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公开(公告)号：US20250009817A1
公开(公告)日：2025-01-09
申请号：US18417720
申请日：2024-01-19
Inventor： Mi-La CHO , Min-Jung PARK , Joo-Yeon JHUN , Seung-Yoon LEE , Se-Gyeong HAN
IPC: A61K35/747 , A61K31/436 , A61K35/00 , A61P37/04
Abstract: Provided is an immunomodulatory treatment composition for a transplantation disease through combined administration of a microbiome and an immunosuppressant. According to the present disclosure, it was confirmed that in an allogeneic transplantation cell model, combined administration of FK506 and the microbiome suppressed alloresponse and regulated the activity of T cells and B cells. Further, it was confirmed that in an acute graft-versus-host disease animal model, the combined administration reduced the disease activity, increased the probability of survival, and protected the tissue damage. In addition, it was confirmed that the combined administration improved transplantation rejection diseases by reducing the activity of Th1 and Th17 and increasing the activity of Tregs, and thus can be usefully used as an immunomodulator for transplantation rejection.
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公开(公告)号：US20240402190A1
公开(公告)日：2024-12-05
申请号：US18594798
申请日：2024-03-04
Inventor： Eun Hui LEE , Jun Hee CHOI
IPC: G01N33/68
Abstract: The present invention relates to a composition for diagnosing limb-girdle muscular dystrophy type 2H, a method of providing information for diagnosis, and a method of screening a drug for the treatment of limb-girdle muscular dystrophy type 2H.
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公开(公告)号：US20240386686A1
公开(公告)日：2024-11-21
申请号：US18642950
申请日：2024-04-23
Inventor： Bo-in LEE , Youngbae HWANG , Sol KIM , Saad KHALIL
IPC: G06T19/20 , G06T7/579 , G06V10/44 , G06V10/764
Abstract: The method for performing endoscopic examination according to an exemplary embodiment of the present invention may include the steps of obtaining an endoscopic image and a 3D model of a target organ; identifying location information of an endoscope on the 3D model in real time based on simultaneous localization and mapping (SLAM); classifying a plurality of areas constituting the 3D model into examination areas and unexamined areas by using the endoscopic image and the location information; and providing feedback information based on the examination areas and unexamined areas.
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公开(公告)号：US20240377415A1
公开(公告)日：2024-11-14
申请号：US18658276
申请日：2024-05-08
Inventor： Young-Bok LEE
Abstract: The present invention relates to extramammary Paget disease biomarkers, such as SPDEF, ARG2, and ABEP1, and uses thereof that were discovered by exploring the molecular profile as well as performing a comprehensive genetic analysis of EMPD. The present invention investigates how EMPD evolves in the context of treatment and may elucidate a potential mechanism of progression to invasion. Furthermore, the biomarkers of the present invention may be usefully used in the diagnosis or treatment of extramammary Paget disease in that the tissue microenvironments and cell types associated with EMPD may be further characterized using spatial transcriptomics.
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公开(公告)号：US12112481B2
公开(公告)日：2024-10-08
申请号：US17625911
申请日：2020-03-18
Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION , KONKUK UNIVERSITY GLOCAL INDUSTRY-ACADEMIC COLLABORATION FOUNDATION
Inventor： Hyun Jeong Kim , Hong Gee Roh
CPC classification number: G06T7/0016 , A61B5/055 , G06T19/20 , G06T2200/04 , G06T2207/10076 , G06T2207/10088 , G06T2207/20092 , G06T2207/20132 , G06T2207/20224 , G06T2207/30096 , G06T2207/30101 , G06T2219/2012
Abstract: A simultaneous implementation method of 3D subtraction magnetic resonance (MR) arteriography, 3D subtraction MR venography, and color-coded 4D MR angiography through post-processing of image information of 4D MR angiography according to an embodiment of the present disclosure may reduce scan time required to individually obtain an MR arteriography and an MR venography. In addition, not only anatomical information of arteries but also more accurate anatomical information of veins and more detailed hemodynamic information may be obtained.
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Patent Agency Ranking
公开(公告)号：US12090039B2
公开(公告)日：2024-09-17
申请号：US17262551
申请日：2019-07-25
Applicant: The Catholic University of Korea Industry-Academic Cooperation Foundation , University-Industry Foundation, Yonsei University , Research Cooperation Foundation of Yeungnam University
Inventor： U-Syn Ha , Jongbaeg Kim , Won Gun Koh , Jin Ho Kim
CPC classification number: A61F2/042 , A61F2/482 , A61F2002/009 , A61F2250/0013
Abstract: An artificial bladder is provided, including: a main body which includes an inlet port, an outlet port, an inner wall that forms a first reservoir portion configured to store urine between the inlet port and the outlet port and that is expandable and contractible. An outer wall forms a second reservoir portion configured to surround at least a partial region of the inner wall. A sensor is attached to the inner wall, has a surface having a wrinkled structure, and is provided so that, when the volume of the first reservoir portion increases, the wrinkled structure stretches out and resistance of the sensor changes. A control unit is provided to discharge the urine in the first reservoir portion through the outlet port according to a result detected by the sensor.
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公开(公告)号：US12054752B2
公开(公告)日：2024-08-06
申请号：US16622687
申请日：2018-06-12
Inventor： Tai Gyu Kim , Hyun Il Cho , Un Hee Kim
CPC classification number: C12N9/12 , A61K35/17 , A61K38/45 , C07K14/70539 , C12N5/0638 , C12Y207/11021 , A61K35/15 , A61K38/00 , C12N2501/727
Abstract: The present invention relates to a HLA-A2 subtype-specific PLK1-derived epitope inducing an antigen-specific T cell immune response to a PLK1 protein. More specifically, a HLA-A2 subtype-specific PLK-1-derived epitope inducing an antigen-specific T cell immune response to a PLK1 protein according to the present invention can provide a CD8+ T cell immune response specific for tumor cells.
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68.发明公开公开(公告)号：US20240252773A1
公开(公告)日：2024-08-01
申请号：US18013323
申请日：2022-08-11
Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY- ACADEMIC COOPERATION FOUNDATION , INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
Inventor： Young Hoon JOO , Hyun Bum KIM , Jong Baeg KIM , Yo Han JUNG , Dae Yeon KOH , Min Hyeong KIM , Hyun Jun HAN
CPC classification number: A61M16/0472 , A61B5/0816 , A61B5/7203 , A61B5/7257 , A61B5/743 , A61M16/0463 , A61M2205/18
Abstract: Proposed are a phlegm suction alarm issuing apparatus and a method for a tracheostomy patient which monitor and analyze a respiratory sound of the tracheostomy patient in real time, then check congestion of phlegm, and issue a phlegm suction alarm.
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69.发明公开公开(公告)号：US20240226150A9
公开(公告)日：2024-07-11
申请号：US18448665
申请日：2023-08-11
Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION , SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , Daegu Gyeongbuk Institute of Science and Technology
Inventor： Kiyuk CHANG , Daehee HWANG , Min-Sik KIM , Eunmin KIM , Eun Hye PARK , Chan Woo KIM
CPC classification number: A61K35/15 , A61K39/4615 , A61K39/4621 , A61P9/04 , C07K14/4702 , C12N5/0018 , C12N5/064
Abstract: The present disclosure relates to the preparation of citrullinated vimentin antigen-specific immune tolerogenic dendritic cells and a composition for preventing or treating heart failure after myocardial infarction comprising the same. According to the present disclosure, it is confirmed that immune tolerogenic dendritic cells differentiated by treating immature dendritic cells with citrullinated vimentin regulate the expression of immune-related factors and have an excellent therapeutic effect on heart failure caused by myocardial infarction.
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公开(公告)号：US20240225773A9
公开(公告)日：2024-07-11
申请号：US18191756
申请日：2023-03-28
Inventor： Hye Young SHIN
IPC: A61B90/00
CPC classification number: A61B90/04 , A61B2090/0427 , A61B2090/08021
Abstract: The inventive concept relates to an eyeball and eyelid protector including an eyeball cover that covers an eyeball, and an eyelid protection part that is bent and extends from one side of the eyeball cover to protect any one of an upper eyelid and a lower eyelid.
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