公开(公告)号：US10189883B2

公开(公告)日：2019-01-29

申请号：US15460917

申请日：2017-03-16

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Paul E. Morin ,  Daniel Cohen ,  Ranjan Mukherjee ,  Timothy P. Reilly ,  Rose C. Christian ,  Dasa Lipovsek ,  Ray Camphausen ,  John Krupinski

IPC: A61K38/18 ,  C07K14/50 ,  A61K45/06 ,  A61K47/60 ,  A61K38/00

Abstract: Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.

公开(公告)号：US10150962B2

公开(公告)日：2018-12-11

申请号：US15142651

申请日：2016-04-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Dasa Lipovsek

IPC: C40B30/04 ,  C12N15/10 ,  G01N33/68

Abstract: This application provides an improved screening method for the selection of target-binding proteins having desirable biophysical properties. The method combines mRNA display and yeast surface display in a way that takes advantage of the desirable attributes of both processes.

公开(公告)号：US20180222960A1

公开(公告)日：2018-08-09

申请号：US15891492

申请日：2018-02-08

Applicant: Bristol-Myers Squibb Company

Inventor： Gene M. DUBOWCHIK ,  Olafur S. Gudmundsson ,  Xiaojun Han ,  R. Michael Lawrence ,  Dasa Lipovsek ,  Cort S. Madsen ,  Claudio Mapelli ,  Paul E. Morin ,  Michael C. Myers

IPC: C07K14/64 ,  C07K1/107 ,  A61P9/00 ,  A61K47/64

CPC classification number: C07K14/64 ,  A61K38/00 ,  A61K45/06 ,  A61K47/64 ,  A61P9/00 ,  C07K1/1077

Abstract: The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.

公开(公告)号：US09765132B2

公开(公告)日：2017-09-19

申请号：US13757668

申请日：2013-02-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Jonathan Davis ,  Dasa Lipovsek ,  Ray Camphausen

IPC: C40B40/10 ,  C07K14/78 ,  C07K14/47 ,  G01N33/68 ,  C12N15/10 ,  C07K16/24 ,  C07K16/28

CPC classification number: C07K14/78 ,  A61K38/00 ,  C07K14/47 ,  C07K16/241 ,  C07K16/244 ,  C07K16/28 ,  C07K16/2833 ,  C07K16/2857 ,  C07K2317/92 ,  C07K2318/20 ,  C12N15/1062 ,  C40B40/10 ,  G01N33/68 ,  G01N33/6887

Abstract: Fibronectin type III (10Fn3) binding domains having novel designs that are associated with reduced immunogenicity are provided. The application describes alternative 10Fn3 binding domains in which certain immunogenic regions are not modified when producing a binder in order to maintain recognition as a self antigen by the host organism. The application also describes 10Fn3 binding domains in which HLA anchor regions have been destroyed thereby reducing the immunogenic contribution of the adjoining region. Also provided are 10Fn3 domains having novel combinations of modified regions that can bind to a desired target with high affinity.

公开(公告)号：US20160237423A1

公开(公告)日：2016-08-18

申请号：US15142651

申请日：2016-04-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Dasa Lipovsek

IPC: C12N15/10

CPC classification number: C12N15/1037 ,  C40B30/04 ,  G01N33/6845

Abstract: This application provides an improved screening method for the selection of target-binding proteins having desirable biophysical properties. The method combines mRNA display and yeast surface display in a way that takes advantage of the desirable attributes of both processes.

Abstract translation: 该应用提供了选择具有所需生物物理性质的靶结合蛋白的改进的筛选方法。 该方法结合mRNA显示和酵母表面显示，以利用两个过程的期望属性。

公开(公告)号：US08933199B2

公开(公告)日：2015-01-13

申请号：US14025253

申请日：2013-09-12

Applicant: Bristol-Myers Squibb Company

Inventor： Sharon Cload ,  Linda Engle ,  Dasa Lipovsek ,  Malavi Madireddi ,  Ginger Chao Rakestraw ,  Joanna Swain ,  Wenjun Zhao ,  Martin J. Corbett ,  Alexander T. Kozhich

IPC: C07K14/00 ,  C07K16/00 ,  C07K14/78 ,  C07K16/46 ,  A61K38/39 ,  A61K47/48 ,  A61K45/06 ,  G01N33/74 ,  C07K14/435

CPC classification number: A61K38/39 ,  A61K38/00 ,  A61K38/17 ,  A61K38/1709 ,  A61K45/06 ,  A61K47/60 ,  A61K47/642 ,  C07K14/435 ,  C07K14/765 ,  C07K14/78 ,  C07K14/79 ,  C07K16/18 ,  C07K16/46 ,  C07K2319/30 ,  C07K2319/31 ,  G01N33/74

Abstract: The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.

公开(公告)号：US20140179551A1

公开(公告)日：2014-06-26

申请号：US14117689

申请日：2012-05-16

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Dasa Lipovsek

IPC: C12N15/10

CPC classification number: C12N15/1037 ,  C40B30/04 ,  G01N33/6845

Abstract: This application provides an improved screening method for the selection of target-binding proteins having desirable biophysical properties. The method combines mRNA display and yeast surface display in a way that takes advantage of the desirable attributes of both processes.

Abstract translation: 该应用提供了选择具有所需生物物理性质的靶结合蛋白的改进的筛选方法。 该方法结合mRNA显示和酵母表面显示，以利用两个过程的期望属性。