请号：US15806660

申请日：2017-11-08

申请人： UDC IRELAND LIMITED

发明人： Koji Takaku ,  Yasunori Yonekuta ,  Wataru Sotoyama ,  Katsuyuki Youfu ,  Yuki Hirai ,  Tetsu Kitamura ,  Toru Watanabe ,  Tianhua Ouyang

IPC分类号： H01L51/00 ,  C07C211/54 ,  C07D213/74 ,  C07D333/36 ,  C07D401/10 ,  C07D239/42 ,  C07D241/20 ,  C07D263/48 ,  C07D493/04 ,  C07D495/04 ,  C07D307/66 ,  C07D307/91 ,  C07C211/58

摘要： The disclosure relates to organic electroluminescent elements, compounds for use in the elements, and devices using the elements, which include a compound represented by the following General Formula (1): where R1 to R3 and R6 to R8 each independently represents a hydrogen atom, which may be a deuterium atom, or a substituent with a Hammett substituent constant σp value of −0.15 or more, R5, R9 and R10 each independently represents a hydrogen atom or a substituent, L1 represents a divalent linking group, DG1 represents a donor group, and n1 represents 1 or 2, and where R1 to R3, R5 to R10, L1, and DG1 are not bound to each other to form a ring.

公开(公告)号：US20220306597A1

公开(公告)日：2022-09-29

申请号：US17212186

申请日：2021-03-25

申请人： WALKER CANCER RESEARCH INSTITUTE, INC.

发明人： Eduardo Palomino

IPC分类号： C07D307/66

摘要： Embodiments of the present invention provide for syntheses and uses of mechanism-based nutritional colorants from vitamin C and amino-containing compounds, wherein the amino-containing compounds can be one of natural compounds or synthetic compounds, wherein the amino-containing compounds can be made through environmentally-friendly radical reactions that follow the antioxidant mechanism of action of vitamin C.

公开(公告)号：US11201294B2

公开(公告)日：2021-12-14

申请号：US16796955

申请日：2020-02-21

申请人： FUJIFILM Corporation

发明人： Eiji Fukuzaki ,  Tomoaki Yoshioka

IPC分类号： H01L51/00 ,  C07D307/66 ,  C07D491/048 ,  C07D491/16 ,  C09K11/06 ,  H01L27/30 ,  H01L51/42 ,  H01L51/44

摘要： The invention provides a photoelectric conversion element exhibiting excellent photoelectric conversion efficiency even in a case where the photoelectric conversion film is a thin film. Also, the invention provides an optical sensor and an imaging element including the photoelectric conversion element.
The invention provides a compound applied to the photoelectric conversion element.
The photoelectric conversion element of the invention includes a conductive film, a photoelectric conversion film, and a transparent conductive film, in this order, in which the photoelectric conversion film contains a compound represented by Formula (1).

公开(公告)号：US10961211B2

公开(公告)日：2021-03-30

申请号：US16791252

申请日：2020-02-14

申请人： Midwestern University

发明人： Mark Jon Olsen ,  Jean Paul Seerden

IPC分类号： C07D307/66 ,  A61P35/04

摘要： Isotopically-stabilized tetronimide compounds comprising one or more deuterium atoms, derivatives, and intermediates, thereof, including methods for their synthesis, pharmaceutical compositions thereof, and methods of using these compounds to interact with target molecules in cell-free samples, cell- and tissue-based assays, animal models, and in a subject are disclosed. One aspect relates to molecules that modulate the expression or catalytic activity of aspartyl (asparaginyl) β-hydroxylase (ASPH) within or on the surface of a cell. Other aspects of the invention relate to use of the molecules disclosed herein to diagnose, ameliorate, or treat cell proliferation disorders and related diseases. Related aspects include uses of the compounds to modulate the activity of viruses, as anti-hyperlipidemia agents, and as agents to ameliorate or treat thrombosis and related cardiovascular and metabolic disorders.

公开(公告)号：US10710995B2

公开(公告)日：2020-07-14

申请号：US15715989

申请日：2017-09-26

申请人： Rhode Island Hospital ,  Midwestern University

发明人： Jack R. Wands ,  Suzanne De La Monte ,  Arihiro Aihara ,  Mark Jon Olsen ,  John-Michael Thomas

IPC分类号： A61K31/34 ,  A61K31/16 ,  C07D417/04 ,  C07D307/66 ,  A61P35/00 ,  C07D307/32 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C12Q1/26

摘要： The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.

公开(公告)号：US10472336B2

公开(公告)日：2019-11-12

申请号：US15759600

申请日：2016-09-22

申请人： GlaxoSmithKline Intellectual Property (No.2) Limited

发明人： Pek Yoke Chong ,  Martha Alicia De La Rosa ,  Hamilton D. Dickson ,  Wieslaw Mieczyslaw Kazmierski ,  Vicente Samano ,  Vincent Wing-Fai Tai

IPC分类号： C07D285/08 ,  C07D263/58 ,  C07D213/74 ,  C07D309/14 ,  C07D333/20 ,  C07D235/30 ,  C07D239/42 ,  C07D241/20 ,  C07D253/06 ,  C07D263/48 ,  C07D277/82 ,  C07D285/00 ,  C07D307/66 ,  C07C229/42 ,  C07D239/47 ,  C07D249/14 ,  C07D277/28 ,  C07D277/42 ,  C07D277/593 ,  C07D285/135 ,  C07D307/52

摘要： Provided are compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of HIV; including the prevention of the progression of AIDS and general immunosuppression.

公开(公告)号：US10351555B2

公开(公告)日：2019-07-16

申请号：US16131275

申请日：2018-09-14

申请人： Midwestern University

发明人： Mark Jon Olsen ,  John Michael Thomas

IPC分类号： C07D307/26 ,  C07D307/32 ,  C07D307/66 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D417/04 ,  C12Q1/26 ,  A61P35/00

摘要： The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.

公开(公告)号：US10166213B2

公开(公告)日：2019-01-01

申请号：US15500006

申请日：2016-04-22

申请人： Pavel Dibrov ,  Elena Dibrov ,  Grant Pierce

发明人： Pavel Dibrov ,  Elena Dibrov ,  Grant Pierce

IPC分类号： A61K31/341 ,  C07D307/66 ,  C07F9/655 ,  A61K31/365 ,  C07D309/30 ,  A61K31/16

摘要： An antibiotic compound is of formula (I): R1-R3, R5 and R6 are independently selected from H, alkyl group, substituted alkyl group, halogen, OH, NH2, or SH; R4 is H, alkyl group or substituted alkyl group. X1-X2 are independently selected from O, S, NH, H, alkyl, halogen, OH, SH, or NH2. Y is an acyclic hydrocarbon chain having 4 to 20 carbon atoms or a substituted acyclic hydrocarbon chain having 4 to 20 carbon atoms, but does not include an oxygen atom. Z is CH3 or any neutral or positively charged group. The compound can also be a salt or stereoisomer of formula (I). The compounds are useful in treating bacterial diseases.

公开(公告)号：US09960362B2

公开(公告)日：2018-05-01

申请号：US15609125

申请日：2017-05-31

申请人： Samsung Electronics Co., Ltd.

发明人： Xavier Bulliard ,  Tadao Yagi ,  Rie Sakurai ,  Hiromasa Shibuya ,  Kwang Hee Lee ,  Dong-Seok Leem ,  Hyesung Choi

IPC分类号： C07D307/66 ,  H01L51/00 ,  H01L51/44 ,  H01L27/30 ,  C07D405/06

CPC分类号： H01L51/0061 ,  C07D307/66 ,  C07D405/06 ,  H01L27/307 ,  H01L51/0046 ,  H01L51/0053 ,  H01L51/006 ,  H01L51/0065 ,  H01L51/0067 ,  H01L51/0068 ,  H01L51/4253 ,  H01L51/441 ,  H01L51/447

摘要： A compound is represented by Chemical Formula 1, and an organic photoelectric device, an image sensor, and an electronic device include the compound. In Chemical Formula 1, each substituent is the same as defined in the detailed description.

公开(公告)号：US20160272605A1

公开(公告)日：2016-09-22

申请号：US15166482

申请日：2016-05-27

申请人： Arrowhead Madison Inc.

发明人： Andrei V. Blokhin ,  David B. Rozema ,  Jonathan D. Benson ,  Jeffrey C. Carlson

IPC分类号： C07D307/66 ,  C07H15/26 ,  C07D307/88

CPC分类号： C07D307/89 ,  C07D307/60 ,  C07D307/66 ,  C07D307/88 ,  C07H15/08 ,  C07H15/26

摘要： We describe anhydride compounds suitable for physiologically labile modification of amine-containing molecules. The described anhydrides form reversible linkages having desirable kinetics for in vivo delivery of biologically active molecules. Also described are endosomolytic polymers formed by modification of membrane active polyamines with the described anhydrides.

摘要翻译： 我们描述适用于含胺分子的生理不稳定修饰的酸酐化合物。 所述的酸酐形成具有用于体内递送生物活性分子的所需动力学的可逆连接。 还描述了通过用所述酸酐修饰膜活性多胺而形成的内体分解聚合物。