公开(公告)号：US20220077936A1

公开(公告)日：2022-03-10

申请号：US17481904

申请日：2021-09-22

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Yossef EHRLICHMAN ,  Ofer AMRANI ,  Shlomo RUSCHIN

IPC: H04B10/516 ,  G02F1/01 ,  G02F7/00 ,  G02F1/225 ,  H04B10/50 ,  H04B10/25 ,  H04B10/2575 ,  H04B10/556 ,  H03M1/70 ,  H04B10/54 ,  H03M1/00

Abstract: In a system for converting digital data into a modulated optical signal, an electrically controllable device having M actuating electrodes provides and optical signal that is modulated in response to binary voltages applied to the actuating electrodes. A digital-to-digital converter provides a mapping of input data words to binary actuation vectors for M bits and supplies the binary actuation vectors as M bits of binary actuation voltages to the M actuating electrodes, where M is larger than the number of bits in each input data word. The digital-to-digital converter maps each digital input data word to a binary actuation vector by selecting a binary actuation vector from a subset of binary actuation vectors available to represent each of the input data words.

公开(公告)号：US11241507B2

公开(公告)日：2022-02-08

申请号：US16616336

申请日：2018-05-23

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Doron Shabat ,  Ori Green

IPC: A61B5/00 ,  A61B8/00 ,  A61B10/00 ,  A61K49/00 ,  C07D407/10

Abstract: The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which emit light in the near-infrared (NIR) region and are therefore useful for in vivo imaging, as well as compositions and uses thereof.

公开(公告)号：US11236344B2

公开(公告)日：2022-02-01

申请号：US15985082

申请日：2018-05-21

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Tamir Tuller ,  Hadas Zur ,  Rachel Cohen-Kupiec

IPC: C12N15/67 ,  C12Q1/6809 ,  C12N15/79

Abstract: Genetically modified cells with at least one codon substituted to a synonymous codon, and with modified replicative fitness as compared to the unmodified cell, wherein a slower translating synonymous codon increases replicative fitness and a faster translating codon decreased replicative fitness are provided. Further, vaccine composition comprising those cells as well as methods for modifying replicative fitness of a cell are provided.

公开(公告)号：US20220012892A1

公开(公告)日：2022-01-13

申请号：US17487082

申请日：2021-09-28

Applicant: Ramot at Tel-Aviv University Ltd. ,  Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Yitzhak AVITAL ,  Nahum KIRYATI ,  Eli KONEN ,  Arnaldo MAYER

IPC: G06T7/11 ,  A61B34/20 ,  A61B34/32 ,  A61B5/00 ,  A61B5/055 ,  G01R33/56 ,  G06N3/08

Abstract: There is provided a computer implemented method of automatic segmentation of three dimensional (3D) anatomical region of interest(s) (ROI) that includes predefined anatomical structure(s) of a target individual, comprising: receiving 3D images of a target individual, each including the predefined anatomical structure(s), each 3D image is based on a different respective imaging modality. In one implementation, each respective 3D image is inputted into a respective processing component of a multi-modal neural network, wherein each processing component independently computes a respective intermediate, and the intermediate outputs are inputted into a common last convolutional layer(s) for computing the indication of segmented 3D ROI(s). In another implementation, each respective 3D image is inputted into a respective encoding-contracting component a multi-modal neural network, wherein each encoding-contracting component independently computes a respective intermediate output. The intermediate outputs are inputted into a single common decoding-expanding component for computing the indication of segmented 3D ROI(s).

公开(公告)号：US20210395312A1

公开(公告)日：2021-12-23

申请号：US17467297

申请日：2021-09-06

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ehud GAZIT ,  Kai TAO ,  Yu CHEN ,  Sharon GILEAD ,  Sigal LAZAR ,  Pandeeswar MAKAM

IPC: C07K7/64

Abstract: Self-assembled structures formed of a plurality of cyclic peptides which are in association with metal ions is provided. The cyclic peptides are each of from 2 to 6 amino acid residues, and two or more of the amino acid residues are each independently an aromatic amino acid residue. The self-assembled structures exhibit photoluminescence and can be used or incorporated in light emitting systems.

公开(公告)号：US20210371906A1

公开(公告)日：2021-12-02

申请号：US17400168

申请日：2021-08-12

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Yuval EBENSTEIN ,  Micha FRIDMAN

IPC: C12Q1/6806 ,  C12P19/30

Abstract: Methodologies for labeling the epigenetic modification 5-hydroxymethyl-cytosine (5hmC) along a DNA molecule, and for determining a presence or a level of this epigenetic modification based on a ratio of fluorescence intensity of a labeled DNA sample to absorption intensity of the DNA sample at 260 nm are disclosed. Related compositions and reagents, and methods of preparing same are also disclosed.

公开(公告)号：US20210361717A1

公开(公告)日：2021-11-25

申请号：US17394008

申请日：2021-08-04

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Daniel OFFEN ,  Nisim PERETS

IPC: A61K35/28 ,  A61P25/28 ,  A61P25/18 ,  A61K9/00 ,  A61K9/127

Abstract: A method of treating a neurological disease (such as autism) in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of microparticles derived from mesenchymal stem cells.

公开(公告)号：US11181804B2

公开(公告)日：2021-11-23

申请号：US16631464

申请日：2018-07-17

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Haim Suchowski ,  Asaf Dahan ,  Assaf Levanon

IPC: G02F1/355 ,  G02F1/37 ,  G02F1/377 ,  G02F1/35 ,  H01S3/00

Abstract: A system for frequency conversion, comprises a laser source and a harmonic generation crystal. The laser source is configured to produce optical pulse energy of less than 100 μJ. The harmonic generation crystal comprises a structure characterized by a nonlinear susceptibility, and a crystal grating period which adiabatically varies along the longitudinal direction in a manner that the crystal grating period is inversely proportional to a crystal grating function of a coordinate z measured along the longitudinal direction.

公开(公告)号：US11142496B2

公开(公告)日：2021-10-12

申请号：US16303604

申请日：2017-05-21

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ehud Gazit ,  Ludmila Buzhansky ,  Michael Ioffe ,  Alon Sayer

IPC: C07C403/24 ,  C07C45/60 ,  C07C67/00 ,  A61K9/00 ,  A61K31/015 ,  A61K47/10 ,  A61K47/14 ,  A61K47/24 ,  A61K47/44 ,  C07C67/44 ,  C07C403/02 ,  C07C403/00

Abstract: The present invention relates to a method for total chemical synthesis of 9-cis-β-carotene (9CBC), and further provides stable formulations thereof.

公开(公告)号：US20210271730A1

公开(公告)日：2021-09-02

申请号：US16800500

申请日：2020-02-25

Applicant: International Business Machines Corporation ,  Trustees of Tufts College ,  Ramot at Tel Aviv University Ltd.

Inventor： Lior Horesh ,  Misha Elena Kilmer ,  Haim Avron ,  Jiani Zhang

IPC: G06F17/13 ,  G06F16/28 ,  G06F17/15 ,  G06F17/16 ,  G06F16/2458

Abstract: An illustrative embodiment includes a method for solving a dynamical system. The method comprises: obtaining multidimensional snapshots representing respective discrete solutions of the dynamical system; storing the multidimensional snapshots within a snapshot tensor having an order of at least three; generating a basis for at least a subspace of a state space of the dynamical system at least in part by performing a decomposition of the snapshot tensor; deriving a reduced order model at least in part by using the basis to project the dynamical system from the state space onto the subspace; and solving the reduced order model of the dynamical system.