公开(公告)号：US07687435B2

公开(公告)日：2010-03-30

申请号：US10581444

申请日：2004-12-17

申请人： Matthias Witschel ,  Michael Puhl ,  Gerhard Hamprecht ,  Liliana Parra Rapado ,  Ulf Misslitz ,  CyrilL Zagar ,  Peter Plath ,  Robert Reinhard ,  Bernd Sievernich ,  Rex Liebl

发明人： Matthias Witschel ,  Michael Puhl ,  Gerhard Hamprecht ,  Liliana Parra Rapado ,  Ulf Misslitz ,  CyrilL Zagar ,  Peter Plath ,  Robert Reinhard ,  Bernd Sievernich ,  Rex Liebl

IPC分类号： A01N37/18 ,  C07C237/42

CPC分类号： C07D213/54 ,  A01N37/48 ,  A01N41/04 ,  A01N47/06 ,  A01N47/12 ,  C07C233/87 ,  C07C237/22 ,  C07C255/60 ,  C07C271/12 ,  C07C271/28 ,  C07C275/24 ,  C07C275/42 ,  C07C309/66 ,  C07C311/06 ,  C07C311/08 ,  C07C311/09 ,  C07C311/53 ,  C07C311/55 ,  C07C323/52 ,  C07C323/60 ,  C07C323/62 ,  C07C323/63 ,  C07D213/80 ,  C07D231/12 ,  C07D239/60 ,  C07D249/08 ,  C07D309/08 ,  C07D317/32 ,  C07D333/24 ,  C07F7/1804

摘要： The present invention relates to benzoyl-substituted phenylalanineamides of the formula I in which the variables R1 to R15 are as defined in the description, and to their agriculturally useful salts, to processes and intermediates for their preparation and to the use of these compounds or of compositions comprising these compounds for controlling unwanted plants.

摘要翻译： 本发明涉及式I的苯甲酰基取代的苯丙氨酰胺，其中变量R1至R15如说明书中所定义，以及其农业上有用的盐，其制备方法和中间体以及这些化合物的使用或 包含这些化合物以控制不想要的植物的组合物。

公开(公告)号：US20110144336A1

公开(公告)日：2011-06-16

申请号：US13058677

申请日：2009-07-30

申请人： Thomas Zierke ,  Eike Hupe ,  Michael Rack ,  Liliana Parra Rapado ,  Timo Frassetto

发明人： Thomas Zierke ,  Eike Hupe ,  Michael Rack ,  Liliana Parra Rapado ,  Timo Frassetto

IPC分类号： C07D241/08

CPC分类号： C07D241/08

摘要： A process for preparing piperazinedione derivatives of the formula I in which R1 is hydrogen, alkyl, alkenyl, alkynyl and alkylcarbonyl, R2 is hydrogen, alkyl, alkenyl, C3-C4-alkynyl and C(═O)R11, R3, R4 are each hydrogen, alkyl and haloalkyl, where the groups may be substituted, which comprises reacting amines of the formula II H2N—R1  II in which R1 is hydrogen and alkyl which may optionally be substituted with N-acylated amino acid derivatives of the formula III in which X is halogen, Y is halogen, alkoxy or phenyloxy which may be substituted and R2, R3 and R4 are each as defined at the outset, under basic conditions in an aqueous solvent.

摘要翻译： 其中R 1是氢，烷基，烯基，炔基和烷基羰基，R 2是氢，烷基，烯基，C 3 -C 4炔基和C（= O）R 11，R 3，R 4各自是式I的哌嗪二酮衍生物的方法 氢，烷基和卤代烷基，其中基团可以被取代，其包括使式II的其中R 1是氢的式IIH 2 N-R 1 II的烷基和可以被式III的N-酰化的氨基酸衍生物任选取代的烷基，其中 X是卤素，Y是可以被取代的卤素，烷氧基或苯氧基，R2，R3和R4各自在碱性条件下在水性溶剂中首先定义。

公开(公告)号：US20090221423A1

公开(公告)日：2009-09-03

申请号：US12162044

申请日：2007-01-19

申请人： Michael Puhl ,  Matthias Pohlman ,  Liliana Parra Rapado ,  Michael Rack ,  Thomas Schmidt ,  Delphine Breuninger ,  Deborah L. Culbertson ,  Douglas D. Anspaugh ,  Henry Van Tuyl Cotter ,  Hassan Oloumi-Sadeghi ,  David G. Kuhn

发明人： Michael Puhl ,  Matthias Pohlman ,  Liliana Parra Rapado ,  Michael Rack ,  Thomas Schmidt ,  Delphine Breuninger ,  Deborah L. Culbertson ,  Douglas D. Anspaugh ,  Henry Van Tuyl Cotter ,  Hassan Oloumi-Sadeghi ,  David G. Kuhn

IPC分类号： A01N43/40 ,  A01N25/26 ,  C07D401/14 ,  C07D401/02 ,  A01N57/10 ,  A01N43/66

CPC分类号： A01N43/44 ,  A01N43/40 ,  C07D401/12

摘要： Pesticidal compositions comprising3-pyridyl derivatives of formula I wherein the variables and indices are as defined in the description, and an agronomically acceptable carrier, processes for the preparation of compounds I and use of compounds I or II and the compositions comprising them for combating pests.

摘要翻译： 包含式I的3-吡啶基衍生物的农药组合物，其中变量和指数如说明书中所定义，和农艺学上可接受的载体，化合物I的制备方法和化合物I或II的用途及其组合物用于防治害虫 。

公开(公告)号：US20110166162A1

公开(公告)日：2011-07-07

申请号：US12999349

申请日：2009-06-17

申请人： Wolfgang von Deyn ,  Michael Puhl ,  Matthias Pohlman ,  Michael Rack ,  Liliana Parra Rapado ,  Jürgen Langewald ,  Douglas D. Anspaugh ,  Hassan Oloumi-Sadeghi ,  Gale F. Matt Hews ,  Deborah L. Culbertson ,  Nancy B. Rankl ,  Hennicke Kamp ,  Bennard van Ravenzwaay

发明人： Wolfgang von Deyn ,  Michael Puhl ,  Matthias Pohlman ,  Michael Rack ,  Liliana Parra Rapado ,  Jürgen Langewald ,  Douglas D. Anspaugh ,  Hassan Oloumi-Sadeghi ,  Gale F. Matt Hews ,  Deborah L. Culbertson ,  Nancy B. Rankl ,  Hennicke Kamp ,  Bennard van Ravenzwaay

IPC分类号： A01N43/54 ,  C07D417/06 ,  C07D401/06 ,  A01N43/40 ,  A01P11/00 ,  A01P15/00 ,  A01P7/04 ,  A01P5/00 ,  A01P7/00

CPC分类号： C07D417/06 ,  A01N43/80 ,  C02F1/001 ,  C02F2209/03 ,  C02F2303/16 ,  C07D417/14

摘要： The present invention relates to sulfonamide compounds of formula (I) wherein R1 is H, halogen, CN, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C4-alkyl, C1-C6-alkoxy, C2-C6-alkenyloxy, C2-C6-alkynyloxy, C1-C6-alkylthio, C2-C6-alkenylthio, C2-C6-alkynylthio, C1-C6-haloalkyl or C1-C6-haloalkoxy; R2 and R3 are H, halogen, CN, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C4-alkyl, C1-C6-alkoxy, C2-C6-alkenyloxy, C2-C6-alkynyloxy, C1-C6-alkylthio, C2-C6-alkenylthio, C2-C6-alkynylthio, C1-C6-haloalkyl or C1-C6-haloalkoxy; or R2 together with R3 form a fused 5 or 6-membered carbocycle or heterocycle; R4 is halogen, CN, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy, C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkyl, C1-C6-haloalkoxy, C1-C6-haloalkylthio, C1-C6-haloalkylsulfinyl or C1-C6-haloalksulfonyl; n is 0, 1, 2 or 3; R5 is phenyl or a 5- or 6-membered heterocycle; X is O or NRx, wherein Rx is H, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C1-C6-alkoxy, C2-C6-alkenyloxy, C2-C6-alkynyloxy, C1-C6-alkylcarbonyl or C1-C6-alkylcarbonyloxy; Y is N or C(Ry), wherein Ry is H, halogen, CN, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C3-7-cycloalkyl-C1-C4-alkyl, C1-C6-alkoxy, C2-C6-alkenyloxy, C2-C6-alkynyloxy, C1-C6-alkylthio, C2-C6-alkenylthio, C2-C6-alkynylthio, C1-C6-haloalkyl and C1-C6-haloalkoxy; and Z is a chemical bond, O or N(Rz), wherein Rz is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C1-C6-alkoxy, C2-C6-alkenyloxy, C1-C6-alkylcarbonyl or C1-C6-alkylcarbonyloxy; as well as to the N-oxides and salts thereof. These compounds are useful for combating animal pests. The invention also relates to a process for the preparation of these compounds and to intermediate compounds used in said process. The invention further relates to a method for controlling animal pests by using the compounds of formula (I), the N-oxides or the salts thereof, to plant propagation material and to an agricultural and veterinary composition comprising said compounds, the N-oxides or the salts thereof.

公开(公告)号：US20090029855A1

公开(公告)日：2009-01-29

申请号：US12282608

申请日：2007-03-12

申请人： Michael Puhl ,  Wassilios Grammenos ,  Joachim Rheinheimer ,  Jan Klaas Lohmann ,  Michael Rack ,  Liliana Parra Rapado ,  Christopher Koradin ,  Jurgen Langewald ,  Deborah L. Culbertson ,  Douglas D. Anspaugh ,  Hassan Oloumi-Sadeghi ,  Henry Van Tuyl Cotter ,  David G. Kuhn

发明人： Michael Puhl ,  Wassilios Grammenos ,  Joachim Rheinheimer ,  Jan Klaas Lohmann ,  Michael Rack ,  Liliana Parra Rapado ,  Christopher Koradin ,  Jurgen Langewald ,  Deborah L. Culbertson ,  Douglas D. Anspaugh ,  Hassan Oloumi-Sadeghi ,  Henry Van Tuyl Cotter ,  David G. Kuhn

IPC分类号： A01N25/26 ,  C07D215/14 ,  A01N43/42 ,  A01N59/26 ,  A01P5/00 ,  A01P7/04

CPC分类号： C07D215/12 ,  C07D215/60

摘要： This invention relates to quinoline derivatives of formula I wherein R1, R2, R3 are each independently halogen, hydroxy, cyano, amino, nitro, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C4-alkyl, C1-C6-alkoxy, C2-C6-alkenyloxy, C2-C6-alkynyloxy, C1-C4-alkoxy-C1-C4-alkoxy, C3-C7-cycloalkyl-C1-C4-alkoxy, C(OH)(CF3)2, C1-C6-haloalkyl, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkylsulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkylsulfonyl, C(Ra)═O, C(Ra)═NORb, C(═O)ORx, or C(═O)NRxRy; Ra is hydrogen or C1-C4-alkyl; Rb is hydrogen, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C1-C4-haloalkyl, or C2-C4-haloalkenyl; Rx, Ry are each independently hydrogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-thioalkyl-C1-C4-alkyl, C1-C4-alkyl-S(═O)C1-C4-alkyl, C1-C4-alkyl-S(═O)2C1-C4-alkyl, C3-C6-cyloalkyl, C1-C4-alkyl-C3-C6-cycloalkyl, C3-C6-alkenyl, C3-C6-alkinyl; R4, R5, R6, R7 are each independently hydrogen, halogen, cyano, amino, nitro, hydroxy, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkylsulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkylsulfonyl, or C(═O)ORc; Rc is hydrogen, C1-C6-alkyl, C2-C6-alkenyl, or C2-C6-alkinyl; m and n are each independently 1, 2, 3, 4, or 5; p is 0, 1, 2, 3, 4, or 5; and the N-oxides, enantiomers, diastereomers and salts thereof, processes and intermediates for the preparation of compounds I, use of compounds I for combating insects, acarids, or nematodes and a method for treating, controlling, preventing or protecting animals against infestation or infection by parasites using compounds I.

摘要翻译： 本发明涉及式I的喹啉衍生物，其中R 1，R 2，R 3各自独立地为卤素，羟基，氰基，氨基，硝基，C 1 -C 6烷基，C 2 -C 6 - 烯基，C 2 -C 6炔基，C 3 -C 7 - 环烷基，C 3 -C 7 - 环烷基-C 1 -C 4 - 烷基，C 1 -C 6 - 烷氧基，C 2 -C 6 - 烯氧基，C 2 -C 6 - 炔氧基，C 1 -C 4烷氧基-C 1 -C 4烷氧基，C 3 -C 7 - 环烷基 - C 1 -C 6烷氧基，C（OH）（CF 3）2，C 1 -C 6卤代烷基，C 1 -C 6卤代烷氧基，C 1 -C 6烷硫基，C 1 -C 6卤代烷硫基，C 1 -C 6烷基亚磺酰基， C 1 -C 6烷基磺酰基，C 1 -C 6卤代烷基磺酰基，C（R a）-O，C（R a）-NOR b，C（-O）OR x或C（-O）NR x R y; R a是氢或C 1 -C 4 - 烷基; R b是氢，C 1 -C 4 - 烷基，C 2 -C 4 - 烯基，C 2 -C 4 - 炔基，C 1 -C 4卤代烷基或C 2 -C 4 - 卤代烯基; R x，R y各自独立地为氢，C 1 -C 4 - 烷基，C 1 -C 4 - 卤代烷基，C 1 -C 4 - 烷氧基-C 1 -C 4烷基，C 1 -C 4 - 硫代烷基-C 1 -C 4烷基，C 1 -C 4烷基 - S（-O）C 1 -C 4 - 烷基，C 1 -C 4烷基-S（-O）2 C 1 -C 4烷基，C 3 -C 6 - 环烷基，C 1 -C 4烷基-C 3 -C 6环烷基，C 3 -C 6 - 烯基，C 3 -C 6 - 炔基; R4，R5，R6，R7各自独立地为氢，卤素，氰基，氨基，硝基，羟基，C1-C6-烷基，C1-C6-烷氧基，C1-C6-卤代烷基，C1-C6-卤代烷氧基，C1-C6- C 1 -C 6烷基亚磺酰基，C 1 -C 6烷基磺酰基，C 1 -C 6卤代烷基磺酰基或C（-O）OR c; R c是氢，C 1 -C 6 - 烷基，C 2 -C 6 - 烯基或C 2 -C 6 - 炔基; m和n各自独立地为1,2,3,4或5; p是0，1，2，3，4或5; 及其N-氧化物，对映异构体，非对映异构体及其盐，制备化合物I的方法和中间体，化合物I用于防治昆虫，螨虫或线虫的用途，以及用于治疗，控制，预防或保护动物免受感染或 使用化合物I的寄生虫感染

公开(公告)号：US20090280982A1

公开(公告)日：2009-11-12

申请号：US12440120

申请日：2007-09-11

申请人： Michael Puhl ,  Liliana Parra Rapado ,  Michael Rack ,  Jan Klaas Lohmann ,  Wassilios Grammenos ,  Wolfgang von Deyn ,  Jürgen Langewald ,  Ernst Baumann ,  Hassan Oloumi-Sadeghi ,  Douglas D. Anspaugh ,  Deborah L. Culbertson

发明人： Michael Puhl ,  Liliana Parra Rapado ,  Michael Rack ,  Jan Klaas Lohmann ,  Wassilios Grammenos ,  Wolfgang von Deyn ,  Jürgen Langewald ,  Ernst Baumann ,  Hassan Oloumi-Sadeghi ,  Douglas D. Anspaugh ,  Deborah L. Culbertson

IPC分类号： A01N25/26 ,  C07D215/36 ,  A01N43/42 ,  A01P7/00 ,  A01P7/04 ,  A01P7/02 ,  A01P5/00

CPC分类号： C07D215/12 ,  C07D215/18 ,  C07D215/20

摘要： The present invention relates to novel biphenyl-4-sulfonicacid (quinolin-4-ylmethyl)-amide compounds of formula (I) wherein R1 and R2 are halogen, OH, CN, NH2, NO2, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-alkyl-sulfinyl, C1-C6-alkylsulfonyl, etc.; R3, R4, R5, R6 are halogen, H, CN, NH2, NO2, OH, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkyl-sulfonyl, etc.; m is 0, 1, 2, 3, 4, or 5; and n is 1 or 2; and the N-oxides and salts thereof, and their use for combating arthropod pests and nematodes, and also to compositions comprising such compounds as active component. The present invention also relates to a method for controlling arthropod pests or nematode pests.

摘要翻译： 本发明涉及式（I）的新型联苯-4-磺酸（喹啉-4-基甲基） - 酰胺化合物，其中R 1和R 2是卤素，OH，CN，NH 2，NO 2，C 1 -C 6烷基，C 2 -C 6 - 烯基，C2-C6-炔基，C3-C7-环烷基，C1-C6-烷氧基，C1-C6-卤代烷基，C1-C6-卤代烷氧基，C1-C6-烷硫基，C1-C6烷基亚磺酰基，C1-C6 - 烷基磺酰基等; R3，R4，R5，R6是卤素，H，CN，NH2，NO2，OH，C1-C6-烷基，C1-C6-烷氧基，C1-C6-卤代烷基，C1-C6-卤代烷氧基，C1-C6-烷硫基， C 1 -C 6烷基亚磺酰基，C 1 -C 6烷基磺酰基等; m为0,1,2,3,4或5; n为1或2; 及其N-氧化物及其盐，以及它们用于防治节肢动物害虫和线虫的用途，以及包含这些化合物作为活性成分的组合物。 本发明还涉及一种防治节肢动物害虫或线虫害虫的方法。