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    System and method of detecting and locating intermittent and other faults
    61.
    发明授权
    System and method of detecting and locating intermittent and other faults 有权
    断断续续故障检测定位系统及方法

    公开(公告)号：US09423443B2

    公开(公告)日：2016-08-23

    申请号：US14261642

    申请日：2014-04-25

    Applicant: Howard University

    Inventor： Charles J. Kim

    IPC: H04L12/26 ,  G06F15/00 ,  H04B10/08 ,  G01R31/02 ,  H04L25/02 ,  H04L27/02 ,  H04L27/10 ,  H04L27/18 ,  H04L12/24 ,  H04B10/077 ,  H04L1/24 ,  H04L1/00

    CPC classification number: G01R31/02 ,  H04B10/0771 ,  H04L1/243 ,  H04L25/0266 ,  H04L25/0268 ,  H04L27/02 ,  H04L27/10 ,  H04L27/18 ,  H04L41/0677 ,  H04L2001/0094 ,  Y04S40/166

    Abstract: Data associated with at least one building condition or status is sensed by one or more sensors. The data from these sensors may be sent over a data bus and received by the central computer. In addition, a modulated signal may be transmitted by one or both of the transmitters across the data bus. The modulated signal is received at the receiver, which analyzes the received modulated signal, and determines whether an intermittent fault has occurred on the data bus based upon the analyzing. For example, the receiver may compare the received signal to an expected pattern and when a discrepancy exists, an intermittent fault is determined to exist. The receiver may also determine the location of the fault based upon the analysis.

    Abstract translation: 与至少一个建筑物状况或状态相关联的数据由一个或多个传感器感测。 来自这些传感器的数据可以通过数据总线发送并由中央计算机接收。 此外，调制信号可以由数据总线中的一个或两个发射器发送。 在接收机处接收调制信号，该接收机分析接收到的调制信号，并基于分析确定数据总线上是否发生了间歇故障。 例如，接收机可以将接收到的信号与预期模式进行比较，并且当存在差异时，确定存在间歇性故障。 接收机还可以基于分析来确定故障的位置。

    Method Of Treating An Ocular Disease And Compositions Effective For Treating An Ocular Disease
    62.
    发明申请
    Method Of Treating An Ocular Disease And Compositions Effective For Treating An Ocular Disease 审中-公开
    治疗有效治疗眼病的眼病和组合物的方法

    公开(公告)号：US20150111833A1

    公开(公告)日：2015-04-23

    申请号：US14395384

    申请日：2013-03-15

    Applicant: Howard University

    Inventor： Pradeep K. Karla ,  Harpal S. Mangat

    IPC: A61K38/13 ,  A61K9/00 ,  A61K31/573 ,  A61K31/496 ,  A61K31/546

    CPC classification number: A61K38/13 ,  A61K9/0048 ,  A61K31/496 ,  A61K31/53 ,  A61K31/546 ,  A61K31/573 ,  A61K38/14 ,  A61K2300/00

    Abstract: Methods and compositions are provided for treating an ocular disease in a subject in need thereof by increasing the bioavailability of a drug in the subjects eye. By one approach, the ocular disease is endophthalmitis. The methods and compositions provided herein include an efflux transporter inhibitor and a drug effective for treating the ocular disease. The efflux transporter inhibitor is effective to reduce the efflux of the drug through at least one of Pglycoprotein (Pgp), breast cancer resistant protein (BCRP), and multidrug resistant associated protein 19 (MRP19). In one aspect, cyclosporine A is the efflux transporter inhibitor.

    Abstract translation: 提供了通过增加受试者眼睛中药物的生物利用度来治疗有需要的受试者的眼部疾病的方法和组合物。 通过一种方法，眼部疾病是眼内炎。 本文提供的方法和组合物包括外排转运蛋白抑制剂和有效治疗眼部疾病的药物。 流出转运蛋白抑制剂通过至少一种糖蛋白（Pgp），乳腺癌抗性蛋白（BCRP）和多药耐药相关蛋白19（MRP19）中的至少一种有效减少药物的流出。 一方面，环孢菌素A是外排转运蛋白抑制剂。

    System And Method Of Detecting And Locating Intermittent And Other Faults
    63.
    发明申请
    System And Method Of Detecting And Locating Intermittent And Other Faults 有权
    检测和定位间歇性和其他故障的系统和方法

    公开(公告)号：US20150008938A1

    公开(公告)日：2015-01-08

    申请号：US14261642

    申请日：2014-04-25

    Applicant: HOWARD UNIVERSITY

    Inventor： Charles J. KIM

    IPC: G01R31/02

    CPC classification number: G01R31/02 ,  H04B10/0771 ,  H04L1/243 ,  H04L25/0266 ,  H04L25/0268 ,  H04L27/02 ,  H04L27/10 ,  H04L27/18 ,  H04L41/0677 ,  H04L2001/0094 ,  Y04S40/166

    Abstract: Data associated with at least one building condition or status is sensed by one or more sensors. The data from these sensors may be sent over a data bus and received by the central computer. In addition, a modulated signal may be transmitted by one or both of the transmitters across the data bus. The modulated signal is received at the receiver, which analyzes the received modulated signal, and determines whether an intermittent fault has occurred on the data bus based upon the analyzing. For example, the receiver may compare the received signal to an expected pattern and when a discrepancy exists, an intermittent fault is determined to exist. The receiver may also determine the location of the fault based upon the analysis.

    Abstract translation: 与至少一个建筑物状况或状态相关联的数据由一个或多个传感器感测。 来自这些传感器的数据可以通过数据总线发送并由中央计算机接收。 此外，调制信号可以由数据总线中的一个或两个发射器发送。 在接收机处接收调制信号，该接收机分析接收到的调制信号，并基于分析确定数据总线上是否发生了间歇故障。 例如，接收机可以将接收到的信号与预期模式进行比较，并且当存在差异时，确定存在间歇性故障。 接收机还可以基于分析来确定故障的位置。

    Methods for treating virus infection or proliferation
    69.
    发明授权
    Methods for treating virus infection or proliferation 有权

    公开(公告)号：US11596623B2

    公开(公告)日：2023-03-07

    申请号：US17289558

    申请日：2019-10-29

    Applicant: HOWARD UNIVERSITY ,  GEORGETOWN UNIVERSITY

    Inventor： Hemayet Ullah ,  Sivanesan Dakshanamurthy

    IPC: A61K31/4196

    Abstract: A method for treating against, or at least inhibiting or suppressing, the proliferation of an internal ribosome entry site-utilizing virus (IRES-utilizing virus) involves administering a compound, a tautomer, or a pharmaceutically acceptable salt thereof, in an amount effective for inhibiting replication of the IRES-utilizing virus in cells, wherein the compound is represented by the formula: wherein each R1 is independent of the other and represents a halogen atom selected from the group consisting of bromo, chloro, fluoro and iodo.

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