公开(公告)号：US20130101095A1

公开(公告)日：2013-04-25

申请号：US13277944

申请日：2011-10-20

Applicant: Riaan Rottier ,  Stuart Thomas ,  Peter Gibson

Inventor： Riaan Rottier ,  Stuart Thomas ,  Peter Gibson

IPC: H04M3/22

CPC classification number: H04M3/22 ,  H04M3/42391

Abstract: A training system is disclosed. The training system includes a server. The server includes a processor, data storage, a data input/output interface, and a voice interface. The data input/output interface is configured to provide a web-based interface to a data terminal and to receive, from the data terminal and via the web-based interface, both an identifier identifying at least one voice terminal and at least one response. The voice interface is configured to transmit at least one audio test signal corresponding to at least one audio test to the at least one voice terminal. The response is a response to the at least one audio test. In one embodiment, the voice terminal and the data terminal are combined in a single device.

Abstract translation: 公开了一种培训系统。 培训系统包括一个服务器。 该服务器包括处理器，数据存储器，数据输入/输出接口和语音接口。 数据输入/输出接口被配置为向数据终端提供基于web的接口，并且从数据终端和基于web的接口接收标识至少一个语音终端的标识符和至少一个响应。 语音接口被配置为向至少一个语音终端发送对应于至少一个音频测试的至少一个音频测试信号。 响应是对至少一个音频测试的响应。 在一个实施例中，语音终端和数据终端被组合在单个设备中。

公开(公告)号：US20130029990A1

公开(公告)日：2013-01-31

申请号：US13638640

申请日：2011-04-01

Applicant: John King-Underwood ,  George Hardy ,  Peter John Murray ,  Jonathan Gareth Williams ,  Stuart Thomas Onions

Inventor： John King-Underwood ,  George Hardy ,  Peter John Murray ,  Jonathan Gareth Williams ,  Stuart Thomas Onions

IPC: A61K31/4439 ,  C07D401/14 ,  A61K31/4709 ,  C07D403/12 ,  A61K31/506 ,  C07D413/14 ,  A61K31/5377 ,  A61K31/4545 ,  A61P11/00 ,  A61P11/06 ,  A61P37/00 ,  A61P11/02 ,  A61P37/08 ,  A61P17/06 ,  A61P1/04 ,  A61P29/00 ,  A61P19/02 ,  A61P1/18 ,  A61P35/04 ,  C07D401/12

CPC classification number: C07D403/12 ,  C07D401/12 ,  C07D401/14

Abstract: There are provided inter alia compounds of formula (I): wherein R1, R2a, R2b, R3, R4, L, X, R5 and R6 are as defined in the description for use in the treatment of inflammatory diseases.

Abstract translation: 特别提供式（I）化合物：其中R 1，R 2a，R 2b，R 3，R 4，L，X，R 5和R 6如用于治疗炎性疾病的描述中所定义。

公开(公告)号：US20130012512A1

公开(公告)日：2013-01-10

申请号：US13616696

申请日：2012-09-14

Applicant: Kazuhiro Ito ,  Peter Strong ,  William Garth Rapeport ,  Peter John Murray ,  John King-Underwood ,  Jonathan Gareth Williams ,  Stuart Thomas Onions ,  Simon Christopher Hirst ,  David Michel Adrien Taddei ,  Catherine Elisabeth Charron

Inventor： Kazuhiro Ito ,  Peter Strong ,  William Garth Rapeport ,  Peter John Murray ,  John King-Underwood ,  Jonathan Gareth Williams ,  Stuart Thomas Onions ,  Simon Christopher Hirst ,  David Michel Adrien Taddei ,  Catherine Elisabeth Charron

IPC: A61K31/4439 ,  C07D405/14 ,  C07D413/14 ,  A61K31/5377 ,  A61P11/06 ,  A61K31/496 ,  C07D403/12 ,  A61K31/506 ,  A61K31/4178 ,  A61P11/00 ,  C07D401/12 ,  C07D401/14

CPC classification number: C07D401/14 ,  C07D401/12 ,  C07D403/12

Abstract: There are provided inter alia compounds of formula (I) wherein R1, Ar, L, X, R3 and Q are as defined in the specification for use in therapy, especially in the treatment of inflammatory diseases.

公开(公告)号：US08293771B2

公开(公告)日：2012-10-23

申请号：US13121445

申请日：2009-10-02

Applicant: Kazuhiro Ito ,  Peter Strong ,  William Garth Rapeport ,  John King-Underwood ,  Jonathan Gareth Williams ,  Stuart Thomas Onions ,  Peter John Murray ,  Catherine Elisabeth Charron

Inventor： Kazuhiro Ito ,  Peter Strong ,  William Garth Rapeport ,  John King-Underwood ,  Jonathan Gareth Williams ,  Stuart Thomas Onions ,  Peter John Murray ,  Catherine Elisabeth Charron

IPC: A61K31/4427 ,  C07D401/02

CPC classification number: C07D401/12

Abstract: There is provided a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, including all tautomers thereof, compositions comprising the same, use of said compound and compositions for treatment, in particular for the treatment of asthma and COPD, and processes for the preparation of said compound.

Abstract translation: 提供式（I）化合物或其药学上可接受的盐或溶剂合物，包括其所有互变异构体，包含其的组合物，所述化合物和组合物用于治疗，特别是用于治疗哮喘和COPD的用途和方法 用于制备所述化合物。

公开(公告)号：US20110294812A1

公开(公告)日：2011-12-01

申请号：US13133998

申请日：2009-12-11

Applicant: Kazuhiro Ito ,  Peter Strong ,  William Garth Rapeport ,  Peter John Murray ,  John King-Underwood ,  Jonathan Gareth Williams ,  Stuart Thomas Onions ,  Simon Christopher Hirst ,  David Michel Adrien Taddei ,  Catherine Elisabeth Charron

Inventor： Kazuhiro Ito ,  Peter Strong ,  William Garth Rapeport ,  Peter John Murray ,  John King-Underwood ,  Jonathan Gareth Williams ,  Stuart Thomas Onions ,  Simon Christopher Hirst ,  David Michel Adrien Taddei ,  Catherine Elisabeth Charron

IPC: A61K31/4439 ,  C07D405/14 ,  C07D413/14 ,  C07D401/14 ,  A61K31/5377 ,  A61K31/496 ,  A61P11/00 ,  A61P11/06 ,  A61P17/00 ,  A61P17/06 ,  A61P1/04 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  C07D401/12

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D403/12

Abstract: The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, including all stereoisomers, tautomers and isotopic derivatives thereof, which are inhibitors of p38 mitogen-activated protein kinase enzymes (referred to herein as p38 MAP kinase inhibitors), particularly the alpha and gamma kinase sub-types thereof, and their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as COPD.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其包括其所有的立体异构体，互变异构体和同位素衍生物，其是p38丝裂原活化蛋白激酶的抑制剂（本文称为p38 MAP激酶抑制剂）， 特别是其α和γ激酶亚型，以及它们在治疗中的用途，包括药物组合，特别是治疗炎症性疾病，包括肺炎性疾病如COPD。

公开(公告)号：US20110212962A1

公开(公告)日：2011-09-01

申请号：US13121999

申请日：2009-10-02

Applicant: Kazuhiro Ito ,  Peter Strong ,  William Garth Rapeport ,  Peter John Murray ,  John King-Underwood ,  Jonathan Gareth Williams ,  Stuart Thomas Onions ,  Simon Christopher Hirst ,  David Michel Adrien Taddei ,  Catherine Elisabeth Charron

Inventor： Kazuhiro Ito ,  Peter Strong ,  William Garth Rapeport ,  Peter John Murray ,  John King-Underwood ,  Jonathan Gareth Williams ,  Stuart Thomas Onions ,  Simon Christopher Hirst ,  David Michel Adrien Taddei ,  Catherine Elisabeth Charron

IPC: A61K31/5377 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07D401/14 ,  C07D403/12 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/506 ,  A61K31/4178 ,  A61P11/00 ,  A61P11/08 ,  A61P11/06 ,  A61P11/02 ,  A61P17/00 ,  A61P17/06 ,  A61P29/00 ,  A61P1/18 ,  A61P35/00 ,  A61P27/14 ,  A61P35/04 ,  A61P19/02

CPC classification number: C07D401/14 ,  C07D401/12 ,  C07D403/12

Abstract: There are provided inter alia compounds of formula (I) wherein R1, Ar, L, X, R3 and Q are as defined in the specification for use in therapy, especially in the treatment of inflammatory diseases.

Abstract translation: 特别是提供式（I）化合物，其中R 1，Ar，L，X，R 3和Q如在说明书中用于治疗，特别是治疗炎性疾病的说明书中所定义。

公开(公告)号：US07601754B2

公开(公告)日：2009-10-13

申请号：US10521232

申请日：2003-07-14

Applicant: Stuart Thomas Caldwell ,  Christopher James Bennett ,  Richard Charles Hartley ,  Donald Barton McPhail ,  Garry Graeme Duthie

Inventor： Stuart Thomas Caldwell ,  Christopher James Bennett ,  Richard Charles Hartley ,  Donald Barton McPhail ,  Garry Graeme Duthie

IPC: A61K31/35 ,  C07D311/00

CPC classification number: C07D311/30 ,  C07D311/32

Abstract: Novel flavonoid compounds having anti-oxidant activity are described. Formula 1. The compounds have been shown to exhibit anti-oxidative properties in biological systems and their utility in a sunscreen or skincare composition or to treat conditions involving oxidative damage, especially curative or prophylactic treatment of Alzheimer's disease or ischaemia-reperfusion injury, is described.

Abstract translation: 描述了具有抗氧化活性的新型类黄酮化合物。 化合物已被证明在生物系统中表现出抗氧化性质，并且其在防晒霜或护肤组合物中的用途或治疗涉及氧化损伤，特别是治疗性或预防性治疗阿尔茨海默病或缺血再灌注损伤的病症被描述 。

公开(公告)号：US20060289528A1

公开(公告)日：2006-12-28

申请号：US10550235

申请日：2004-03-26

Applicant: Heng-Mao Chiu ,  Ananda Sanagavarapu ,  Stuart Thomas ,  David Ross ,  Duncan Guy

Inventor： Heng-Mao Chiu ,  Ananda Sanagavarapu ,  Stuart Thomas ,  David Ross ,  Duncan Guy

IPC: H05B6/72

CPC classification number: A61B18/1815 ,  A61B18/18 ,  A61B2017/00243 ,  A61B2018/00375 ,  A61B2018/1861

Abstract: A microwave antenna suitable for cardiac ablation, in particular for catheter ablation, and a method for making such an antenna. The antenna comprises a transmission line having an inner conductor, an outer conductor, and a dielectric insulator to provide insulation between the inner and outer conductors. An energy emitting antenna element is located at the distal end of the transmission line. The antenna element has an inner conductor which is electrically coupled to the inner conductor of the transmission line, and, around the inner conductor, a sheath of dielectric insulator continuous with the insulator of the transmission line. At its distal end, a hollow metallic cap is electrically connected to the inner conductor, surrounding a length of the insulator.

Abstract translation: 适用于心脏消融的微波天线，特别是用于导管消融的微波天线，以及制造这种天线的方法。 天线包括具有内导体，外导体和绝缘绝缘体的传输线，以在内导体和外导体之间提供绝缘。 能量发射天线元件位于传输线的远端。 天线元件具有内部导体，该内部导体电耦合到传输线的内部导体，并且围绕内部导体，与传输线的绝缘体连接的绝缘绝缘体的护套。 在其远端，中空的金属帽电连接到内部导体，围绕绝缘体的长度。

公开(公告)号：US20050202141A1

公开(公告)日：2005-09-15

申请号：US10983316

申请日：2004-11-05

Applicant: David Corbin ,  Vasantha Nagarajan ,  Vidya Pai ,  Stuart Thomas

Inventor： David Corbin ,  Vasantha Nagarajan ,  Vidya Pai ,  Stuart Thomas

IPC: A23P1/00 ,  C13B35/06

CPC classification number: C13K11/00 ,  A23L5/273 ,  A23L11/34 ,  A23L33/105 ,  A23L33/20 ,  A61K31/045 ,  C13B20/123 ,  C13B20/165 ,  Y10S423/21

Abstract: The present invention relates to a process for selectively removing undesired oligosaccharides from aqueous mixtures such as plant processing waste products, including soy whey and other vegetable wheys, using an ultrastabilized large pore, hydrophobic zeolite Y. The resulting solution, which contains isoflavones and digestible sugars such as glucose, fructose and sucrose, can serve as the basis for a nutritious new product.

Abstract translation: 本发明涉及使用超稳定大孔，疏水性沸石Y从含水混合物如植物加工废物（包括大豆乳清和其它植物乳清）中选择性除去不需要的寡糖的方法。所得的溶液含有异黄酮和可消化的糖 如葡萄糖，果糖和蔗糖，可作为营养新产品的基础。

公开(公告)号：US20050202140A1

公开(公告)日：2005-09-15

申请号：US10983125

申请日：2004-11-05

Applicant: David Corbin ,  Vasantha Nagarajan ,  Vidya Pai ,  Stuart Thomas

Inventor： David Corbin ,  Vasantha Nagarajan ,  Vidya Pai ,  Stuart Thomas

IPC: A23P1/00

CPC classification number: A23L33/185 ,  A23L5/273 ,  Y10S423/21 ,  Y10S423/27

Abstract: The present invention provides a process using zeolites for recovering isoflavones and removing undesired oligosaccharides from aqueous mixtures, such as soy whey and other plant processing waste products. The aqueous mixture is treated with a large pore hydrophobic zeolite, such as zeolite Beta, to remove isoflavones, followed by treatment with an ultrastabilized, hydrophobic zeolite Y, such as CBV-901 or HiSiv™ 4000, to remove the undesired oligosaccharides raffinose and stachyose. The recovered isoflavones and digestible sugars, glucose, sucrose, and fructose, are useful in food products.

Abstract translation: 本发明提供了一种使用沸石回收异黄酮并从含水混合物如大豆乳清和其它植物加工废物中除去不期望的寡糖的方法。 用大孔疏水性沸石如β沸石处理含水混合物以除去异黄酮，然后用超稳定的疏水性沸石Y（例如CBV-901或HiSiv TM 4000）处理以除去不期望的寡糖棉子糖 和水苏糖 回收的异黄酮和可消化糖，葡萄糖，蔗糖和果糖，可用于食品。