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    MEASUREMENT OF AN ANLYTE WITH A CARTRIDGE
    1.
    发明申请
    MEASUREMENT OF AN ANLYTE WITH A CARTRIDGE 有权

    公开(公告)号：US20220280938A1

    公开(公告)日：2022-09-08

    申请号：US17804013

    申请日：2022-05-25

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Christoph Boehm ,  Thorsten Brueckner ,  Sascha Lutz

    IPC: B01L3/00 ,  G01N30/74

    Abstract: A method of performing an optical measurement of an analyte in a processed biological sample using a cartridge is provided. The cartridge is operable for being spun around a rotational axis. The method comprises: placing the biological sample into a sample inlet; controlling the rotational rate of the cartridge to process a biological sample into the processed biological sample using a fluidic structure; controlling the rotational rate of the cartridge to allow the processed biological sample to flow from the measurement structure inlet to an absorbent structure via a chromatographic membrane, and performing an optical measurement of a detection zone on the chromatographic membrane with an optical instrument. An inlet air baffle reduces evaporation of the processed biological sample from the chromatographic membrane during rotation of the cartridge.

    Cartridge with a rotatable lid
    2.
    发明授权
    Cartridge with a rotatable lid 有权

    公开(公告)号：US10086373B2

    公开(公告)日：2018-10-02

    申请号：US15352698

    申请日：2016-11-16

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Christoph Boehm ,  Sascha Lutz ,  Juergen Spinke ,  Thorsten Brueckner

    IPC: B01L3/00 ,  G01N35/00 ,  G01N21/07 ,  G01N21/64 ,  G01N21/03

    Abstract: An automatic analyzer cartridge, spinnable around a rotational axis, has a support structure with a front face perpendicular to the rotational axis, a fluidic structure for processing a biological sample into the processed biological sample, a measurement structure with at least one detection zone on the front face, and a rotatable lid covering the front face. The rotatable lid is rotatable about the rotational axis relative to the support structure from a first position relative to the support structure to a second position relative to the support structure. The rotatable lid has a sample inlet opening and a detection zone opening. In the first position, a sample inlet is aligned with the sample inlet opening and the measurement structure is covered by the rotatable lid. In the second position, the sample inlet is covered by the rotatable lid and the measurement structure is aligned with the detection zone opening.

    Cartridge for stirring and dispensing a fluid, automatic analyzer and method of analyzing a biological sample
    6.
    发明授权
    Cartridge for stirring and dispensing a fluid, automatic analyzer and method of analyzing a biological sample 有权

    公开(公告)号：US10345322B2

    公开(公告)日：2019-07-09

    申请号：US15138474

    申请日：2016-04-26

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Thorsten Brueckner ,  Christoph Boehm ,  Juergen Spinke

    IPC: G01N35/10 ,  B01F7/00 ,  B01F7/16 ,  B01F13/10 ,  B01F15/02 ,  B01L3/00 ,  B01F15/00

    Abstract: A cartridge for dispensing a fluid is provided, the cartridge comprising: a reservoir chamber configured for receiving the fluid, the reservoir chamber having a fluid outlet and a cover with a first bearing; and a stirring assembly comprising a stirrer located inside the reservoir chamber, the stirring assembly comprising a shaft connected to the stirrer. The stirring assembly can be moved between first and second positions, wherein in the first position the stirring assembly can seal the fluid outlet, the stirring assembly in the first position being configured to form a second bearing with the reservoir chamber or the fluid outlet such that the stirrer can be rotated about an axis defined by the first and second bearing, and wherein if the stirring assembly is in the second position the fluid can pass through the fluid outlet, the shaft being configured to transmit rotational power to the stirrer.

    CARTRIDGE FOR DISPENSING A FLUID, AUTOMATIC ANALYZER AND METHOD OF ANALYZING A BIOLOGICAL SAMPLE
    10.
    发明申请
    CARTRIDGE FOR DISPENSING A FLUID, AUTOMATIC ANALYZER AND METHOD OF ANALYZING A BIOLOGICAL SAMPLE 有权
    液体分配盒，自动分析仪和分析生物样品的方法

    公开(公告)号：US20160139164A1

    公开(公告)日：2016-05-19

    申请号：US15006476

    申请日：2016-01-26

    Applicant: Roche Diagnostics Operations, Inc. ,  Hitachi High-Technologies Corporation

    Inventor： Thorsten Brueckner ,  Christoph Boehm ,  Juergen Spinke ,  Terumi Tamura ,  Taku Sakazume ,  Kyoko Imai

    IPC: G01N35/10 ,  B01L3/02

    CPC classification number: G01N35/1002 ,  B01L3/0268 ,  B01L3/0286 ,  B01L2200/04 ,  B01L2200/0684 ,  B01L2300/0609 ,  B01L2300/0832 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/082 ,  G01N35/1009

    Abstract: A cartridge for dispensing a fluid is presented. The cartridge comprises a reservoir chamber for receiving the fluid. The reservoir chamber has a fluid outlet. The cartridge further comprises a controllable dispenser component for dispensing a dispensing volume of the fluid from the reservoir chamber. The dispenser component is connected to the fluid outlet of the reservoir. The cartridge further comprises a single compressible fluid pump with a single elastic pumping element and a conduit extending from the fluid pump towards the fluid outlet. The fluid pump discharges a mixing volume of the fluid from the conduit into the reservoir chamber upon compression of the elastic pumping element. The mixing volume depends on the degree of compression of the elastic pumping element. The fluid pump sucks in the mixing volume from the reservoir into the conduit upon decompression of the elastic pumping element.

    Abstract translation: 呈现用于分配流体的盒。 墨盒包括用于接收流体的储存室。 储存室具有流体出口。 墨盒还包括可控分配器部件，用于从储存室分配流体的分配体积。 分配器部件连接到储存器的流体出口。 墨盒还包括具有单个弹性抽吸元件的单个可压缩流体泵和从流体泵朝向流体出口延伸的导管。 当压缩弹性抽吸元件时，流体泵将流体的混合体积从管道排出到储存室中。 混合体积取决于弹性泵送元件的压缩程度。 当弹性抽吸元件减压时，流体泵从储存器吸入混合容积。

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