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    METHODS OF TREATING MOTOR NEURON DISEASES
    681.
    发明申请
    METHODS OF TREATING MOTOR NEURON DISEASES 审中-公开

    公开(公告)号：US20200246372A1

    公开(公告)日：2020-08-06

    申请号：US16854978

    申请日：2020-04-22

    Applicant: Yeda Research and Development Co. Ltd.

    Inventor： Eran HORNSTEIN ,  Irit REICHENSTEIN ,  Alon CHEN

    IPC: A61K31/7105 ,  A61P25/00 ,  A61K45/06 ,  C12N15/113

    Abstract: A method of treating a subject having MND is provided. The method comprising administering to the subject a therapeutically effective amount of an agent selected from the group consisting of miR-218, miR-218*, precursor thereof and a polynucleotide sequence encoding miR-218 or miR-218* or precursor thereof, thereby treating the MND in the subject. A method of treating a subject having MND, the method comprising administering to the subject a therapeutically effective amount of an agent capable of downregulating an activity or expression of a gene product selected from the group consisting of KCND2, KCNH1, GABRB2, SLC6A1, SLC6A11, KCNA1, CACNB4, GRIA2, GRIK2, GABRG1 and GRIK3, is also provided.

    METHOD FOR PLATINUM GROUP METALS RECOVERY FROM SPENT CATALYSTS
    687.
    发明申请
    METHOD FOR PLATINUM GROUP METALS RECOVERY FROM SPENT CATALYSTS 审中-公开

    公开(公告)号：US20200032370A1

    公开(公告)日：2020-01-30

    申请号：US16591644

    申请日：2019-10-03

    Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

    Inventor： Igor LUBOMIRSKY ,  Valery Kaplan

    IPC: C22B11/06 ,  C01G55/00 ,  B01J19/08 ,  C22B3/00

    Abstract: A method for recovery of platinum group metals from a spent catalyst is described. The method includes crushing the spent catalyst to obtain a catalyst particulate material including particles having a predetermined grain size. The method includes subjecting the catalyst particulate material to a chlorinating treatment in the reaction zone at a predetermined temperature for a predetermined time period by putting the catalyst particulate material in contact with the chlorine containing gas. The method also includes applying an electromagnetic field to the chlorine-containing gas in the reaction zone to provide ionization of chlorine; thereby to cause a chemical reaction between platinum group metals and chlorine ions and provide a volatile platinum group metal-containing chloride product in the reaction zone. Following this, the volatile platinum group metal-containing chloride product is cooled to convert the product into solid phase platinum group metal-containing materials.

    Ruthenium complexes and their uses as catalysts in processes for formation and/or hydrogenation of esters, amides and related reactions
    689.
    发明授权
    Ruthenium complexes and their uses as catalysts in processes for formation and/or hydrogenation of esters, amides and related reactions 有权

    公开(公告)号：US10533028B2

    公开(公告)日：2020-01-14

    申请号：US15508114

    申请日：2015-09-03

    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

    Inventor： David Milstein ,  Peng Hu ,  Eran Fogler ,  Jai Anand Garg Narayana Rao

    IPC: C07F15/00 ,  C07C29/149 ,  C07C213/00 ,  C07C227/02 ,  C07C231/08 ,  C07C231/10 ,  B01J31/24 ,  C07C67/40 ,  C07C249/02 ,  C07D207/16 ,  C07D241/08

    Abstract: The present invention relates to novel Ruthenium complexes of formulae A1-A4 and their use, inter alia, for (1) dehydrogenative coupling of alcohols to esters; (2) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones), or polyesters); (3) preparing amides from alcohols and amines—(including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or polymerization of amino alcohols and/or forming cyclic dipeptides from p-aminoalcohols; (4) hydrogenation of amides (including cyclic dipeptides, polypeptides and polyamides) to alcohols and amines; (5) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (6) dehydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e., synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water and a base to form carboxylic acids; and (10) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. The present, invention further relates to the use of certain known Ruthenium complexes for the preparation of amino acids or their salts from amino alcohols.

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