摘要:
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds
摘要:
A file system can be provided in a capture system to efficiently read and write captured objects. In one embodiment, such a file system includes a plurality of queues to queue captured objects to be written to a disk, each queue being associated with one of a plurality of object types, and each queue containing captured objects of the type associated with each queue. A scheduler can be provided to select one of the plurality of queues, and a block manager to select a partition of a disk, the partition being associated with the object type of the captured objects in the selected queue. A disk controller configured to write contiguous blocks of data from the selected queue to the selected partition is connected to the block manager to enable writing to a disk.
摘要:
Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要:
A method and device for authenticating a MS has an R-UIM by using CAVE Algorithm are provided. The hardware structure of the device includes a cdma2000/HRPD dual-mode chip, a User Identity Module supporting the CAVE algorithm. The dual-mode terminal forms the NAI value with the domain name stored in a memory of the dual-mode terminal in advance by the IMSI. The dual-mode terminal extracts a RAND that is necessary for the calculation of an authentication parameters from the Random values included in a Chap Challenge message, instructs the R-UIM card to use the CAVE algorithm to calculate the authentication parameters with the RAND and an exsiting SSD_A in the R-UIM card, and bears the authentication parameters by the Result domain of a Chap Response message. With the present invention, the wastes caused by the replacement of R-UIM cards can be avoided.
摘要:
Disclosed are compounds of formula (I): wherein the variables R1, R2, R3 and Z are described herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要:
Compounds according to the following formula (I): wherein the variables Q and R1 to R6 are as described herein, which reversibly inhibit the cysteine proteases, such as cathepsins K, S, F, L and B; pharmaceutical compositions containing such compounds, and method of treating diseases and pathological conditions exacerbated by these cysteine proteases such as, but not limited to rheumatoid arthritis, multiple sclerosis and other autoimmune diseases, osteoporosis, asthma, Alzheimer's disease, atherosclerosis and endometriosis.
摘要:
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds.
摘要:
The present invention, generally speaking, provides compact design of optical couplers for combining two differently polarized light beams onto a collimator or splitting a composed light beam into two differently polarized light beams. According to another embodiment, the size of the polarization beam combiner is minimized by using a pair of specially designed fiber collimators that use an asymmetrical sleeve. As a result, a coupler, according to the present invention, uses less components, is of small in size and provides an easy-aligning structure. Further the coupler offers lower optical insertion loss with minimized physical size.
摘要:
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds.
摘要:
Using wireless packet loss data in the encoding of video data. In one embodiment, the method includes receiving wireless packet loss data at a wireless transmit receive unit (WTRU); generating video packet loss data from the wireless packet loss data, and providing the video packet loss data to a video encoder application running on the WTRU for use in encoding video data. The video encoder may perform an error propagation reduction process in response to the video packet loss data. The error propagation reduction process includes one or more of generating an instantaneous Decode Refresh frame or generating an Intra Refresh frame. Some embodiments may be characterized as using a reference picture selection method, or a reference set of pictures selection method.