公开(公告)号：US20220412991A1

公开(公告)日：2022-12-29

申请号：US17891458

申请日：2022-08-19

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dirk Block ,  Roberto Latini ,  Serge Masson ,  Ursula-Henrike Wienhues-Thelen ,  Christian Zaugg

IPC: G01N33/68 ,  A61B5/055 ,  A61B8/08

Abstract: The present invention relates to a method for assessing whether a subject shall be subjected to an imaging based diagnostic assessment. The method is based on the determination of the amount(s) of a cardiac Troponin and/or Fibroblast Growth Factor 23 (FGF-23) in a sample from the subject, and on the comparison of the, thus, determined amount(s) with a reference amount (reference amounts). The present invention also relates to a system for performing an assessment whether a subject shall be subjected to an imaging based diagnostic assessment and to reagents and kits used in performing the methods disclosed herein. Moreover, the present invention is directed to a method for predicting the risk of mortality and/or of a cardiovascular event. Also encompassed is a method for diagnosing an early stage of LVH in a subject having a preserved left ventricular ejection.

公开(公告)号：US11530943B2

公开(公告)日：2022-12-20

申请号：US17066692

申请日：2020-10-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Stefan Quint ,  Dieter Kempken

IPC: G01F25/20 ,  G01F3/22 ,  G01N35/10

Abstract: An automated method for detecting and/or monitoring a state of a degasser of an analyzer is provided, the degasser including a container configured to be evacuated. The method includes obtaining a time series of values indicative of pressures inside the container. The time series spans a period during which the container is evacuated or pressurized. The method further includes determining a liquid level state of the degasser which is determined by an amount of liquid present in the container based on the time series.

公开(公告)号：US20220391799A1

公开(公告)日：2022-12-08

申请号：US17825682

申请日：2022-05-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Chloe de Magalhaes ,  José Carlos Pérez Pérez ,  Yasser Mohamed Reda Abdelgawad Ibrahim

IPC: G06Q10/06

Abstract: A method of automatically customizing user training on a laboratory system is presented. The method comprises retrieving a configuration file of the laboratory system, logging into the laboratory system by a laboratory user, identifying and authenticating the laboratory user for use and training on the laboratory system, after the laboratory user is identified and authenticated by the laboratory system, retrieving training credentials required for that laboratory user for the laboratory system based on a user profile of the laboratory user, and based on the training credentials of the laboratory user, automatically assigning training material required for the laboratory user to use the laboratory system based on the training credentials of the laboratory user and the configuration file of the laboratory system and loading the assigned training material.

公开(公告)号：US20220373379A1

公开(公告)日：2022-11-24

申请号：US17660966

申请日：2022-04-27

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christopher Espy

IPC: G01F23/292 ,  G01N15/04 ,  G01N15/05 ,  G01N35/04

Abstract: An apparatus for determining a vertical position of at least one interface between a first component and at least one second component, the components comprised as different layers in a sample container. The apparatus comprises a first sensing unit and a first light detector configured to generate a first sensing signal, a second sensing unit comprising a second light detector configured to generate a second sensing signal, a driving unit configured to move the sample container, a position sensing unit configured to output a position sensing signal indicative of a vertical position of the sample container, a vertical position determining unit configured to match the first and the second sensing signal such that first and the second sensing signal correspond to identical vertical positions, and to determine the vertical position of the at least one interface in response to the matched sensing signals and the position sensing signal.

公开(公告)号：US20220371020A1

公开(公告)日：2022-11-24

申请号：US17660763

申请日：2022-04-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Avinash Addihalli Narayana ,  Tobias Huber

IPC: B01L9/06

Abstract: The present disclosure relates to a laboratory sample container carrier handling apparatus comprising a revolving device, being adapted to move a sample container carrier supplied to the revolving device along a circular path P, and wherein the circular path P has at least one ascending ramp. The present disclosure relates further to a laboratory sample distribution system comprising such a laboratory sample container carrier handling apparatus.

公开(公告)号：US20220355303A1

公开(公告)日：2022-11-10

申请号：US17660299

申请日：2022-04-22

Applicant: Roche Diagnostics Operations, Inc

Inventor： Angelos Chotzidis ,  Stefan Soentges ,  Hans van Mierlo

IPC: B01L9/06 ,  G01N35/00 ,  B01L9/00

Abstract: A preanalytic system is disclosed. The preanalytic system comprises a cap gripper configured to grip a cap of a laboratory sample container, wherein the cap is connected to a rod of a swab located within the laboratory sample container, wherein the cap gripper is further configured to release the cap from the laboratory sample container, and a cutting device configured to cut the rod of the swab when the cap is in a position released from the laboratory sample container.

公开(公告)号：US20220317119A1

公开(公告)日：2022-10-06

申请号：US17838568

申请日：2022-06-13

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Toralf ZARNT ,  Dieter HEINDL ,  Alfons NICHTL ,  Frank SICHERL-BIRK

IPC: G01N33/543

Abstract: Disclosed is a method for measurement of an analyte in a microparticle-based analyte-specific binding assay, wherein the microparticles are coated with the first partner of a binding pair, the method involving mixing the coated microparticles, an analyte-specific binding agent conjugated to the second partner of the binding pair, and a sample suspected of containing or containing the analyte, wherein the second partner of the binding pair is bound to the analyte-specific binding agent via a linker having from 12 to 30 ethylene glycol units (PEG 12 to 30), thereby binding the analyte via the conjugated analyte-specific binding agent to the coated microparticles, separating the microparticles having the analyte bound via the binding pair and the analyte-specific binding agent from the mixture and measuring the analyte bound to the microparticles.

公开(公告)号：US11454634B2

公开(公告)日：2022-09-27

申请号：US15911699

申请日：2018-03-05

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dirk Block ,  Roberto Latini ,  Serge Masson ,  Ursula-Henrike Wienhues-Thelen ,  Christian Zaugg

IPC: G01N33/68 ,  A61B5/055 ,  A61B8/08

Abstract: The present invention relates to a method for assessing whether a subject shall be subjected to an imaging based diagnostic assessment. The method is based on the determination of the amount(s) of a cardiac Troponin and/or Fibroblast Growth Factor 23 (FGF-23) in a sample from the subject, and on the comparison of the, thus, determined amount(s) with a reference amount (reference amounts). The present invention also relates to a system for performing an assessment whether a subject shall be subjected to an imaging based diagnostic assessment and to reagents and kits used in performing the methods disclosed herein. Moreover, the present invention is directed to a method for predicting the risk of mortality and/or of a cardiovascular event. Also encompassed is a method for diagnosing an early stage of LVH in a subject having a preserved left ventricular ejection.

公开(公告)号：US20220293404A1

公开(公告)日：2022-09-15

申请号：US17805133

申请日：2022-06-02

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Andrea Geistanger ,  Daniel Intelmann ,  Shirin Shahriari ,  Anton Hilger

IPC: H01J49/00

Abstract: A method for calibrating at least one mass spectrometry device having a first defined hardware configuration comprises at least one manufacturer-site pre-calibration step establishing at least one reference calibration function fp for a generic type of mass spectrometry devices having a second defined hardware configuration, wherein the second defined hardware configuration is equivalent to the first defined hardware configuration, wherein the reference calibration function fp describes a relationship of at least one concentration c of at least one analyte in at least one calibrator sample, wherein the reference calibration function fp is a parametrized function fp(concentration), with p=(p1,p2, . . . pn) being a set of parameters of the reference calibration function and n being a positive integer; determining calibration values {circumflex over (p)}=({circumflex over (p)}1,{circumflex over (p)}2, . . . {circumflex over (p)}n) for the set of parameters of the reference calibration function for the generic type of mass spectrometry devices.

公开(公告)号：US20220280938A1

公开(公告)日：2022-09-08

申请号：US17804013

申请日：2022-05-25

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Thorsten Brueckner ,  Sascha Lutz

IPC: B01L3/00 ,  G01N30/74

Abstract: A method of performing an optical measurement of an analyte in a processed biological sample using a cartridge is provided. The cartridge is operable for being spun around a rotational axis. The method comprises: placing the biological sample into a sample inlet; controlling the rotational rate of the cartridge to process a biological sample into the processed biological sample using a fluidic structure; controlling the rotational rate of the cartridge to allow the processed biological sample to flow from the measurement structure inlet to an absorbent structure via a chromatographic membrane, and performing an optical measurement of a detection zone on the chromatographic membrane with an optical instrument. An inlet air baffle reduces evaporation of the processed biological sample from the chromatographic membrane during rotation of the cartridge.