公开(公告)号：US11447514B2

公开(公告)日：2022-09-20

申请号：US17055101

申请日：2019-05-17

申请人： Roche Diagnostics Operations, Inc.

发明人： Urs Spitz ,  Günter Schabert ,  Aysel Soydemir ,  Lukas Wick

IPC分类号： C07H1/06 ,  C07H19/048

摘要： The present invention relates to crystalline (thio)nicotinamide ribofuranoside salts, methods of making such crystalline salts, a pharmaceutical composition comprising same, and use of said crystalline salts as nutritional (dietary) supplements. Furthermore, the present invention relates to a composition comprising amorphous (thio)nicotinamide ribofuranoside salts and its use as nutritional (dietary) supplement.

公开(公告)号：US11445945B2

公开(公告)日：2022-09-20

申请号：US16908963

申请日：2020-06-23

申请人： Roche Diagnostics Operations, Inc.

发明人： Klaus Thome ,  Reiner Stein ,  Lars Fischheiter ,  Jerome Greenhalgh

IPC分类号： G01N33/487 ,  G01N35/00 ,  A61B5/145

摘要： A medical instrument and method thereof for performing a measurement on a biological sample using a test strip are disclosed. The medical instrument may comprise: an analytical unit for analyzing the test strip, wherein the analytical unit comprises a test strip mount which receives the test strip to perform the measurement; a test strip port which receives the test strip, wherein the test strip port is aligned with the test strip mount along an insertion direction; and a shutter movable between open and closed positions, the shutter comprises a test strip opening, wherein the test strip opening is aligned with the test strip port and the test strip mount when the shutter is in the open position, wherein the shutter comprises a shutter mechanism that rotates the shutter parallel to the insertion direction about a rotational axis to move the shutter between the open position and the closed position.

公开(公告)号：US20220283094A1

公开(公告)日：2022-09-08

申请号：US17631061

申请日：2019-07-31

申请人： Hitachi High-Tech Corporation ,  Roche Diagnostics Operations, Inc.

发明人： Toshiro SAITO ,  Kyoko IMAI ,  Francesco PAOLUCCI ,  Massimo MARCACCIO ,  Giovanni VALENTI ,  Alessandra ZANUT ,  Michaela WINDFUHR ,  Hans-Peter JOSEL

IPC分类号： G01N21/66 ,  G01N33/543 ,  B01L3/00

摘要： An analysis method includes: an inflow process of a solution containing a test object, a magnetic support on the surface of which a complex including an antibody labeled with a luminescent agent and recognizes the test object is formed, and a reaction aid to assist reaction of the luminescent agent in a flow cell; a process of capturing the magnetic support over a working electrode by a magnetic field; a process of making the luminescent agent illuminate by applying a voltage to the working electrode; and a process of measuring an amount of luminescence of the luminescent agent. The luminescent process includes: luminescence from action of a first neutral radical, produced from the reaction aid through a cation radical; and luminescence from action of a second neutral radical, produced not through a cation radical, on the luminescent agent. This increases the luminous efficiency of ECL and enhances detection sensitivity.

公开(公告)号：US11419790B2

公开(公告)日：2022-08-23

申请号：US14619207

申请日：2015-02-11

申请人： Roche Diagnostics Operations, Inc.

发明人： Ofer Yodfat ,  Illai J Gescheit ,  Iddo M. Gescheit

IPC分类号： A61J1/20 ,  A61J1/22 ,  A61M5/14

摘要： A transfer station for transferring a medical fluid between at least one supply container and at least one administration container of an infusion device is described. In an embodiment, the transfer station comprises at least one supply port configured for fluidic connection of the at least one supply container to the transfer station, and at least one exit port configured for fluidic connection of the at least one administration container to the transfer station. A transfer mechanism for automatically transferring a predetermined amount of medical fluid from the at least one supply container to the at least one administration container, and an electronic processing unit connected to an actuation means are provided with the transfer station. A processing unit controls the transfer mechanism and fluid transfer conditions according to a predetermined transfer demand entered by the actuation means.

公开(公告)号：US20220258169A1

公开(公告)日：2022-08-18

申请号：US17650021

申请日：2022-02-04

申请人： Roche Diagnostics Operations, Inc.

发明人： Leon Felipe Apodaca Lujan

IPC分类号： B01L9/00

摘要： An enclosure device for a decapper for removing a cap from a laboratory sample container, a decapper and an apparatus comprising a decapper. The decapper comprises a cap gripper comprising at least two gripping jaws. At least one of the at least two gripping jaws is displaceable between a holding position and a release position in a radial direction. The enclosure device comprises an outer enclosure portion and an inner enclosure portion disposed within the outer enclosure portion. The outer enclosure portion comprises a wall portion and a reservoir portion at a bottom of the wall portion. The wall portion is configured to enclose the two gripping jaws. The inner enclosure portion is configured to receive a laboratory sample container and comprises at least two openings configured to allow the two gripping jaws to extend therethrough. The enclosure device is configured to be mounted to the cap gripper.

公开(公告)号：US11415576B2

公开(公告)日：2022-08-16

申请号：US15614856

申请日：2017-06-06

申请人： Roche Diagnostics Operations, Inc.

发明人： Elke Faatz ,  Michael Gerg ,  Hans-Peter Josel ,  Christian Vogl

IPC分类号： G01N33/537 ,  C07K16/26 ,  G01N33/82 ,  G01N33/541

摘要： The present invention concerns an in vitro method for measurement of 25-hydroxyvitamin D, wherein the potentially interfering compound 24,25-dihydroxyvitamin D3 is blocked by a binding agent specifically binding to 24,25-dihydroxyvitamin D3 and not binding to 25-hydroxyvitamin D.

公开(公告)号：US11385250B2

公开(公告)日：2022-07-12

申请号：US16551783

申请日：2019-08-27

申请人： Roche Diagnostics Operations, Inc.

发明人： Barbara Upmeier ,  Andreas Woeste ,  Vanessa Balassa

IPC分类号： G01N35/10 ,  G01N21/62 ,  G01N35/00

摘要： An automated analyzer system for biological samples is provided and includes a sample processing system and a controller configured to receive a selection of one of multiple workflows for determining a presence and/or concentration of an analyte in a biological sample and prompt the automated analyzer system to automatically carry out the selected workflow using the sample processing system and output a result classifying the biological sample.

公开(公告)号：US20220197578A1

公开(公告)日：2022-06-23

申请号：US17456003

申请日：2021-11-22

申请人： Roche Diagnostics Operations, Inc.

发明人： Natalie Kunert

IPC分类号： G06F3/14 ,  B01L3/00 ,  B01L9/00 ,  G06F3/01 ,  G06F3/041

摘要： A laboratory analyzer is disclosed. The laboratory analyzer comprises a housing at least partially enclosing at least one analyzing instrument and at least one display device, wherein the display device comprises at least one screen, wherein the screen is partially transparent and reflective, wherein the screen is integrated into the housing, wherein the display device is configured for displaying screen information on the screen such that the screen information is visible and/or readable from outside the housing.

公开(公告)号：US20220196689A1

公开(公告)日：2022-06-23

申请号：US17128268

申请日：2020-12-21

申请人： Roche Diagnostics Operations, Inc.

发明人： Christopher Bates ,  Julian Pfaff ,  Noelia Gonzalez Vila ,  Adrian Fernandez Vazquez ,  Kyle Benton ,  Attila Sapi

IPC分类号： G01N35/04 ,  B01L9/06

摘要： A support element for a modular transport plane with a plurality of transport module units each comprising a driving surface assembly is presented. The support element has an upper support surface supporting the driving surface assemblies of at least two neighboring transport module units. The upper support surface has driving surface assembly interfaces engaged with complementary interfaces of the supported driving surface assemblies. The support element comprises a lower part having a mounting structure and an upper part having the upper support surface. The upper part connects lengthwise to the lower part via a connection structure. The connection structure restrains a relative movement between the lower part and the upper part in the longitudinal direction of the support element and allows a limited relative movement between the lower part and the upper part in a plane perpendicular to the longitudinal direction of the support element.

公开(公告)号：US20220178957A1

公开(公告)日：2022-06-09

申请号：US17452781

申请日：2021-10-29

申请人： Roche Diagnostics Operations, Inc.

发明人： Mauro Alvarez ,  Jordi Sans Pena

IPC分类号： G01N35/04

摘要： A diagnostic laboratory distribution system, wherein the distribution system comprises a number of carriers adapted to carry one or more goods. The distribution system comprises a transport plane adapted to support the carriers and a drive device, wherein the drive device is adapted to move the carriers on the transport plane, and a control device to control the drive device. The distribution system comprises a cover for the transport plane, and humidity sensors connected to the control device and airflow generating devices connected to the control device. The airflow generating devices are distributed over the distribution system to generate an airflow between the cover and the transport plane. The control device is configured to start the airflow generating devices if the humidity sensors measure a humidity above a predefined threshold value.