Tetrahydrofuran derivatives having cis substituent, their intermediates, and their preparation method
    651.
    发明授权
    Tetrahydrofuran derivatives having cis substituent, their intermediates, and their preparation method 失效
    具有顺式取代基的四氢​​呋喃衍生物及其制备方法

    公开(公告)号:US07388101B1

    公开(公告)日:2008-06-17

    申请号:US11732602

    申请日:2007-04-04

    CPC classification number: C07D307/12

    Abstract: The present invention relates to a tetrahydrofuran compound having cis substituents, the derivatives thereof and a process for preparing the same, and in particular relates to a dihydrofuran-3-ylidene triflate compound having cis substituents at C2 and C5 positions prepared through Prins-type cyclization using a homopropargylic alcohol derivative as a starting material in the presence of Lewis acid catalyst, a tetrahydrofuran compound having cis substituents at C2, C3 and C5 positions prepared through the hydrolysis of triflate group in the derivatives of the dihydrofuran-3-ylidene triflate compound, and a preparation method thereof.The derivatives and the target tetrahydrofuran compound prepared according to the present invention are hydrofuran compounds with novel structures having cis substituents at C2, C3 and/or C5 positions, which are useful as a derivative for synthesizing drugs such as an antagonist for neurokinin receptor.

    Abstract translation: 本发明涉及具有顺式取代基的四氢​​呋喃化合物及其衍生物及其制备方法,特别涉及在C 2上具有顺式取代基的二氢呋喃-3-亚基三氟甲磺酸酯化合物和 在路易斯酸催化剂存在下,使用均二炔醇衍生物作为起始原料,在C 2 N 2上具有顺式取代基的四氢​​呋喃化合物,通过Prins-型环化制备的C 5 H 3位, 通过在二氢呋喃-3-亚基三氟甲磺酸酯化合物的衍生物中水解三氟甲磺酸酯基制备的C 3和C 5 H 3位及其制备方法。 根据本发明制备的衍生物和目标四氢呋喃化合物是具有在C 2,C 3和/或C 5上具有顺式取代基的新结构的氢呋喃化合物 其可用作合成药物的衍生物,例如用于神经激肽受体的拮抗剂。

    Iris recognition system and method using multifocus image sequence

    公开(公告)号:US20080037835A1

    公开(公告)日:2008-02-14

    申请号:US11704223

    申请日:2007-02-09

    CPC classification number: G06K9/00604 G06K9/0061

    Abstract: The present invention relates to an iris recognition system and method using a multifocus image sequence, the iris recognition system including: an eye image input unit calculating the distance between an image obtaining apparatus and a user using a distance sensor to receive a multifocus eye image sequence having focus information of the user's eye varied at regular time intervals within a predetermined distance using the image obtaining apparatus; an eye image pretreatment unit calculating a fuzzy entropy for the multifocus eye image sequence input from the eye image input unit to select eye images of N number that can effectively express eye image data of various focusing levels, and extracting a multifocus iris image sequence by separating an iris image between pupil and collarette that has various iris patterns, from which an area unnecessary for configuring a feature vector is removed, from the selected eye images; a feature vector extraction unit multi-dividing the multifocus iris image sequence extracted in the eye image pretreatment unit, forming a wavelet feature vector from the multi-divided images using a subband including only a low-frequency area, and generating a wavelet feature vector reduced to a dimension having a high discrimination performance and a dimension-reducing transform function P; a recognition unit discriminating the user's authenticity by measuring a dissimilarity between the feature vector extracted from the feature vector extraction unit and a feature vector already registered; a register unit registering the reduced wavelet feature vector extracted from the feature vector extraction unit and the dimension-reducing transform function P in a storage unit; and a storage unit storing the dimension-reducing transform function P and the reduced wavelet feature vector. Accordingly, the iris recognition system and method using a multifocus image sequence can effectively recognize low-resolution images and poorly focused images as well as high-resolution images and well focused images. Moreover, the iris recognition system and method using a multifocus image sequence can extract the feature vector having a high discrimination performance, enhance the efficiency of a storage device by effectively reducing the dimension of the feature vector, and minimize recognition errors even using a simple recognition apparatus using a wavelet analysis and a direct linear discriminant analysis.

    Method and apparatus for communication between inside and outside of transmission medium using transmission medium as communication line
    654.
    发明授权
    Method and apparatus for communication between inside and outside of transmission medium using transmission medium as communication line 有权
    使用传输介质作为通信线的传输介质内外通信的方法和装置

    公开(公告)号:US07307544B2

    公开(公告)日:2007-12-11

    申请号:US10158503

    申请日:2002-05-30

    CPC classification number: A61B5/0031 H04B13/005

    Abstract: A method for communication between inside and outside of a transmission medium using the transmission medium as a communication line, includes the steps of: receiving an electric signal having information related to a transmission medium from a plurality of sensors inside the transmission medium; conducting the electric signal to the transmission medium; and sensing the electric signal flowing to the outside of the transmission medium. Because a modulating unit is not necessary, a power consumption is minimized. In addition, since an electric signal is directly conducted to a medium, it is not necessary to use an antenna, and thus, degradation of a reception rate according to a directional property of the antenna can be prevented. Moreover, since the electric signal is directly generated in the medium and the medium is directly used as an electric conductor, the overall size of a transmitter is reduced.

    Abstract translation: 一种使用传输介质作为通信线路的传输介质的内部和外部之间的通信方法包括以下步骤:从传输介质内的多个传感器接收具有与传输介质相关的信息的电信号; 将电信号传送到传输介质; 并感测流向传输介质外部的电信号。 因为不需要调制单元,所以功耗最小化。 此外,由于电信号直接传导到介质,因此不需要使用天线,因此可以防止根据天线的方向特性导致的接收速率的劣化。 此外,由于电信号直接在介质中产生并且介质直接用作电导体,所以发射器的总体尺寸减小。

    1,3-DIOXOISOINDOLE DERIVATIVES HAVING SELECTIVE ANTAGONISM OF T-TYPE CALCIUM CHANNEL
    656.
    发明申请
    1,3-DIOXOISOINDOLE DERIVATIVES HAVING SELECTIVE ANTAGONISM OF T-TYPE CALCIUM CHANNEL 失效
    具有T型钙通道选择性拮抗剂的1,3-二氧化物衍生物

    公开(公告)号:US20070259867A1

    公开(公告)日:2007-11-08

    申请号:US11600391

    申请日:2006-11-16

    CPC classification number: C07D209/48

    Abstract: The present invention relates to 1,3-dioxoisoindole derivatives of Formula (1) or pharmaceutically acceptable salts thereof, a preparation method thereof and use thereof as a T-type calcium channel antagonist, based on the fact that 1,3-dioxoisoindole derivatives of Formula (1) show selective antagonistic activity against T-type calcium channel, thus being effective in treating brain diseases, cardiac diseases and neurogenic pains: wherein R1 is a phenyl or a benzyl group, optionally substituted with a moiety selected from the group consisting of a halogen atom, a C1-C6 alkoxy, a C1-C6 alkyl, and a cyano group; R2 is a heterocyclic group selected from the group consisting of piperidinyl, pyrrolidinyl, morpholinyl, and piperazinyl groups, wherein the heterocyclic group is optionally substituted with a C1-C6 alkyl group; and n is 1 or 2.

    Abstract translation: 本发明涉及式(1)的1,3-二氧代异吲哚衍生物或其药学上可接受的盐,其制备方法及其作为T型钙通道拮抗剂的用途,基于以下事实: 式(1)表示对T型钙通道的选择性拮抗活性,因此有效治疗脑疾病,心脏病和神经源性疼痛:其中R 1是苯基或苄基,任选被 选自卤素原子,C 1 -C 6 - 烷氧基,C 1 -C 6烷氧基,C 1 -C 6 - 烷基和氰基; R 2是选自哌啶基,吡咯烷基,吗啉基和哌嗪基的杂环基,其中杂环基任选被C 1 -C 6烷基取代, C 1-6烷基; n为1或2。

    Uniform-sized hydrophilic metal oxide nanoparticles and preparation method thereof
    657.
    发明申请
    Uniform-sized hydrophilic metal oxide nanoparticles and preparation method thereof 审中-公开
    均匀尺寸的亲水性金属氧化物纳米粒子及其制备方法

    公开(公告)号:US20070248678A1

    公开(公告)日:2007-10-25

    申请号:US11235915

    申请日:2005-09-26

    CPC classification number: A61K49/1833 A61K49/1836 B82Y5/00 Y10T428/12028

    Abstract: The present invention provides for a metal oxide nanoparticle that contains a metal core, a shell formed on the surface of the core and consisted of the same metal as the core, and an organic compound containing an element capable of covalently bonding with the nanoparticle and a hydrophilic functional group. According to the examples, uniform-sized hydrophilic metallic oxide-based nanoparticles are obtained when superparamagnetic iron oxide particles, which have a globular shape and are less than 20 nanometers in size, are first synthesized in an organic solution, and then are converted to hydrophilic particles after undergoing surface modification.

    Abstract translation: 本发明提供了一种金属氧化物纳米颗粒,其包含金属芯,形成在芯的表面上并由与芯相同的金属组成的壳,以及含有能够与纳米颗粒共价结合的元素的有机化合物,以及 亲水官能团。 根据实施例,当在有机溶液中首先合成尺寸小于20纳米的超顺磁性氧化铁颗粒,然后转化为亲水性时,得到均匀尺寸的亲水性金属氧化物基纳米颗粒 经过表面改性后的颗粒。

    Continuous wave supercontinuum light source and medical diagnostic apparatus using the same
    658.
    发明申请
    Continuous wave supercontinuum light source and medical diagnostic apparatus using the same 审中-公开
    连续波超连续光源和使用其的医疗诊断装置

    公开(公告)号:US20070160091A1

    公开(公告)日:2007-07-12

    申请号:US11583152

    申请日:2006-10-19

    CPC classification number: H01S3/067 H01S3/06791 H01S3/108 H01S3/1608

    Abstract: Disclosed are a continuous wave supercontinuum laser source resonator using low-priced multimode semiconductor lasers as pumping light and applying a rare-earth doped optical fiber and a Highly Nonlinear Dispersion Shifted Fiber (HNL-DSF) to a ring resonator structure to embody a continuous wave supercontinuum light source, and a medical diagnostic apparatus using the same. The resonator consists of a pump combiner for inputting pumping light into the resonator; a rare-earth doped optical fiber for receiving and converting the pumping light into seed light of a predetermined wavelength band; a Highly Nonlinear Dispersion Shifted Fiber (HNL-DSF) for converting the light converted by the rare-earth doped optical fiber and oscillating in the resonator into a continuous wave supercontinuum laser source; and a coupler for outputting the supercontinuum laser source generated from the Highly Nonlinear Dispersion Shifted Fiber (HNL-DSF). Accordingly, it is possible to embody a simple and inexpensive continuous wave supercontinuum laser source.

    Abstract translation: 公开了一种使用低价多模半导体激光器作为泵浦光并将稀土掺杂光纤和高非线性色散移位光纤(HNL-DSF)应用于环形谐振器结构的连续波超连续光谱激光源谐振器,以体现连续波 超连续光源,以及使用其的医疗诊断装置。 谐振器由用于将泵浦光输入谐振器的泵组合器组成; 用于接收并将泵送光转换成预定波长带的种子光的稀土掺杂光纤; 用于将由稀土掺杂光纤转换并在谐振器中振荡的光转换成连续波超连续光源的高非线性色散位移光纤(HNL-DSF); 以及用于输出由高非线性色散移位光纤(HNL-DSF)产生的超连续光谱激光源的耦合器。 因此,可以体现简单廉价的连续波超连续谱激光源。

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