公开(公告)号：US20230287481A1

公开(公告)日：2023-09-14

申请号：US18324720

申请日：2023-05-26

Applicant: 10x Genomics, Inc.

Inventor： Anna-Maria Katsori ,  Christina Galonska ,  Paulius Mielinis ,  Marlon Stoeckius

IPC: C12Q1/6837 ,  C12Q1/6874

CPC classification number: C12Q1/6837 ,  C12Q1/6874

Abstract: The present disclosure relates to materials and methods for spatially analyzing nucleic acids fragmented with a transposase enzyme, optionally complexed to an antibody-binding moiety (e.g., an antibody-binding protein) bound to an antibody for at least one chromatin protein, in a biological sample.

公开(公告)号：US20230228762A1

公开(公告)日：2023-07-20

申请号：US18160084

申请日：2023-01-26

Applicant: 10x Genomics, Inc.

Inventor： Cedric Uytingco ,  James Michael Chell ,  Marlon Stoeckius ,  Albert Dale Kim ,  Dulce Ovando Morales ,  Andrej Hartnett ,  Yifeng Yin ,  Jennifer Chew

IPC: G01N33/68 ,  C12N15/10 ,  C12Q1/6804 ,  C12Q1/6874 ,  G01N1/30 ,  G01N21/64 ,  G01N33/58

CPC classification number: G01N33/6803 ,  C12N15/1065 ,  C12Q1/6804 ,  C12Q1/6874 ,  G01N1/30 ,  G01N21/6428 ,  G01N21/6456 ,  G01N33/582 ,  G01N2021/6439

Abstract: Provided herein are methods for preparing biological samples for spatial proteomic analysis, methods of determining a location of a protein analyte in a biological sample, and methods of determining a location of a protein analyte and a nucleic acid analyte in a biological sample.

公开(公告)号：US20230175045A1

公开(公告)日：2023-06-08

申请号：US18074081

申请日：2022-12-02

Applicant: 10x Genomics, Inc.

Inventor： Anna-Maria Katsori ,  Christina Galonska ,  Paulius Mielinis ,  Marlon Stoeckius

IPC: C12Q1/6837 ,  C12Q1/6874

CPC classification number: C12Q1/6837 ,  C12Q1/6874

Abstract: The present disclosure relates to materials and methods for spatially analyzing nucleic acids fragmented with a transposase enzyme, optionally complexed to an antibody-binding moiety (e.g., an antibody-binding protein) bound to an antibody for at least one chromatin protein, in a biological sample.

公开(公告)号：US11661626B2

公开(公告)日：2023-05-30

申请号：US17882241

申请日：2022-08-05

Applicant: 10x Genomics, Inc.

Inventor： Layla Katiraee ,  Michael Schnall-Levin ,  Christina Galonska ,  Marlon Stoeckius

IPC: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6876

CPC classification number: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6876 ,  C12Q2600/154

Abstract: Provided herein are methods of identifying a methylation status of an analyte in a biological sample. Also provided herein are methods that combine identifying the methylation status with spatial technology to identify the location of a methylation status in a biological sample.

公开(公告)号：US11608498B2

公开(公告)日：2023-03-21

申请号：US17963749

申请日：2022-10-11

Applicant: 10x Genomics, Inc.

Inventor： Caroline Julie Gallant ,  Marlon Stoeckius ,  Katherine Pfeiffer

IPC: C12N15/10 ,  C12Q1/6837 ,  C12Q1/6874

Abstract: Provided herein are methods, compositions, and kits for removing a portion of a sequence in a member of a nucleic acid library.

公开(公告)号：US11560593B2

公开(公告)日：2023-01-24

申请号：US17707189

申请日：2022-03-29

Applicant: 10x Genomics, Inc.

Inventor： James Michael Chell ,  Marlon Stoeckius ,  Jonathan Alles ,  Caroline Julie Gallant ,  Christina Galonska ,  Felice Alessio Bava ,  Layla Katiraee

IPC: C12Q1/6876 ,  C12Q1/6811 ,  C12Q1/25 ,  C12Q1/6816 ,  C12Q1/6841 ,  C12Q1/6851

Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.

公开(公告)号：US11512308B2

公开(公告)日：2022-11-29

申请号：US17690628

申请日：2022-03-09

Applicant: 10x Genomics, Inc.

Inventor： Caroline Julie Gallant ,  Marlon Stoeckius ,  Katherine Pfeiffer

IPC: C12N15/10 ,  C12Q1/6837 ,  C12Q1/6874

Abstract: Provided herein are methods, compositions, and kits for removing a portion of a sequence in a member of a nucleic acid library.

公开(公告)号：US11408029B2

公开(公告)日：2022-08-09

申请号：US17573119

申请日：2022-01-11

Applicant: 10x Genomics, Inc.

Inventor： Layla Katiraee ,  Michael Schnall-Levin ,  Christina Galonska ,  Marlon Stoeckius

IPC: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6876

Abstract: Provided herein are methods of identifying a methylation status of an analyte in a biological sample. Also provided herein are methods that combine identifying the methylation status with spatial technology to identify the location of a methylation status in a biological sample.

公开(公告)号：US20210348221A1

公开(公告)日：2021-11-11

申请号：US17220529

申请日：2021-04-01

Applicant: 10x Genomics, Inc.

Inventor： James Michael Chell ,  Marlon Stoeckius ,  Jonathan Alles ,  Caroline Julie Gallant ,  Christina Galonska ,  Felice Alessio Bava ,  Layla Katiraee

IPC: C12Q1/6841 ,  C12Q1/6876 ,  C12Q1/6816 ,  C12Q1/6851 ,  C12Q1/25

Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.