公开(公告)号：US11090469B2

公开(公告)日：2021-08-17

申请号：US16363644

申请日：2019-03-25

申请人： Surmodics, Inc.

发明人： Ralph A. Chappa ,  Mark F. Carlson

IPC分类号： A61M25/10 ,  B05D1/02 ,  B05B13/02 ,  B05D1/00 ,  B05C13/00 ,  B05D3/12

摘要： A coating apparatus for coating the balloon portion of a balloon catheter is described. The coating apparatus includes a rotatable member in which the catheter portion of the balloon catheter is mounted and fixed, and which causes rotation of the balloon catheter. The apparatus also includes a support member in which the distal tip of the catheter is inserted and free to rotate; and a spray nozzle directing sprayed material on the balloon surface. The inventive configuration of the coating apparatus allows the balloon catheter to be rotated along its axis with insubstantial or no wobble, which significantly improves the quality of the coating applied to the surface of the balloon.

公开(公告)号：US11090468B2

公开(公告)日：2021-08-17

申请号：US14063113

申请日：2013-10-25

申请人： SurModics, Inc.

发明人： Ralph A. Chappa ,  Mark F. Carlson

IPC分类号： A61M25/10 ,  A61M25/00 ,  B05D1/00 ,  B05B13/02

摘要： Embodiments of the invention include apparatus and methods for coating medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit including a fluid applicator; a first rotation mechanism and a second rotation mechanism; and a controller, wherein the controller causes the first rotation mechanism and the second rotation mechanism to rotate a medical device at substantially the same speed, wherein the speed is greater than 500 rotations per minute. In an embodiment, the invention includes a method of coating a medical device including rotating a medical device with a rotation mechanism at a speed of greater than 500 rotations per minute; contacting the medical device with a fluid applicator; and applying a coating solution to the device. In an embodiment, the invention includes a medical device. In some embodiments a surface of a shaft of the device comprises high points and low points.

公开(公告)号：US20210220525A1

公开(公告)日：2021-07-22

申请号：US17161396

申请日：2021-01-28

申请人： Surmodics, Inc.

发明人： David E. Babcock

IPC分类号： A61L29/08 ,  A61L27/34 ,  A61L29/14 ,  A61L31/10

摘要： Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; and a first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.

公开(公告)号：US11020513B2

公开(公告)日：2021-06-01

申请号：US15866930

申请日：2018-01-10

申请人： Surmodics, Inc.

发明人： James Howard Arps ,  Andrew G. Bach

IPC分类号： A61L29/16 ,  A61L29/08 ,  A61M25/10 ,  A61L29/04 ,  A61L29/14 ,  A61K31/337

摘要： The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.

公开(公告)号：US10980918B2

公开(公告)日：2021-04-20

申请号：US15056478

申请日：2016-02-29

申请人： SurModics, Inc.

发明人： David E. Babcock ,  Timothy M. Kloke ,  Joseph S. McGonigle ,  Nathan Lockwood ,  Bruce Jelle

IPC分类号： A61L29/14 ,  A61L29/08 ,  C10M169/04 ,  C10M107/42 ,  A61L29/04 ,  C10M107/48 ,  C10M177/00 ,  C10M107/46 ,  C10M107/50 ,  B05D7/00 ,  C10M107/28 ,  C10M135/36 ,  C10N20/00 ,  C10N50/00

摘要： Embodiments of the disclosure include lubricious coatings. In an embodiment the disclosure includes a lubricious coating for a medical device including first and second coated layers. The first coated layer is between the second coated layer and the device surface and includes a vinyl pyrrolidone polymer and a photo reactive group. The second coated layer is in direct contact with the first coated layer and is a top coating that includes an acrylic acid polymer. The second coated layer can optionally include photoreactive groups. The coating was found to have a very low number of particulates (e.g., 10 μm or greater) which is very desirable for in vivo use.

公开(公告)号：US20210052878A1

公开(公告)日：2021-02-25

申请号：US17007770

申请日：2020-08-31

申请人： Surmodics, Inc.

发明人： Charles Olson

IPC分类号： A61M39/06 ,  A61B17/34

摘要： Aspects herein relate to a low-friction septum for providing a leak-resistant seal for use in a vascular access device. In an embodiment, a device for vascular access hemostasis is included having an enclosure defining a cavity and configured to at least partially receive a medical device. The device can include a first seal portion and a second seal portion, the cavity disposed between the first seal portion and the second seal portion. The device can include a barrel in structural communication with the second seal portion, the second seal portion including a septum seal. The second seal portion can define two or more discrete portions, each separated by one or more split lines. The discrete portions can include a mating surface to interface with mating surfaces of other discrete portions. The mating surface can include a surface topology including raised portions and depressions. Other embodiments are also included herein.

公开(公告)号：US10918835B2

公开(公告)日：2021-02-16

申请号：US15467530

申请日：2017-03-23

申请人： Surmodics, Inc.

发明人： Rick Murphy

IPC分类号： A61M25/01 ,  A61L29/08 ,  A61M25/10 ,  A61L29/04 ,  A61L29/06 ,  A61L29/14 ,  A61L29/16 ,  A61L29/18 ,  A61M25/06 ,  A61M25/00

摘要： Embodiments herein include delivery systems for active agent coated balloons and related methods. In an embodiment, a delivery system can include a tunneling sheath and a balloon catheter. The tunneling sheath can include a tubular shaft having an outer diameter and defining a lumen. The tunneling sheath can include a proximal collar defining a lumen. The balloon catheter can include a balloon catheter shaft disposed within the tubular shaft. The balloon catheter shaft can include a lumen for the passage of a fluid therein. The balloon catheter can include an expandable balloon disposed on the balloon catheter shaft. The balloon catheter shaft can include an active agent layer disposed on the expandable balloon. The position of the expandable balloon can be configured to be stationary relative to the tubular shaft as the delivery system is passed through a blood vessel of a patient. Other embodiments are also included herein.

公开(公告)号：US10745573B2

公开(公告)日：2020-08-18

申请号：US16378222

申请日：2019-04-08

申请人： Surmodics, Inc.

发明人： Aleksey V. Kurdyumov ,  Dale G. Swan

IPC分类号： C07F7/18 ,  C09D7/63 ,  A61L17/14 ,  A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  C07F7/10 ,  C07F9/12 ,  C07F9/145 ,  C07F9/40 ,  C08F2/48 ,  C07F9/06 ,  C08K5/51 ,  C08K5/5419 ,  C08K5/544

摘要： Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.

公开(公告)号：US10449180B2

公开(公告)日：2019-10-22

申请号：US15959589

申请日：2018-04-23

申请人： Surmodics, Inc.

发明人： Joram Slager

IPC分类号： A61K31/435 ,  A61K31/436 ,  A61K9/00 ,  A61K9/107 ,  A61K9/19 ,  A61K9/51 ,  A61L29/08 ,  A61L29/16 ,  A61K9/14 ,  A61K9/16

摘要： The disclosure provides macrolide particulates including a macrolide therapeutic agent such as rapamycin at high concentration in the particulate. In one method the particulates are made by adding a composition containing an polyoxyethylene sorbitan n-acyl ester, poly(ethyleneimine), or alkylated quaternary ammonium salt to a composition including macrolide dissolved in an alcohol such as ethanol. In another method the particulates are made by adding a non-solvent composition to a composition including macrolide and an alkyl-substituted chromanol dissolved in an alcohol such as ethanol. The formed macrolide particulates have one or more desirable properties including sizes in the range of 0.1 μm to 10 μm, spherical or near spherical shapes, low polydispersity, and/or stability. The macrolide particulates can be used for therapeutic compositions, or in association with an implantable or insertable medical device, such as associated with a polymeric coating on a device.

公开(公告)号：US10213529B2

公开(公告)日：2019-02-26

申请号：US13793390

申请日：2013-03-11

申请人： SurModics, Inc.

发明人： Joram Slager

IPC分类号： A61L29/16 ,  A61L29/08 ,  A61L29/14 ,  A61K31/337 ,  A61K9/50

摘要： Embodiments of the invention include devices and coatings for devices including coated hydrophobic active agent particles. In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a cationic agent in contact with the particulate hydrophobic therapeutic agent. Other embodiments are also included herein.