公开(公告)号：US20180161430A1

公开(公告)日：2018-06-14

申请号：US15890576

申请日：2018-02-07

Applicant: UNIVERSITY OF EXETER

Inventor： Mark Elliott WOOD ,  Paul Graham WINYARD ,  Daniel Colin Jeremy FERGUSON ,  Matthew WHITEMAN ,  Alison CURNOW ,  Alexis PERRY

IPC: A61K41/00 ,  A61K31/67

CPC classification number: A61K41/0061 ,  A61K31/385 ,  A61K31/44 ,  A61K31/445 ,  A61K31/454 ,  A61K31/67 ,  A61K31/7135 ,  A61K33/24 ,  A61K41/0071 ,  A61K47/54

Abstract: The invention relates to a combination comprising(i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or a pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy.

公开(公告)号：US20160310587A1

公开(公告)日：2016-10-27

申请号：US15106199

申请日：2014-12-18

Applicant: University of Exeter ,  Universiteit Gent

Inventor： Richard William Titball ,  Sergio Paulo Fernandes Da Costa ,  Filip Van Immerseel ,  Richard Ducatelle ,  Dorien Mot

IPC: A61K39/08 ,  C07K14/33

CPC classification number: A61K39/08 ,  A61K2039/552 ,  C07K14/33

Abstract: The invention provides a composition comprising a reduced toxicity NetB epitope polypeptide and a reduced toxicity Clostridium perfringens alpha-toxin epitope polypeptide. The composition is useful as a vaccine providing complete protection against infection by C. perfringens.

Abstract translation: 本发明提供了包含降低毒性的NetB表位多肽和降低毒性的产气荚膜梭菌α-毒素表位多肽的组合物。 该组合物可用作提供完全防止产气荚膜梭菌感染的疫苗。

公开(公告)号：US20150364614A1

公开(公告)日：2015-12-17

申请号：US14761233

申请日：2014-01-14

Applicant: UNIVERSITY OF EXETER

Inventor： Freddie Withers ,  Thomas H. Bointon ,  Monica F. Craciun ,  Saverio Russo ,  Steven Martins

IPC: H01L31/028 ,  H01L31/103

CPC classification number: H01L31/028 ,  H01L27/305 ,  H01L31/0288 ,  H01L31/036 ,  H01L31/103 ,  H01L31/108 ,  H01L51/4246 ,  Y02E10/547

Abstract: A detector is described comprising a first graphene element (12), the first graphene element (12) comprising a few layer graphene element functionally doped with a dopant material and to which at least one electrode is connected.

Abstract translation: 描述了一种包括第一石墨烯元件（12）的检测器，所述第一石墨烯元件（12）包括在功能上掺杂有掺杂剂材料并且连接有至少一个电极的几层石墨烯元件。

公开(公告)号：US20150210642A1

公开(公告)日：2015-07-30

申请号：US14425385

申请日：2013-09-02

Applicant: UNIVERSITY OF EXETER

Inventor： Alison Curnow ,  Mark Wood ,  Alexis Perry

IPC: C07D213/69

CPC classification number: C07D213/69 ,  A61K8/4926 ,  A61K41/0057 ,  A61K49/0021 ,  A61K2800/81 ,  A61Q19/00

Abstract: A compound which is a compound of formula (I) or any salt thereof: wherein R1 is a Ci-C6 alkyl group, R2 is H or a Ci-C6 alkyl group, R3 is H or a Ci-C6 alkyl group, and n is an integer from 0 to 5.

Abstract translation: 化合物，其为式（I）化合物或其盐：其中R 1为C 1 -C 6烷基，R 2为H或C 1 -C 6烷基，R 3为H或C 1 -C 6烷基，n为 是从0到5的整数。

公开(公告)号：US20150064207A1

公开(公告)日：2015-03-05

申请号：US14387809

申请日：2013-03-28

Applicant: UNIVERSITY OF EXETER

Inventor： Richard W. Titball ,  Monika Bokori-Brown ,  Claire Naylor

IPC: C07K14/33 ,  C07K16/12

CPC classification number: C07K14/33 ,  A61K39/00 ,  A61K39/08 ,  C07K16/1282

Abstract: There is provided an epsilon toxin epitope polypeptide comprising a sequence of at least 10 contiguous amino acids from SEQ ID NO:3, the sequence comprising a mutation of at least one tyrosine residue compared to the equivalent sequence in SEQ ID NO:3, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:5 and having reduced toxicity compared with the toxicity of SEQ ID NO:5. The polypeptide is useful in a method of vaccinating a subject against developing a disease caused by Clostridium perfringens and/or caused by (or associated with the presence of) active epsilon toxin.

Abstract translation: 提供了包含SEQ ID NO：3的至少10个连续氨基酸的序列的ε-毒素表位多肽，所述序列包含与SEQ ID NO：3中的等同序列相比至少一个酪氨酸残基的突变，所述多肽 能够结合与SEQ ID NO：5结合的抗体，并且与SEQ ID NO：5的毒性相比具有降低的毒性。 该多肽可用于接种受试者以发展由产气荚膜梭菌引起的疾病和/或由活动性ε毒素（或与其存在）引起的疾病的疫苗接种的方法。

公开(公告)号：US20140174513A1

公开(公告)日：2014-06-26

申请号：US13724105

申请日：2012-12-21

Applicant: UNIVERSITY OF EXETER

Inventor： Saverio Russo ,  Monica Felicia Craciun

IPC: H01B1/04 ,  H01L31/0224

CPC classification number: H01B1/04 ,  H01L31/022466 ,  H01L31/1884 ,  H01L51/442 ,  Y02E10/549 ,  Y02P70/521 ,  Y10T428/24802 ,  Y10T428/30

Abstract: The present invention relates to a transparent chemically functionalized graphene with high electrical conductivity and which is stable in air. It also relates to a method of manufacturing a conductive and transparent graphene-based material.

Abstract translation: 本发明涉及具有高导电性且在空气中稳定的透明化学官能化石墨烯。 它还涉及一种制造导电和透明的石墨烯材料的方法。