利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

349 条记录 (耗时 0.045 秒)

    Mechanical punch apparatus and method of using same
    62.
    发明授权
    Mechanical punch apparatus and method of using same 失效
    机械冲孔装置及其使用方法

    公开(公告)号：US5862729A

    公开(公告)日：1999-01-26

    申请号：US541664

    申请日：1995-10-10

    申请人： Noel Rolon ,  William Pagels

    发明人： Noel Rolon ,  William Pagels

    IPC分类号： B26F1/04 ,  G01N1/28 ,  B26F1/02

    CPC分类号： B26F1/04 ,  G01N1/286 ,  G01N2001/288 ,  Y10T83/0448 ,  Y10T83/0481

    摘要： A punch assembly for punching samples of dried blood spots (DBSs) from paper card samples includes: a base member, a cartridge and at least one cutting pin. The base member includes a bottom platform having an upper surface defining a track therein, an upper platform, at least one support post disposed between and spacing the bottom platform and the upper platform, a biasing element for biasing the upper platform in a direction away from the bottom platform, and a mechanism associated with the base member for moving the upper platform toward the bottom platform. The upper platform is slidably connected to the at least one support post such that the upper platform is movable therealong with respect to the bottom platform. The cartridge functions to hold an object to be punched and at least one cutting pin. The cartridge defines at least one hole therethrough for receiving the cutting pin. In addition, the cartridge is sized to be received in the track defined in the bottom platform. In use, the lever is moved against the upper platform to force the cutting pin through the object held in the cartridge to thereby create a punched object.

    摘要翻译： 用于从纸卡样品冲压干血点（DBS）样品的冲头组件包括：基部构件，筒和至少一个切割销。 所述基座构件包括底部平台，所述底部平台具有在其中限定轨道的上表面，上平台，设置在所述底平台和所述上平台之间并且间隔所述底平台和所述上平台的至少一个支撑柱;偏置元件，用于沿远离 底部平台，以及与基部构件相关联的用于将上部平台朝向底部平台移动的机构。 上平台可滑动地连接到至少一个支撑柱，使得上平台相对于底平台可移动。 墨盒用于保持要冲压的物体和至少一个切割销。 该盒限定了至少一个穿过其中的孔以接收切割销。 此外，盒的尺寸被设计成被接纳在底部平台中定义的轨道中。 在使用中，杠杆相对于上平台移动，以迫使切割销穿过保持在盒中的物体，从而形成冲孔物体。

    2-substituted amino and thio alkyl benzoxazine antimicrobial agents
    67.
    发明授权
    2-substituted amino and thio alkyl benzoxazine antimicrobial agents 失效
    2-取代氨基和硫代烷基苯并恶嗪抗菌剂

    公开(公告)号：US5707990A

    公开(公告)日：1998-01-13

    申请号：US594020

    申请日：1996-01-30

    申请人： Roger Frechette ,  Michael Beach

    发明人： Roger Frechette ,  Michael Beach

    IPC分类号： A61K31/538 ,  C07D265/36 ,  C07D413/12 ,  C07D498/04 ,  A61K31/535

    CPC分类号： C07D413/12 ,  A61K31/538 ,  C07D265/36

    摘要： The invention relates to benzoxazine and pyrido-oxazine antibacterial compounds of the general formula: ##STR1## wherein the moiety Q is a fused phenyl or fused pyridyl moiety and R is a substituted amine or substituted thio moiety as herein described, pharmaceutical compositions containing the compounds, methods for their production and their use in treating bacterial infections.

    摘要翻译： 本发明涉及以下通式的苯并恶嗪和吡啶并恶嗪抗菌化合物：其中部分Q是稠合的苯基或稠合吡啶基部分，R是如本文所述的取代的胺或取代的硫代部分，含有化合物的药物组合物 ，其生产方法及其在治疗细菌感染中的应用。

    Multilayered controlled release pharmaceutical dosage form
    69.
    发明授权
    Multilayered controlled release pharmaceutical dosage form 失效
    多层控释药物剂型

    公开(公告)号：US5645858A

    公开(公告)日：1997-07-08

    申请号：US568907

    申请日：1995-12-07

    申请人： Pramod M. Kotwal ,  Stephen A. Howard

    发明人： Pramod M. Kotwal ,  Stephen A. Howard

    IPC分类号： A61K9/36 ,  A61K9/50

    CPC分类号： A61K9/5078

    摘要： This invention is directed to a multilayered controlled release pharmaceutical dosage form. More particularly the dosage form is adapted for water soluble drugs and comprises a plurality of coated particles wherein each has multiple layers about a core containing a drug active whereby the drug containing core and at least one other layer of drug active is overcoated with a controlled release barrier layer and preferably an outer layer of additional drug is adapted for immediate release to preferably provide one immediate releasing layer and at least two controlled releasing layers of a water soluble drug from the multilayered coated particle.

    摘要翻译： 本发明涉及多层控释药物剂型。 更具体地，剂型适用于水溶性药物，并且包含多个包被的颗粒，其中每个具有围绕含有药物活性物质的多个层，其中含有药物的核心和至少一个其他药物活性剂层被外敷涂层 优选地，另外的药物的外层适于立即释放，优选地提供一个立即释放层和至少两个来自多层涂覆颗粒的水溶性药物的受控释放层。