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公开(公告)号：US09334540B2
公开(公告)日：2016-05-10
申请号：US14063534
申请日：2013-10-25
Applicant: Rosetta Genomics Ltd. , Mor Research Applications
Inventor： Yaron Goren , Shlomit Gilad , Moshe Hod , Yariv Yogev
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/158 , C12Q2600/178
Abstract: The present invention provides methods and compositions for identifying subjects at risk of developing a complication of pregnancy, such as preeclampsia or preterm labor. The compositions are microRNAs and associated nucleic acids.
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公开(公告)号：US20160103130A1
公开(公告)日：2016-04-14
申请号：US14881728
申请日：2015-10-13
Applicant: MOR RESEARCH APPLICATIONS LTD.
Inventor： Shmuel ARIAD , Jacob GOPAS , Daniel BENHARROCH , Irina LAZAREV
IPC: G01N33/574 , A61N5/10 , A61K45/06 , A61K39/165 , C12N7/00
CPC classification number: G01N33/57423 , A61K39/165 , A61K45/06 , A61K2039/525 , A61K2039/53 , A61K2039/54 , A61K2039/57 , A61K2039/585 , A61N5/10 , C07K14/005 , C12N7/00 , C12N2760/18422 , C12N2760/18432 , C12N2760/18434 , G01N1/30 , G01N33/57415 , G01N2333/12 , G01N2800/52
Abstract: The present invention provides methods for treating specific populations of cancer patients by immunotherapy. The methods comprise administering an immunogenic composition eliciting an immune response to measles virus to patients having measles virus-immunoreactive cancer cells.
Abstract translation: 本发明提供了通过免疫治疗来治疗癌症患者的特定群体的方法。 所述方法包括向具有麻疹病毒免疫反应性癌细胞的患者施用引发针对麻疹病毒的免疫应答的免疫原性组合物。
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63.发明申请公开(公告)号：US20160101063A1
公开(公告)日：2016-04-14
申请号：US14787515
申请日：2014-04-29
Applicant: MOR RESEARCH APPLICATIONS LTD.
Inventor： Moshe YESHURUN
CPC classification number: A61K31/05 , A61K9/0053 , A61K31/436 , A61K31/519 , A61K31/573 , A61K38/13 , A61K45/06 , A61K2300/00
Abstract: The invention provides methods for preventing, ameliorating and treating the acute and chronic forms of graft-versus-host disease (GVHD) by using Cannabidiol compositions.
Abstract translation: 本发明提供了通过使用大麻素组合物预防，改善和治疗急性和慢性形式的移植物抗宿主病（GVHD）的方法。
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公开(公告)号：US20140316207A1
公开(公告)日：2014-10-23
申请号：US14114692
申请日：2012-05-08
Applicant: MOR RESEARCH APPLICATIONS LTD.
Inventor： Moshe Hain
CPC classification number: A61B1/267 , A61B1/00073 , A61B1/00082 , A61B1/00105 , A61M16/0459 , A61M16/0488
Abstract: A flexible laryngoscope (10) is disclosed, comprising a flexible body with a plurality of longitudinal channels (150) therethrough, an external groove (110) for an intubation tube, and two inflatable zones (120,130). The laryngoscope is adapted to be inserted intra-orally and to sit in place in the upper hypopharynx and oral cavity in a bent fashion. The laryngoscope is used as a platform for microsurgery by passing flexible microsurgery tools through the channels. In preferred embodiments of the invention, the laryngoscope body comprises a flexible corrugated intermediate portion (102) that allows the body to be bent to fit within the patient's hypopharynx and oral cavity. The inflatable zones are adapted to allow the laryngoscope to be fixed in place when they are inflated.
Abstract translation: 公开了一种灵活的喉镜（10），包括具有穿过其中的多个纵向通道（150）的柔性主体，用于插管的外部凹槽（110）和两个可充气区域（120,130）。 喉镜适于插入口腔内，并以弯曲的方式坐在上咽下和口腔中。 通过通过通过灵活的显微外科手术工具，将喉镜用作显微手术的平台。 在本发明的优选实施例中，喉镜主体包括柔性波纹状中间部分（102），其允许身体弯曲以适合患者的下咽和口腔。 充气区域适于使喉镜在充气时固定就位。
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65.发明申请公开(公告)号：US20140303233A1
公开(公告)日：2014-10-09
申请号：US14201970
申请日：2014-03-10
Applicant: Ben-Gurion University of the Negev Research and Development Authority , Mor Research Applications Ltd.
Inventor： Rachel LEVY
IPC: C12N15/113
CPC classification number: C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2320/30 , C12Y301/01004
Abstract: Antisense oligonucleotides against cPLA2 are provided, which are capable of inhibiting cPLA2 expression as well as superoxide production, especially in phagocytes. These antisense oligonucleotides are powerful agents for the treatment of inflammatory conditions, in particular arthritis, as well as in neurodegenerative diseases. The antisense oligonucleotides or compositions comprising the same may be used in methods of treatment of such diseases.
Abstract translation: 提供了针对cPLA2的反义寡核苷酸，其能够抑制cPLA2表达以及超氧化物的产生，特别是在吞噬细胞中。 这些反义寡核苷酸是用于治疗炎性病症，特别是关节炎以及神经变性疾病的强力药剂。 反义寡核苷酸或包含其的组合物可用于治疗这些疾病的方法中。
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Patent Agency Ranking
公开(公告)号：US20140087967A1
公开(公告)日：2014-03-27
申请号：US14063534
申请日：2013-10-25
Applicant: Mor Research Applications , Rosetta Genomics Ltd.
Inventor： Yaron GOREN , Shlomit Gilad , Moshe Hod , Yariv Yogev
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/158 , C12Q2600/178
Abstract: The present invention provides methods and compositions for identifying subjects at risk of developing a complication of pregnancy, such as preeclampsia or preterm labor. The compositions are microRNAs and associated nucleic acids.
Abstract translation: 本发明提供了用于鉴定发生怀孕并发症风险的受试者的方法和组合物，例如先兆子痫或早产。 组合物是微小RNA和相关核酸。
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公开(公告)号：US20240398330A1
公开(公告)日：2024-12-05
申请号：US18695851
申请日：2022-09-29
Applicant: A.Y.Y.T. - TECHNOLOGICAL APPLICATIONS AND DATA UPDATE LTD , Mor Research Applications Ltd.
Inventor： Michal Balberg , Jonathan Rubin , Avihai Aharon , Heftsi Ragones , Yael Avni , Daniil Umansky , Hagit Shoffel Havakuk , Saja Assi
Abstract: Disclosed herein is a multi-modal sensor system, including a wearable device configured to receive signals relating to a swallowing process of a subject, the wearable device including one or more surface Electromyograph sensors configured to receive signals relating to electrical potential in muscles of the throat, one or more bio-impedance sensors, one or more memories, one or more processors configured to operate one or more sensors of the wearable device, synchronize the signals to one or more predetermined events to generate a synchronization feature, receive the signals as a first diagnostic data set, analyze the first diagnostic data set, assess, based on the analysis, the swallowing process of the subject to yield an assessment output, and present the assessment output and determine a bio-impedance signal.
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公开(公告)号：US12006357B2
公开(公告)日：2024-06-11
申请号：US17255796
申请日：2019-06-26
Applicant: Mor Research Applications Ltd.
Inventor： Michael Fassler , Jacob George
CPC classification number: C07K16/18 , A61K49/0008 , A61P9/00 , G01N33/6893 , C07K2317/14 , C07K2317/76
Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human transthyretin (TTR). The anti-TTR antibodies or antigen-binding fragments thereof are useful, for example, in detecting TTR and in treating TTR amyloidosis in a subject.
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公开(公告)号：US11925643B2
公开(公告)日：2024-03-12
申请号：US17057845
申请日：2019-05-23
Applicant: MOR RESEARCH APPLICATIONS LTD. , BAR ILAN UNIVERSITY
Inventor： Edith Hochhauser , Arie-Lev Gruzman , Elena Trifonov
IPC: A61K31/513 , A61K38/06 , A61K38/07 , A61P9/10 , C07D239/47 , C07K5/083 , C07K5/087 , C07K5/103 , C07K5/107 , C07K5/113
CPC classification number: A61K31/513 , A61K38/06 , A61K38/07 , A61P9/10 , C07D239/47 , C07K5/0808 , C07K5/0812 , C07K5/1008 , C07K5/101 , C07K5/1016 , C07K5/1021
Abstract: Peptides, peptidomimetics and small molecules, collectively referred to as “decoy peptides”, are provided, which interfere with binding to a TIR domain of a toll-like receptor 4 (TLR4), and inhibit a TLR4-induced signaling pathway. These decoy peptides may be useful for treating diseases associated with induction of TLR4 signaling pathway such as a disease or disorder secondary to a cardiovascular disease, sepsis or an inflammatory disease.
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公开(公告)号：US20230237848A1
公开(公告)日：2023-07-27
申请号：US18009798
申请日：2021-06-21
Applicant: MOR RESEARCH APPLICATIONS LTD.
Inventor： Menahem CHOURAQUI
CPC classification number: G06V40/197 , G06V40/171 , G06V10/70 , G06Q40/08
Abstract: Embodiments pertain to a method for characterizing a droopy upper eyelid performed on a computer having a processor, memory, and one or more code sets stored in the memory and executed in the processor. The method may comprise capturing an image of a patient's facial features comprising an eye and a droopy upper eyelid; identifying at least one geometric feature of a pupil of the eye within the image; and determining, based on the at least one geometric feature, whether the droopy upper eyelid is vision impairing or not, or whether the droopy upper eyelid is more likely vision impairing than not vision-impairing.
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