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61.发明授权Microparticles with adsorbent surfaces, methods of making same, and uses thereof 失效具有吸附剂表面的微粒，其制备方法及其用途公开(公告)号：US06884435B1
公开(公告)日：2005-04-26
申请号：US09581772
申请日：1999-07-29
Applicant: Derek O'Hagan , Manmohan Singh , Gary Ott
Inventor： Derek O'Hagan , Manmohan Singh , Gary Ott
IPC: A61K9/00 , A61K9/16 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/245 , A61K39/39 , A61K9/14 , A61K31/70 , C07H21/00 , C12N15/00
CPC classification number: A61K39/245 , A61K9/1647 , A61K9/167 , A61K39/12 , A61K39/21 , A61K39/39 , A61K2039/53 , A61K2039/543 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , C12N2740/16111 , C12N2740/16134 , C12N2740/16234 , C12N2770/24211 , C12N2770/24234
Abstract: The present invention is directed to microparticles, to microparticle compositions containing the same, to methods of forming the same, and to uses for the same, including use for a vaccine, for raising an immune response, for treatment of a disease and for diagnosis of a disease. The microparticles comprise a biodegradable polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, or a polycyanoacrylate, and a detergent selected from a cationic detergent and an anionic detergent. The microparticles further comprise an antigen adsorbed on the surface of the microparticle.
Abstract translation: 本发明涉及微粒，含有该微粒的微粒组合物，其形成方法及其用途，包括用于疫苗的用途，用于提高免疫应答，治疗疾病和诊断疾病 疾病。 微粒包括可生物降解的聚合物，例如聚（α-羟基酸），多羟基丁酸，聚己内酯，聚原酸酯，聚酐或聚氰基丙烯酸酯，以及选自阳离子洗涤剂和阴离子洗涤剂的洗涤剂。 微粒还包含吸附在微粒表面上的抗原。
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公开(公告)号：US06458370B1
公开(公告)日：2002-10-01
申请号：US09935466
申请日：2001-08-20
Applicant: Derek O'Hagan , Gary Van Nest , Gary S. Ott , Manmohan Singh
Inventor： Derek O'Hagan , Gary Van Nest , Gary S. Ott , Manmohan Singh
IPC: A61K3900
CPC classification number: A61K39/29 , A61K9/1075 , A61K9/1647 , A61K39/12 , A61K39/21 , A61K39/39 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/575 , C12N2740/16134 , C12N2770/24234 , Y02A50/401 , Y02A50/412 , Y10S977/802 , Y10S977/915 , Y10S977/918
Abstract: Compositions are provided which include biodegradable microparticles with entrapped or adsorbed antigens, in combination with submicron oil-in-water emulsions. Also provided are methods of immunization which comprise administering to a vertebrate subject (a) a submicron oil-in-water emulsion, and (b) a therapeutically effective amount of a selected antigen entrapped in a microparticle.
Abstract translation: 提供了包含与亚微米水包油乳剂组合的具有包埋或吸附的抗原的可生物降解的微粒的组合物。 还提供了免疫方法，其包括给予脊椎动物受试者（a）亚微米水包油乳剂，和（b）治疗有效量的包埋在微粒中的选择的抗原。
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公开(公告)号：US6086901A
公开(公告)日：2000-07-11
申请号：US15736
申请日：1998-01-29
Applicant: Derek O'Hagan , Gary Van Nest , Gary S. Ott , Manmohan Singh
Inventor： Derek O'Hagan , Gary Van Nest , Gary S. Ott , Manmohan Singh
IPC: A61K9/00 , A61K9/107 , A61K9/16 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/29 , A61K39/39 , A61P31/00 , A61P31/12 , A61P37/04 , A61K7/08 , A61K45/00 , A61K47/44
CPC classification number: A61K39/29 , A61K39/12 , A61K39/21 , A61K39/39 , A61K9/1075 , A61K9/1647 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/575 , C12N2740/16134 , C12N2770/24234 , Y10S977/802 , Y10S977/915 , Y10S977/918
Abstract: Compositions are provided which include biodegradable microparticles with entrapped or adsorbed antigens, in combination with submicron oil-in-water emulsions. Also provided are methods of immunization which comprise administering to a vertebrate subject (a) a submicron oil-in-water emulsion, and (b) a therapeutically effective amount of a selected antigen entrapped in a microparticle.
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公开(公告)号：US11291635B2
公开(公告)日：2022-04-05
申请号：US13808089
申请日：2011-07-06
Applicant: Andrew Geall , Christian Mandi , Derek O'Hagan , Manmohan Singh
Inventor： Andrew Geall , Christian Mandi , Derek O'Hagan , Manmohan Singh
IPC: A61K9/50 , A61K39/155 , A61K39/245 , C12N15/86 , C12N15/88 , A61K39/12 , A61K9/127 , A61K9/00 , A61K39/00
Abstract: Nucleic acid immunisation is achieved by delivering a self-replicating RNA encapsulated within a small particle. The RNA encodes an immunogen of interest, and the particle may deliver this RNA by mimicking the delivery function of a natural RNA virus. Thus the invention provides a non-virion particle for in vivo delivery of RNA to a vertebrate cell, wherein the particle comprises a delivery material encapsulating a self-replicating RNA molecule which encodes an immunogen. These particles are useful as components in pharmaceutical compositions for immunising subjects against various diseases.
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公开(公告)号：US10602923B2
公开(公告)日：2020-03-31
申请号：US16112649
申请日：2018-08-25
Applicant: Manish Dinkarrao Kulkarni , Manmohan Singh Sidhu
Inventor： Manish Dinkarrao Kulkarni , Manmohan Singh Sidhu
Abstract: There is a need for robust and portable system, and apparatus for ophthalmology. We propose use of foldable ophthalmic system. Our system will have a chin-rest (or face-rest or forehead rest) that can be folded so that the ocular device could be transported in a brief-case type casing. Our system can be used for many modalities including optical coherence tomography.
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Patent Agency Ranking
公开(公告)号：US20170347873A1
公开(公告)日：2017-12-07
申请号：US15624689
申请日：2017-06-15
Applicant: Manish Dinkarrao Kulkarni , Manmohan Singh Sidhu
Inventor： Manish Dinkarrao Kulkarni , Manmohan Singh Sidhu
CPC classification number: A61B3/0083 , A61B3/0033 , A61B3/0041 , A61B3/102 , A61B34/25 , A61B2560/0431
Abstract: There is a need for robust and portable system, and apparatus for ophthalmology. We propose use of foldable ophthalmic system. Our system will have a chin-rest (or face-rest or forehead rest) that can be folded so that the ocular device could be transported in a brief-case type casing. Our system can be used for many modalities including optical coherence tomography.
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公开(公告)号：US09247869B2
公开(公告)日：2016-02-02
申请号：US13744415
申请日：2013-01-18
Applicant: Manish Dinkarrao Kulkarni , Manmohan Singh Sidhu
Inventor： Manish Dinkarrao Kulkarni , Manmohan Singh Sidhu
CPC classification number: A61B3/0083 , A61B3/0033 , A61B3/0041 , A61B3/102 , A61B34/25 , A61B2560/0431
Abstract: There is a need for robust and portable system, and apparatus for ophthalmology. We propose use of folding apparatus for ocular purposes for the first time. Our system will have a chin-rest (or face-rest or forehead rest) that can be folded so that the ocular device could be transported in a brief-case type casing.
Abstract translation: 需要强大的便携式系统和用于眼科的装置。 我们建议首次使用折叠装置进行目视。 我们的系统将具有可以折叠的下颚休息（或平面休息或前额休息），使得眼睛装置可以在短型壳体中运输。
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68.发明授权Immunogenic compositions containing anthrax antigen, biodegradable polymer microparticles, and polynucleotide-containing immunological adjuvant 有权含有炭疽抗原，可生物降解的聚合物微粒和含多核苷酸的免疫佐剂的免疫原性组合物公开(公告)号：US09107813B2
公开(公告)日：2015-08-18
申请号：US11667642
申请日：2005-11-15
Applicant: Derek T. O'Hagan , Manmohan Singh , Dennis M. Klinman
Inventor： Derek T. O'Hagan , Manmohan Singh , Dennis M. Klinman
CPC classification number: A61K9/0019 , A61K9/1647 , A61K9/167 , A61K39/00 , A61K39/07 , A61K2039/55555 , A61K2039/55561
Abstract: Immunogenic compositions and kits, as well as methods of stimulating immune responses and methods of immunization using the same. The compositions and kits comprise: (a) an antigen derived from Bacillus anthracis; (b) polymer microparticles comprising a biodegradable polymer; and (c) a polynucleotide-containing immunological adjuvant.
Abstract translation: 免疫原性组合物和试剂盒，以及刺激免疫应答的方法和使用其免疫的方法。 组合物和试剂盒包括：（a）源自炭疽芽孢杆菌的抗原; （b）包含可生物降解聚合物的聚合物微粒; 和（c）含有多核苷酸的免疫佐剂。
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公开(公告)号：US20140220083A1
公开(公告)日：2014-08-07
申请号：US14130886
申请日：2012-07-06
Applicant: Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
Inventor： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
CPC classification number: A61K39/39 , A61K9/1075 , A61K39/12 , A61K39/155 , A61K39/245 , A61K47/02 , A61K47/06 , A61K47/12 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/34 , A61K2039/5256 , A61K2039/53 , A61K2039/55555 , A61K2039/55566 , A61K2039/575 , C12N7/00 , C12N2710/16134 , C12N2710/16171 , C12N2710/16734 , C12N2710/16771 , C12N2760/18534 , C12N2760/18571 , C12N2770/36134 , C12N2770/36143 , C12N2840/203 , Y02A50/386 , Y02A50/388 , Y02A50/412
Abstract: This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are useful for delivering negatively charged molecules, such as nucleic acid molecules to cells, and for formulating nucleic acid-based vaccines.
Abstract translation: 本发明一般涉及含有高浓度阳离子脂质并具有确定的油脂比例的阳离子水包油乳剂。 阳离子脂质可以与带负电荷的分子相互作用，从而将分子固定在乳液颗粒上。 本文所述的阳离子乳液可用于将带负电荷的分子（例如核酸分子）递送至细胞，以及配制基于核酸的疫苗。
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公开(公告)号：US20140212498A1
公开(公告)日：2014-07-31
申请号：US14130880
申请日：2012-07-06
Applicant: Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
Inventor： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
IPC: A61K9/107 , A61K31/713
CPC classification number: A61K9/107 , A61K9/0019 , A61K31/713 , A61K39/12 , A61K39/155 , A61K2039/53 , A61K2039/55566 , C12N2760/18534 , Y02A50/412
Abstract: This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The emulsion particles have an average diameter of about 80 nm to about 180 nm, and the emulsion have an N/P ratio of at least 1.1:1.
Abstract translation: 本发明一般涉及可用于递送核酸分子（例如RNA分子）的阳离子水包油乳液。 乳剂颗粒包含油芯和阳离子脂质。 乳剂颗粒的平均直径为约80nm至约180nm，乳液的N / P比至少为1.1:1。
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